公开(公告)号：WO2015175487A1

公开(公告)日：2015-11-19

申请号：PCT/US2015/030303

申请日：2015-05-12

Applicant: NOVARTIS AG ,  CHOI, Ha-Soon ,  LAJINESS, James Paul ,  NATALA, Srinivasa Reddy ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James ,  WANG, Zhicheng

Inventor： CHOI, Ha-Soon ,  LAJINESS, James Paul ,  NATALA, Srinivasa Reddy ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James ,  WANG, Zhicheng

IPC: C07D491/18 ,  C07D493/08 ,  A61K31/352 ,  A61K31/44 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/506 ,  A61P19/02

CPC classification number: A61K31/443 ,  A61K31/34 ,  A61K31/351 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4245 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/06 ,  C07D491/18 ,  C07D493/08 ,  C12N5/0655 ,  C12N2501/999 ,  C12N2506/1346

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用这些化合物治疗哺乳动物的关节损伤或关节损伤以及诱导间充质干细胞分化为软骨细胞的方法。

公开(公告)号：WO2009042711A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/077558

申请日：2008-09-24

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  CAO, Sheldon X. ,  FEHER, Victoria ,  ICHIKAWA, Takashi ,  JONES, Benjamin ,  KALDOR, Stephen W. ,  KIRYANOV, Andre A. ,  LIU, Yan ,  MCBRIDE, Christopher ,  NATALA, Srinivasa Reddy ,  NIE, Zhe ,  STAFFORD, Jeffrey A. ,  LAM, Betty

Inventor： CAO, Sheldon X. ,  FEHER, Victoria ,  ICHIKAWA, Takashi ,  JONES, Benjamin ,  KALDOR, Stephen W. ,  KIRYANOV, Andre A. ,  LIU, Yan ,  MCBRIDE, Christopher ,  NATALA, Srinivasa Reddy ,  NIE, Zhe ,  STAFFORD, Jeffrey A. ,  LAM, Betty

IPC: A61K31/4545 ,  C07D487/04 ,  C07D487/14 ,  A61P37/08 ,  A61P11/00

CPC classification number: C07D487/04 ,  C07D487/14 ,  C07D519/00

Abstract: Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供下式的化合物与激酶一起使用：（I）其中变量如本文所定义。 还提供了包含此类化合物的药物组合物，试剂盒和制品; 用于制备该化合物的方法和中间体; 和使用所述化合物的方法。

公开(公告)号：WO2010025073A1

公开(公告)日：2010-03-04

申请号：PCT/US2009/054414

申请日：2009-08-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  CAO, Sheldon X. ,  ICHIKAWA, Takashi ,  KIRYANOV, Andre, A. ,  MCBRIDE, Christopher ,  NATALA, Srinivasa, Reddy ,  KALDOR, Stephen, W. ,  STAFFORD, Jeffrey, A.

Inventor： CAO, Sheldon X. ,  ICHIKAWA, Takashi ,  KIRYANOV, Andre, A. ,  MCBRIDE, Christopher ,  NATALA, Srinivasa, Reddy ,  KALDOR, Stephen, W. ,  STAFFORD, Jeffrey, A.

IPC: C07D487/14 ,  A61K31/519 ,  A61P35/00 ,  A61P29/00

CPC classification number: C07D487/14

Abstract: The present invention provides PLK inhibitors of the formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.

Abstract translation: 本发明提供式（I）的PLK抑制剂，其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用该化合物的方法。

公开(公告)号：WO2009042711A4

公开(公告)日：2009-06-04

申请号：PCT/US2008077558

申请日：2008-09-24

Applicant: TAKEDA PHARMACEUTICAL ,  CAO SHELDON X ,  FEHER VICTORIA ,  ICHIKAWA TAKASHI ,  JONES BENJAMIN ,  KALDOR STEPHEN W ,  KIRYANOV ANDRE A ,  LIU YAN ,  MCBRIDE CHRISTOPHER ,  NATALA SRINIVASA REDDY ,  NIE ZHE ,  STAFFORD JEFFREY A ,  LAM BETTY

Inventor： CAO SHELDON X ,  FEHER VICTORIA ,  ICHIKAWA TAKASHI ,  JONES BENJAMIN ,  KALDOR STEPHEN W ,  KIRYANOV ANDRE A ,  LIU YAN ,  MCBRIDE CHRISTOPHER ,  NATALA SRINIVASA REDDY ,  NIE ZHE ,  STAFFORD JEFFREY A ,  LAM BETTY

IPC: A61K31/4545 ,  A61P11/00 ,  A61P37/08 ,  C07D487/04 ,  C07D487/14

CPC classification number: C07D487/04 ,  C07D487/14 ,  C07D519/00

Abstract: Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供下式的化合物用于激酶：（I），其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：WO2009067547A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084078

申请日：2008-11-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  CAO, Sheldon X. ,  FEHER, Victoria ,  ICHIKAWA, Takashi ,  JONES, Benjamin ,  KALDOR, Stephen W. ,  KIRYANOV, Andre A. ,  LAM, Betty ,  LIU, Yan ,  MCBRIDE, Christopher ,  NATALA, Srinivasa Reddy ,  NIE, Zhe ,  STAFFORD, Jeffrey A.

Inventor： CAO, Sheldon X. ,  FEHER, Victoria ,  ICHIKAWA, Takashi ,  JONES, Benjamin ,  KALDOR, Stephen W. ,  KIRYANOV, Andre A. ,  LAM, Betty ,  LIU, Yan ,  MCBRIDE, Christopher ,  NATALA, Srinivasa Reddy ,  NIE, Zhe ,  STAFFORD, Jeffrey A.

IPC: C07D487/04 ,  A61K31/551 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: Compounds of the following formula are provided for use with kinases, wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供下式的化合物用于激酶，其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。