公开(公告)号：WO2012087616A2

公开(公告)日：2012-06-28

申请号：PCT/US2011/064207

申请日：2011-12-09

Applicant: ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC ,  COOPER, Kevin, L. ,  MARTIN, Alisha ,  NATARAJAN, Sriram ,  VETRECIN, Robert ,  LIU, Changdeng

Inventor： COOPER, Kevin, L. ,  MARTIN, Alisha ,  NATARAJAN, Sriram ,  VETRECIN, Robert ,  LIU, Changdeng

IPC: C08J3/28

CPC classification number: C08J3/28 ,  B29C59/14 ,  C08J7/12 ,  Y10T428/24355

Abstract: A method of surface modification of a biocompatible, biodegradable polymer substrate using RF plasma treatment is disclosed. This method and the resulting surface provide for enhanced adhesion and proliferation of cells, such as hKDCs, and can be used with scaffolds for tissue regeneration and with other delivery vehicles such as medical devices.

Abstract translation: 公开了使用RF等离子体处理对生物相容性生物可降解聚合物基材进行表面改性的方法。 这种方法和所产生的表面提供了增强的细胞如hKDC的粘附和增殖，并且可以与用于组织再生的支架以及与其他递送载体如医疗装置一起使用。

公开(公告)号：WO2012030570A1

公开(公告)日：2012-03-08

申请号：PCT/US2011/048584

申请日：2011-08-22

Applicant: ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATARAJAN, Sriram ,  COOPER, Kevin ,  ELMOUELHI, Noha ,  VYAKARNAM, Murty, N. ,  YEE, Low, Hong ,  RODRIGUEZ, Isabel ,  TIONG, Lim, Chee ,  YEE, Audrey, Ho Yoke

Inventor： NATARAJAN, Sriram ,  COOPER, Kevin ,  ELMOUELHI, Noha ,  VYAKARNAM, Murty, N. ,  YEE, Low, Hong ,  RODRIGUEZ, Isabel ,  TIONG, Lim, Chee ,  YEE, Audrey, Ho Yoke

IPC: C09J7/00 ,  A61B17/08 ,  A61L31/04 ,  A61L31/06 ,  A61F2/00 ,  B29C33/52

CPC classification number: C09J7/00 ,  A61B2017/00871 ,  A61B2017/00938 ,  A61B2017/00942 ,  A61B2017/00951 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  A61L24/106 ,  B29C33/424 ,  B29C33/52 ,  C09J2201/626 ,  C09J2423/106 ,  C09J2467/006 ,  Y10T428/24008 ,  C08L67/04 ,  C08L23/12

Abstract: An adhesive structure is provided comprising a surface from which extend substantially cylindrical protrusions comprising a stiff resin having a Young's modulus of greater than 17 MPa. The protrusions are of sufficiently low diameter to promote adhesion by physical attractive forces, e.g., Van der Waals attractive forces, as measured by shear adhesion between the adhesive structure and a target surface. A method for preparing the structure is provided as well as a combination of the adhesive structure and target surface.

Abstract translation: 提供了一种粘合剂结构，其包括表面，从该表面延伸出基本上圆柱形的突起，其包括具有大于17MPa的杨氏模量的刚性树脂。 突起具有足够低的直径，以通过物理吸引力（例如，通过粘合剂结构和目标表面之间的剪切粘合力测量的范德华力吸引力）来促进粘附。 提供了制备该结构的方法以及粘合剂结构和目标表面的组合。

公开(公告)号：WO2007100356A3

公开(公告)日：2007-12-13

申请号：PCT/US2006038505

申请日：2006-10-02

Applicant: UNIV UTAH RES FOUND ,  GALE BRUCE K ,  MYSZKA DAVID ,  CHANG-YEN DAVID A ,  NATARAJAN SRIRAM ,  ECKMAN JOSH

Inventor： GALE BRUCE K ,  MYSZKA DAVID ,  CHANG-YEN DAVID A ,  NATARAJAN SRIRAM ,  ECKMAN JOSH

IPC: B01L3/02 ,  G01N1/10

CPC classification number: G01N33/553 ,  B01J19/0046 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/021 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2400/0487 ,  C12N15/1093 ,  G01N35/1074 ,  G01N2035/00158 ,  G01N2035/1039 ,  Y10T436/2575

Abstract: Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter (10) may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells (22, 24), microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connect to two wells via microconduits (26, 28). When the spotter contacts a surface (30), a seal is formed between th orifices (27) and the surface. The same or different substances may be flowed across each orifice. Any numb of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.

Abstract translation: 公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。 斑点（10）可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。 它也可以用于在同一点上执行各种化学步骤。 点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。 识别器可以由井板处理设备装载。 点样器使用井（22,24），微流体导管和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。 每个孔通过微管连接到两个孔（26,28）。 当检测器接触表面（30）时，在孔口（27）和表面之间形成密封。 相同或不同的物质可能流过每个孔口。 任何麻木的孔都可以并入到一个点样器中。 鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

公开(公告)号：WO2007100356A2

公开(公告)日：2007-09-07

申请号：PCT/US2006/038505

申请日：2006-10-02

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  GALE, Bruce, K. ,  MYSZKA, David ,  CHANG-YEN, David, A. ,  NATARAJAN, Sriram ,  ECKMAN, Josh

Inventor： GALE, Bruce, K. ,  MYSZKA, David ,  CHANG-YEN, David, A. ,  NATARAJAN, Sriram ,  ECKMAN, Josh

CPC classification number: G01N33/553 ,  B01J19/0046 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/021 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2400/0487 ,  C12N15/1093 ,  G01N35/1074 ,  G01N2035/00158 ,  G01N2035/1039 ,  Y10T436/2575

Abstract: Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein, cells, or other substances on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microconduits, and orifices to deliver the substances. Each orifice may be connected to two wells via microconduits. When the spotter face contacts a surface, a seal is formed between the orifices in the spotter face and the surface. The same or different substances may be flowed to each orifice and over the surface, thereby forming an array of spots on the surface. Any number of wells, microconduits, and orifices may be incorporated into a spotter.

Abstract translation: 公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。 斑点斑块可用于将高浓度的蛋白质，细胞或其他物质的斑点沉积在微阵列载玻片，晶片或其他表面上。 它也可以用于在同一点上执行各种化学步骤。 点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。 识别器可以由井板处理设备装载。 检测员使用井，微管道和孔口来输送物质。 每个孔可以通过微管连接到两个孔。 当检查器面接触表面时，在检查器面和表面之间的孔口之间形成密封。 相同或不同的物质可以流到每个孔口和表面上，从而在表面上形成点阵列。 任何数量的井，微管和孔可以并入到一个点样器中。

公开(公告)号：WO2005065161A2

公开(公告)日：2005-07-21

申请号：PCT/US2004/041730

申请日：2004-12-13

Applicant: CISCO TECHNOLOGY, INC. ,  NATARAJAN, Sriram ,  SHARAT, Prasad

Inventor： NATARAJAN, Sriram ,  SHARAT, Prasad

IPC: G06F3/00 ,  H04L12/56

CPC classification number: H04L47/10 ,  H04L47/30 ,  H04L47/39 ,  H04L49/357

Abstract: Oversubscription of Fibre Channel links over a transport network is provided. A transport interface according to the present invention may maintain a small ingress buffer in addition to the normal egress buffer. The ingress buffer is primarily used for oversubscription and the egress buffer is primarily used for flow control. Ready indications to multiple local Fibre Channel ports may be locally generated when flow control conditions permit and may be distributed among the local Fibre Channel ports in response to preconfigured bandwidth sharing weights. Transport network efficiency is achieved by statistical multiplexing without significant increase in buffer memory requirements or introduction of latency into the flow control mechanism.

Abstract translation: 提供了通过传输网络的光纤通道链路的超订阅。 根据本发明的传输接口除了普通出口缓冲器之外，还可以保持小的入口缓冲器。 入口缓冲区主要用于超额预订，出口缓冲区主要用于流量控制。 当流量控制条件允许并且可以在本地光纤通道端口之间分配以响应预配置的带宽共享权重时，本地可以在本地生成多个本地光纤通道端口的就绪指示。 传输网络效率是通过统计复用来实现的，而不会显着增加缓冲存储器要求或将延迟引入流控制机制。

公开(公告)号：WO2004095233A2

公开(公告)日：2004-11-04

申请号：PCT/US2004/008603

申请日：2004-03-22

Applicant: CISCO TECHNOLOGY, INC. ,  NATARAJAN, Sriram ,  PRASAD, Sharat ,  DENG, Yu ,  WANG, Yanfeng

Inventor： NATARAJAN, Sriram ,  PRASAD, Sharat ,  DENG, Yu ,  WANG, Yanfeng

IPC: G06F

CPC classification number: H04L47/10 ,  H04J3/1617 ,  H04L47/30 ,  H04L47/39

Abstract: The Fibre-Channel flow control mechanism is augmented to facilitate efficient data exchange between Fibre-Channel ports over extended distances. A supplemental buffer mechanism may be maintained as part of an interface to a transport network used to carry Fibre-Channel traffic. The transport network interface makes a remote Fibre-Channel port aware of the augmented local receiver buffer capacity by intercepting certain frames used in link establishment and substituting an enhanced buffer capacity for the local Fibre-Channel port's internal buffer capacity. This technique provides improved throughput and readily accommodates large distances and large frame sizes.

公开(公告)号：WO2012162452A2

公开(公告)日：2012-11-29

申请号：PCT/US2012039256

申请日：2012-05-24

Applicant: ATRM LLC ,  AGENCY SCIENCE TECH & RES ,  ELMOUELHI NOHA ,  COOPER KEVIN ,  NATARAJAN SRIRAM ,  LOW HONG YEE ,  RODRIGUEZ ISABEL ,  LUONG-VAN EMMA KIM

Inventor： ELMOUELHI NOHA ,  COOPER KEVIN ,  NATARAJAN SRIRAM ,  LOW HONG YEE ,  RODRIGUEZ ISABEL ,  LUONG-VAN EMMA KIM

IPC: B01J20/26 ,  B01J20/28 ,  B01J20/30

CPC classification number: B01J20/3057 ,  B01J20/265 ,  B01J20/268 ,  B01J20/28042 ,  B01J20/3007

Abstract: A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm - 50 µm and height greater than 1 µm.

Abstract translation: 通过将聚合物底物形成具有可以控制其生物吸附性能的高表面积形貌的结构来制备生物吸附剂，例如蛋白质吸附剂材料。 这些优化的高表面积形貌的这些结构的生物吸附通过温和处理表面，例如通过氧等离子体而没有基本上改变形貌而增加。 结构可以具有定制的几何特征，包括直径为100nm-50μm，高度大于1μm的微结构，例如柱。

公开(公告)号：WO2012087616A3

公开(公告)日：2012-08-23

申请号：PCT/US2011064207

申请日：2011-12-09

Applicant: ATRM LLC ,  COOPER KEVIN L ,  MARTIN ALISHA ,  NATARAJAN SRIRAM ,  VETRECIN ROBERT ,  LIU CHANGDENG

Inventor： COOPER KEVIN L ,  MARTIN ALISHA ,  NATARAJAN SRIRAM ,  VETRECIN ROBERT ,  LIU CHANGDENG

IPC: C08J3/28 ,  B29C59/14 ,  C08J7/12

CPC classification number: C08J3/28 ,  B29C59/14 ,  C08J7/12 ,  Y10T428/24355

Abstract: A method of surface modification of a biocompatible, biodegradable polymer substrate using RF plasma treatment is disclosed. This method and the resulting surface provide for enhanced adhesion and proliferation of cells, such as hKDCs, and can be used with scaffolds for tissue regeneration and with other delivery vehicles such as medical devices.

Abstract translation: 公开了使用RF等离子体处理的生物相容性可生物降解的聚合物基材的表面改性方法。 该方法和所得表面提供细胞如hKDC的增强的粘附和增殖，并且可以与用于组织再生的支架以及与其它递送载体如医疗装置一起使用。

公开(公告)号：WO2010034010A3

公开(公告)日：2010-07-08

申请号：PCT/US2009057901

申请日：2009-09-22

Applicant: WASATCH MICROFLUIDICS ,  MYSZKA DAVID ,  GALE BRUCE K ,  ECKMAN JOSHUA WAYNE ,  NATARAJAN SRIRAM

Inventor： MYSZKA DAVID ,  GALE BRUCE K ,  ECKMAN JOSHUA WAYNE ,  NATARAJAN SRIRAM

IPC: G01N33/48 ,  G01N33/50

CPC classification number: C40B60/12 ,  B01J2219/0036 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01L3/0262 ,  B01L3/5027 ,  B01L2200/0689 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2400/0487 ,  G01N33/54366

Abstract: Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.

Abstract translation: 利用专门的微流体网络将物质沉积在传感器表面上。 特别是，基于流动的微流体打印头被用作将多种分析物传送到传感器以进行同时分析的接口。 此外，内部参考被纳入传感器区域以提高灵敏度。

公开(公告)号：WO2005065161A3

公开(公告)日：2006-07-27

申请号：PCT/US2004041730

申请日：2004-12-13

Applicant: CISCO TECH INC ,  NATARAJAN SRIRAM ,  SHARAT PRASAD

Inventor： NATARAJAN SRIRAM ,  SHARAT PRASAD

IPC: H04L12/28 ,  G06F3/00 ,  H04L12/56

CPC classification number: H04L47/10 ,  H04L47/30 ,  H04L47/39 ,  H04L49/357

Abstract: Oversubscription of Fibre Channel links over a transport network (110) is provided. A transport interface (112) according to the present invention may maintain a small ingress buffer (109) in addition to the normal egress buffer (116). The ingress buffer is primarily used for oversubscription and the egress buffer is primarily used for flow control. Ready indications to multiple local Fibre Channel ports (102) may be locally generated when flow control conditions permit and may be distributed among the local Fibre Channel ports in response to preconfigured bandwidth sharing weights. Transport network efficiency is achieved by statistical multiplexing without significant increase in buffer memory requirements or introduction of latency into the flow control mechanism.

Abstract translation: 提供了通过传输网络（110）的光纤通道链路的超订阅。 根据本发明的传输接口（112）除了普通出口缓冲器（116）之外，还可以保持小的入口缓冲器（109）。 入口缓冲区主要用于超额预订，出口缓冲区主要用于流量控制。 当流量控制条件允许并且可以在本地光纤通道端口之间分配响应于预配置的带宽共享权重时，可以在本地生成多个本地光纤通道端口（102）的就绪指示。 传输网络效率是通过统计复用来实现的，而不会显着增加缓冲存储器要求或将延迟引入流控制机制。