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1.发明申请ENHANCING DNA REPAIR AND PREVENTING AGING AND ITS CONSEQUENCES IN REPRODUCTIVE AND OTHER CELLS 审中-公开增强生殖细胞和其他细胞的DNA修复和预防衰老及其后果
公开(公告)号：WO2017223152A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038456
申请日：2017-06-21
发明人： OKTAY, Kutluk
IPC分类号： A61K31/66 , A61K31/661 , A61P15/08
CPC分类号： A61K31/661 , A61P15/08 , C12N5/061
摘要： Embodiments of the present invention generally relate to methods for improving male fertility, and in particular for using sphingosine 1 phosphate (S I P) for improving the quality and/or longevity of sperm.
摘要翻译： 本发明的实施方案一般涉及用于改善雄性生育能力的方法，特别是用于使用鞘氨醇1磷酸盐（SIP）来改善精子的质量和/或寿命。
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公开(公告)号：WO2012048010A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/054941
申请日：2011-10-05
发明人： ANVERSA, Piero
IPC分类号： A61K35/12 , C12N5/02 , A61K35/28 , A61K35/34 , A61K35/407 , A61K35/39 , A61K35/42 , A61K35/38 , A61K35/30 , A61K35/44 , A61K35/36
CPC分类号： A61K35/34 , A61K2035/124 , C12N5/0647 , C12N5/0657 , C12N5/0687 , C12N2500/25 , C12N2500/40 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12
摘要： Compositions of isolated adult organ stem cells, including hematopoietic stem cells, cardiac stem cells, and kidney stem cells, are disclosed. In particular, the present invention provides c-kit positive, lineage negative adult stem cells that can be isolated from adult organ tissue. Such stem cells are capable of generating all the cell lineages of the organ tissue from which they were isolated. Methods for repairing damaged organ tissue with the isolated organ stem cells are also disclosed.
摘要翻译： 公开了分离的成体器官干细胞，包括造血干细胞，心脏干细胞和肾干细胞的组合物。 特别地，本发明提供可从成体器官组织分离的c-kit阳性，谱系阴性成体干细胞。 这样的干细胞能够产生它们被分离的器官组织的全部细胞谱系。 还公开了用分离的器官干细胞修复损伤的器官组织的方法。
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3.发明申请METHODS FOR THE REPAIR AND/OR REGENERATION OF DAMAGED MYOCARDIUM USING VARIANTS OF HEPATOCYTE GROWTH FACTOR 审中-公开使用肝细胞生长因子变量修复和/或再生损伤的心肌细胞的方法
公开(公告)号：WO2009062143A3
公开(公告)日：2010-01-07
申请号：PCT/US2008082967
申请日：2008-11-10
发明人： ANVERSA PIERO
CPC分类号： A61K38/1833 , A61K33/04 , A61K35/16 , A61K38/1808 , A61K38/1825 , A61K38/28 , A61K38/30 , A61K38/40 , A61K45/06 , A61K2300/00
摘要： Methods for repairing damaged myocardium and/or myocardial cells including the administration of variants of hepatocyte growth factor or activated cardiac stem cells are disclosed and claimed. In addition, methods for forming coronary vasculature including the administration of variants of hepatocyte growth factor or activated cardiac stem cells are described. In particular, administration of variants of hepatocyte growth factor, such as NK1, 1K1, and HP11, are useful for the repair and/or regeneration of damaged myocardium or formation of coronary vasculature. Methods of activating cardiac stem cells in vitro are also disclosed.
摘要翻译： 公开并要求保护用于修复损伤的心肌和/或心肌细胞的方法，包括给予肝细胞生长因子或活化的心脏干细胞的变体。 此外，描述了形成冠状动脉脉管系统的方法，包括给予肝细胞生长因子或活化的心脏干细胞的变体。 特别地，肝细胞生长因子（例如NK1，1K1和HP11）的变体的施用可用于损伤心肌的修复和/或再生或冠状动脉脉管系统的形成。 还公开了体外激活心脏干细胞的方法。
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4.发明申请METHODS AND COMPOSITIONS FOR THE REPAIR AND/OR REGENERATION OF DAMAGED MYOCARDIUM USING CYTOKINES AND VARIANTS THEREOF 审中-公开使用细胞因子及其变体修复和/或再生损伤的心肌细胞的方法和组合物
公开(公告)号：WO2009062143A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/082967
申请日：2008-11-10
发明人： ANVERSA, Piero
CPC分类号： A61K38/1833 , A61K33/04 , A61K35/16 , A61K38/1808 , A61K38/1825 , A61K38/28 , A61K38/30 , A61K38/40 , A61K45/06 , A61K2300/00
摘要： Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of cytokines, variants of cytokines, cardiac stem cells, or combinations thereof are disclosed and claimed. In addition, methods, compositions, and kits for forming coronary vasculature including the administration of cytokines, variants of cytokines, cardiac stem cells, or combinations thereof are described. In particular, administration of variants of hepatocyte growth factor, such as NK1, 1K1, and HP11, are useful for the repair and/or regeneration of damaged myocardium or formation of coronary vasculature. Methods of activating cardiac stem cells in vitro are also disclosed.
摘要翻译： 公开和要求保护用于修复损伤的心肌和/或心肌细胞的方法，组合物和试剂盒，包括细胞因子的施用，细胞因子的变体，心脏干细胞或其组合。 此外，描述了用于形成冠状动脉脉管系统的方法，组合物和试剂盒，包括细胞因子的施用，细胞因子的变体，心脏干细胞或其组合。 特别地，肝细胞生长因子（例如NK1，1K1和HP11）的变体的施用可用于损伤心肌的修复和/或再生或冠状动脉脉管系统的形成。 还公开了体外激活心脏干细胞的方法。
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公开(公告)号：WO2009038742A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/010860
申请日：2008-09-18
申请人： CARITAS ST. ELIZABETH'S MEDICAL CENTER OF BOSTON, INC. , NEW YORK MEDICAL COLLEGE , LIANGOS, Orfeas , ADDABBO, Francesco , GOLIGORSKY, Michael , JABER, Bertrand, L.
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/50
摘要： Methods and products for identifying subjects at risk of acute kidney injury (AKI) are provided according to the invention. Included, for instance, are diagnostic kits and methods involving the use of at least two AKI associated markers.
摘要翻译： 根据本发明提供了用于鉴定处于急性肾损伤（AKI）风险中的受试者的方法和产品。 例如，包括使用至少两个AKI相关标记的诊断试剂盒和方法。
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公开(公告)号：WO2007126653A3
公开(公告)日：2008-10-23
申请号：PCT/US2007007008
申请日：2007-03-21
发明人： WOLIN MICHAEL
IPC分类号： A61K38/16 , A61K31/195
CPC分类号： A61K31/195
摘要： The invention relates to methods of inducing smooth muscle relaxation, for example, a method of inducing relaxation of a vascular or a non-vascular muscle or a method of inducing relaxation of the microvasculature, in a subject in need thereof by promoting the accumulation of protoporphyrin IX in the smooth muscle.
摘要翻译： 本发明涉及通过促进原卟啉的积累来诱导平滑肌松弛的方法，例如诱导血管或非血管肌松弛的方法或诱导微血管松弛的方法 IX在平滑肌中。
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7.发明申请PURINES ARE SELF-RENEWAL SIGNALS FOR NEURAL STEM CELLS, AND PURINE RECEPTOR ANTAGONISTS PROMOTE NEURONAL AND GLIAL DIFFERENTIATION THEREFROM 审中-公开产品是神经干细胞的自我更新信号，以及嘌呤受体拮抗剂促进神经元和神经元的分化
公开(公告)号：WO2005079250A3
公开(公告)日：2008-06-19
申请号：PCT/US2005004017
申请日：2005-02-10
发明人： GOLDMAN STEVEN A , NEDERGAARD MAIKEN , LIN JANE
IPC分类号： A01N61/00 , A01N37/18 , C12N5/0797
CPC分类号： C12N5/0623 , C12N2500/40 , C12N2501/999
摘要： The present invention relates to a method of inhibiting differentiation of a population of neural stem cells by contacting a purinergic receptor agonist and a population of neural stem cells under conditions effective to inhibit differentiation of the population of neural stem cells. Another aspect of the present invention relates to a method of producing neurons and/or glial cells from a population of neural stem cells by culturing a population of neural stem cells with a purinergic receptor antagonist under conditions effective to cause the neural stem cells to differentiate into neurons and/or glial cells. The purinergic receptor agonist can also be used in a method of inducing proliferation and self-renewal of neural stem cells in a subject and a method of treating a neurological disease or neurodegenerative condition in a subject. The purinergic receptor antagonist can also be used in treating a neoplastic disease of the brain or spinal cord in a subject.
摘要翻译： 本发明涉及通过在有效抑制神经干细胞群分化的条件下使嘌呤能受体激动剂和神经干细胞群接触来抑制神经干细胞群体的分化的方法。 本发明的另一方面涉及通过在有效地使神经干细胞分化成为的神经干细胞的条件下用嘌呤能受体拮抗剂培养一群神经干细胞来从神经干细胞群体产生神经元和/或神经胶质细胞的方法 神经元和/或神经胶质细胞。 嘌呤能受体激动剂也可以用于诱导受试者神经干细胞的增殖和自我更新的方法以及治疗受试者的神经疾病或神经变性病症的方法。 嘌呤能受体拮抗剂也可用于治疗受试者中脑或脊髓的肿瘤性疾病。
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公开(公告)号：WO2007100530A3
公开(公告)日：2007-09-07
申请号：PCT/US2007/004287
申请日：2007-02-15
发明人： ANVERSA, Piero
IPC分类号： C12N5/08
摘要： Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and activation of human cardiac stem cells.
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9.发明申请PURINE RECEPTOR INHIBITION AS A THERAPEUTIC STRATEGY IN SPINAL CORD AND BRAIN 审中-公开嘌呤受体抑制作为脊髓和脑的治疗策略
公开(公告)号：WO2005041892A3
公开(公告)日：2005-08-11
申请号：PCT/US2004036355
申请日：2004-11-02
IPC分类号： A61K20060101 , A61K31/33 , A61K31/47 , A61K31/496 , A61K31/4965 , A61K31/655 , A61K31/7076
摘要： The present invention is directed to a method of treating a subject with acute spinal cord injury by administering a purine receptor antagonist to the subject under conditions effective to treat spinal cord injury. The purine receptor antagonist inhibits P2X purine receptor activation. The inhibition of P2X purine receptor activation can also be used in conjunction with methods of treating a subject with spinal cord ischemia resulting from stroke or vascular insult, interruption, or mechanical injury, treating a subject with ischemic or traumatic insults of brain tissue in regions expressing P2X receptors, and for inhibiting ATP-triggered brain or spinal cord cell death.
摘要翻译： 本发明涉及通过在有效治疗脊髓损伤的条件下向受试者施用嘌呤受体拮抗剂来治疗患有急性脊髓损伤的受试者的方法。 嘌呤受体拮抗剂抑制P2X嘌呤受体激活。 P2X嘌呤受体激活的抑制还可以与治疗患有中风或血管损伤，中断或机械损伤引起的脊髓缺血的受试者的方法联合使用，治疗患有缺血性或创伤性脑组织缺血性或创伤性损伤的受试者 P2X受体，并用于抑制ATP引发的脑或脊髓细胞死亡。
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10.发明申请PURINE RECEPTOR INHIBITION AS A THERAPEUTIC STRATEGY IN SPINAL CORD AND BRAIN 审中-公开嘌呤受体抑制作为脊髓和脑中的治疗策略
公开(公告)号：WO2005041892A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036355
申请日：2004-11-02
IPC分类号： A61K
摘要： The present invention is directed to a method of treating a subject with acute spinal cord injury by administering a purine receptor antagonist to the subject under conditions effective to treat spinal cord injury. The purine receptor antagonist inhibits P2X purine receptor activation. The inhibition of P2X purine receptor activation can also be used in conjunction with methods of treating a subject with spinal cord ischemia resulting from stroke or vascular insult, interruption, or mechanical injury, treating a subject with ischemic or traumatic insults of brain tissue in regions expressing P2X receptors, and for inhibiting ATP-triggered brain or spinal cord cell death.
摘要翻译： 本发明涉及通过在有效治疗脊髓损伤的条件下向受试者施用嘌呤受体拮抗剂来治疗患有急性脊髓损伤的受试者的方法。 嘌呤受体拮抗剂抑制P2X嘌呤受体活化。 P2X嘌呤受体活化的抑制也可以与由中风或血管损伤，中断或机械损伤引起的脊髓缺血治疗受试者的方法一起使用，在表达的区域中治疗脑组织的缺血性或创伤性损伤的受试者 P2X受体，并用于抑制ATP触发的脑或脊髓细胞死亡。
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