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    METHOD FOR MODIFYING A MEDICAL IMPLANT SURFACE FOR PROMOTING TISSUE GROWTH
    1.
    发明申请
    METHOD FOR MODIFYING A MEDICAL IMPLANT SURFACE FOR PROMOTING TISSUE GROWTH 审中-公开
    用于修复用于促进组织生长的医用植入物表面的方法

    公开(公告)号：WO2008039521A2

    公开(公告)日：2008-04-03

    申请号：PCT/US2007/020865

    申请日：2007-09-26

    Applicant: NMT MEDICAL, INC. ,  KLADAKIS, Stephanie, M.

    Inventor： KLADAKIS, Stephanie, M.

    IPC: A61B17/03 ,  B29C59/00

    CPC classification number: A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00243 ,  A61L27/18 ,  A61L27/34 ,  A61L27/50 ,  B29C59/14 ,  C08L67/04 ,  C08L89/06 ,  C08L5/10

    Abstract: Disclosed is an occluder for closing an intracardiac defect, such as a patent foramen ovale (PFO), and a method for making the same. The occluder includes a frame and at least one scaffold which are formed from a bioabsorbable polymer, such as poly-4-hydroxybutyrate. The surface of the frame and scaffold are textured to promote cell attachment. Texturing of the surface can be achieved by any number of mechanical or chemical procedures. The device is coated with collagen and heparin which are covalently bound to the surface of the device. The occluder provides improved defect closure compared to other septal occluders known in the art. In particular, the occluder described is specifically designed to improve host cell attachment to and tissue ingrowth over the device when implanted in a patient as compared to the level of host cell attachment and tissue ingrowth achieved with other implantable devices made of bioabsorbable polymers.

    Abstract translation: 公开了用于闭合心内缺损的封堵器，例如卵圆孔卵孔（PFO）及其制造方法。 闭塞器包括由生物可吸收聚合物如聚-4-羟基丁酸酯形成的框架和至少一个支架。 框架和支架的表面被纹理化以促进细胞附着。 表面的纹理可以通过任何数量的机械或化学程序来实现。 该装置涂覆有共价结合到装置表面的胶原和肝素。 与本领域已知的其它间隔闭塞器相比，封堵器提供改善的缺陷闭合。 特别地，所描述的闭塞器特别设计成与植入患者体内的装置相比，与由其他可生物吸收聚合物制成的可植入装置实现的宿主细胞附着和组织向内生长相比，改善宿主细胞与组织向内生长。

    SYRINGE ACTIVATED-VALVE FOR FLUSHING A CATHETER AND METHODS THEREOF
    2.
    发明申请
    SYRINGE ACTIVATED-VALVE FOR FLUSHING A CATHETER AND METHODS THEREOF 审中-公开
    用于冲洗导管的喷射活化阀及其方法

    公开(公告)号：WO2007079135A1

    公开(公告)日：2007-07-12

    申请号：PCT/US2006/049414

    申请日：2006-12-28

    Applicant: NMT MEDICAL, INC. ,  CAHILL, Ryan, Joseph ,  KLADAKIS, Stephanie, M.

    Inventor： CAHILL, Ryan, Joseph ,  KLADAKIS, Stephanie, M.

    IPC: A61M25/00 ,  A61M39/26

    CPC classification number: A61M39/02 ,  A61M25/0097 ,  A61M39/045 ,  A61M39/225 ,  A61M39/26 ,  A61M2039/0205

    Abstract: This application relates to a syringe-activated valve (100) for flushing a catheter for delivering an implant to an anatomical site, such as a patent foramen ovale in a patient and method thereof . In one embodiment, a catheter includes a proximal end, a distal end, a "Y" connector (320) at the proximal end, the "Y" connector having a guide wire port (301) and a connector port (310), a syringe activated valve having a first end and a second end, the second end of syringe-activated valve connecting to the connector port of the "Y" connector, and a syringe (200) connecting to the first end of the syringe-activated valve. Saline is injected by the syringe through the syringe-activated valve into the proximal end of the catheter, thereby flushing air from the catheter lumen out of the distal end of the catheter.

    Abstract translation: 本申请涉及一种用于冲洗用于将植入物递送到解剖部位的导管的注射器致动阀（100），例如患者的卵圆孔卵孔及其方法。 在一个实施例中，导管包括近端，远端，在近端处的“Y”连接器（320），“Y”连接器具有导丝端口（301）和连接器端口（310） 注射器激活的阀具有第一端和第二端，注射器启动阀的连接到“Y”型连接器的连接器端口的第二端以及连接到注射器启动阀的第一端的注射器（200）。 盐水通过注射器通过注射器激活的阀注射到导管的近端中，从而将导管腔中的空气从导管的远端冲出。

    DEVICES AND METHODS FOR TREATING CARDIAC TISSUE
    3.
    发明申请
    DEVICES AND METHODS FOR TREATING CARDIAC TISSUE 审中-公开
    用于治疗心脏组织的装置和方法

    公开(公告)号：WO2007030430B1

    公开(公告)日：2007-05-24

    申请号：PCT/US2006034496

    申请日：2006-09-06

    Applicant: NMT MEDICAL INC ,  FORDE SEAN

    Inventor： FORDE SEAN

    IPC: A61B17/00

    CPC classification number: A61B18/1492 ,  A61B17/12022 ,  A61B17/12122 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475

    Abstract: The invention generally relates to devices and methods for treating cardiac tissue, including percutaneous closure of cardiac openings such as a patent foramen ovale (PFO) and obliteration of the cardiac cul-de-sacs. The invention includes a device having at least one elongated member. The elongated member has a first material and a second material interwoven with at least a portion of the first material. The second material is capable of transferring energy to tissue in need of treatment.

    Abstract translation: 本发明一般涉及用于治疗心脏组织的装置和方法，包括心脏开放的经皮闭合，例如卵圆孔卵孔（PFO）和闭塞的心脏死亡。 本发明包括具有至少一个细长构件的装置。 细长构件具有与第一材料的至少一部分交织的第一材料和第二材料。 第二种材料能够将能量转移到需要治疗的组织上。

    DEVICES AND METHODS FOR TREATING CARDIAC TISSUE
    4.
    发明申请
    DEVICES AND METHODS FOR TREATING CARDIAC TISSUE 审中-公开
    装置和方法治疗心脏组织

    公开(公告)号：WO2007030430A1

    公开(公告)日：2007-03-15

    申请号：PCT/US2006/034496

    申请日：2006-09-06

    Applicant: NMT MEDICAL, INC. ,  FORDE, Sean

    Inventor： FORDE, Sean

    IPC: A61B17/00

    CPC classification number: A61B18/1492 ,  A61B17/12022 ,  A61B17/12122 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475

    Abstract: The invention generally relates to devices and methods for treating cardiac tissue, including percutaneous closure of cardiac openings such as a patent foramen ovale (PFO) and obliteration of the cardiac cul-de-sacs. The invention includes a device having at least one elongated member. The elongated member has a first material and a second material interwoven with at least a portion of the first material. The second material is capable of transferring energy to tissue in need of treatment.

    Abstract translation: 本发明一般涉及用于治疗心脏组织的装置和方法，包括经皮闭合诸如卵圆孔未闭（PFO）等心脏开口以及闭塞心脏穹窿。 本发明包括具有至少一个细长构件的装置。 细长构件具有第一材料和与第一材料的至少一部分交织的第二材料。 第二种材料能够将能量转移至需要治疗的组织。

    SEPTAL PUNCTURE DEVICE
    8.
    发明申请
    SEPTAL PUNCTURE DEVICE 审中-公开
    SEPTAL PUNCTURE设备

    公开(公告)号：WO2004026147A3

    公开(公告)日：2004-08-12

    申请号：PCT/US0328532

    申请日：2003-09-11

    Applicant: NMT MEDICAL INC

    Inventor： CHANDUSZKO ANDRZEJ ,  CALLAGHAN DAVID J ,  WIDOMSKI DAVID

    IPC: A61B17/00 ,  A61B17/02 ,  A61B17/30 ,  A61B17/32 ,  A61B17/34

    CPC classification number: A61B17/0057 ,  A61B17/0218 ,  A61B17/30 ,  A61B17/32053 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2018/00392

    Abstract: Apparatus, systems, and methods for forming a hole in biological material, such as tissue walls, adjacent vessels or adjacent regions of an organ such that access to opposing surfaces of the biological material can be achieved. In general overview the system may include ,an elongate member for positioning and deploying a flexible member in the heart. In one embodiment apparatus and methods are provided for aligning and fixing the position of the tip of a cutting member for cutting a hole in the septal wall of a heart. In another embodiment, subsequent to cutting a tissue wall an apparatus for obstructing holes in the septal wall is inserted to limit the flow of blood through a plurality of holes in a tissue wall.

    Abstract translation: 用于在生物材料（例如组织壁，相邻容器或器官的相邻区域）中形成孔的装置，系统和方法，使得可以实现对生物材料的相对表面的接近。 总体而言，系统可以包括用于在心脏中定位和展开柔性构件的细长构件。 在一个实施例中，提供了用于对准和固定用于切割心脏隔膜壁中的孔的切割构件的尖端的位置的装置和方法。 在另一个实施例中，在切割组织壁之后，插入用于阻塞隔壁中的孔的装置以限制血液流过组织壁中的多个孔。

    HEMOSTASIS VALVE
    9.
    发明申请
    HEMOSTASIS VALVE 审中-公开
    HEMOSTASIS阀

    公开(公告)号：WO2004032993A3

    公开(公告)日：2004-07-01

    申请号：PCT/US0332133

    申请日：2003-10-10

    Applicant: NMT MEDICAL INC ,  CORE LEE A

    Inventor： CORE LEE A

    IPC: A61M20060101 ,  A61M1/00 ,  A61M5/00 ,  A61M5/14 ,  A61M5/178 ,  A61M39/06 ,  B29C33/40

    CPC classification number: A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/064

    Abstract: A hemostasis valve includes a single gland (16) with multiple offset longitudinal slits (32/34) that do no extend through the gland (16) completely. The multiple slits (32/34) from a complex pathway for the guide dilator/catheter (58) and thus a better seal. The offset slits (32/34) are joined by a lateral cut (36) in the gland. When a guide wire or dilator/catheter (58) is introduced into the introducer, the gland (16) deforms sufficiently to allow the guide wire or other device (58) to move through the first slits (32), the lateral cut (36) and the second slits (34). This complex pathway or slit provides a larger sealing surface thereby creating a better seal. As a result, effective seals may be formed around relatively large, as compared to the inner diameter of an introducer sheath, catheters.

    Abstract translation: 止血阀包括具有多个偏移纵向狭缝（32/34）的单个压盖（16），其不完全延伸穿过压盖（16）。 来自用于引导扩张器/导管（58）的复合路径的多个狭缝（32/34），因此更好的密封。 偏移狭缝（32/34）通过腺体中的横向切口（36）连接。 当引导线或扩张器/导管（58）被引入导引器时，压盖（16）充分变形，以允许引导线或其他装置（58）移动通过第一狭缝（32），横向切口（36） ）和第二狭缝（34）。 这个复杂的路径或狭缝提供了更大的密封面，从而形成更好的密封。 结果，与引导器套管的内径相比，导管可以相对较大地形成有效的密封。

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