公开(公告)号：WO2008045952A2

公开(公告)日：2008-04-17

申请号：PCT/US2007/080975

申请日：2007-10-10

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  SWAROOP, Anand ,  AKIMOTO, Masayuki ,  MEARS, Alan ,  CHENG, Hong ,  OH, Edwin, C.t.

Inventor： SWAROOP, Anand ,  AKIMOTO, Masayuki ,  MEARS, Alan ,  CHENG, Hong ,  OH, Edwin, C.t.

IPC: C12N5/06

CPC classification number: C12N5/062 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K35/44 ,  C12N15/8509 ,  C12N2501/385 ,  C12N2830/008

Abstract: The present invention relates to photoreceptor cells. In particular, the present invention provides photoreceptor cells comprising heterologous nucleic acid sequences and transgenic animals comprising the same. The present invention also provides photoreceptor precursor cells (e.g., rod photoreceptor precursor cells), and methods of identifying, characterizing, isolating and utilizing the same. Compositions and methods of the present invention find use in, among other things, research, clinical, diagnostic, drug discovery, and therapeutic applications.

Abstract translation: 本发明涉及感光细胞。 特别地，本发明提供包含异源核酸序列的感光细胞和包含其的转基因动物。 本发明还提供感光体前体细胞（例如，棒状感光体前体细胞），以及识别，表征，分离和利用该感光体前体细胞的方法。 本发明的组合物和方法尤其可用于研究，临床，诊断，药物发现和治疗应用。