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    SWEETENER COMPOSITIONS AND METHODS OF PRODUCTION THEREOF
    3.
    发明申请
    SWEETENER COMPOSITIONS AND METHODS OF PRODUCTION THEREOF 审中-公开

    公开(公告)号：WO2023031625A1

    公开(公告)日：2023-03-09

    申请号：PCT/GB2022/052252

    申请日：2022-09-02

    申请人： OPTIBIOTIX LIMITED

    发明人： O'HARA, Stephen ,  KOLIDA, Sofia

    IPC分类号： A23L27/30

    摘要： The present invention relates to a composition comprising a levansucrase modified high intensity sweetener glycoside, a polysaccharide and an unmodified high intensity sweetener glycoside. The invention also relates to a method for enzymatically modifying a high intensity sweetener glycoside comprising contacting the high intensity sweetener glycoside with a levansucrase in the presence of a monosaccharide acceptor to produce an enzymatically modified high intensity sweetener glycoside and a polysaccharide. The invention also relates to the use of the composition as a low calorie sweet functional fibre, sweet prebiotic or as a bulk sugar replacement. The invention also relates to the use of a levansucrase for fructosylating a high intensity sweetener glycoside.

    METHODS OF SCREENING
    4.
    发明申请
    METHODS OF SCREENING 审中-公开
    筛选方法

    公开(公告)号：WO2016189305A1

    公开(公告)日：2016-12-01

    申请号：PCT/GB2016/051515

    申请日：2016-05-25

    申请人： OPTIBIOTIX LIMITED

    发明人： O'HARA, Stephen Patrick ,  KOLIDA, Sofia

    IPC分类号： C12Q1/02 ,  G01N33/50

    CPC分类号： A23L33/135 ,  A23L33/21 ,  A23V2002/00 ,  A23V2200/3202 ,  C12Q1/02 ,  G01N33/50 ,  G01N33/56944 ,  G01N2333/195 ,  G01N2333/315 ,  G01N2333/335 ,  G01N2400/00

    摘要： The present invention relates to a discovery platform for screening one or more Streptococcus , Lactobacillus or Propionibacterium bacterial strains for the ability to produce and/or produce a high yield of galactooligosaccharides (GOS) comprising assessing the β- galactosidase activity of a strain under growth conditions and identifying whether the activity has: a) Miller Unit which are equal to or greater than about 60 for Streptococcus or Lactobacillus strains; or b) Miller Unit which are equal to or greater than about 3 for Propionibacterium strains. The present invention also relates to compositions incorporating GOS produced from bacterial strains identified by the screening process.

    摘要翻译： 本发明涉及一种用于筛选一种或多种链球菌，乳杆菌或丙酸杆菌菌株产生和/或产生高产量的低聚半乳糖（GOS）的发现平台，其包括在生长条件下评估菌株的β-半乳糖苷酶活性 并确定活动是否具有：a）对于链球菌或乳杆菌属菌株等于或大于约60的米勒单位; 或b）对于丙酸杆菌菌株等于或大于约3的米勒单位。 本发明还涉及结合通过筛选过程鉴定的细菌菌株产生的GOS的组合物。

    COMPOSITION
    5.
    发明申请
    COMPOSITION 审中-公开
    组成

    公开(公告)号：WO2016071693A1

    公开(公告)日：2016-05-12

    申请号：PCT/GB2015/053350

    申请日：2015-11-05

    申请人： OPTIBIOTIX LIMITED

    发明人： O'HARA, Stephen Patrick

    IPC分类号： A23L29/20 ,  A23L29/244 ,  A23L33/00 ,  A23L33/135 ,  A23L33/16 ,  A23L33/20 ,  A23L33/21 ,  A61K31/736 ,  A23C9/123 ,  A23C9/154

    CPC分类号： A61K45/06 ,  A23C9/1238 ,  A23C9/1307 ,  A23C9/1322 ,  A23C9/133 ,  A23C9/137 ,  A23C17/02 ,  A23C19/062 ,  A23L33/135 ,  A23L33/21 ,  A23L33/30 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/30 ,  A23V2200/3202 ,  A23V2200/3204 ,  A23V2200/326 ,  A23V2200/3262 ,  A23V2200/328 ,  A23V2200/332 ,  A23V2250/1586 ,  A23V2250/5058

    摘要： The present invention relates to compositions for use and formulation as weight management products and in particular fermented dairy foodstuffs. The compositions generally comprise two or more of the following components: a) a microbiome modifying component; b) a satiety modifying component; and c) a metabolic modifying 5 component and at least one of the following: d) St reptococcus thermophilus CBS 139100 and L actobacillus delbrueckii subsp. bulgaricus CBS 139099 microbial strains or mutant strains or fragments or fractions thereof; e) a combination of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus microbial strains which together, or individually, are capable of secreting polysaccharides having high levels of galactosamine 10 and no or low levels of rhamnose and glucuronic acid when grown on a dairy substrate; or f) polysaccharides formed of: i) 15 – 25 % galactosamine; ii) 45 – 60 % galactose; and iii) 20 – 30 % glucose. The compositions may also be useful in the management or treatment of obesity, elevated cholesterol, diabetes, hypertension or heart disease.

    摘要翻译： 本发明涉及用作和配制作为重量管理产品，特别是发酵乳制食品的组合物。 组合物通常包含两种或更多种以下组分：a）微生物组织修饰组分; b）饱腹感修饰组件; 和c）代谢修饰5组分和以下至少一种：d）嗜热链球菌CBS 139100和德氏乳杆菌 保加利亚乳杆菌CBS 139099微生物菌株或突变菌株或其片段或级分; e）嗜热链球菌和德氏乳酸杆菌亚种的组合。 保加利亚微生物菌株一起或分别能够分泌具有高水平的半乳糖胺10的多糖，当在乳制品基质上生长时，没有或低水平的鼠李糖和葡萄糖醛酸; 或f）由以下物质形成的多糖：i）15-25％半乳糖胺; ii）45-60％半乳糖; 和iii）20-30％的葡萄糖。 组合物还可用于治疗或治疗肥胖症，升高的胆固醇，糖尿病，高血压或心脏病。

    COMPOSITION
    8.
    发明申请
    COMPOSITION 审中-公开

    公开(公告)号：WO2019021023A1

    公开(公告)日：2019-01-31

    申请号：PCT/GB2018/052147

    申请日：2018-07-27

    申请人： OPTIBIOTIX LIMITED

    发明人： O'HARA, Stephen Patrick ,  KOLIDA, Sofia

    IPC分类号： A23L33/135 ,  A23L33/16 ,  A23L33/125 ,  A23L33/22 ,  A23L2/52 ,  A23L7/126 ,  A23L33/00

    摘要： The present invention relates to compositions and foodstuffs for use in increasing gastrointestinal microbiota diversity comprising: a) glucomannan; b) chromium; and c) a prebiotic (FOS). The compositions and foodstuffs are particularly suited for that increasing gastrointestinal microbiota diversity over a prolonged period of time which can assist individuals in reducing their weight and, more importantly, maintaining their lower weight over the longer term.

    COMPOSITION COMPRISING LACTOBACILLUS PLANTARUM 2830 (ECGC 13110402)
    9.
    发明申请
    COMPOSITION COMPRISING LACTOBACILLUS PLANTARUM 2830 (ECGC 13110402) 审中-公开
    包含乳酸杆菌2830的组合物（ECGC 13110402）

    公开(公告)号：WO2017077285A1

    公开(公告)日：2017-05-11

    申请号：PCT/GB2016/053389

    申请日：2016-11-02

    申请人： OPTIBIOTIX LIMITED

    发明人： O'HARA, Stephen Patrick

    IPC分类号： A61K35/74 ,  A61P3/06

    CPC分类号： A61K35/74

    摘要： The present invention relates to compositions comprising Lactobacillus plantarum 2830 (ECGC 13110402), or mutant strain or strains thereof, for use in the treatment or prevention of hypercholesterolaemia, and in particular reducing the total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels, in an individual. Specific dosage regimes and methods of production are also claimed and described.

    摘要翻译： 本发明涉及包含植物乳杆菌2830（ECGC 13110402）或其突变体菌株或其菌株的组合物，其用于治疗或预防高胆固醇血症，并且特别是降低总胆固醇（TC） 和低密度脂蛋白胆固醇（LDL-C）水平。 要求和描述具体的剂量方案和生产方法。