公开(公告)号：WO2013068720A1

公开(公告)日：2013-05-16

申请号：PCT/GB2012/052571

申请日：2012-10-18

Applicant: DEPUY (IRELAND) ,  LESLIE, Ian ,  REEVE, Michael ,  ROCK, Michael

Inventor： LESLIE, Ian ,  REEVE, Michael ,  ROCK, Michael

IPC: A61B17/15

CPC classification number: A61F2/4657 ,  A61B17/155 ,  A61B17/1764 ,  A61B90/06 ,  A61B2090/061 ,  A61F2/3859 ,  A61F2002/30617 ,  A61F2002/4658 ,  A61F2250/0097

Abstract: A bone sizing guide for assessing the size of an end of a bone includes a body (6) having a foot component (2) with a first surface (10) to rest against an end surface of the bone and a foot (12) extending transverse to the first surface to contact a side surface of the bone. A superstructure (40) is coupled to the body so that the superstructure can slide relative to the body towards and away from the body, at least one of the superstructure and the body being adjustable so that the rotational direction in which the superstructure extends relative to the foot component about a first axis extending transverse to the first surface is adjustable. A stylus (53) extends from the superstructure transverse to the first surface of the body, the stylus having a tip to contact a surface of the bone, and a scale (64) is coupled to or formed on a first one of the superstructure and the body. An indicator (52) is coupled to or formed on a second one of the superstructure and the body to identify a position on the scale. The identified position on the scale shifts as the superstructure slides towards or away from the body, and the identified position shifts as the superstructure rotates relative to the body without sliding motion between the superstructure and the body, such that the identified position on the scale is indicative of the distance between the stylus and the foot.

Abstract translation: 用于评估骨头端部尺寸的骨尺寸引导件包括具有脚部件（2）的主体（6），其具有第一表面（10）以抵靠在骨的端面上;以及脚部（12），其延伸 横向于第一表面以接触骨的侧表面。 上部结构（40）联接到主体，使得上部结构能够相对于主体朝向和远离主体滑动，上部结构和主体中的至少一个是可调节的，使得上部结构相对于 围绕围绕第一表面延伸的第一轴线的脚部件是可调节的。 触针（53）从上部结构横向延伸到主体的第一表面，触针具有与骨表面接触的尖端，并且刻度（64）联接到或形成在上部结构的第一个上， 身体。 指示器（52）联接到或形成在上部结构和身体的第二个上以识别刻度上的位置。 当上层结构向身体滑动或远离身体时，标尺上的识别位置发生变化，并且当上层建筑物相对于身体旋转时，所识别的位置将不会在上层建筑物和身体之间产生滑动运动而移动，使得标尺上的识别位置为 指示触针和脚之间的距离。

公开(公告)号：WO2011141723A1

公开(公告)日：2011-11-17

申请号：PCT/GB2011/050582

申请日：2011-03-23

Applicant: DEPUY (IRELAND) ,  REEVE, Michael

Inventor： REEVE, Michael

IPC: A61B17/15

CPC classification number: A61B17/15 ,  A61B17/155 ,  A61B2090/061 ,  A61F2/3859 ,  A61F2/4657

Abstract: A surgical instrument comprising a first component (2) having a first face (76) and a second component (4) coupled to the first component (2) such that the first and second components (2, 4) can rotate relative to one another. The instrument further comprises a locking mechanism comprising a third component (32) having a second face (74) coupled to the second component (4). Movement of the third component (32) relative to the second component (4) is arranged to bring the second face (74) into or out of engagement with the first face (76) so as to selectively restrict or allow rotation between the first and second components (2, 4). One of said faces (7, 76) comprises a first array (78) of two or more grooves or teeth spaced apart at a first angular pitch about the centre of rotation between the first and second components (2, 4) and at least one further groove (82) or further tooth which does not correspond to the first angular pitch. The other of said faces (74, 76) comprises a first tooth (84) or a first groove arranged to engage one of the first array (78) of grooves or teeth so as to selectively restrict rotation to two or more predetermined rotational positions within a first range of rotational positions between the first and second components (2, 4). Said other of said faces (74, 76) being arranged to engage the at least one further groove (82) or further tooth so as to selectively restrict rotation between the first and second components (2, 4) at a further predetermined rotational position.

Abstract translation: 一种外科器械，包括具有第一面（76）的第一部件（2）和与第一部件（2）连接的第二部件（4），使得第一和第二部件（2,4）能够相对于彼此旋转 。 仪器还包括锁定机构，其包括具有联接到第二部件（4）的第二面（74）的第三部件（32）。 第三部件（32）相对于第二部件（4）的运动被布置成使第二面（74）与第一面（76）接合或脱离接合，以便选择性地限制或允许第一部分 第二组件（2,4）。 所述面（7,76）中的一个包括第一阵列（78），所述第一阵列（78）具有围绕所述第一和第二部件（2,4）之间的旋转中心以第一角度间距间隔开的两个或更多个凹槽或齿，并且至少一个 另外的凹槽（82）或与第一角度间距不对应的另外的齿。 所述面（74,76）中的另一个包括第一齿（84）或第一凹槽，所述第一齿（84）或第一凹槽被布置成接合凹槽或齿的第一阵列（78）中的一个，以便选择性地限制旋转到两个或更多个预定的旋转位置 第一和第二部件（2,4）之间的第一旋转位置范围。 所述另一个所述面（74,76）被布置成与所述至少一个另外的凹槽（82）或另外的齿接合，以便在另一预定旋转位置选择性地限制所述第一和第二部件（2,4）之间的旋转。

公开(公告)号：WO2011141722A1

公开(公告)日：2011-11-17

申请号：PCT/GB2011/050575

申请日：2011-03-23

Applicant: DEPUY (IRELAND) ,  REEVE, Michael ,  ROCK, Michael

Inventor： REEVE, Michael ,  ROCK, Michael

IPC: A61B17/15

CPC classification number: A61B17/1764 ,  A61B17/155 ,  A61B2090/061 ,  A61F2/3859 ,  A61F2002/30617 ,  A61F2002/4658 ,  A61F2250/0097

Abstract: A femoral sizing guide comprises a body (6), a superstructure (40) and a stylus (53). The body (6) is arranged to rest against a resected femoral surface and has first and second feet (12) arranged to extend underneath respective posterior condyles and rest against posterior condylar surfaces of the femur. The superstructure (40) is coupled to the body (6) and is arranged to slide parallel to the resected femoral surface towards and away from the feet (12). The stylus (53) is coupled to the superstructure (40) and arranged such that when the body (6) rests against the resected femoral surface a tip (60) of the stylus (53) extends over the femur such that sliding the superstructure (40) towards the feet (12) causes the stylus tip (60) to contact the anterior cortex of the femur. The superstructure (40) further comprises a first guide hole (52) defining a first alignment axis extending into the resected femoral surface at a predetermined distance from the level of the stylus tip (60) in the plane of the resected femoral surface. The body (6) defines a second guide hole (22) defining a second alignment axis extending into the resected femoral surface at a predetermined distance from the feet (12), the distance between the first and second guide holes (52, 22) varying as the superstructure (40) slides relative to the body (6).

Abstract translation: 股骨上钉引导件包括主体（6），上部结构（40）和触针（53）。 身体（6）被布置成抵靠被切除的股骨表面，并且具有布置成在相应的后髁下方延伸并抵靠股骨的后髁表面的第一和第二脚部（12）。 上部结构（40）联接到主体（6）并且被布置成朝向和远离脚部（12）平行于切除的股骨表面滑动。 触针（53）联接到上部结构（40）并且布置成使得当主体（6）靠在被切除的股骨表面上时，触针（53）的尖端（60）延伸到股骨上方，使得滑动上部结构 40）朝向脚部（12）导致触针尖端（60）接触股骨的前皮质。 所述上部结构（40）还包括第一引导孔（52），所述第一引导孔（52）限定第一对准轴线，所述第一对准轴线延伸到所述被切除的股骨表面中与所述切除的股骨表面的平面内的所述触针尖端（60）的高度预定距离。 本体（6）限定了第二引导孔（22），该第二引导孔限定了与脚部（12）预定距离延伸到切除的股骨表面中的第二对准轴线，第一和第二引导孔（52,22）之间的距离变化 当上部结构（40）相对于主体（6）滑动时。

公开(公告)号：WO2007072976A1

公开(公告)日：2007-06-28

申请号：PCT/JP2006/325698

申请日：2006-12-19

Applicant: SHARP KABUSHIKI KAISHA ,  ANDERSON, Sally ,  REEVE, Michael, A.

Inventor： ANDERSON, Sally ,  REEVE, Michael, A.

IPC: G01N33/53 ,  C07K1/04 ,  C07K4/00 ,  C12M1/00 ,  G01N37/00

CPC classification number: G01N33/54386 ,  G01N33/6845

Abstract: The current invention relates to a method of fabricating a multimeric capture agent for binding a ligand, the capture agent comprising at least first and second monomers units, the first monomer unit further comprising a first ligand-binding moiety, a first reactive group and an attachment moiety, the second monomer unit further comprising a second ligand-binding moiety, and a second reactive group, wherein the reactive groups may be the same or different for each monomer unit, the method comprising the steps of; a) reacting the first monomer unit with the second monomer unit such that reactive groups present on the monomer units react to form a multimeric capture agent. b) immobilising the first monomer unit on a substrate via the attachment moiety, wherein, step a) can be performed before, simultaneously with, or subsequently to step b).

Abstract translation: 本发明涉及一种制备用于结合配体的多聚捕获剂的方法，所述捕获剂包含至少第一和第二单体单元，所述第一单体单元还包含第一配体结合部分，第一反应性基团和附着物 部分，所述第二单体单元还包含第二配体结合部分和第二反应性基团，其中所述反应性基团对于每个单体单元可以相同或不同，所述方法包括以下步骤： a）使第一单体单元与第二单体单元反应，使得存在于单体单元上的反应性基团反应以形成多聚体捕获剂。 b）通过附着部分将第一单体单元固定在基质上，其中步骤a）可以在步骤b）之前，同时或之后进行。

公开(公告)号：WO2007072975A1

公开(公告)日：2007-06-28

申请号：PCT/JP2006/325697

申请日：2006-12-19

Applicant: SHARP KABUSHIKI KAISHA ,  REEVE, Michael, A. ,  ANDERSON, Sally

Inventor： REEVE, Michael, A. ,  ANDERSON, Sally

IPC: G01N33/53 ,  C07K1/04 ,  C07K4/00 ,  C12M1/00 ,  G01N37/00

CPC classification number: C07K17/08 ,  C07K7/06 ,  C07K7/08

Abstract: The current invention relates to a method of functionalising a substrate comprising immobilising at least one multimeric peptide on the substrate, wherein, the at least one multimeric peptide comprises at least first and second peptide chains, the first peptide chain comprising at least one hydrophobic amino acid residue and at least one functionalising moiety, wherein the at least one hydrophobic amino acid residue and at least one functionalising moiety are positioned in the peptide primary structure so as to result in a hydrophobic face, and a substantially non hydrophobic face comprising the functionalising moiety, and wherein, contacting the peptide with the substrate causes the peptide to be immobilised thereon.

Abstract translation: 本发明涉及一种使底物功能化的方法，包括固定底物上的至少一种多聚体肽，其中至少一种多聚体肽包含至少第一和第二肽链，第一肽链包含至少一个疏水性氨基酸 残基和至少一个官能化部分，其中所述至少一个疏水性氨基酸残基和至少一个官能化部分位于所述肽一级结构中，以便产生疏水性面，以及包含所述官能化部分的基本上非疏水性的面， 并且其中，使所述肽与所述底物接触导致所述肽被固定在其上。

公开(公告)号：WO1995014108A1

公开(公告)日：1995-05-26

申请号：PCT/GB1994002527

申请日：1994-11-17

Applicant: AMERSHAM INTERNATIONAL PLC ,  REEVE, Michael, Alan ,  HOWE, Roland, Paul ,  SCHWARZ, Terek

Inventor： AMERSHAM INTERNATIONAL PLC

IPC: C12Q01/68

CPC classification number: C12Q1/6872 ,  C12Q1/6874

Abstract: A method of sequencing a target nucleic acid using primer extension mass spectroscopy to generate an observed mass spectrum, on which base calling cycles are carried out using calibrated inter-peak mass difference values such that: each called base allows mass calculation for the base-called peak in the observed mass spectrum; this calculated mass is then used as a further calibration point for subsequent rounds of base calling. A reaction mixture of all four base-specific chain extension nucleotides and four chain termination nucleotide analogues. A method of performing mass spectroscopy, which method comprises subjecting molecular ions which have been chemically charged in a predetermined manner to time-of-flight or Fourier transform mass spectroscopy.

Abstract translation: 使用引物延伸质谱法测序靶核酸以产生观察质谱的方法，其中使用校准的峰间质量差值进行碱基调用循环，使得：每个被称为碱基允许质量计算基本称为 观测质谱峰; 然后将该计算质量用作下一轮基地呼叫的另一校准点。 所有四个碱基特异性链延伸核苷酸和四个链终止核苷酸类似物的反应混合物。 一种执行质谱法的方法，该方法包括以已知化学方式对分子离子进行飞行时间或傅里叶变换质谱。

公开(公告)号：WO1985001802A1

公开(公告)日：1985-04-25

申请号：PCT/GB1984000354

申请日：1984-10-19

Applicant: BRITISH TELECOMMUNICATIONS PLC ,  KASHYAP, Raman ,  REEVE, Michael, Harry ,  CASSIDY, Stephen, Anthony ,  HORNUNG, Stephen

Inventor： BRITISH TELECOMMUNICATIONS PLC

IPC: G02B06/10

CPC classification number: G02B6/02 ,  G02B6/02033 ,  G02B6/2861 ,  G02B6/3628 ,  G02F1/0115 ,  G02F1/132

Abstract: An optical fibre has a coating of, for example, liquid crystal polymer which causes temperature-dependent stress-induced changes in the optical fibre such as to counteract temperature-induced changes in the transmission delay of the fibre.

公开(公告)号：WO0055364A3

公开(公告)日：2001-10-11

申请号：PCT/GB0000916

申请日：2000-03-10

Applicant: AMERSHAM PHARM BIOTECH UK LTD ,  REEVE MICHAEL ALAN ,  WORKMAN NICHOLAS IAN ,  MARTIN PARRAS LUIS

Inventor： REEVE MICHAEL ALAN ,  WORKMAN NICHOLAS IAN ,  MARTIN-PARRAS LUIS

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N1/28 ,  G01N33/566 ,  G01N37/00

CPC classification number: C12Q1/683 ,  C12Q1/6837

Abstract: A method is described for use in whole genome analysis. The method - termed inter-population perfectly matched duplex depletion - can overcome many of the limitations of current approaches based upon SNPs and linkage disequilibrium within isolated populations. Inter-population perfectly matched duplex depletion isolates a fragment (or fragments) containing differences between the "affected" and "unaffected" populations or cells. A convenient method - terminal restriction site profiling arrays (TRSPAs) - is described for the analysis of such fragments. A totally diagnostic internal control DNA is also described which allows both the extent and exact nature of any partial digestion to be unambiguously determined for inter-population perfectly matched duplex depletion or TRSPA restriction.

Abstract translation: 描述了用于全基因组分析的方法。 该方法 - 称为群体间完全匹配的双相消耗 - 可以克服基于孤立群体内的SNP和连锁不平衡的当前方法的许多限制。 种群间完全匹配的双相缺失分离了包含“受影响”和“未受影响”群体或细胞之间差异的片段（或片段）。 描述了一种方便的方法 - 终端限制性位点分析阵列（TRSPAs），用于分析这些片段。 还描述了完全诊断的内部对照DNA，其允许明确地确定任何部分消化的程度和确切性质，用于群体间完美匹配的双相消耗或TRSPA限制。

公开(公告)号：WO1997001645A1

公开(公告)日：1997-01-16

申请号：PCT/GB1996001536

申请日：1996-06-26

Applicant: AMERSHAM INTERNATIONAL PLC ,  REEVE, Michael, Alan ,  ROBINSON, Philip, Steven ,  BALL, Stuart

Inventor： AMERSHAM INTERNATIONAL PLC

IPC: C12Q01/68

CPC classification number: C12Q1/6832 ,  C12Q1/6869 ,  C40B40/00 ,  Y10S435/81

Abstract: The invention provides a method for primer walking sequencing of nucleic acid wherein a presynthesised set of walking primers is used, the said primers having a raised annealing temperature and/or improved annealing properties without increasing sequence complexity.

Abstract translation: 本发明提供了一种用于核酸的引物走向测序的方法，其中使用预合成的步行引物组，所述引物具有升高的退火温度和/或改进的退火性能，而不增加序列复杂性。

公开(公告)号：WO1991009478A1

公开(公告)日：1991-06-27

申请号：PCT/GB1990001916

申请日：1990-12-07

Applicant: BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY ,  COOPER, Anthony, James ,  FENNING, Simon, Charles ,  REEVE, Michael, Harry ,  BICKERS, Lawrence ,  ROSHER, Paul, Adrian

Inventor： BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY

IPC: H04G11/00

CPC classification number: H04J14/0298

Abstract: An optical fibre communications system includes an exchange (E) and a plurality of subscriber lines (1). The exchange (E) provides a plurality of services in different subcarrier frequencies (6, 8, 9, 10). Each subscriber line (1) is provided with terminal apparatus (5) operable at different subcarrier frequencies, and a control (11) at the exchange (E) tunes the terminal apparatus to transmit and/or receive on a particular frequency in response to a request. The request may be a signal from the terminal apparatus (5), or an incoming service request addressed to the particular terminal apparatus.

Abstract translation: 光纤通信系统包括交换机（E）和多条用户线路（1）。 交换机（E）在不同的子载波频率（6,8,9,10）中提供多个业务。 每个用户线路（1）设置有可在不同子载波频率下操作的终端设备（5），并且交换机（E）处的控制（11）响应于一个特定频率来调谐终端设备发送和/或接收特定频率 请求。 请求可以是来自终端装置（5）的信号，或者是寻址到特定终端装置的传入服务请求。