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    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS
    3.
    发明申请
    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
    用于免疫组化应用的方法和装置

    公开(公告)号：WO2012106478A2

    公开(公告)日：2012-08-09

    申请号：PCT/US2012/023553

    申请日：2012-02-01

    Applicant: KNUTSON, Chistopher, R. ,  GRANT, Christopher, F. ,  KLINE, Timothy, R. ,  DOORNEWEERD, Derek, D. ,  KURELLA, Sridevi ,  MUETH, Daniel, M. ,  RUNYON, Matthew, K. ,  FU, Haojun ,  GUEVARA, Sergio, O.

    Inventor： KNUTSON, Chistopher, R. ,  GRANT, Christopher, F. ,  KLINE, Timothy, R. ,  DOORNEWEERD, Derek, D. ,  KURELLA, Sridevi ,  MUETH, Daniel, M. ,  RUNYON, Matthew, K. ,  FU, Haojun ,  GUEVARA, Sergio, O.

    IPC: B04B7/02 ,  B01D43/00

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject, for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), thus allowing for more efficient detection and reduced test time. In one embodiment, the optimized antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. In another embodiment, an optimized antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed.

    Abstract translation: 公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。 在一个实施方案中，优化的抗体筛选方法和装置显着降低了与表面的非特异性结合（例如，与红细胞（rbcm）制剂结合的测试表面）的水平，从而允许更有效的检测和减少的测试时间 。 在一个实施方案中，优化的抗体筛选方法包括免疫球蛋白G（IgG）结合部分，所述免疫球蛋白G（IgG）结合部分选择性且特异性地结合相对于裂解的rbcm制剂的结合而存在的血浆IgG。 在另一个实施方案中，公开了一种优化的抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。 在其他实施例中，本发明提供了用于目标捕获的方法和装置，其包括用于捕获的可选地具有优化角度的基本平坦的表面。 公开了用于捕获的替代固相几何形状。 还公开了细胞沉积的优化方法。 因此，公开了用于评估样品的优化方法，装置，试剂盒测定。

    METHOD AND APPARATUS FOR ASSAYING BLOOD CLOTTING
    5.
    发明申请
    METHOD AND APPARATUS FOR ASSAYING BLOOD CLOTTING 审中-公开
    用于测定血液粘贴的方法和装置

    公开(公告)号：WO2007089777A2

    公开(公告)日：2007-08-09

    申请号：PCT/US2007/002532

    申请日：2007-01-31

    Applicant: UNIVERSITY OF CHICAGO ,  ISMAGILOV, Rustem, F. ,  KASTRUP, Christian, J. ,  RUNYON, Matthew, K. ,  SONG, Helen ,  FENG, Shen

    Inventor： ISMAGILOV, Rustem, F. ,  KASTRUP, Christian, J. ,  RUNYON, Matthew, K. ,  SONG, Helen ,  FENG, Shen

    IPC: A61B5/00

    CPC classification number: G01N33/86

    Abstract: This invention provides an apparatus for assaying clotting activity. The apparatus includes an inlet for a blood fluid and two or more patches of material in the vessel. The material is capable of initiating a clotting pathway in a blood fluid. This invention also provides an apparatus for measuring clot propagation, which includes a region with material capable of initiating a clotting pathway, and a region where the clot propagation is monitored. Also provided are methods for assaying clotting activity, assaying the integrity of a blood clotting pathway, assaying the effect of a substance on the integrity of a blood clotting pathway, monitoring clot propagation, and preventing clot propagation from one vessel to another.

    Abstract translation: 本发明提供了用于测定凝血活性的装置。 该装置包括用于血液流体的入口和容器中的两个或更多个材料块。 该材料能够在血液中引发凝血途径。 本发明还提供了一种用于测量凝块传播的装置，其包括具有能够引发凝血途径的材料的区域以及监测凝块传播的区域。 还提供了用于测定凝血活性，测定血液凝固途径的完整性，测定物质对血液凝固途径的完整性的影响，监测凝块传播以及防止血块从一个血管传播到另一个血管的方法。

    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS
    6.
    发明申请
    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
    用于免疫组化应用的方法和装置

    公开(公告)号：WO2012106478A3

    公开(公告)日：2012-10-18

    申请号：PCT/US2012023553

    申请日：2012-02-01

    Applicant: KNUTSON CHISTOPHER R ,  GRANT CHRISTOPHER F ,  KLINE TIMOTHY R ,  DOORNEWEERD DEREK D ,  KURELLA SRIDEVI ,  MUETH DANIEL M ,  RUNYON MATTHEW K ,  FU HAOJUN ,  GUEVARA SERGIO O

    Inventor： KNUTSON CHISTOPHER R ,  GRANT CHRISTOPHER F ,  KLINE TIMOTHY R ,  DOORNEWEERD DEREK D ,  KURELLA SRIDEVI ,  MUETH DANIEL M ,  RUNYON MATTHEW K ,  FU HAOJUN ,  GUEVARA SERGIO O

    IPC: C12N5/07 ,  C07K16/18 ,  G01N33/555

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject for detecting a target red blood cell protein or antibody are disclosed. Antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), allowing for more efficient detection and reduced test time. The antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. An antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. Additional methods and devices for target capturing include a substantially planar surface having an optimized angle for capture, or alternative solid phase geometries for capture.

    Abstract translation: 公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。 抗体筛选方法和装置显着降低了与表面（例如，与红细胞（rbcm）制剂结合的测试表面）的非特异性结合的水平，允许更有效的检测和减少的测试时间。 抗体筛选方法包括免疫球蛋白G（IgG）结合部分，其与选择性且特异性结合相对于与裂解的rbcm制剂的结合存在的血浆IgG。 公开了一种抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。 用于靶捕获的附加方法和装置包括具有用于捕获的优化角度或用于捕获的替代固相几何形状的基本平坦的表面。

    CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS
    7.
    发明申请
    CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS 审中-公开
    用于分离和加工复合流体的离心转子

    公开(公告)号：WO2012106442A1

    公开(公告)日：2012-08-09

    申请号：PCT/US2012/023503

    申请日：2012-02-01

    Applicant: ARRYX, INC. ,  RUNYON, Matthew, K. ,  MUETH, Daniel, M. ,  GUEVARA, Sergio, O. ,  FU, Haojun

    Inventor： RUNYON, Matthew, K. ,  MUETH, Daniel, M. ,  GUEVARA, Sergio, O. ,  FU, Haojun

    IPC: B04B5/02

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.

    Abstract translation: 提供转子用于离心机系统，该离心机系统构造成旋转转子以分离复杂流体。 转子包括构造成由离心机系统固定的壳体和形成在壳体中的若干室。 每个室包括具有形成在其中的端口的第一室部分和与第一室部分的端口流体连通的第二室部分。 第二室部分可以大致设置在第一室部分的端口下方。 进一步公开了用于分离复杂流体的其它转子设计和方法。

    METHOD AND APPARATUS FOR ASSAYING BLOOD CLOTTING
    8.
    发明申请
    METHOD AND APPARATUS FOR ASSAYING BLOOD CLOTTING 审中-公开
    用于测定血液粘贴的方法和装置

    公开(公告)号：WO2007089777A3

    公开(公告)日：2008-02-07

    申请号：PCT/US2007002532

    申请日：2007-01-31

    Applicant: UNIV CHICAGO ,  ISMAGILOV RUSTEM F ,  KASTRUP CHRISTIAN J ,  RUNYON MATTHEW K ,  SONG HELEN ,  FENG SHEN

    Inventor： ISMAGILOV RUSTEM F ,  KASTRUP CHRISTIAN J ,  RUNYON MATTHEW K ,  SONG HELEN ,  FENG SHEN

    IPC: A61B5/00

    CPC classification number: G01N33/86

    Abstract: This invention provides an apparatus for assaying clotting activity. The apparatus includes an inlet for a blood fluid and two or more patches of material in the vessel. The material is capable of initiating a clotting pathway in a blood fluid. This invention also provides an apparatus for measuring clot propagation, which includes a region with material capable of initiating a clotting pathway, and a region where the clot propagation is monitored. Also provided are methods for assaying clotting activity, assaying the integrity of a blood clotting pathway, assaying the effect of a substance on the integrity of a blood clotting pathway, monitoring clot propagation, and preventing clot propagation from one vessel to another.

    Abstract translation: 本发明提供了用于测定凝血活性的装置。 该装置包括用于血液流体的入口和容器中的两个或更多个材料块。 该材料能够在血液中引发凝血途径。 本发明还提供了一种用于测量凝块传播的装置，其包括具有能够引发凝血途径的材料的区域以及监测凝块传播的区域。 还提供了用于测定凝血活性，测定血液凝固途径的完整性，测定物质对血液凝固途径的完整性的影响，监测凝块传播以及防止血块从一个血管传播到另一个血管的方法。

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