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    AUTOMATED EXTRACTION AND PURIFICATION OF SAMPLES USING OPTICAL TWEEZERS
    2.
    发明申请
    AUTOMATED EXTRACTION AND PURIFICATION OF SAMPLES USING OPTICAL TWEEZERS 审中-公开
    使用光学自动提取和纯化样品

    公开(公告)号：WO2006063335A2

    公开(公告)日：2006-06-15

    申请号：PCT/US2005/044880

    申请日：2005-12-12

    Applicant: ARRYX, INC. ,  PLEWA, Joseph, S. ,  TANNER, Evan, B. ,  MUETH, Daniel, M. ,  DUKE, Crystal, J. ,  EHRENREICH, Kevin, J.

    Inventor： PLEWA, Joseph, S. ,  TANNER, Evan, B. ,  MUETH, Daniel, M. ,  DUKE, Crystal, J. ,  EHRENREICH, Kevin, J.

    IPC: C12Q1/00

    CPC classification number: G02B21/32 ,  B01L3/502761 ,  G01N1/34 ,  G01N15/1463 ,  G01N2001/007 ,  G01N2015/1454 ,  G01N2015/149 ,  G02B5/32 ,  Y10T436/25375

    Abstract: An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; and an output through which unselected particles of the sample are removed. At least one buffer input channel is provided. The input channel may allow sedimentation of the sample into the chamber by gravity. In another arrangement, the system includes an optical trapping system; a first channel through which the sample is introduced; a second channel through which buffer is introduced; wherein the optical tweezers are used to move selected particles of the sample from the first channel to the second channel. The selected particles may be sperm. The optical tweezers preferably utilize holographic optical trapping.

    Abstract translation: 使用自动提取和净化系统来净化法医样品的装置和方法包括光学镊子; 导入样品的输入通道; 从输入通道接收样品的室; 取出样品的所选粒子的收集通道; 以及去除样品的未选择的颗粒的输出。 提供至少一个缓冲器输入通道。 输入通道可以允许样品通过重力沉降到室中。 在另一种布置中，该系统包括光学捕获系统; 引入样品的第一通道; 引入缓冲液的第二通道; 其中所述光学镊子用于将所述样品的选定颗粒从所述第一通道移动到所述第二通道。 所选择的颗粒可能是精子。 光学镊子优选利用全息光学捕获。

    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS
    3.
    发明申请
    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
    用于免疫组化应用的方法和装置

    公开(公告)号：WO2012106478A3

    公开(公告)日：2012-10-18

    申请号：PCT/US2012023553

    申请日：2012-02-01

    Applicant: KNUTSON CHISTOPHER R ,  GRANT CHRISTOPHER F ,  KLINE TIMOTHY R ,  DOORNEWEERD DEREK D ,  KURELLA SRIDEVI ,  MUETH DANIEL M ,  RUNYON MATTHEW K ,  FU HAOJUN ,  GUEVARA SERGIO O

    Inventor： KNUTSON CHISTOPHER R ,  GRANT CHRISTOPHER F ,  KLINE TIMOTHY R ,  DOORNEWEERD DEREK D ,  KURELLA SRIDEVI ,  MUETH DANIEL M ,  RUNYON MATTHEW K ,  FU HAOJUN ,  GUEVARA SERGIO O

    IPC: C12N5/07 ,  C07K16/18 ,  G01N33/555

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject for detecting a target red blood cell protein or antibody are disclosed. Antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), allowing for more efficient detection and reduced test time. The antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. An antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. Additional methods and devices for target capturing include a substantially planar surface having an optimized angle for capture, or alternative solid phase geometries for capture.

    Abstract translation: 公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。 抗体筛选方法和装置显着降低了与表面（例如，与红细胞（rbcm）制剂结合的测试表面）的非特异性结合的水平，允许更有效的检测和减少的测试时间。 抗体筛选方法包括免疫球蛋白G（IgG）结合部分，其与选择性且特异性结合相对于与裂解的rbcm制剂的结合存在的血浆IgG。 公开了一种抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。 用于靶捕获的附加方法和装置包括具有用于捕获的优化角度或用于捕获的替代固相几何形状的基本平坦的表面。

    CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS
    4.
    发明申请
    CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS 审中-公开
    用于分离和加工复合流体的离心转子

    公开(公告)号：WO2012106442A1

    公开(公告)日：2012-08-09

    申请号：PCT/US2012/023503

    申请日：2012-02-01

    Applicant: ARRYX, INC. ,  RUNYON, Matthew, K. ,  MUETH, Daniel, M. ,  GUEVARA, Sergio, O. ,  FU, Haojun

    Inventor： RUNYON, Matthew, K. ,  MUETH, Daniel, M. ,  GUEVARA, Sergio, O. ,  FU, Haojun

    IPC: B04B5/02

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.

    Abstract translation: 提供转子用于离心机系统，该离心机系统构造成旋转转子以分离复杂流体。 转子包括构造成由离心机系统固定的壳体和形成在壳体中的若干室。 每个室包括具有形成在其中的端口的第一室部分和与第一室部分的端口流体连通的第二室部分。 第二室部分可以大致设置在第一室部分的端口下方。 进一步公开了用于分离复杂流体的其它转子设计和方法。

    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS
    5.
    发明申请
    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
    用于免疫组化应用的方法和装置

    公开(公告)号：WO2012106478A2

    公开(公告)日：2012-08-09

    申请号：PCT/US2012/023553

    申请日：2012-02-01

    Applicant: KNUTSON, Chistopher, R. ,  GRANT, Christopher, F. ,  KLINE, Timothy, R. ,  DOORNEWEERD, Derek, D. ,  KURELLA, Sridevi ,  MUETH, Daniel, M. ,  RUNYON, Matthew, K. ,  FU, Haojun ,  GUEVARA, Sergio, O.

    Inventor： KNUTSON, Chistopher, R. ,  GRANT, Christopher, F. ,  KLINE, Timothy, R. ,  DOORNEWEERD, Derek, D. ,  KURELLA, Sridevi ,  MUETH, Daniel, M. ,  RUNYON, Matthew, K. ,  FU, Haojun ,  GUEVARA, Sergio, O.

    IPC: B04B7/02 ,  B01D43/00

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject, for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), thus allowing for more efficient detection and reduced test time. In one embodiment, the optimized antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. In another embodiment, an optimized antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed.

    Abstract translation: 公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。 在一个实施方案中，优化的抗体筛选方法和装置显着降低了与表面的非特异性结合（例如，与红细胞（rbcm）制剂结合的测试表面）的水平，从而允许更有效的检测和减少的测试时间 。 在一个实施方案中，优化的抗体筛选方法包括免疫球蛋白G（IgG）结合部分，所述免疫球蛋白G（IgG）结合部分选择性且特异性地结合相对于裂解的rbcm制剂的结合而存在的血浆IgG。 在另一个实施方案中，公开了一种优化的抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。 在其他实施例中，本发明提供了用于目标捕获的方法和装置，其包括用于捕获的可选地具有优化角度的基本平坦的表面。 公开了用于捕获的替代固相几何形状。 还公开了细胞沉积的优化方法。 因此，公开了用于评估样品的优化方法，装置，试剂盒测定。

    AUTOMATED EXTRACTION AND PURIFICATION OF SAMPLES USING OPTICAL TWEEZERS
    6.
    发明申请
    AUTOMATED EXTRACTION AND PURIFICATION OF SAMPLES USING OPTICAL TWEEZERS 审中-公开
    使用光学自动提取和纯化样品

    公开(公告)号：WO2006063335A3

    公开(公告)日：2009-04-16

    申请号：PCT/US2005044880

    申请日：2005-12-12

    Applicant: ARRYX INC ,  PLEWA JOSEPH S ,  TANNER EVAN B ,  MUETH DANIEL M ,  DUKE CRYSTAL J ,  EHRENREICH KEVIN J

    Inventor： PLEWA JOSEPH S ,  TANNER EVAN B ,  MUETH DANIEL M ,  DUKE CRYSTAL J ,  EHRENREICH KEVIN J

    IPC: G01N33/48 ,  G06G7/48

    CPC classification number: G02B21/32 ,  B01L3/502761 ,  G01N1/34 ,  G01N15/1463 ,  G01N2001/007 ,  G01N2015/1454 ,  G01N2015/149 ,  G02B5/32 ,  Y10T436/25375

    Abstract: An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; and an output through which unselected particles of the sample are removed. At least one buffer input channel is provided. The input channel may allow sedimentation of the sample into the chamber by gravity. In another arrangement, the system includes an optical trapping system; a first channel through which the sample is introduced; a second channel through which buffer is introduced; wherein the optical tweezers are used to move selected particles of the sample from the first channel to the second channel. The selected particles may be sperm. The optical tweezers preferably utilize holographic optical trapping.

    Abstract translation: 使用自动提取和净化系统来净化法医样品的装置和方法包括光学镊子; 导入样品的输入通道; 从输入通道接收样品的室; 取出样品的所选粒子的收集通道; 以及去除样品的未选择的颗粒的输出。 提供至少一个缓冲器输入通道。 输入通道可以允许样品通过重力沉降到室中。 在另一种布置中，该系统包括光学捕获系统; 引入样品的第一通道; 引入缓冲液的第二通道; 其中所述光学镊子用于将所述样品的选定颗粒从所述第一通道移动到所述第二通道。 所选择的颗粒可能是精子。 光学镊子优选利用全息光学捕获。

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