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    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS
    2.
    发明申请
    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
    用于免疫组化应用的方法和装置

    公开(公告)号：WO2012106478A3

    公开(公告)日：2012-10-18

    申请号：PCT/US2012023553

    申请日：2012-02-01

    Applicant: KNUTSON CHISTOPHER R ,  GRANT CHRISTOPHER F ,  KLINE TIMOTHY R ,  DOORNEWEERD DEREK D ,  KURELLA SRIDEVI ,  MUETH DANIEL M ,  RUNYON MATTHEW K ,  FU HAOJUN ,  GUEVARA SERGIO O

    Inventor： KNUTSON CHISTOPHER R ,  GRANT CHRISTOPHER F ,  KLINE TIMOTHY R ,  DOORNEWEERD DEREK D ,  KURELLA SRIDEVI ,  MUETH DANIEL M ,  RUNYON MATTHEW K ,  FU HAOJUN ,  GUEVARA SERGIO O

    IPC: C12N5/07 ,  C07K16/18 ,  G01N33/555

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject for detecting a target red blood cell protein or antibody are disclosed. Antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), allowing for more efficient detection and reduced test time. The antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. An antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. Additional methods and devices for target capturing include a substantially planar surface having an optimized angle for capture, or alternative solid phase geometries for capture.

    Abstract translation: 公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。 抗体筛选方法和装置显着降低了与表面（例如，与红细胞（rbcm）制剂结合的测试表面）的非特异性结合的水平，允许更有效的检测和减少的测试时间。 抗体筛选方法包括免疫球蛋白G（IgG）结合部分，其与选择性且特异性结合相对于与裂解的rbcm制剂的结合存在的血浆IgG。 公开了一种抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。 用于靶捕获的附加方法和装置包括具有用于捕获的优化角度或用于捕获的替代固相几何形状的基本平坦的表面。

    CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS
    3.
    发明申请
    CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS 审中-公开
    用于分离和加工复合流体的离心转子

    公开(公告)号：WO2012106442A1

    公开(公告)日：2012-08-09

    申请号：PCT/US2012/023503

    申请日：2012-02-01

    Applicant: ARRYX, INC. ,  RUNYON, Matthew, K. ,  MUETH, Daniel, M. ,  GUEVARA, Sergio, O. ,  FU, Haojun

    Inventor： RUNYON, Matthew, K. ,  MUETH, Daniel, M. ,  GUEVARA, Sergio, O. ,  FU, Haojun

    IPC: B04B5/02

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.

    Abstract translation: 提供转子用于离心机系统，该离心机系统构造成旋转转子以分离复杂流体。 转子包括构造成由离心机系统固定的壳体和形成在壳体中的若干室。 每个室包括具有形成在其中的端口的第一室部分和与第一室部分的端口流体连通的第二室部分。 第二室部分可以大致设置在第一室部分的端口下方。 进一步公开了用于分离复杂流体的其它转子设计和方法。

    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS
    6.
    发明申请
    METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
    用于免疫组化应用的方法和装置

    公开(公告)号：WO2012106478A2

    公开(公告)日：2012-08-09

    申请号：PCT/US2012/023553

    申请日：2012-02-01

    Applicant: KNUTSON, Chistopher, R. ,  GRANT, Christopher, F. ,  KLINE, Timothy, R. ,  DOORNEWEERD, Derek, D. ,  KURELLA, Sridevi ,  MUETH, Daniel, M. ,  RUNYON, Matthew, K. ,  FU, Haojun ,  GUEVARA, Sergio, O.

    Inventor： KNUTSON, Chistopher, R. ,  GRANT, Christopher, F. ,  KLINE, Timothy, R. ,  DOORNEWEERD, Derek, D. ,  KURELLA, Sridevi ,  MUETH, Daniel, M. ,  RUNYON, Matthew, K. ,  FU, Haojun ,  GUEVARA, Sergio, O.

    IPC: B04B7/02 ,  B01D43/00

    CPC classification number: G01N33/80 ,  B04B5/04 ,  G01N21/07

    Abstract: Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject, for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), thus allowing for more efficient detection and reduced test time. In one embodiment, the optimized antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. In another embodiment, an optimized antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed.

    Abstract translation: 公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。 在一个实施方案中，优化的抗体筛选方法和装置显着降低了与表面的非特异性结合（例如，与红细胞（rbcm）制剂结合的测试表面）的水平，从而允许更有效的检测和减少的测试时间 。 在一个实施方案中，优化的抗体筛选方法包括免疫球蛋白G（IgG）结合部分，所述免疫球蛋白G（IgG）结合部分选择性且特异性地结合相对于裂解的rbcm制剂的结合而存在的血浆IgG。 在另一个实施方案中，公开了一种优化的抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。 在其他实施例中，本发明提供了用于目标捕获的方法和装置，其包括用于捕获的可选地具有优化角度的基本平坦的表面。 公开了用于捕获的替代固相几何形状。 还公开了细胞沉积的优化方法。 因此，公开了用于评估样品的优化方法，装置，试剂盒测定。

    METHODS AND APPARATUSES FOR DETECTION OF POSITIONAL FREEDOM OF PARTICLES IN BIOLOGICAL AND CHEMICAL ANALYSES AND APPLICATIONS IN IMMUNODIAGNOSTICS
    7.
    发明申请
    METHODS AND APPARATUSES FOR DETECTION OF POSITIONAL FREEDOM OF PARTICLES IN BIOLOGICAL AND CHEMICAL ANALYSES AND APPLICATIONS IN IMMUNODIAGNOSTICS 审中-公开
    用于检测生物和化学分析中颗粒的位置自由的方法和装置及其在免疫组织化学中的应用

    公开(公告)号：WO2011149526A3

    公开(公告)日：2012-03-15

    申请号：PCT/US2011000930

    申请日：2011-05-25

    Applicant: KNUTSON CHRISTOPHER ,  AKCAKIR OSMAN ,  FU HAOJUN ,  ARRYX INC

    Inventor： KNUTSON CHRISTOPHER ,  AKCAKIR OSMAN ,  FU HAOJUN

    IPC: C12M1/00

    CPC classification number: G01N33/80 ,  C40B30/04 ,  G01N15/0211 ,  G01N15/1463 ,  G01N21/453 ,  G01N33/5029 ,  G01N33/53 ,  G01N33/54313 ,  G01N2015/0216 ,  G01N2015/1497 ,  G06F19/10

    Abstract: The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes.

    Abstract translation: 本发明涉及用于检测生物，生化，物理，生物物理和化学分析中使用的颗粒的位置自由度的方法和装置。 特别地，本发明涉及可以基于其检测到的移动性来检测和表征粒子/细胞群体的方法和装置。 在与本发明一致的一个实施方案中，某些细胞的检测基于在与底物结合的细胞群体中检测到的差异以及显示较弱结合力的细胞的差异。 最初，细胞沉积在基底上，并且在重力，天然热力学压力波动和其它随机或施加的力的存在下，一些颗粒可能表现出平移运动。 检测到颗粒运动，并且根据本发明的方法和装置计算测量值，以确定特定分析物的结合。

    SURFACE MAPPING BY OPTICAL MANIPULATION OF PARTICLES IN RELATION TO A FUNCTIONALIZED SURFACE
    9.
    发明申请
    SURFACE MAPPING BY OPTICAL MANIPULATION OF PARTICLES IN RELATION TO A FUNCTIONALIZED SURFACE 审中-公开
    光学操纵粒子的表面映射与功能化表面的关系

    公开(公告)号：WO2008034102A2

    公开(公告)日：2008-03-20

    申请号：PCT/US2007/078561

    申请日：2007-09-14

    Applicant: HAEMONETICS CORPORATION ,  KNUTSON, Christopher ,  DUKE, Crystal ,  STACEY, Gary ,  MUETH, Dan ,  TANNER, Evan ,  AKCAKIR, Osman ,  FU, Haojun ,  LANCELOT, Robert ,  CHAKRABARTY, Tania ,  BRADLEY, Kenneth

    Inventor： KNUTSON, Christopher ,  DUKE, Crystal ,  STACEY, Gary ,  MUETH, Dan ,  TANNER, Evan ,  AKCAKIR, Osman ,  FU, Haojun ,  LANCELOT, Robert ,  CHAKRABARTY, Tania ,  BRADLEY, Kenneth

    CPC classification number: G01N33/48 ,  G01N33/54373 ,  G01N33/80

    Abstract: Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided.

    Abstract translation: 提供了用于分析颗粒表面性质的方法和设备。 用于分析颗粒的表面性质的方法包括将第一颗粒与对第一化学物质具有特异性结合亲和力的第一捕获区域相关联，将光学力施加到第一颗粒，感测第一颗粒对 光力，并使用感测到的响应来确定第一颗粒表面上第一化学物质的存在，不存在或数量。 该过程可以并行重复以测试多个粒子。 除了直接测试颗粒的表面特性之外，该方法还可用于直接，间接和竞争性测定，以确定游离或固定化分析物的存在，不存在或数量。 提供具有捕捉区域的射流卡盘，所述捕捉区域具有为了使用光学力而调整的灵活性。 还提供了用于执行该方法的软件例程。

    METHODS AND APPARATUSES FOR DETECTION OF POSITIONAL FREEDOM OF PARTICLES IN BIOLOGICAL AND CHEMICAL ANALYSES AND APPLICATIONS IN IMMUNODIAGNOSTICS
    10.
    发明申请
    METHODS AND APPARATUSES FOR DETECTION OF POSITIONAL FREEDOM OF PARTICLES IN BIOLOGICAL AND CHEMICAL ANALYSES AND APPLICATIONS IN IMMUNODIAGNOSTICS 审中-公开
    用于检测生物和化学分析中颗粒的位置自由的方法和装置及其在免疫组织化学中的应用

    公开(公告)号：WO2011149526A2

    公开(公告)日：2011-12-01

    申请号：PCT/US2011/000930

    申请日：2011-05-25

    Applicant: KNUTSON, Christopher ,  AKCAKIR, Osman ,  FU, Haojun ,  ARRYX, INC.

    Inventor： KNUTSON, Christopher ,  AKCAKIR, Osman ,  FU, Haojun

    IPC: C40B30/06

    CPC classification number: G01N33/80 ,  C40B30/04 ,  G01N15/0211 ,  G01N15/1463 ,  G01N21/453 ,  G01N33/5029 ,  G01N33/53 ,  G01N33/54313 ,  G01N2015/0216 ,  G01N2015/1497 ,  G06F19/10

    Abstract: The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes.

    Abstract translation: 本发明涉及用于检测生物，生化，物理，生物物理和化学分析中使用的颗粒的位置自由度的方法和装置。 特别地，本发明涉及可以基于其检测到的移动性来检测和表征粒子/细胞群体的方法和装置。 在与本发明一致的一个实施方案中，某些细胞的检测基于在与底物结合的细胞群体中检测到的差异以及显示较弱结合力的细胞的差异。 最初，细胞沉积在基底上，并且在重力，天然热力学压力波动和其它随机或施加的力的存在下，一些颗粒可能表现出平移运动。 检测到颗粒运动，并且根据本发明的方法和装置计算测量值，以确定特定分析物的结合。

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