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    BALL LOCK MOUNTING ARRANGEMENT
    1.
    发明申请
    BALL LOCK MOUNTING ARRANGEMENT 审中-公开
    球锁安装布置

    公开(公告)号：WO2009108616A1

    公开(公告)日：2009-09-03

    申请号：PCT/US2009/034951

    申请日：2009-02-24

    Applicant: ILLINOIS TOOL WORKS INC. ,  ROGERS, John, Anthony ,  SCHOFIELD, David, Simon

    Inventor： ROGERS, John, Anthony ,  SCHOFIELD, David, Simon

    IPC: B05B15/06 ,  F16B2/16

    CPC classification number: B05B15/62 ,  B05B7/0815 ,  Y10T403/583 ,  Y10T403/592

    Abstract: A paint gun assembly comprises two connected body parts, the spray head 1 and the connecting manifold 2. The spray head is provided with a bore which terminates in a radially extending space 3 of gradually increasing radius. Received in the bore is a shaft 4. The shaft has an axially extending bore which connects with radially extending bores in which balls 5 are contained. Received in the shaft is a plunger 6 which has a rounded end and which engages with the balls 5. When forced into the axial bore, the plunger 6 forces the balls 5 into the radially extending bores and out into the tapered, radially extending space 3. Engaging with the plunger 6 in the manifold body 2 is a cam 7. The cam body 7 is exposed at a surface of the manifold body 2 and includes a hexagon drive 8 by means of which the angular rotation of the cam can be adjusted using a suitable key. The manifold body further includes a recess 9 for receiving a retaining pin (not shown). The end of the retaining pin is received in the cam guide profile 10. Axial movement of the cam 7 in its housing is further resisted by compression spring 11.

    Abstract translation: 喷枪组件包括两个连接的主体部分，即喷头1和连接歧管2.喷头设有孔，其终止于逐渐增加的半径的径向延伸空间3中。 在孔中接收的是轴4.轴具有轴向延伸的孔，其与容纳球5的径向延伸的孔连接。 在轴中接收的是柱塞6，其具有圆形端并与球5接合。当被迫进入轴向孔中时，柱塞6迫使球5进入径向延伸的孔并且进入锥形的径向延伸的空间3 与歧管主体2中的柱塞6接合是凸轮7.凸轮体7暴露在歧管主体2的表面处，并且包括六边形驱动器8，通过该六边形驱动器8可以使用 一个合适的钥匙。 歧管主体还包括用于接收保持销（未示出）的凹部9。 保持销的端部容纳在凸轮引导件轮廓10中。凸轮7在其壳体中的轴向运动被压缩弹簧11进一步抵抗。

    YEAST BIOCATALYSTS FOR DEGRADATION OF BIOWARFARE AGENTS
    2.
    发明申请
    YEAST BIOCATALYSTS FOR DEGRADATION OF BIOWARFARE AGENTS 审中-公开
    用于降解生物活性剂的酵母生物催化剂

    公开(公告)号：WO2008134090A8

    公开(公告)日：2009-02-26

    申请号：PCT/US2008050378

    申请日：2008-01-07

    Applicant: GUILD ASS INC ,  SCHOFIELD DAVID ALEXANDER ,  DINOVO AUGUSTINE ANTHONY

    Inventor： SCHOFIELD DAVID ALEXANDER ,  DINOVO AUGUSTINE ANTHONY

    IPC: C12N9/50 ,  C12N1/19 ,  C12N1/36

    CPC classification number: C12N9/14 ,  A61K38/00 ,  A61L2/18 ,  A62D3/02 ,  A62D2101/02 ,  C12N1/18 ,  C12N1/36 ,  C12N9/2402 ,  C12N9/503 ,  C12N9/80

    Abstract: The present disclosure relates to yeast biocatalysts and methods of using yeast biocatalysts for detoxifying a biowarfare agent. In some embodiments, a yeast biocatalyst may include a nucleic acid encoding a phage lysin operably linked to a prepro leader sequence, an expression control sequence operably linked to the nucleic acid, and a bioeffective amount (e.g., enough to detoxify) of the phage lysin. A yeast biocatalyst may include an engineered strain of a Saccharomyces cerevisiae. A phage lysin may be selected from the group consisting of PlyG and PlyPH. A method of detoxifying a biowarfare agent may include contacting a biowarfare agent with a yeast biocatalyst under conditions that permit detoxification. Conditions that permit detoxification, according to some embodiments, may include conditions that permit expression and secretion of a phage lysin. In some embodiments, conditions that permit detoxification may include conditions that permit germination of a spore. For example, a method of detoxifying a biowarfare agent spore may include contacting the spore with growth media (e.g., complete media or complex media) having alanine.

    Abstract translation: 本公开涉及酵母生物催化剂和使用酵母生物催化剂解毒生物战剂的方法。 在一些实施方案中，酵母生物催化剂可以包括编码与前原引导序列可操作连接的噬菌体溶素的核酸，与核酸可操作连接的表达控制序列和噬菌体溶素的生物有效量（例如足以解毒） 。 酵母生物催化剂可以包括酿酒酵母的工程菌株。 噬菌体溶素可以选自PlyG和PlyPH。 解毒生物战剂的方法可以包括使生物战剂与酵母生物催化剂在允许解毒的条件下接触。 根据一些实施方案，允许解毒的条件可以包括允许表达和分泌噬菌体溶素的条件。 在一些实施方案中，允许解毒的条件可以包括允许孢子萌发的条件。 例如，解毒生物试验剂孢子的方法可以包括使孢子与具有丙氨酸的生长培养基（例如完全培养基或复合培养基）接触。

    DIFFERENTIALLY FLUORESCENT YEAST BIOSENSORS FOR THE DETECTION AND BIODEGRADATION OF CHEMICAL AGENTS
    6.
    发明申请
    DIFFERENTIALLY FLUORESCENT YEAST BIOSENSORS FOR THE DETECTION AND BIODEGRADATION OF CHEMICAL AGENTS 审中-公开
    差分荧光酵母生物传感器用于化学试剂的检测和生物降解

    公开(公告)号：WO2009082525A3

    公开(公告)日：2009-12-23

    申请号：PCT/US2008078256

    申请日：2008-09-30

    Applicant: GUILD ASS INC ,  SCHOFIELD DAVID ALEXANDER ,  DINOVO AUGUSTINE A

    Inventor： SCHOFIELD DAVID ALEXANDER ,  DINOVO AUGUSTINE A

    IPC: C12N15/09

    CPC classification number: C12Q1/025 ,  G01N33/84 ,  G01N2333/39

    Abstract: The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical agent, modify that agent to a form with reduced toxicity, and and/or detect the modified form of the chemical agent. The present disclosure also relates, in some embodiments, to variant organophosphorus hydrolase having one or more desirable amino acid substitutions.

    Abstract translation: 本公开提供了用于检测和/或修饰化学试剂的方法，装置，系统和组合物。 在一些实施例中，生物传感器可以被配置成检测化学试剂，将该试剂修改成具有降低的毒性的形式，和/或检测化学试剂的修饰形式。 在一些实施方案中，本公开还涉及具有一个或多个期望的氨基酸取代的变体有机磷水解酶。

    BIOLOGICAL DETECTION SYSTEM AND METHOD
    7.
    发明申请
    BIOLOGICAL DETECTION SYSTEM AND METHOD 审中-公开
    生物检测系统和方法

    公开(公告)号：WO2009005869A2

    公开(公告)日：2009-01-08

    申请号：PCT/US2008/059465

    申请日：2008-04-04

    Applicant: GUILD ASSOCIATES, INC. ,  SCHOFIELD, David Alexander

    Inventor： SCHOFIELD, David Alexander

    IPC: C12Q1/04 ,  C12Q1/66 ,  G01N33/569

    CPC classification number: C12Q1/04 ,  C12N15/1086 ,  C12N2795/00011 ,  C12N2795/10311 ,  C12N2795/14111 ,  C12Q1/66 ,  G01N33/569 ,  G01N33/56983 ,  G01N2333/32

    Abstract: The present disclosure, according to some embodiments, relates to phage-based biological detection systems, compositions, and methods. In some embodiments, it relates to a detection system and method using phage binding and bacterial infection to detect the presence of a target molecule (e.g., a toxin). One detection system may include a genetically engineered phage that expresses a surface molecule able to bind a target molecule and/or target microorganism; a bacterium susceptible to infection by the phage; and a detection component able to determine whether the bacterium has been infected by the phage. Infection of a bacterium by a phage may be indicative of phage binding to the target molecule and/or target microorganism. One method may include placing a sample suspected of containing the target molecule and/or target microorganism with a binder; adding a genetically engineered phage having reporter genetic material and able to bind the target molecule and/or target microorganism; washing away unbound phage; releasing phage bound to the target molecule and/or target microorganism; infecting a bacterium with the released phage; and detecting the presence of any reporter genetic material in the bacterium. Reporter material in the bacterium may correlate with target molecule and/or target microorganism in the sample. In some embodiments, the disclosure relates to a detection system and method using phage comprising a reporter to infect a microorganism (e.g., Bacillus anthracis), wherein the reporter is selectively (e.g., only) detectable upon phage infection.

    Abstract translation: 根据一些实施方案，本公开涉及基于噬菌体的生物检测系统，组合物和方法。 在一些实施方案中，其涉及使用噬菌体结合和细菌感染来检测靶分子（例如毒素）的存在的检测系统和方法。 一种检测系统可以包括表达能够结合靶分子和/或靶微生物的表面分子的基因工程噬菌体; 易受噬菌体感染的细菌; 以及能够确定细菌是否已被噬菌体感染的检测组分。 通过噬菌体感染细菌可以指示噬菌体与靶分子和/或靶微生物的结合。 一种方法可以包括将怀疑含有靶分子和/或靶微生物的样品与粘合剂一起放置; 添加具有报道基因材料并能够结合靶分子和/或靶微生物的基因工程噬菌体; 洗去未结合的噬菌体; 释放与靶分子和/或靶微生物结合的噬菌体; 用释放的噬菌体感染细菌; 并检测细菌中任何报道基因物质的存在。 细菌中的报道物质可能与样品中的靶分子和/或靶微生物相关。 在一些实施方案中，本公开涉及使用包含报道分子的噬菌体来感染微生物（例如炭疽芽孢杆菌）的检测系统和方法，其中报道分子在噬菌体感染后选择性地（例如，仅）可检测到。

    TISSUE-SPECIFIC AND PATHOGEN-SPECIFIC TOXIC AGENTS, RIBOZYMES, DNAZYMES AND ANTISENSE OLIGONUCLEOTIDES, AND METHODS OF USE THEREOF
    9.
    发明申请
    TISSUE-SPECIFIC AND PATHOGEN-SPECIFIC TOXIC AGENTS, RIBOZYMES, DNAZYMES AND ANTISENSE OLIGONUCLEOTIDES, AND METHODS OF USE THEREOF 审中-公开
    组织特异性和病原特异性毒性剂，RIBOZYMES，DNAZYMES和抗原寡核苷酸及其使用方法

    公开(公告)号：WO0179524A2

    公开(公告)日：2001-10-25

    申请号：PCT/US0112130

    申请日：2001-04-13

    Applicant: UNIV SOUTH CAROLINA ,  PENN STATE RES FOUND ,  NORRIS JAMES S ,  CLAWSON GARY A ,  WESTWATER CAROLINE ,  SCHOFIELD DAVID ,  SCHMIDT MICHAEL G ,  HOEL BRIAN ,  DOLAN JOSEPH ,  PAN WEI HUA

    Inventor： NORRIS JAMES S ,  CLAWSON GARY A ,  WESTWATER CAROLINE ,  SCHOFIELD DAVID ,  SCHMIDT MICHAEL G ,  HOEL BRIAN ,  DOLAN JOSEPH ,  PAN WEI-HUA

    IPC: C12N15/09 ,  A61K9/06 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/00 ,  A61K47/42 ,  A61K48/00 ,  A61P1/16 ,  A61P15/00 ,  A61P17/12 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  C12N9/00 ,  C12N15/113 ,  C12N15/74 ,  C12Q

    CPC classification number: C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N15/1131 ,  C12N15/74 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/317

    Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agent to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).

    Abstract translation: 本发明涉及对病原体致死的毒物的发现，鉴定和表征以及用于将这些毒性试剂靶向病原体或病原体感染的细胞以便治疗和/或根除感染的方法。 特别地，本发明涉及针对细菌生命周期不同阶段的细菌的毒性试剂，它们单独或组合递送至细菌或细菌感染细胞。 本发明涉及对患病细胞致死的毒性试剂以及将这种毒性试剂靶向病变细胞以治疗和/或根除疾病的方法。 本发明涉及作为病原体特异性或组织特异性的启动子元件以及这些启动子元件用于实现本发明的毒性剂和/或核酶的病原体特异性或组织特异性表达的启动子元件 发明。 具体地，本发明涉及递送一种或多种有毒基因产物，反义RNA或核酶或其组合。 本发明提供了一种新的系统，通过该系统可以同时靶向多种致病性靶标以引起病原体或感染病原体的细胞的死亡。 此外，本发明对消除耐药细菌和细菌病原体具有重要的意义。 本发明提供了一种新颖的系统，通过该系统可以同时靶向多个靶标以引起患病细胞的死亡。 本发明对消除耐药性病原体（如抗生素抗性细菌）和耐药性疾病细胞（如耐药性癌细胞）具有重要意义。

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