公开(公告)号：WO2013087096A1

公开(公告)日：2013-06-20

申请号：PCT/EP2011/072637

申请日：2011-12-13

Applicant: ETHICON ENDO-SURGERY, INC. ,  ZEINER, Mark, Steven ,  ORTIZ, Mark, Steven ,  BERGER, José, M. ,  SEELEY, Randy, J. ,  VOEGELE, James, W. ,  MURRAY, Michael, A. ,  D'ARCANGELO, Michele ,  HARRIS, Jason ,  PASTORELLI, Alessandro ,  BENZINGER, Carrie ,  CAGLE, David

Inventor： ZEINER, Mark, Steven ,  ORTIZ, Mark, Steven ,  BERGER, José, M. ,  SEELEY, Randy, J. ,  VOEGELE, James, W. ,  MURRAY, Michael, A. ,  D'ARCANGELO, Michele ,  HARRIS, Jason ,  PASTORELLI, Alessandro ,  BENZINGER, Carrie ,  CAGLE, David

IPC: A61F2/04

CPC classification number: A61F2/04 ,  A61F5/0076 ,  A61F2002/045

Abstract: An endoluminal sleeve device (1) for internally lining a section of the Gl tract comprises a sleeve (2) having a longitudinal extension and a transverse extension defining a cross section of the sleeve (2), compacting means attached to the sleeve (2) and constraining a sleeve wall (8) in a transversally folded shape which narrows the cross section of the wall (8) along a prevalent portion of the longitudinal extension during longitudinally deploying the wall (8) to its full longitudinal extension, wherein the compacting means can be released when the wall (8) is longitudinally unfolded, thereby allowing the wall (8) to transversally unfold from said narrowed cross-section to an expanded cross section.

Abstract translation: 用于在内部衬里Gl道的一部分的腔内套筒装置（1）包括具有纵向延伸的套筒（2）和限定套筒（2）的横截面的横向延伸部，附接到套筒（2）的压实装置 并且以横向折叠的形式约束套管壁（8），其沿纵向展开所述壁（8）至其全部纵向延伸部，沿着所述纵向延伸部的普通部分使所述壁（8）的横截面变窄，其中所述压实装置 当壁（8）纵向展开时可以释放，从而允许壁（8）从所述变窄的横截面横向展开至扩展的横截面。

公开(公告)号：WO2011150032A1

公开(公告)日：2011-12-01

申请号：PCT/US2011/037868

申请日：2011-05-25

Applicant: ETHICON ENDO-SURGERY, INC. ,  UNIVERSITY OF CINCINNATI ,  ALBRECHT, Thomas, E. ,  ALDRIDGE, Jeffrey, L. ,  CHEKAN, Edward, G. ,  CONLON, Sean, P. ,  CROPPER, Michael, S. ,  DLUGLOS, Daniel, F. ,  HARRIS, Jason, L. ,  HESS, Christopher, J. ,  HOUSER, Kevin, L. ,  HUNT, John, V. ,  LONG, Gary, L. ,  MALAVIYA, Prasanna ,  MARCOTTE, Amy, L. ,  NOBIS, Rudolph, H. ,  ORTIZ, Mark, S. ,  OVERMYER, Mark, D. ,  PASTORELLI, Alessandro ,  PLESCIA, David, N. ,  ROBERTSON, Galen C. ,  SEELEY, Randy J. ,  SHELTON, Frederick E., IV ,  STOKES, Michael J. ,  STULEN, Foster B. ,  TIMM, Richard W. ,  VOEGELE, James W. ,  WEISENBURGH, William B., II ,  WOODWARD, James A., Jr. ,  YATES, David C. ,  ZWOLINSKI, Andrew M.

Inventor： ALBRECHT, Thomas, E. ,  ALDRIDGE, Jeffrey, L. ,  CHEKAN, Edward, G. ,  CONLON, Sean, P. ,  CROPPER, Michael, S. ,  DLUGLOS, Daniel, F. ,  HARRIS, Jason, L. ,  HESS, Christopher, J. ,  HOUSER, Kevin, L. ,  HUNT, John, V. ,  LONG, Gary, L. ,  MALAVIYA, Prasanna ,  MARCOTTE, Amy, L. ,  NOBIS, Rudolph, H. ,  ORTIZ, Mark, S. ,  OVERMYER, Mark, D. ,  PASTORELLI, Alessandro ,  PLESCIA, David, N. ,  ROBERTSON, Galen C. ,  SEELEY, Randy J. ,  SHELTON, Frederick E., IV ,  STOKES, Michael J. ,  STULEN, Foster B. ,  TIMM, Richard W. ,  VOEGELE, James W. ,  WEISENBURGH, William B., II ,  WOODWARD, James A., Jr. ,  YATES, David C. ,  ZWOLINSKI, Andrew M.

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/32 ,  A61F5/00

CPC classification number: A61N1/00 ,  A61F5/0026 ,  A61N1/0509 ,  A61N1/327 ,  A61N1/36007

Abstract: A method for regulating hormone production comprises placing at least one electrode in a gastrointestinal tract of a patient and recording an electrical signal during a preselected event produced by the gastrointestinal tract. The method further involves the steps of storing the electrical signal, and playing back the electrical signal by activating the electrode during the absence of the preselected event.

Abstract translation: 用于调节激素产生的方法包括将至少一个电极放置在患者的胃肠道中，并在由胃肠道产生的预选事件期间记录电信号。 该方法还包括存储电信号的步骤，以及在没有预选事件期间激活电极来播放电信号。

公开(公告)号：WO2003075751A3

公开(公告)日：2003-09-18

申请号：PCT/US2003/007253

申请日：2003-03-07

Applicant: UNIVERSITY OF CINCINNATI ,  SEELEY, Randy, J.

Inventor： SEELEY, Randy, J.

IPC: C12Q1/68

Abstract: Methods for determining therapeutic strategies and/or targets for examining weight loss in an individual, comprising administering to the individual a prolonged overfeeding regimen and identifying gene and/or protein expression that occur in the individual with the prolonged overfeeding regimen.

公开(公告)号：WO03075751A2

公开(公告)日：2003-09-18

申请号：PCT/US0307253

申请日：2003-03-07

Applicant: UNIV CINCINNATI ,  SEELEY RANDY J

Inventor： SEELEY RANDY J

IPC: A61B20060101 ,  A61K49/00 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G06F19/00 ,  A61B

CPC classification number: A61K49/0004 ,  A61K49/0008 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5091

Abstract: Methods for determining therapeutic strategies and/or targets for examining weight loss in an individual, comprising administering to the individual a prolonged overfeeding regimen and identifying gene and/or protein expression that occur in the individual with the prolonged overfeeding regimen.

Abstract translation: 用于确定用于检查个体体重减轻的治疗策略和/或靶标的方法，包括对所述个体施用延长的过度摄取方案，以及用延长的过度喂养方案鉴定发生在个体中的基因和/或蛋白质表达。

公开(公告)号：WO2011150033A1

公开(公告)日：2011-12-01

申请号：PCT/US2011/037869

申请日：2011-05-25

Applicant: ETHICON ENDO-SURGERY, INC. ,  UNIVERSITY OF CINCINNATI ,  BAKOS, Gregory ,  CHEKAN, Edward, G. ,  HERRERA-DAVIS, Denzel, Z. ,  HARRIS, Jason, L. ,  LONG, Gary, L. ,  NOBIS, Rudolph, H. ,  ORTIZ, Mark, S. ,  OVERMYER, Mark, D. ,  PLESCIA, David, N. ,  SEELEY, Randy, J. ,  WEISENBURGH, William, B. ,  WIDENHOUSE, Tamara, S. Vetro ,  ZEINER, Mark, S. ,  ZWOLINSKI, Andrew, M.

Inventor： BAKOS, Gregory ,  CHEKAN, Edward, G. ,  HERRERA-DAVIS, Denzel, Z. ,  HARRIS, Jason, L. ,  LONG, Gary, L. ,  NOBIS, Rudolph, H. ,  ORTIZ, Mark, S. ,  OVERMYER, Mark, D. ,  PLESCIA, David, N. ,  SEELEY, Randy, J. ,  WEISENBURGH, William, B. ,  WIDENHOUSE, Tamara, S. Vetro ,  ZEINER, Mark, S. ,  ZWOLINSKI, Andrew, M.

IPC: C12N5/071 ,  A61K35/38 ,  A61P1/00 ,  A61L27/38

CPC classification number: C12N5/0679 ,  A61K35/12 ,  A61K35/38 ,  A61L27/14 ,  A61L27/3882 ,  A61L27/58 ,  A61L31/04 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/64

Abstract: L-cells may be introduced in the gastrointestinal tract. L-cells are used in the digestive process to produce a more efficient and lasting means of regulating feelings of satiation in a patient. Desired metabolic effects may be achieved by manipulating L-cells via delivery sites, frequency of delivery, or type of biological substance delivered.

Abstract translation: L细胞可能被引入胃肠道。 L细胞用于消化过程，以产生更有效和持久的调节患者饱腹感的手段。 所需的代谢作用可以通过经由递送部位操纵L细胞，递送频率或递送的生物物质的类型来实现。