公开(公告)号：WO2009131423A3

公开(公告)日：2009-12-23

申请号：PCT/KR2009002173

申请日：2009-04-24

Applicant: UNIV KYUNG HEE UNIV IND COOP GROUP ,  MEDIKAN INC ,  CHUNG IN SIK ,  KIM KYUNG IL ,  LEE JONG MIN ,  LEE HYUN HO ,  SHON DONG HWA ,  KIM WON YONG ,  LEE HEEYOUNG ,  CHUNG HO YONG ,  CHUNG HA YOUNG ,  HWANG BO JEON ,  YOO KI HYUN ,  KIM JONG BUM

Inventor： CHUNG IN SIK ,  KIM KYUNG IL ,  LEE JONG MIN ,  LEE HYUN HO ,  SHON DONG HWA ,  KIM WON YONG ,  LEE HEEYOUNG ,  CHUNG HO YONG ,  CHUNG HA YOUNG ,  HWANG BO JEON ,  YOO KI HYUN

IPC: C12N15/33 ,  C12N15/63

CPC classification number: C12N15/8258

Abstract: The present invention relates to a novel hepatitis A virus antigen gene and transformed plants with the gene, more particularly to a novel hepatitis A virus antigen gene synthesized by optimization of a genetic code, a recombinant vector containing the gene and plants transformed with the recombinant vector. According to the invention, the use of a synthesized antigen gene of hepatitis A virus makes it possible to prepare recombinant hepatitis A virus vaccine materials at a high efficiency, and transformed plants expressing a hepatitis A virus antigen are useful as functional food materials and orally administrated vaccine materials.

Abstract translation: 本发明涉及一种新型甲型肝炎病毒抗原基因和具有该基因的转化植物，更具体地涉及通过优化遗传密码合成的新型甲型肝炎病毒抗原基因，含有该基因的重组载体和用该重组载体转化的植物 。 根据本发明，甲型肝炎病毒合成抗原基因的使用使得能够以高效率制备重组甲型肝炎病毒疫苗材料，表达甲型肝炎病毒抗原的转化植物可用作功能性食品材料并经口服 疫苗材料。

公开(公告)号：WO2011136506A3

公开(公告)日：2012-04-19

申请号：PCT/KR2011002937

申请日：2011-04-22

Applicant: UNIV CHUNG ANG IND ,  KIM WON YONG ,  CHUNG IN SIK ,  KIM JONG-BUM ,  SHON DONG-HWA ,  THAN VAN THAI ,  YOON JANG WON ,  PARK JOO HYOUNG ,  BAEK IN-HYUK

Inventor： KIM WON YONG ,  CHUNG IN SIK ,  KIM JONG-BUM ,  SHON DONG-HWA ,  THAN VAN THAI ,  YOON JANG WON ,  PARK JOO HYOUNG ,  BAEK IN-HYUK

IPC: C12N15/46 ,  C07K19/00 ,  C12N15/51 ,  C12N15/866

CPC classification number: A61K39/29 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2720/12322 ,  C12N2720/12334 ,  C12N2770/32234 ,  C12N2770/32422 ,  C12N2770/32434 ,  G01N33/56983 ,  G01N2333/14

Abstract: The present invention relates to a construct for expressing rotavirus complex antigens having heterologous virus antigen epitopes, to a vaccine composition comprising the rotavirus complex antigens, to rotavirus-like particles comprising the rotavirus complex antigens, and to a vaccine composition comprising the rotavirus-like particles. According to the present invention, complex antigens comprising both the rotavirus antigens and epitopes of heterologous viruses different from the rotaviruses, and rotavirus-like particles comprising the complex antigens can be mass-produced at low costs. The method of the present invention can be applied to the study and development of novel complex vaccines against rotaviruses and heterologous viruses.

Abstract translation: 本发明涉及用于表达具有异源病毒抗原表位的轮状病毒复合抗原，包含轮状病毒复合抗原的疫苗组合物，包含轮状病毒复合抗原的轮状病毒样颗粒的构建体，以及包含轮状病毒样颗粒 。 根据本发明，包含轮状病毒抗原和不同于轮状病毒的异源病毒表位的复合抗原和包含复合抗原的轮状病毒样颗粒可以以低成本大量生产。 本发明的方法可以应用于研究和开发针对轮状病毒和异源病毒的新型复合疫苗。

公开(公告)号：WO2011136506A9

公开(公告)日：2012-03-01

申请号：PCT/KR2011002937

申请日：2011-04-22

Applicant: UNIV CHUNG ANG IND ,  KIM WON YONG ,  CHUNG IN SIK ,  KIM JONG-BUM ,  SHON DONG-HWA ,  THAN VAN THAI ,  YOON JANG WON ,  PARK JOO HYOUNG ,  BAEK IN-HYUK

Inventor： KIM WON YONG ,  CHUNG IN SIK ,  KIM JONG-BUM ,  SHON DONG-HWA ,  THAN VAN THAI ,  YOON JANG WON ,  PARK JOO HYOUNG ,  BAEK IN-HYUK

IPC: C12N15/46 ,  C07K19/00 ,  C12N15/51 ,  C12N15/866

CPC classification number: A61K39/29 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2720/12322 ,  C12N2720/12334 ,  C12N2770/32234 ,  C12N2770/32422 ,  C12N2770/32434 ,  G01N33/56983 ,  G01N2333/14

Abstract: The present invention relates to a construct for expressing rotavirus complex antigens having heterologous virus antigen epitopes, to a vaccine composition comprising the rotavirus complex antigens, to rotavirus-like particles comprising the rotavirus complex antigens, and to a vaccine composition comprising the rotavirus-like particles. According to the present invention, complex antigens comprising both the rotavirus antigens and epitopes of heterologous viruses different from the rotaviruses, and rotavirus-like particles comprising the complex antigens can be mass-produced at low costs. The method of the present invention can be applied to the study and development of novel complex vaccines against rotaviruses and heterologous viruses.

Abstract translation: 本发明涉及将含有异源病毒抗原表位的轮状病毒复合抗原，包含轮状病毒复合抗原的疫苗组合物，包含轮状病毒复合物抗原的轮状病毒样颗粒，以及包含轮状病毒样颗粒的疫苗组合物 。 根据本发明，可以以低成本批量生产包含轮状病毒抗原和不同于轮状病毒的异源病毒的表位的复合抗原和包含复合抗原的轮状病毒样颗粒。 本发明的方法可用于研究和开发抗轮状病毒和异源病毒的新型复合疫苗。