公开(公告)号：WO2010006071A1

公开(公告)日：2010-01-14

申请号：PCT/US2009/049968

申请日：2009-07-08

Applicant: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY ,  WARE, Carl, F. ,  CHEUNG, Timothy, C. ,  STEINBERG, Marcos

Inventor： WARE, Carl, F. ,  CHEUNG, Timothy, C. ,  STEINBERG, Marcos

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: A61K39/0005 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/30 ,  G01N2333/70578

Abstract: The invention provides HVEM cis complexes which include, for example, HVEM/BTLA, HVEM/CD160 and HVEM/gD cis complexes. The invention provides ligands and agents that bind to HVEM cis complexes, such as antibodies. The invention further provides methods of use of the HVEM cis complexes, and the ligands and agents (e.g., antibodies) that bind to the HVEM cis complexes.

Abstract translation: 本发明提供HVEM顺式复合物，其包括例如HVEM / BTLA，HVEM / CD160和HVEM / gD顺式复合物。 本发明提供了与HVEM顺式复合物如抗体结合的配体和试剂。 本发明还提供使用HVEM顺式复合物的方法，以及结合HVEM顺式复合物的配体和试剂（例如抗体）。

公开(公告)号：WO2005117989A1

公开(公告)日：2005-12-15

申请号：PCT/EP2005/005992

申请日：2005-06-03

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PIERRE ET MARIE CURIE ,  UNIVERSITE MONTPELLIER II ,  SITBON, Naomi ,  KLATZMANN, David ,  MONGELLAZ, Cédric ,  ADJALI, Oumeya ,  JACQUET, Chantal ,  STEINBERG, Marcos ,  MARODON, Gilles

Inventor： SITBON, Naomi ,  KLATZMANN, David ,  MONGELLAZ, Cédric ,  ADJALI, Oumeya ,  JACQUET, Chantal ,  STEINBERG, Marcos ,  MARODON, Gilles

IPC: A61K48/00

CPC classification number: A61K48/0075 ,  A61K38/00 ,  A61K38/28 ,  A61K38/45 ,  A61K2039/5256 ,  A61K2039/57 ,  C07K14/005 ,  C12N15/86 ,  C12N15/90 ,  C12N2740/16043 ,  C12N2760/16122 ,  C12N2830/00 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2830/50 ,  C12N2840/203 ,  H01B3/441 ,  H01B7/295

Abstract: The invention relates to the use of viral vectors able to stably integrate into the genome of thymic stromal cells, or of intrathymic lymphocytes or lymphocytes precursors, for the manufacture of a medicine intended for intrathymic administration in the frame of the prevention or treatment of genetic immunodeficiencies, acquired immunodeficiencies, or for the induction of immune tolerance of the organism to self or non-self gene products, cells or tissues, or for the prevention or treatment of autoimmune diseases.

Abstract translation: 本发明涉及能够稳定整合到胸腺基质细胞或胸腺淋巴细胞或淋巴细胞前体的基因组中的病毒载体在预防或治疗基因免疫缺陷的框架中用于制造用于胸腺内给药的药物的用途 ，获得性免疫缺陷，或诱导生物体对自身或非自身基因产物，细胞或组织的免疫耐受，或用于预防或治疗自身免疫性疾病。

公开(公告)号：WO2005117989A9

公开(公告)日：2006-02-02

申请号：PCT/EP2005005992

申请日：2005-06-03

Applicant: CENTRE NAT RECH SCIENT ,  UNIV PARIS CURIE ,  UNIV MONTPELLIER II ,  SITBON NAOMI ,  KLATZMANN DAVID ,  MONGELLAZ CEDRIC ,  ADJALI OUMEYA ,  JACQUET CHANTAL ,  STEINBERG MARCOS ,  MARODON GILLES

Inventor： SITBON NAOMI ,  KLATZMANN DAVID ,  MONGELLAZ CEDRIC ,  ADJALI OUMEYA ,  JACQUET CHANTAL ,  STEINBERG MARCOS ,  MARODON GILLES

IPC: H01B7/295 ,  A61K38/11 ,  A61K38/28 ,  A61K38/45 ,  A61K48/00 ,  C07K14/11 ,  C12N5/06 ,  C12N15/867 ,  C12N15/90 ,  H01B3/44 ,  H01B7/02 ,  C12N5/10

CPC classification number: A61K48/0075 ,  A61K38/00 ,  A61K38/28 ,  A61K38/45 ,  A61K2039/5256 ,  A61K2039/57 ,  C07K14/005 ,  C12N15/86 ,  C12N15/90 ,  C12N2740/16043 ,  C12N2760/16122 ,  C12N2830/00 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2830/50 ,  C12N2840/203 ,  H01B3/441 ,  H01B7/295

Abstract: The invention relates to the use of viral vectors able to stably integrate into the genome of thymic stromal cells, or of intrathymic lymphocytes or lymphocytes precursors, for the manufacture of a medicine intended for intrathymic administration in the frame of the prevention or treatment of genetic immunodeficiencies, acquired immunodeficiencies, or for the induction of immune tolerance of the organism to self or non-self gene products, cells or tissues, or for the prevention or treatment of autoimmune diseases.

Abstract translation: 本发明涉及能够稳定地整合到胸腺基质细胞或胸腺内淋巴细胞或淋巴细胞前体的基因组中的病毒载体在预防或治疗基因免疫缺陷的框架中用于制造用于胸腺内给药的药物的用途 ，获得性免疫缺陷，或诱导生物体对自身或非自身基因产物，细胞或组织的免疫耐受，或用于预防或治疗自身免疫性疾病。