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    METHOD OF LAYERED OBJECT MANUFACTURING, SHEET ELEMENT, OBJECT MANUFACTURING DEVICE, AND OBJECT
    1.
    发明申请
    METHOD OF LAYERED OBJECT MANUFACTURING, SHEET ELEMENT, OBJECT MANUFACTURING DEVICE, AND OBJECT 审中-公开
    层状物体制造方法，片材元件，物体制造装置和物体

    公开(公告)号：WO2016068697A1

    公开(公告)日：2016-05-06

    申请号：PCT/NL2015/050742

    申请日：2015-10-27

    Applicant: STICHTING VU-VUMC

    Inventor： BOS, Ernst Jan

    IPC: B29C67/00

    CPC classification number: B29C64/141

    Abstract: The present invention provides a method of layered object manufacturing using multiple sheet elements each having a predetermined dimension, wherein the sheet elements comprise first interlocking elements configured to interlock with at least a first further sheet element arranged at a first side of the sheet element, and second interlocking elements configured to interlock with at least a second further sheet element arranged at a second side of the sheet element, wherein the second side is opposite the first side. The method comprises stacking the multiple sheet elements on top of each other, wherein the first interlocking elements of a first one of the multiple sheet elements interlock with the second interlocking elements of a second one of the multiple sheet elements arranged at the first side of the first sheet element, and the second interlocking elements interlock with first interlocking elements of a third one of the multiple sheet elements arranged at the second side of the first sheet element. The invention also provides a sheet element, an object manufacturing device, and object constructed with the method.

    Abstract translation: 本发明提供了一种使用多个片材元件的分层物体制造方法，每个片材元件具有预定的尺寸，其中片材元件包括构造成与布置在片材元件的第一侧的至少第一另外的片元件互锁的第一互锁元件，以及 第二互锁元件构造成与布置在片材元件的第二侧处的至少第二另外的片元件互锁，其中第二侧与第一侧相对。 该方法包括将多个片材元件堆叠在彼此的顶部上，其中多个片材元件中的第一个片材的第一互锁元件与布置在第一侧面上的多个片状元件中的第二个互补元件的第二互锁元件互锁 第一片状元件，并且第二互锁元件与布置在第一片元件的第二侧的多个片状元件中的第三个的第一互锁元件互锁。 本发明还提供了一种片材元件，一种物体制造装置和用该方法构造的物体。

    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER
    6.
    发明申请
    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER 审中-公开
    一种分析疾病标记物存在的受试者血样的方法

    公开(公告)号：WO2012008839A9

    公开(公告)日：2012-05-03

    申请号：PCT/NL2011050518

    申请日：2011-07-15

    Applicant: STICHTING VU VUMC ,  WUERDINGER THOMAS ,  NILSSON ROLF JONAS

    Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

    IPC: G01N33/48

    CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

    Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

    Abstract translation: 本发明涉及分析受试者的血液样品中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的无核血细胞中提取核酸以提供无核血细胞提取 核酸组分，和b）分析所述无核血细胞提取的核酸组分是否存在疾病标志物，其中所述疾病标志物是所述对象细胞基因中的疾病特异性突变，或其中所述疾病标志物 是所述受试者细胞的基因的疾病特异性表达谱。

    VERAPAMIL LIKE COMPOUNDS
    8.
    发明申请
    VERAPAMIL LIKE COMPOUNDS 审中-公开
    VERAPAMIL类化合物

    公开(公告)号：WO2014098593A1

    公开(公告)日：2014-06-26

    申请号：PCT/NL2013050925

    申请日：2013-12-19

    Applicant: STICHTING TECH WETENSCHAPP ,  STICHTING VU VUMC ,  UNIV GRONINGEN ,  GRONINGEN ACAD ZIEKENHUIS

    Inventor： RAAPHORST RENSKE ,  LUURTSEMA GERT ,  WINDHORST ALBERT DIRK ,  LAMMERTSMA ADRIAAN

    IPC: A61K51/04 ,  A61K31/277 ,  C07B59/00

    CPC classification number: A61K31/277 ,  A61K51/04 ,  C07B59/001

    Abstract: The invention is directed to a compound, a salt or a solvate thereof according to (I) wherein R1 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group, R2, R3, R4 and R5 are eacn independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein R1 is a methyl group, and R3 is a R3 is a fluoroalkyl group or a [18F]fluoroalkyl group, R2, R4 and R5 are each independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein if R1 is hydrogen, at least one of R2, R3, R4 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group.

    Abstract translation: 本发明涉及根据（I）的化合物，其盐或溶剂合物，其中R 1是任选支链的氟代烷基或[18 F]氟代烷基，R 2，R 3，R 4和R 5独立地是甲基，[3 H] 甲基，氟代烷基或[18 F]氟烷基，R 6为（R） - 氰基或（S） - 氰基; 或其中R 1为甲基，R 3为R 3为氟烷基或[18 F]氟代烷基，R 2，R 4和R 5各自独立地为甲基，[3 H]甲基，氟代烷基或[18 F]氟代烷基，和 R6是（R） - 氰基或（S） - 氰基; 或其中如果R 1是氢，则R 2，R 3，R 4中的至少一个是任选支链的氟代烷基或[18 F]氟代烷基。

    METHOD FOR DETERMINING TOXICITY
    9.
    发明申请
    METHOD FOR DETERMINING TOXICITY 审中-公开
    确定毒性的方法

    公开(公告)号：WO2013151440A3

    公开(公告)日：2014-01-09

    申请号：PCT/NL2013050256

    申请日：2013-04-05

    Applicant: STICHTING VU VUMC

    Inventor： VAN STRAALEN NICOLAAS MARIA ,  ROELOFS THEODORUS FRANK MARIA

    IPC: C12Q1/68

    CPC classification number: C12Q1/689 ,  C12Q2600/142 ,  C12Q2600/158

    Abstract: A method for determining toxicity of a sample, particularly a soil sample suspected of containing polycyclic aromatic hydrocarbon pollutants, is provided. The method allows for quantification of toxicity levels based on gene expression profiling of a test organism, for example Folsomia candida,exposed to the sample.

    Abstract translation: 提供了一种确定样品毒性的方法，特别是怀疑含有多环芳烃污染物的土壤样品。 该方法允许基于暴露于样品的测试生物（例如，假丝酵母​​菌）的基因表达谱来定量毒性水平。

    miRNA IN BLOOD BRAIN BARRIER OF MS PATIENTS
    10.
    发明申请
    miRNA IN BLOOD BRAIN BARRIER OF MS PATIENTS 审中-公开
    miRNA在血清脑膜障碍患者中的​​作用

    公开(公告)号：WO2013070079A8

    公开(公告)日：2013-10-24

    申请号：PCT/NL2012050793

    申请日：2012-11-09

    Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU VUMC

    Inventor： REIJERKERK ARIE ,  DE VRIES HELGA EVELINE

    IPC: C12Q1/68

    CPC classification number: C12Q1/6809 ,  C12Q2600/178

    Abstract: The blood-brain barrier (BBB) separates the blood and the central nervous system (CNS). Here it is disclosed that blood-brain barrier function can be increased with particular nucleic acid sequences, in particular in patients suffering from or diagnosed with Multiple Sclerosis. The use of compounds comprising such nucleic acid sequences for increasing blood-brain barrier function is described.

    Abstract translation: 血脑屏障（BBB）分离血液和中枢神经系统（CNS）。 这里公开了可以使用特定的核酸序列，特别是患有或诊断为多发性硬化症的患者来增加血脑屏障功能。 描述了包含这种核酸序列的化合物用于增加血脑屏障功能的用途。

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