公开(公告)号：WO2008085538A3

公开(公告)日：2008-11-20

申请号：PCT/US2007072298

申请日：2007-06-27

Applicant: INTEL CORP ,  ZHANG JINGWU ,  LI HANDONG ,  SUNDARARAJAN NARAYAN ,  SU XING ,  SUN LEI

Inventor： ZHANG JINGWU ,  LI HANDONG ,  SUNDARARAJAN NARAYAN ,  SU XING ,  SUN LEI

IPC: G01N21/66 ,  G01J3/44 ,  G01N21/956

CPC classification number: G01N33/585 ,  C12Q1/6816 ,  G01N21/658 ,  G01N33/54373 ,  C12Q2563/155 ,  C12Q2565/632

Abstract: The embodiments of the invention are directed to a SERS cluster comprising a capture particle that is at least partially surrounded by analyte molecules, wherein both the capture particle and the analyte molecules surrounding the capture particle are at least partially surrounded by enhancer particles, wherein a majority of the analyte molecules are either sandwiched between capture and enhancer particles or located between junctions of the enhancer particles. The embodiments of the invention also relate to methods of manufacturing and detecting the SERS cluster. The embodiments of the invention also relate to a SERS active particle comprising a tag molecule comprising a Raman active compound and a probe or a linker having a specific biochemical binding capability and to a method for detecting of a target molecule using a SERS active particle having a tag molecule comprising a Raman active compound and a probe or a linker.

Abstract translation: 本发明的实施方案涉及包含至少部分被分析物分子包围的捕获颗粒的SERS簇，其中捕获颗粒和围绕捕获颗粒的分析物分子至少部分被增强剂颗粒包围，其中大部分 的分析物分子夹在捕获和增强剂颗粒之间或位于增强剂颗粒的连接点之间。 本发明的实施例还涉及制造和检测SERS群集的方法。 本发明的实施方案还涉及包含标签分子的SERS活性颗粒，所述标签分子包含拉曼活性化合物和具有特定生物化学结合能力的探针或接头，并涉及使用SERS活性颗粒检测靶分子的方法，所述SERS活性颗粒具有 标签分子，其包含拉曼活性化合物和探针或接头。

公开(公告)号：WO2008091364A2

公开(公告)日：2008-07-31

申请号：PCT/US2007/072297

申请日：2007-06-27

Applicant: INTEL CORPORATION ,  PARK, Chang-Min ,  RAMANATHAN, Shriram ,  SU, Xing

Inventor： PARK, Chang-Min ,  RAMANATHAN, Shriram ,  SU, Xing

CPC classification number: G01N24/08 ,  G01N24/10 ,  G01N33/587 ,  G01R33/302 ,  G01R33/3415 ,  G01R33/465

Abstract: Embodiments of the invention relate to detecting biological molecules with ultra-sensitivity and convenience. The embodiments are especially directed to utilizing nanoparticles as tags and identifying the tags using a nuclear magnetic resonance device. The probes containing the nanoparticles can be used in solution or attached to a substrate.

Abstract translation: 本发明的实施方案涉及以超灵敏度和方便性检测生物分子。 实施方案特别涉及使用纳米颗粒作为标签并使用核磁共振装置识别标签。 含有纳米颗粒的探针可用于溶液中或附着于底物。

公开(公告)号：WO2005066367A3

公开(公告)日：2007-03-01

申请号：PCT/US2004043364

申请日：2004-12-24

Applicant: INTEL CORP ,  SU XING ,  SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO ,  BERLIN ANDREW ,  SUN LEI ,  ZHANG YUEGANG

Inventor： SU XING ,  SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO ,  BERLIN ANDREW ,  SUN LEI ,  ZHANG YUEGANG

IPC: C01B31/02 ,  C12Q1/68 ,  D01F9/127 ,  H01L51/00 ,  H01L51/30

CPC classification number: B82Y40/00 ,  B82Y10/00 ,  B82Y30/00 ,  C01B32/162 ,  C01B2202/08 ,  C01B2202/36 ,  D01F9/127 ,  H01L51/0048 ,  H01L51/0052

Abstract: The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.

Abstract translation: 本文公开的方法，装置和系统涉及碳纳米管的有序阵列。 在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成，将聚合物（120,210）分子附着到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。 聚合物（120,210）分子对齐技术。 纳米管阵列可以附着到基板的选定区域（110,310）。 在所选择的区域（110,310）内，纳米管是非随机分布的。 本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。 在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

公开(公告)号：WO2005066373A1

公开(公告)日：2005-07-21

申请号：PCT/US2004/044091

申请日：2004-12-28

Applicant: INTEL CORPORATION ,  BERLIN, Andrew ,  SU, Xing ,  CHAN, Selena ,  KOO, Tae-Woong ,  SUN, Lei

Inventor： BERLIN, Andrew ,  SU, Xing ,  CHAN, Selena ,  KOO, Tae-Woong ,  SUN, Lei

IPC: C12Q1/68

CPC classification number: G01N21/658 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  C12Q1/6816 ,  C12Q1/6834 ,  G01N33/543 ,  G01N33/68 ,  G01N33/6818 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  C12Q2565/125 ,  C12Q2565/632

Abstract: Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the protein-containing analytes in a body fluid are provided. The probe moieties in the Raman-active constructs are selected to bind to and identify specific known analytes in the biological sample or the probe moieties are designed to chemically interact with functional groups commonly found in certain amino acids so that the invention methods provide information about the amino acid composition of protein-containing analytes or fragments in the samples. In some cases, the Raman­active or SERS-active probe constructs, when used in the invention methods, can identify particular protein-containing analytes or types of such analytes so that a protein profile of a patient sample can be made. When compared to a data base of Raman or SERS spectra of normal samples, a disease state of a patient can be identified using the methods disclosed.

Abstract translation: 提供了使用拉曼活性或SERS-活性探针构建体检测生物样品中的分析物的各种方法，例如体液中含蛋白质的分析物。 选择拉曼活性构建体中的探针部分以结合并识别生物样品中的特定已知分析物，或者将探针部分设计为与通常在某些氨基酸中发现的官能团进行化学相互作用，使得本发明方法提供关于 样品中含蛋白质的分析物或片段的氨基酸组成。 在一些情况下，当在本发明方法中使用时，拉曼活性或SERS-活性探针构建体可以鉴定特定的含蛋白质的分析物或这种分析物的类型，使得可以制备患者样品的蛋白质谱。 当与正常样品的拉曼或SERS光谱的数据库相比时，可以使用所公开的方法鉴定患者的疾病状态。

公开(公告)号：WO2005030997A1

公开(公告)日：2005-04-07

申请号：PCT/US2004/031308

申请日：2004-09-24

Applicant: INTEL CORPORATION ,  SU, Xing ,  CHAN, Selena

Inventor： SU, Xing ,  CHAN, Selena

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  B01L3/5027 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/653 ,  G01N2021/656 ,  C12Q2565/632 ,  C12Q2521/319 ,  C12Q2563/155 ,  C12Q2565/629

Abstract: The methods and apparatus disclosed herein concern nucleic acid characterization by enhanced Raman spectroscopy. In certain embodiments of the invention, exonuclease treatment of the nucleic acids results in the release of nucleotides. The nucleotides may pass from a reaction chamber through a microfluidic channel and enter a nanochannel or microchannel. The nanochannel or microchannel may be packed with nanoparticle aggregates containing hot spots for Raman detection. As the nucleotides pass through the nanoparticle hot spots, they may be detected by Raman spectroscopy. Identification of the sequence of nucleotides released from the nucleic acid is used to characterize the nucleic acid, for example by sequencing or identifying the nucleic acid. Other embodiments of the invention concern apparatus for nucleic acid sequencing.

Abstract translation: 本文公开的方法和装置涉及通过增强拉曼光谱进行的核酸表征。 在本发明的某些实施方案中，核酸外切核酸酶处理导致核苷酸的释放。 核苷酸可以从反应室通过微流体通道并进入纳米通道或微通道。 纳米通道或微通道可以填充含有用于拉曼检测的热点的纳米颗粒聚集体。 当核苷酸通过纳米颗粒热点时，它们可以通过拉曼光谱法检测。 使用从核酸释放的核苷酸序列的鉴定来表征核酸，例如通过测序或鉴定核酸。 本发明的其它实施方案涉及用于核酸测序的装置。

公开(公告)号：WO2003010328A3

公开(公告)日：2003-02-06

申请号：PCT/US2002/023570

申请日：2002-07-23

Applicant: AFFYMETRIX, INC. ,  SU, Xing ,  MATSUZAKI, Hajime ,  KENNEDY, Giulia

Inventor： SU, Xing ,  MATSUZAKI, Hajime ,  KENNEDY, Giulia

IPC: C12Q1/68

Abstract: The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for size fractionation. In a preferred embodiment, size fractionation can be accomplished by varying conditions or reagents of a PCR reaction to amplify fragments of specific size ranges. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the desired fragments for particular characteristics, such as, for example, the presence or absence of a polymorphism.

公开(公告)号：WO2003010328A2

公开(公告)日：2003-02-06

申请号：PCT/US2002/023570

申请日：2002-07-23

Applicant: AFFYMETRIX, INC. ,  SU, Xing ,  MATSUZAKI, Hajime ,  KENNEDY, Giulia

Inventor： SU, Xing ,  MATSUZAKI, Hajime ,  KENNEDY, Giulia

IPC: C12Q

CPC classification number: C12Q1/6855 ,  C12Q2527/143 ,  C12Q2527/113

Abstract: The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for size fractionation. In a preferred embodiment, size fractionation can be accomplished by varying conditions or reagents of a PCR reaction to amplify fragments of specific size ranges. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the desired fragments for particular characteristics, such as, for example, the presence or absence of a polymorphism.

Abstract translation: 目前要求保护的发明提供了用于通过提供用于尺寸分级分离的非基于凝胶的方法来降低核酸样品的复杂性的新颖方法和试剂盒。 在优选的实施方案中，大小分级可以通过改变PCR反应的条件或试剂来扩增特定大小范围的片段来实现。 本发明进一步提供了通过与阵列的杂交分析上述样品，所述阵列可被特别设计为询问特定特征的期望片段，例如多态性的存在或不存在。

公开(公告)号：WO2012074849A1

公开(公告)日：2012-06-07

申请号：PCT/US2011/061919

申请日：2011-11-22

Applicant: CHICAGO MERCANTILE EXCHANGE INC. ,  CO, Richard ,  WANG, TuenTuen ,  SU, Xing ,  LABUSZEWSKI, John

Inventor： CO, Richard ,  WANG, TuenTuen ,  SU, Xing ,  LABUSZEWSKI, John

IPC: G06Q40/00

CPC classification number: G06Q40/04

Abstract: Systems and method are disclosed for quoting, adjusting and settling futures contracts by successively removing the just-realized variables from the quoted futures price to focus the quoted contract value to the remaining unrealized economic variables. Further, such systems and method for quoting, adjusting and settling the futures contracts preserve the underlying economic consideration for the trade when compared with the traditional way of quoting futures based on the same cumulative sum.

Abstract translation: 披露了引用，调整和结算期货合约的制度和方法，连续从被引用的期货价格中删除了刚刚实现的变量，将其合并价值重点放在剩余的未实现经济变量上。 此外，引用，调整和解决期货合约的这种制度和方法与传统的基于相同累计金额的期货方式相比较，保持了贸易的潜在经济考虑。

公开(公告)号：WO2008091364A3

公开(公告)日：2008-12-11

申请号：PCT/US2007072297

申请日：2007-06-27

Applicant: INTEL CORP ,  PARK CHANG-MIN ,  RAMANATHAN SHRIRAM ,  SU XING

Inventor： PARK CHANG-MIN ,  RAMANATHAN SHRIRAM ,  SU XING

IPC: G01N33/53 ,  A61B5/055 ,  C12Q1/68 ,  G01N24/08 ,  G01N24/10

CPC classification number: G01N24/08 ,  G01N24/10 ,  G01N33/587 ,  G01R33/302 ,  G01R33/3415 ,  G01R33/465

Abstract: Embodiments of the invention relate to detecting biological molecules with ultra-sensitivity and convenience. The embodiments are especially directed to utilizing nanoparticles as tags and identifying the tags using a nuclear magnetic resonance device. The probes containing the nanoparticles can be used in solution or attached to a substrate.

Abstract translation: 本发明的实施例涉及以超灵敏度和便利性检测生物分子。 这些实施例特别针对利用纳米粒子作为标签并使用核磁共振装置来识别标签。 包含纳米颗粒的探针可以溶液使用或附着于基底。

公开(公告)号：WO2008085538A2

公开(公告)日：2008-07-17

申请号：PCT/US2007/072298

申请日：2007-06-27

Applicant: INTEL CORPORATION ,  ZHANG, Jingwu ,  LI, Handong ,  SUNDARARAJAN, Narayan ,  SU, Xing ,  SUN, Lei

Inventor： ZHANG, Jingwu ,  LI, Handong ,  SUNDARARAJAN, Narayan ,  SU, Xing ,  SUN, Lei

CPC classification number: G01N33/585 ,  C12Q1/6816 ,  G01N21/658 ,  G01N33/54373 ,  C12Q2563/155 ,  C12Q2565/632

Abstract: The embodiments of the invention are directed to a SERS cluster comprising a capture particle that is at least partially surrounded by analyte molecules, wherein both the capture particle and the analyte molecules surrounding the capture particle are at least partially surrounded by enhancer particles, wherein a majority of the analyte molecules are either sandwiched between capture and enhancer particles or located between junctions of the enhancer particles. The embodiments of the invention also relate to methods of manufacturing and detecting the SERS cluster. The embodiments of the invention also relate to a SERS active particle comprising a tag molecule comprising a Raman active compound and a probe or a linker having a specific biochemical binding capability and to a method for detecting of a target molecule using a SERS active particle having a tag molecule comprising a Raman active compound and a probe or a linker.

Abstract translation: 本发明的实施方案涉及包含被分析物分子至少部分包围的捕获颗粒的SERS簇，其中捕获颗粒和捕获颗粒周围的分析物分子至少部分地被增强子颗粒包围，其中多数 分析物分子被夹在捕获和增强剂颗粒之间或位于增强剂颗粒的结之间。 本发明的实施例还涉及制造和检测SERS簇的方法。 本发明的实施方案还涉及包含包含拉曼活性化合物的标签分子和具有特定生物化学结合能力的探针或接头的SERS活性颗粒以及使用具有下列化合物的SERS活性颗粒检测靶分子的方法： 标签分子，其包含拉曼活性化合物和探针或接头。