-
公开(公告)号：WO2006040125A1
公开(公告)日：2006-04-20
申请号：PCT/EP2005/010923
申请日：2005-10-11
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS , KIESSLING, Fabian , SEMMLER, Wolfhard , HEILMANN, Melanie , DEBUS, Jürgen , PESCHKE, Peter , ULBRICH, Karel , SUBR, Vladimir
发明人： KIESSLING, Fabian , SEMMLER, Wolfhard , HEILMANN, Melanie , DEBUS, Jürgen , PESCHKE, Peter , ULBRICH, Karel , SUBR, Vladimir
IPC分类号： A61K49/12
CPC分类号： A61K49/12 , A61K49/124
摘要： The present invention relates to a contrast agent comprising a copolymer having at least a first monomer unit which comprises a metal chelating moiety and a second monomer unit without a chelating moiety and a contrast enhancing metal bound to the chelating moiety. The invention also relates to a process for the preparation of such a contrast agent and the use in magnetic resonance imaging (MRI).
摘要翻译： 本发明涉及造影剂，其包含具有至少第一单体单元的共聚物，所述第一单体单元包含金属螯合部分和没有螯合部分的第二单体单元和与螯合部分结合的对比增强金属。 本发明还涉及制备这种造影剂的方法和在磁共振成像（MRI）中的应用。
-
公开(公告)号：WO2010084157A8
公开(公告)日：2011-12-29
申请号：PCT/EP2010050693
申请日：2010-01-21
申请人： CENTRE NAT RECH SCIENT , UNIV STRASBOURG , INST OF MACROMOLECULAR CHEMISTRY AS CR V V I , SCHNEIDER GREGORY F , DECHER GERO , ULBRICH KAREL , SUBR VLADIMIR
发明人： SCHNEIDER GREGORY F , DECHER GERO , ULBRICH KAREL , SUBR VLADIMIR
CPC分类号： B82Y5/00 , A61K47/58 , A61K47/6923 , A61K47/6929
摘要： The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them.
摘要翻译： 本发明涉及药物递送纳米系统领域。 更准确地说，本发明涉及一种具有用于各种纳米颗粒的外涂层的有利特性的共聚物。 所述共聚物分别包含具有隐形，偶联和治疗性质的至少三种类型的单体，以及具有靶向特性的任选的第四类单体。 本发明还涉及由根据本发明的共聚物的外层涂覆的核 - 壳或中空壳纳米颗粒。 设想了几种类型的核 - 壳纳米颗粒。 本发明还涉及制备所述纳米颗粒的方法以及包含它们的药物组合物或药物。
-
3.发明申请HYDROXYPROPYL METHACRYLAMIDE POLYMERS AND COPOLYMERS COMPRISING REACTIVE THIAZOLINE-2-THIONE 审中-公开包含反应性噻唑啉-2-酮的羟丙基甲基丙烯酰胺聚合物和共聚物
公开(公告)号：WO2005007798A3
公开(公告)日：2006-04-06
申请号：PCT/IB2004052127
申请日：2004-07-15
申请人： USTAV MAKROMOLEKULARNI CHEMIE , MIKROBIOLOGICK USTAV AVCR , SUBR VLADIMIR , ULBRICH KAREL , RIHOVA BLANKA
发明人： SUBR VLADIMIR , ULBRICH KAREL , RIHOVA BLANKA
IPC分类号： A61K47/30 , A61K47/48 , C07D277/04 , C08F8/34 , C08F120/56 , C08F128/02 , C08F220/56 , C08F220/58 , C08F228/02 , C12N20060101 , A61P35/00
CPC分类号： C08F220/58 , A61K47/58 , A61K47/6883 , C08F8/34 , C08F2810/40 , C08F20/58
摘要： The solution concerns reactive polymers and copolymers based on N-(2hydroxypropyl)methacrylamide, which contain reactive thiazolidine-2-thione groups in side chains of the polymers or at the ends of polymer chains. The solution also includes a method of their preparation and their use for synthesis of polymer drugs and conjugates with proteins and preparation of gene delivery systems.
摘要翻译： 该溶液涉及基于N-（2-羟丙基）甲基丙烯酰胺的反应性聚合物和共聚物，其在聚合物的侧链或聚合物链的末端含有活性噻唑烷-2-硫酮基团。 该溶液还包括其制备方法及其用于合成聚合物药物和与蛋白质偶联物以及基因递送系统的制备的用途。
-
公开(公告)号：WO2010084157A3
公开(公告)日：2010-11-04
申请号：PCT/EP2010050693
申请日：2010-01-21
申请人： CENTRE NAT RECH SCIENT , UNIV STRASBOURG , INST OF MACROMOLECULAR CHEMIST , SCHNEIDER GREGORY F , DECHER GERO , ULBRICH KAREL , SUBR VLADIMIR
发明人： SCHNEIDER GREGORY F , DECHER GERO , ULBRICH KAREL , SUBR VLADIMIR
CPC分类号： B82Y5/00 , A61K47/58 , A61K47/6923 , A61K47/6929
摘要： The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them.
摘要翻译： 本发明涉及药物递送纳米系统领域。 更确切地说，本发明涉及对各种纳米颗粒的外涂层具有有利性能的共聚物。 所述共聚物分别包含至少三种具有隐身性，偶联性和治疗性的单体，以及任选的具有靶向性质的第四类单体。 本发明还涉及由根据本发明的共聚物的外层涂覆的核 - 壳或中空壳纳米粒子。 设想了几种类型的核壳纳米粒子。 本发明还涉及制备所述纳米颗粒的方法，以及包含它们的药物组合物或药物。
-
5.发明申请MODIFICATIONS OF NUCLEIC ACID VECTORS WITH POLYMERS COMPRISING CHARGED QUATERNARY AMINO GROUPS 审中-公开含有包含四价氨基团的聚合物的核酸向量的修改
公开(公告)号：WO2010067081A3
公开(公告)日：2010-11-04
申请号：PCT/GB2009002869
申请日：2009-12-11
CPC分类号： C12N15/86 , A61K47/549 , A61K47/58 , A61K47/642 , A61K47/645 , A61K47/65 , A61K48/0041 , C12N7/00 , C12N2710/10343 , C12N2710/10351 , C12N2800/95 , C12N2810/10
摘要： The present invention provides a polymer modified nucleic acid vector in which the nucleic acid vector is covalently linked to a polymer, which polymer comprises one or more positively charged quaternary amino groups, wherein the nucleic acid vector is a micro-organism selected from the group consisting of a virus, a bacteria or a bacteriophage, a fungus, a spore, a eukaryotic cell nucleus or other micro-organism fragment or a component containing genetic information, and wherein (a) the polymer and/or the linkages between it and the nucleic acid vector are hydrolytically, reducibly or enzymatically degradable; and/or (b) wherein each of the positively charged quaternary amino groups is linked to the polymer backbone via one or more degradable or biodegradable linkages.
摘要翻译： 本发明提供一种聚合物修饰的核酸载体，其中所述核酸载体与聚合物共价连接，所述聚合物包含一个或多个带正电荷的季氨基，其中所述核酸载体是选自以下的微生物： 病毒，细菌或噬菌体，真菌，孢子，真核细胞核或其他微生物片段或含有遗传信息的成分，并且其中（a）聚合物和/或其与核酸之间的连接 酸载体水解，还原或酶促降解; 和/或（b）其中每个带正电荷的季氨基通过一个或多个可降解或可生物降解的键连接到聚合物主链上。
-
公开(公告)号：WO2010084157A2
公开(公告)日：2010-07-29
申请号：PCT/EP2010/050693
申请日：2010-01-21
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE STRASBOURG , INSTITUTE OF MACROMOLECULAR CHEMISTRY AS CR, v. v. i. , SCHNEIDER, Grégory F. , DECHER, Gero , ULBRICH, Karel , SUBR, Vladimir
CPC分类号： B82Y5/00 , A61K47/58 , A61K47/6923 , A61K47/6929
摘要： The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them.
摘要翻译： 本发明涉及药物递送纳米系统领域。 更准确地说，本发明涉及一种具有用于各种纳米颗粒的外涂层的有利特性的共聚物。 所述共聚物分别包含具有隐形，偶联和治疗性质的至少三种类型的单体，以及具有靶向特性的任选的第四类单体。 本发明还涉及由根据本发明的共聚物的外层涂覆的核 - 壳或中空壳纳米颗粒。 设想了几种类型的核 - 壳纳米颗粒。 本发明还涉及制备所述纳米颗粒的方法以及包含它们的药物组合物或药物。
-
公开(公告)号：WO2010067081A2
公开(公告)日：2010-06-17
申请号：PCT/GB2009/002869
申请日：2009-12-11
申请人： HYBRID BIOSYSTEMS LIMITED , SEYMOUR, Leonard, William , FISHER, Kerry , ULBRICH, Karel , SUBR, Vladimir
CPC分类号： C12N15/86 , A61K47/549 , A61K47/58 , A61K47/642 , A61K47/645 , A61K47/65 , A61K48/0041 , C12N7/00 , C12N2710/10343 , C12N2710/10351 , C12N2800/95 , C12N2810/10
摘要： The present invention provides a polymer modified nucleic acid vector in which the nucleic acid vector is covalently linked to a polymer, which polymer comprises one or more positively charged quaternary amino groups, wherein the nucleic acid vector is a micro-organism selected from the group consisting of a virus, a bacteria or a bacteriophage, a fungus, a spore, a eukaryotic cell nucleus or other micro-organism fragment or a component containing genetic information, and wherein (a) the polymer and/or the linkages between it and the nucleic acid vector are hydrolytically, reducibly or enzymatically degradable; and/or (b) wherein each of the positively charged quaternary amino groups is linked to the polymer backbone via one or more degradable or biodegradable linkages.
摘要翻译： 本发明提供一种聚合物修饰的核酸载体，其中所述核酸载体与聚合物共价连接，所述聚合物包含一个或多个带正电荷的季氨基，其中所述核酸载体是选自以下的微生物： 病毒，细菌或噬菌体，真菌，孢子，真核细胞核或其他微生物片段或含有遗传信息的成分，并且其中（a）聚合物和/或其与核酸之间的连接 酸载体水解，还原或酶促降解; 和/或（b）其中每个带正电荷的季氨基通过一个或多个可降解或可生物降解的键连接到聚合物主链上。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.014 秒)
