公开(公告)号：WO1995017417A1

公开(公告)日：1995-06-29

申请号：PCT/JP1994002151

申请日：1994-12-20

Applicant: TEIKOKU HORMONE MFG. CO., LTD. ,  KOIZUMI, Naoyuki ,  TAKEGAWA, Shigehiro ,  IWASHITA, Shigeki ,  KAWACHI, Tomoko ,  DOGUCHI, Koji ,  HONMA, Seijiro ,  NAKAYAMA, Mitsuya ,  MIEDA, Mamoru ,  TAKAHASHI, Hiroo ,  SHIBATA, Kenyu

Inventor： TEIKOKU HORMONE MFG. CO., LTD.

IPC: C07J73/00

CPC classification number: C07J73/003 ,  C07J73/005

Abstract: A 6-substituted oxa- or azasteroid compound represented by general formula (I), having an excellent aromatase inhibitory activity, and being useful for preventing or treating diseases caused by estrogens, such as mammary cancer, uterus carcinoma, prostatic hypertrophy, and so forth. This compound has an oxygen or nitrogen atom in the steroidal D ring and the 6-position (R ) is substituted by -S-R (R representing hydrogen, lower alkyl, cyano or acyl), -O-R (R representing hydrogen, lower alkyl, or acyl), azido or amino.

Abstract translation: 由通式（I）表示的6-取代的氧杂 - 或氮杂甾族化合物，具有优异的芳香酶抑制活性，并且可用于预防或治疗由雌激素如乳腺癌，子宫癌，前列腺肥大等引起的疾病 。 该化合物在甾体D环中具有氧或氮原子，6位（R 1）被-SR 2（R 2代表氢，低级烷基，氰基或酰基），-OR （3）代表氢，低级烷基或酰基），叠氮基或氨基。

公开(公告)号：WO1993010113A1

公开(公告)日：1993-05-27

申请号：PCT/JP1992001465

申请日：1992-11-11

Applicant: TEIKOKU HORMONE MFG. CO., LTD. ,  KOIZUMI, Naoyuki ,  TAKEGAWA, Shigehiro ,  IWASHITA, Shigeki ,  KAWACHI, Tomoko ,  MATSUI, Teruaki ,  MIEDA, Mamoru ,  TAKAHASHI, Hiroo ,  SAITO, Tomoyuki ,  SHIBATA, Kenyu

Inventor： TEIKOKU HORMONE MFG. CO., LTD.

IPC: C07D333/56

CPC classification number: C07D333/54 ,  C07D333/56 ,  C07D333/62

Abstract: A benzothiophene derivative represented by general formula (I) or a salt thereof, which has an excellent antiestrogenic activity and is useful for treating breast cancer, endometrial cancer, endometriosis, mastopathy, and so forth. This compound is characterized in that the 2-position, i.e. substituent R , of the benzothiophene ring is substituted by a halogen atom, a lower alkyl group, or a cycloalkyl or cycloalkenyl group which may be substituted by a lower alkyl, hydroxy, acyloxy or oxo.

Abstract translation: 由通式（I）表示的苯并噻吩衍生物或其盐具有优异的抗雌激素活性，可用于治疗乳腺癌，子宫内膜癌，子宫内膜异位症，乳腺病等。 该化合物的特征在于苯并噻吩环的2位，即取代基R 2被卤素原子，低级烷基或可被低级烷基取代的环烷基或环烯基取代，羟基 ，酰氧基或氧代。

公开(公告)号：WO1985003738A1

公开(公告)日：1985-08-29

申请号：PCT/JP1985000058

申请日：1985-02-14

Applicant: MITSUBISHI JIDOSHA KOGYO KABUSHIKI KAISHA ,  MORIYASU, Takeshi; ,  ISOMOTO, Jun; ,  NAKAGAMI, Tatsuro; ,  TAKAHASHI, Hiroo; ,  MAEDA, Takuo;

Inventor： MITSUBISHI JIDOSHA KOGYO KABUSHIKI KAISHA

IPC: F02B23/06

CPC classification number: F02B23/0636 ,  F02B3/06 ,  F02B23/06 ,  F02B23/0621 ,  F02B23/0624 ,  F02B23/0651 ,  F02B23/0669 ,  F02B23/0693 ,  F02B23/0696 ,  F02B2275/14 ,  F02B2275/40 ,  F02F3/26 ,  Y02T10/123 ,  Y02T10/125

Abstract: In a combustion chamber structure for a direct ejection type Diesel engine, a guide wall (34), which is formed so that the inner diameter thereof increases gradually from an open edge portion (33) of a combustion chamber (32) to the lower end of the wall (34), and fuel reflecting walls (36, 38), which are formed under the guide wall (34) so as to project toward the axis $(1,3)$O of the combustion chamber (32) and thereby divide the combustion chamber (32) into upper and lower portions, i.e. first and second combustion chamber portions (44, 48), are provided for the purpose of reflecting the atomized fuel in the combustion chamber (32) effectively in accordance with the displacement of a piston (30) and mix the atomized fuel with air sufficiently in the combustion chamber (32) or a cylinder (28). This arrangement can prevent an outflow of flames, which causes the flames to be cooled, from the combustion chamber (32), which is opened at a top portion (30a) of the piston (30), to a quench zone Q, and the concentration of the atomized fuel in a lower portion of the combustion chamber (32).

公开(公告)号：WO2007029222A1

公开(公告)日：2007-03-15

申请号：PCT/IE2006/000097

申请日：2006-09-08

Applicant: KINGSPAN HOLDINGS (IRL) LIMITED ,  COPPOCK, Vincent ,  ZEGGELAAR, Ruud ,  TAKAHASHI, Hiroo ,  TOSHIYUKI, Kato

Inventor： COPPOCK, Vincent ,  ZEGGELAAR, Ruud ,  TAKAHASHI, Hiroo ,  TOSHIYUKI, Kato

IPC: C08J9/00 ,  C08L61/06 ,  C08J9/14

CPC classification number: C08L71/08 ,  C08J9/0066 ,  C08J9/141 ,  C08J2361/06

Abstract: A phenolic foam is made by foaming and curing a foamable phenolic resin composition that comprises a phenolic resin, a blowing agent, an acid catalyst and an inorganic filler. The blowing agent comprises an aliphatic hydrocarbon containing from 1 to 8 carbon atoms and the inorganic filler is at least one selected from a metal hydroxide, a metal oxide, a metal carbonate and a metal powder. The phenolic foam has a pH of 5 or more. The phenolic foam has a higher pH value compared with conventional phenolic foam and reduces corrosion risk when in contact with metallic materials. The phenolic foam maintains excellent long-term stable thermal insulation performance, low water uptake and fire resistance performance and by using a hydrocarbon blowing agent, does not harm the environment as an ozone depleting or global warming material.

Abstract translation: 通过发泡和固化包含酚醛树脂，发泡剂，酸催化剂和无机填料的可发泡酚醛树脂组合物来制备酚醛泡沫。 发泡剂包含含有1至8个碳原子的脂族烃，无机填料是选自金属氢氧化物，金属氧化物，金属碳酸盐和金属粉末中的至少一种。 酚醛泡沫体的pH为5以上。 与常规酚醛泡沫相比，酚醛泡沫体具有较高的pH值，并降低与金属材料接触时的腐蚀风险。 酚醛泡沫塑料具有优异的长期稳定的隔热性能，低吸水性和耐火性能，并且通过使用碳氢化合物发泡剂，不会对作为臭氧消耗或全球变暖材料的环境造成危害。

公开(公告)号：WO2007029221A1

公开(公告)日：2007-03-15

申请号：PCT/IE2006/000096

申请日：2006-09-08

Applicant: KINGSPAN HOLDINGS (IRL) LIMITED ,  COPPOCK, Vincent ,  ZEGGELAAR, Ruud ,  TAKAHASHI, Hiroo ,  TOSHIYUKI, Kato

Inventor： COPPOCK, Vincent ,  ZEGGELAAR, Ruud ,  TAKAHASHI, Hiroo ,  TOSHIYUKI, Kato

IPC: C08J9/00 ,  C08L61/06

CPC classification number: C08J9/145 ,  C08J9/0066 ,  C08J9/149 ,  C08J2203/14 ,  C08J2203/142 ,  C08J2361/06 ,  C08J2361/10 ,  C08L71/08 ,  Y10T428/249953 ,  Y10T442/647

Abstract: A phenolic foam is made by foaming and curing a foamable phenolic resin composition that comprises a phenolic resin, a blowing agent, an acid catalyst and an inorganic filler. The blowing agent comprises a blend of chlorinated aliphatic hydrocarbon containing 2 to 5 carbon atoms and an aliphatic hydrocarbon containing from 3 to 6 carbon atoms mixed in a ratio of 60/40 to 95/5 parts by weight. The inorganic filler is at least one selected from a metal hydroxide, a metal oxide, a metal carbonate and a metal powder. The phenolic foam has a pH of 5 or more and a water uptake less than 1 kg/m 2 . A phenolic foam with a higher pH value compared with conventional phenolic foam reduces corrosion risk when in contact with metallic materials. The phenolic foam maintains excellent long-term stable thermal insulation performance, low water uptake and fire resistance performance and by using the said blowing agent, does not harm the environment as an ozone or global warming depleting material.

Abstract translation: 通过发泡和固化包含酚醛树脂，发泡剂，酸催化剂和无机填料的可发泡酚醛树脂组合物来制备酚醛泡沫。 发泡剂包含含有2至5个碳原子的氯化脂族烃和含有3-6个碳原子的脂族烃的混合物，其混合比例为60/40至95/5重量份。 无机填料是选自金属氢氧化物，金属氧化物，金属碳酸盐和金属粉末中的至少一种。 酚醛泡沫体的pH为5以上，吸水量小于1kg / m 2。 与常规酚醛泡沫相比，具有较高pH值的酚醛泡沫体在与金属材料接触时可降低腐蚀风险。 酚醛泡沫塑料具有优异的长期稳定的隔热性能，低吸水性和耐火性能，并且通过使用所述发泡剂，不会对臭氧或全球变暖消耗材料造成危害。

公开(公告)号：WO1994007908A1

公开(公告)日：1994-04-14

申请号：PCT/JP1993001390

申请日：1993-09-29

Applicant: TEIKOKU HORMONE MFG. CO., LTD. ,  KOIZUMI, Naoyuki ,  TAKEGAWA, Shigehiro ,  IWASHITA, Shigeki ,  KAWACHI, Tomoko ,  INOUE, Fumiko ,  HONMA, Seijiro ,  TAKAHASHI, Hiroo ,  MIEDA, Manoru ,  UEDA, Kaoru ,  SHIBATA, Kenyu

Inventor： TEIKOKU HORMONE MFG. CO., LTD.

IPC: C07J31/00

CPC classification number: C07J73/005 ,  C07J73/003

Abstract: A 7-substituted oxa- or azasteroid compound represented by general formula (I), which has an excellent aromatase-inhibiting effect and is useful for preventing or treating diseases caused by estrogens, such as breast cancer, uterine cancer and prostatomegaly. This compound has an oxygen or nitrogen atom as the heteroatom at the position A of the ring D and the 7-position (substituent R1) of the skeleton is substituted by -S-R2 (wherein R2 represents hydrogen, lower alkyl which may be substituted by hydroxy, amino or lower alkoxycarbonyl, lower alkenyl, aralkyl, aryl which may be substituted by halogen, amino, di(lower alkyl)amino, lower alkoxy or lower alkyl, acyl, or lower alkoxycarbonyl), -S(O)m-R3 (wherein R3 represents lower alkyl; and m represents 1 or 2), or aralkyl.

Abstract translation: 由通式（I）表示的7-取代的氧杂 - 或氮杂甾族化合物，其具有优异的芳香酶抑制作用，并且可用于预防或治疗由雌激素如乳腺癌，子宫癌和前列腺肥大引起的疾病。 该化合物在环D的位置A具有氧原子或氮原子作为杂原子，并且骨架的7-位（取代基R 1）被-S-R 2取代（其中R 2表示氢，可被取代的低级烷基 可被卤素取代的芳基，氨基，二（低级烷基）氨基，低级烷氧基或低级烷基，酰基或低级烷氧羰基），-S（O）m - R3（其中R3表示低级烷基，m表示1或2）或芳烷基。

公开(公告)号：WO1992017489A1

公开(公告)日：1992-10-15

申请号：PCT/JP1992000364

申请日：1992-03-26

Applicant: TEIKOKU HORMONE MFG. CO., LTD. ,  KOIZUMI, Naoyuki ,  TAKEGAWA, Shigehiro ,  IWASHITA, Shigeki ,  KAWACHI, Tomoko ,  MATSUI, Teruaki ,  HONMA, Seijiro ,  TAKAHASHI, Hiroo ,  MIEDA, Mamoru ,  MINATO, Koichi ,  SHIBATA, Kenyu ,  NUMAZAWA, Mitsuteru

Inventor： TEIKOKU HORMONE MFG. CO., LTD.

IPC: C07J73/00

CPC classification number: C07J73/005 ,  C07J73/003

Abstract: A compound represented by general formula (I), which has an aromatase inhibitory activity and is useful for preventing and treating diseases caused by hyperestrogenosis, such as mastocarcinoma, metrocarcinoma and prostatomegaly. In formula (I) A represents C=O, CH2, C=CH2 or C=CH-lower alkyl; B represents O, NH or N-lower alkyl; X is nil, or represents C=O or CH2; n is 2 or 3 when X is nil, or 1 or 2 when X represents C=O or CH2; and the broken line between the 1-position and the 2-position in the steroidal skeleton means an optional presence of a double bond therebetween.