公开(公告)号：WO2013028643A1

公开(公告)日：2013-02-28

申请号：PCT/US2012/051632

申请日：2012-08-20

Applicant: INTEGENX INC. ,  TANNER, Michael ,  JOVANOVICH, Stevan, B. ,  VAN GELDER, Ezra ,  HARRIS, Dennis ,  PARK, Charles ,  STERN, Seth

Inventor： TANNER, Michael ,  JOVANOVICH, Stevan, B. ,  VAN GELDER, Ezra ,  HARRIS, Dennis ,  PARK, Charles ,  STERN, Seth

IPC: C07H21/04 ,  C40B30/04

CPC classification number: C07C49/753 ,  C12Q1/6855 ,  C12Q2521/507 ,  C12Q2535/122 ,  C12Q2565/543

Abstract: The present invention provides methods and devices for performing nucleic acid amplification and sequencing on a solid substrate (e.g., a flow cell), including preparation of libraries of amplified DNA fragments for massively parallel (next-generation) sequencing.

Abstract translation: 本发明提供了用于在固体基质（例如流动细胞）上进行核酸扩增和测序的方法和装置，包括用于大规模并行（下一代）扩增的DNA片段文库的制备， 测序

公开(公告)号：WO2006122049A3

公开(公告)日：2006-11-16

申请号：PCT/US2006/017764

申请日：2006-05-05

Applicant: APPLERA CORPORATION ,  HYLDIG-NIELSEN, Jens, J. ,  RIGBY, Susan ,  BREHM-STECHER, Byron, F. ,  LEE, Ditte, S. ,  TANNER, Michael

Inventor： HYLDIG-NIELSEN, Jens, J. ,  RIGBY, Susan ,  BREHM-STECHER, Byron, F. ,  LEE, Ditte, S. ,  TANNER, Michael

IPC: C07H21/04 ,  C12Q1/68 ,  C12P19/34

Abstract: This invention is related to PNA probes, probe sets, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes.

公开(公告)号：WO0229101A2

公开(公告)日：2002-04-11

申请号：PCT/US0130343

申请日：2001-09-28

Applicant: KAIROS SCIENT INC ,  COLEMAN WILLIAM J ,  TANNER MICHAEL A ,  BYLINA EDWARD J ,  YOUVAN DOUGLAS C

Inventor： COLEMAN WILLIAM J ,  TANNER MICHAEL A ,  BYLINA EDWARD J ,  YOUVAN DOUGLAS C

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q1/68 ,  C12Q1/6897

Abstract: Methods are described for obtaining functional gene and regulatory sequences from complex populations of microorganisms, termed a 'plethogenome'. These methods are based on random sequencing of genetic material isolated from an ensemble of organisms, followed by computer analysis to assign a putative function to each sequence. These assignments can be confirmed by subsequent activity screening. The plethogenomic sequence database and corresponding clone library can be used to discover and manufacture new industrial enzymes and pharmaceuticals.

Abstract translation: 描述了从微生物的复杂群体获得功能基因和调控序列的方法，称为“原核生物基因组”。 这些方法是基于从生物群体分离的遗传物质的随机测序，随后进行计算机分析，为每个序列分配推定的功能。 这些作业可以通过随后的活动筛选来确认。 原核基因组序列数据库和相应的克隆文库可用于发现和制造新的工业酶和药物。

公开(公告)号：WO2012128954A1

公开(公告)日：2012-09-27

申请号：PCT/US2012/028168

申请日：2012-03-08

Applicant: AMERICAN SUPERCONDUCTOR CORPORATION ,  VALCOUR III, Henry C. ,  ANTAYA, Peter D. ,  GANNON, John ,  PODTBURG, Eric R. ,  ANANDAKUGAN, Subramaniam ,  CARTER, William L. ,  CAI, Hong ,  TANNER, Michael A. ,  CROTZER, David ,  OTTO, Alexander ,  KRAUSE, Dana

Inventor： VALCOUR III, Henry C. ,  ANTAYA, Peter D. ,  GANNON, John ,  PODTBURG, Eric R. ,  ANANDAKUGAN, Subramaniam ,  CARTER, William L. ,  CAI, Hong ,  TANNER, Michael A. ,  CROTZER, David ,  OTTO, Alexander ,  KRAUSE, Dana

IPC: H01L39/14

CPC classification number: H01L39/2464 ,  H01L39/02

Abstract: A method includes locating a defect (202) in a first segment of high temperature superconducting wire (200). A second segment of high temperature superconducting wire (310) is then positioned onto the first segment of high temperature superconducting wire such that the second segment of high temperature superconducting wire overlaps the defect. A path is then created such that current flows through the second segment of high temperature superconducting wire. The first segment of high temperature superconducting wire and second segment of high temperature superconducting wire are then laminated together.

Abstract translation: 一种方法包括将缺陷（202）定位在高温超导线（200）的第一段中。 然后将第二段高温超导线（310）定位在高温超导线的第一段上，使得第二段高温超导线与缺陷重叠。 然后产生路径，使得电流流过高温超导线的第二段。 然后将第一段高温超导线和第二段高温超导线层压在一起。

公开(公告)号：WO2005003346A1

公开(公告)日：2005-01-13

申请号：PCT/US2004/000959

申请日：2004-01-15

Applicant: APPLERA CORPORATION ,  LIM, Gary ,  RUFF, David, W. ,  TANNER, Michael, A. ,  BIT, Somaya, L.

Inventor： LIM, Gary ,  RUFF, David, W. ,  TANNER, Michael, A. ,  BIT, Somaya, L.

IPC: C12N15/10

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01L3/50255 ,  B01L2200/0631 ,  B01L2400/049 ,  C12N15/1017 ,  G01N1/34

Abstract: A device, system, kit, and method are provided for filtering relatively large volumes of whole blood to recover purified RNA for analysis. The device can include: a filter including a body having an interior, a first filter connector in communication with the interior of the body, a ribonucleic acid-capturing (RNA-capturing) membrane disposed within the interior, and an optional filter fit disposed within the interior adjacent the RNA-capturing membrane. The system can include a vacuum adapter plate including a substrate having a first surface, a second surface, and one or more through-holes each extending at least from the first surface to the second surface. The first filter connector can connect to a respective through-hole to form a fluid communication between the filter and the vacuum adapter plate. The system can include a collection vessel in fluid communication with the filter.

Abstract translation: 提供了一种装置，系统，试剂盒和方法，用于过滤相对较大体积的全血以回收纯化的RNA用于分析。 该装置可以包括：过滤器，包括具有内部的主体，与主体内部连通的第一过滤连接器，设置在内部的核糖核酸捕获（RNA捕获）膜，以及布置在内部的任选的过滤器配合 邻近RNA捕获膜的内部。 该系统可以包括真空适配器板，其包括具有第一表面，第二表面和至少从第一表面延伸到第二表面的一个或多个通孔的基底。 第一过滤器连接器可以连接到相应的通孔，以在过滤器和真空适配器板之间形成流体连通。 该系统可以包括与过滤器流体连通的收集容器。

公开(公告)号：WO2013028643A8

公开(公告)日：2013-04-25

申请号：PCT/US2012051632

申请日：2012-08-20

Applicant: INTEGENX INC ,  TANNER MICHAEL ,  JOVANOVICH STEVAN B ,  VAN GELDER EZRA ,  HARRIS DENNIS ,  PARK CHARLES ,  STERN SETH

Inventor： TANNER MICHAEL ,  JOVANOVICH STEVAN B ,  VAN GELDER EZRA ,  HARRIS DENNIS ,  PARK CHARLES ,  STERN SETH

IPC: C07H21/04 ,  C40B30/04

CPC classification number: C07C49/753 ,  C12Q1/6855 ,  C12Q2521/507 ,  C12Q2535/122 ,  C12Q2565/543

Abstract: The present invention provides methods and devices for performing nucleic acid amplification and sequencing on a solid substrate (e.g., a flow cell), including preparation of libraries of amplified DNA fragments for massively parallel (next-generation) sequencing.

Abstract translation: 本发明提供用于在固体底物（例如流动池）上进行核酸扩增和测序的方法和装置，包括制备用于大规模并行（下一代）测序的扩增的DNA片段的文库。

公开(公告)号：WO2006122049A2

公开(公告)日：2006-11-16

申请号：PCT/US2006017764

申请日：2006-05-05

Applicant: APPLERA CORP ,  HYLDIG-NIELSEN JENS J ,  RIGBY SUSAN ,  BREHM-STECHER BYRON F ,  LEE DITTE S ,  TANNER MICHAEL

Inventor： HYLDIG-NIELSEN JENS J ,  RIGBY SUSAN ,  BREHM-STECHER BYRON F ,  LEE DITTE S ,  TANNER MICHAEL

IPC: C12Q1/68 ,  C07K14/195

CPC classification number: C12Q1/6816 ,  C12Q2525/313 ,  C12Q2525/107

Abstract: This invention is related to PNA probes, probe sets, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes.

Abstract translation: 本发明涉及与确定支原体和相关的Mollicutes有关的PNA探针，探针组，混合物，方法和试剂盒。

公开(公告)号：WO2002029101A3

公开(公告)日：2002-04-11

申请号：PCT/US2001/030343

申请日：2001-09-28

Applicant: KAIROS SCIENTIFIC INC. ,  COLEMAN, William, J. ,  TANNER, Michael, A. ,  BYLINA, Edward, J. ,  YOUVAN, Douglas, C.

Inventor： COLEMAN, William, J. ,  TANNER, Michael, A. ,  BYLINA, Edward, J. ,  YOUVAN, Douglas, C.

IPC: C12Q1/68

Abstract: Methods are described for obtaining functional gene and regulatory sequences from complex populations of microorganisms, termed a 'plethogenome'. These methods are based on random sequencing of genetic material isolated from an ensemble of organisms, followed by computer analysis to assign a putative function to each sequence. These assignments can be confirmed by subsequent activity screening. The plethogenomic sequence database and corresponding clone library can be used to discover and manufacture new industrial enzymes and pharmaceuticals.