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公开(公告)号：WO2009108260A3
公开(公告)日：2009-09-03
申请号：PCT/US2009/000419
申请日：2009-01-21
Applicant: MICROCHIP BIOTECHNOLOGIES, INC. , VANGBO, Mattias , NIELSEN, William, D. , BLAGA, Luliu, I. , STERN, Seth , HORN, Joanne , VAN NGUYEN, Michael , JOVANOVICH, Stevan
Inventor： VANGBO, Mattias , NIELSEN, William, D. , BLAGA, Luliu, I. , STERN, Seth , HORN, Joanne , VAN NGUYEN, Michael , JOVANOVICH, Stevan
Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.
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2.发明申请UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 审中-公开通用样品制备系统及其在综合分析系统中的应用
公开(公告)号：WO2009108260A2
公开(公告)日：2009-09-03
申请号：PCT/US2009000419
申请日：2009-01-21
Applicant: MICROCHIP BIOTECHNOLOGIES INC , VANGBO MATTIAS , NIELSEN WILLIAM D , BLAGA LULIU I , STERN SETH , HORN JOANNE , VAN NGUYEN MICHAEL , JOVANOVICH STEVAN
Inventor： VANGBO MATTIAS , NIELSEN WILLIAM D , BLAGA LULIU I , STERN SETH , HORN JOANNE , VAN NGUYEN MICHAEL , JOVANOVICH STEVAN
CPC classification number: G01N1/34 , B01D17/06 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2300/0819 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N1/40 , G01N27/44791 , G01N35/1095 , G01N2035/00158 , Y10T436/143333 , Y10T436/25375
Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.
Abstract translation: 本发明提供了用于将微芯片连接到盒和气动歧管的装置和方法。 墨盒，微芯片和气动歧管可与下游准备设备（如热调节设备和分离和分析设备）集成在一起。
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3.发明申请QUANTITATIVE AMPLIFICATION AND DETECTION OF SMALL NUMBERS OF TARGET POLYNUCLEOTIDES 审中-公开定量放大和检测目标多核苷酸的小数字
公开(公告)号：WO2005066372A3
公开(公告)日：2006-01-19
申请号：PCT/US2004044052
申请日：2004-12-30
Applicant: APPLERA CORP , VANN CHARLES S , LAO KAIQIN , REED MARK , STERN SETH R , LEHTO DENNIS
Inventor： VANN CHARLES S , LAO KAIQIN , REED MARK , STERN SETH R , LEHTO DENNIS
CPC classification number: B01L7/52 , B01L3/502707 , B01L3/502715 , B01L2300/0861 , B01L2300/18 , B01L2400/06 , C12Q1/686 , C12Q2527/125
Abstract: Devices, assemblies, systems and methods described herein enable detection of as few as a single copy of a target nucleic acid molecule. Polynucleotides copied from a single or a small number of target nucleotide(s) within regions near to an initial copying site may be detected by optical or other methods as disclosed herein. Devices, assemblies and systems may comprise probes and/or primer molecules. Systems comprising optical assemblies, thermal assemblies and reaction assemblies (having reaction chambers for amplification of target nucleic acid molecules) are provided in which used reaction assemblies may be replaced to provide reusable devices. Systems comprising analytical assemblies and detection assemblies are provided in which an assay cartridge having assay chambers may engage a thermal assembly for amplification of target nucleic acid molecules. These devices, systems and methods offer the advantages of detection of as few as a single copy of a target nucleic acid molecule.
Abstract translation: 本文描述的装置，组件，系统和方法能够检测目标核酸分子的单拷贝数。 从初始复制部位附近的区域内单个或少数目标核苷酸复制的多核苷酸可以通过本文公开的光学或其它方法检测。 装置，组件和系统可以包括探针和/或引物分子。 提供了包括光学组件，热组件和反应组件（具有用于扩增靶核酸分子的反应室）的系统，其中可以更换所使用的反应组件以提供可重复使用的装置。 提供了包括分析组件和检测组件的系统，其中具有测定室的测定盒可以接合热组件以扩增靶核酸分子。 这些装置，系统和方法提供了检测目标核酸分子的单拷贝的优点。
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4.发明申请QUANTITATIVE AMPLIFICATION AND DETECTION OF SMALL NUMBERS OF TARGET POLYNUCLEOTIDES 审中-公开定量放大和检测目标多核苷酸的小数字
公开(公告)号：WO2005066372A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/044052
申请日：2004-12-30
Applicant: APPLERA CORPORATION , VANN, Charles, S. , LAO, Kaiqin , REED, Mark , STERN, Seth, R. , LEHTO, Dennis
Inventor： VANN, Charles, S. , LAO, Kaiqin , REED, Mark , STERN, Seth, R. , LEHTO, Dennis
IPC: C12Q1/68
CPC classification number: B01L7/52 , B01L3/502707 , B01L3/502715 , B01L2300/0861 , B01L2300/18 , B01L2400/06 , C12Q1/686 , C12Q2527/125
Abstract: Devices, assemblies, systems and methods described herein enable detection of as few as a single copy of a target nucleic acid molecule. Polynucleotides copied from a single or a small number of target nucleotide(s) within regions near to an initial copying site may be detected by optical or other methods as disclosed herein. Devices, assemblies and systems may comprise probes and/or primer molecules. Systems comprising optical assemblies, thermal assemblies and reaction assemblies (having reaction chambers for amplification of target nucleic acid molecules) are provided in which used reaction assemblies may be replaced to provide reusable devices. Systems comprising analytical assemblies and detection assemblies are provided in which an assay cartridge having assay chambers may engage a thermal assembly for amplification of target nucleic acid molecules. These devices, systems and methods offer the advantages of detection of as few as a single copy of a target nucleic acid molecule.
Abstract translation: 本文描述的装置，组件，系统和方法能够检测目标核酸分子的单拷贝数。 从初始复制部位附近的区域内单个或少数目标核苷酸复制的多核苷酸可以通过本文公开的光学或其它方法检测。 装置，组件和系统可以包括探针和/或引物分子。 提供了包括光学组件，热组件和反应组件（具有用于扩增靶核酸分子的反应室）的系统，其中可以更换所使用的反应组件以提供可重复使用的装置。 提供了包括分析组件和检测组件的系统，其中具有测定室的测定盒可以接合热组件以扩增靶核酸分子。 这些装置，系统和方法提供了检测目标核酸分子的单拷贝的优点。
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公开(公告)号：WO2013028643A8
公开(公告)日：2013-04-25
申请号：PCT/US2012051632
申请日：2012-08-20
Applicant: INTEGENX INC , TANNER MICHAEL , JOVANOVICH STEVAN B , VAN GELDER EZRA , HARRIS DENNIS , PARK CHARLES , STERN SETH
Inventor： TANNER MICHAEL , JOVANOVICH STEVAN B , VAN GELDER EZRA , HARRIS DENNIS , PARK CHARLES , STERN SETH
CPC classification number: C07C49/753 , C12Q1/6855 , C12Q2521/507 , C12Q2535/122 , C12Q2565/543
Abstract: The present invention provides methods and devices for performing nucleic acid amplification and sequencing on a solid substrate (e.g., a flow cell), including preparation of libraries of amplified DNA fragments for massively parallel (next-generation) sequencing.
Abstract translation: 本发明提供用于在固体底物（例如流动池）上进行核酸扩增和测序的方法和装置，包括制备用于大规模并行（下一代）测序的扩增的DNA片段的文库。
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Patent Agency Ranking
公开(公告)号：WO2012024658A3
公开(公告)日：2012-05-31
申请号：PCT/US2011048528
申请日：2011-08-20
Applicant: INTEGENX INC , JOVANOVICH STEVAN B , STERN SETH , VAN GELDER EZRA , VANGBO MATTIAS
Inventor： JOVANOVICH STEVAN B , STERN SETH , VAN GELDER EZRA , VANGBO MATTIAS
CPC classification number: B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
Abstract translation: 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，库构建，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 可以对组织样品，临床样品或环境样品进行综合分析。 集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。
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公开(公告)号：WO2012024658A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/048528
申请日：2011-08-20
Applicant: INTEGENX, INC. , JOVANOVICH, Stevan, B. , STERN, Seth , VAN GELDER, Ezra , VANGBO, Mattias
Inventor： JOVANOVICH, Stevan, B. , STERN, Seth , VAN GELDER, Ezra , VANGBO, Mattias
IPC: C12M1/34
CPC classification number: B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
Abstract translation: 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，文库构建，扩增和测序。 综合分析可以在彼此流体连接的一个或多个模块内执行。 一个或多个模块可以由计算机控制和/或自动化。 综合分析可以在组织样本，临床样本或环境样本上进行。 综合分析系统可以有一个紧凑的格式，并在指定的时间内返回结果。
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公开(公告)号：WO2008133640A3
公开(公告)日：2008-12-31
申请号：PCT/US2007021741
申请日：2007-10-11
Applicant: ARCXIS BIOTECHNOLOGIES INC , HUKARI KYLE W , BARTOSIEWICZ MATTHEW J , STERN SETH R , DE RENZI MICHAEL C , VAN DE GRAAF FABIEN M , THOMPSON JESSE B , WEST JAY A A
Inventor： HUKARI KYLE W , BARTOSIEWICZ MATTHEW J , STERN SETH R , DE RENZI MICHAEL C , VAN DE GRAAF FABIEN M , THOMPSON JESSE B , WEST JAY A A
CPC classification number: B01L7/52 , B01L3/502 , B01L2200/0647 , B01L2300/0681 , B01L2300/14 , B01L2300/18 , G01N1/34 , G01N30/6091 , G01N2030/009 , G01N2030/085 , G01N2035/00158
Abstract: Disclosed herein are micropurification cards, systems, systems and methods, backspace. A micropurification cards include a plurality of fluidic components capable of extracting molecules from samples. Samples include biological cells and the extracted molecules include nucleic acids.
Abstract translation: 本文公开了微型卡，系统，系统和方法，退格。 微量化卡包括能够从样品中提取分子的多种流体组分。 样品包括生物细胞，提取的分子包括核酸。
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公开(公告)号：WO2013028643A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051632
申请日：2012-08-20
Applicant: INTEGENX INC. , TANNER, Michael , JOVANOVICH, Stevan, B. , VAN GELDER, Ezra , HARRIS, Dennis , PARK, Charles , STERN, Seth
Inventor： TANNER, Michael , JOVANOVICH, Stevan, B. , VAN GELDER, Ezra , HARRIS, Dennis , PARK, Charles , STERN, Seth
CPC classification number: C07C49/753 , C12Q1/6855 , C12Q2521/507 , C12Q2535/122 , C12Q2565/543
Abstract: The present invention provides methods and devices for performing nucleic acid amplification and sequencing on a solid substrate (e.g., a flow cell), including preparation of libraries of amplified DNA fragments for massively parallel (next-generation) sequencing.
Abstract translation: 本发明提供了用于在固体基质（例如流动细胞）上进行核酸扩增和测序的方法和装置，包括用于大规模并行（下一代）扩增的DNA片段文库的制备， 测序
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公开(公告)号：WO2008133640A2
公开(公告)日：2008-11-06
申请号：PCT/US2007/021741
申请日：2007-10-11
Applicant: ARCXIS BIOTECHNOLOGIES, INC. , HUKARI, Kyle, W. , BARTOSIEWICZ, Matthew, J. , STERN, Seth, R. , DE RENZI, Michael, C. , VAN DE GRAAF, Fabien, M. , THOMPSON, Jesse, B. , WEST, Jay, A., A.
Inventor： HUKARI, Kyle, W. , BARTOSIEWICZ, Matthew, J. , STERN, Seth, R. , DE RENZI, Michael, C. , VAN DE GRAAF, Fabien, M. , THOMPSON, Jesse, B. , WEST, Jay, A., A.
CPC classification number: B01L7/52 , B01L3/502 , B01L2200/0647 , B01L2300/0681 , B01L2300/14 , B01L2300/18 , G01N1/34 , G01N30/6091 , G01N2030/009 , G01N2030/085 , G01N2035/00158
Abstract: Disclosed herein are micropurification cards, systems, systems and methods, backspace. A micropurification cards include a plurality of fluidic components capable of extracting molecules from samples. Samples include biological cells and the extracted molecules include nucleic acids.
Abstract translation: 本文公开的是微孔化卡，系统，系统和方法，退格。 微量化微孔板包括能够从样品中提取分子的多个流体组分。 样品包括生物细胞，提取的分子包括核酸。
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