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    TRAY
    2.
    发明申请
    TRAY 审中-公开
    托盘

    公开(公告)号：WO2014029729A1

    公开(公告)日：2014-02-27

    申请号：PCT/EP2013/067228

    申请日：2013-08-19

    Applicant: MARS INCORPORATED ,  TERRAMARK MARKENCREATION GMBH

    Inventor： BERGER, Gerd

    IPC: B32B15/085 ,  B32B15/20 ,  B32B27/08 ,  B32B27/32 ,  B65D1/34 ,  B65D1/36

    CPC classification number: B32B15/085 ,  B32B15/20 ,  B32B27/08 ,  B32B27/32 ,  B32B2439/70 ,  B65D1/28

    Abstract: The present invention relates to a tray for foodstuffs, comprising, in this order: a first inner polymer layer, a second polymer layer and an outer aluminium layer, the first inner polymer layer having a thickness in a range from 200 - 400 μm, the second polymer layer having a thickness in a range from 20 - 40 μm and the outer aluminium layer having a thickness in a range from 40 - 80 μm.

    Abstract translation: 本发明涉及一种用于食品的托盘，其中包括：第一内聚合物层，第二聚合物层和外铝层，第一内聚合物层的厚度在200-400μm的范围内， 第二聚合物层，其厚度在20-40μm的范围内，外部铝层的厚度在40-80μm的范围内。

    METHODS FOR PRODUCING INDUCIBLE AND/OR REPRESSIBLE EXPRESSION ACTIVE LINEAR RNA INTERFERENCE CASSETTES AND INDUCIBLE AND/OR REPRESSIBLE EXPRESSION ACTIVE LINEAR GENE CASSETTES AND THEIR USES
    5.
    发明申请
    METHODS FOR PRODUCING INDUCIBLE AND/OR REPRESSIBLE EXPRESSION ACTIVE LINEAR RNA INTERFERENCE CASSETTES AND INDUCIBLE AND/OR REPRESSIBLE EXPRESSION ACTIVE LINEAR GENE CASSETTES AND THEIR USES 审中-公开
    用于产生可诱导和/或可表达的表达活性线性RNA干扰物质的方法和可诱导和/或可表达的表达活性线性基因座及其用途

    公开(公告)号：WO2009156030A1

    公开(公告)日：2009-12-30

    申请号：PCT/EP2009/003686

    申请日：2009-05-25

    Applicant: KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE ,  TERRAMARK MARKENCREATION GMBH ,  KHABAR, Khalid, S., Abu

    Inventor： KHABAR, Khalid, S., Abu

    IPC: C12Q1/68

    CPC classification number: C12N15/64

    Abstract: The present invention relates to a (first) method for producing inducible and/or repressible expression active linear RNA interference constructs comprising a PCR amplification of a source polynucleotide comprising the inhibitory RNA coding sequence of interest or comprising a PCR amplification of a DNA source comprising a promoter using a reverse primer comprising the inhibitory RNA coding sequence of interest. The present invention furthermore relates to a (second) method for producing inducible and/or repressible expression active linear gene constructs comprising a PCR amplification of a source expression polynucleotide comprising a promoter sequence and the DNA sequence of interest or comprising a PCR amplification using the DNA sequence as a template. The present invention furthermore relates to libraries, arrays, cells and cell lines and kits utilizing the inducible and/or repressible expression active linear RNA interference constructs or the inducible and/or repressible expression active linear gene constructs.

    Abstract translation: 本发明涉及用于产生可诱导和/或阻抑性表达的活性线性RNA干扰构建体的（第一）方法，其包含含有所述抑制性RNA编码序列的源多核苷酸的PCR扩增，或包含DNA扩增的DNA源，所述DNA源包含 使用包含感兴趣的抑制性RNA编码序列的反向引物。 本发明还涉及用于产生诱导型和/或阻抑性表达活性线性基因构建体的第二种方法，其包括含有启动子序列和目的DNA序列的源表达多核苷酸的PCR扩增，或包含使用DNA的PCR扩增 序列作为模板。 本发明还涉及利用可诱导和/或抑制性表达的活性线性RNA干扰构建体或可诱导和/或阻抑的表达活性线性基因构建体的文库，阵列，细胞和细胞系和试剂盒。

    A MULTICOMPONENT OR MONOCOMPONENT VACCINE TO BE USED AGAINST CHAGAS DISEASE
    6.
    发明申请
    A MULTICOMPONENT OR MONOCOMPONENT VACCINE TO BE USED AGAINST CHAGAS DISEASE 审中-公开
    用于治疗CHAGAS疾病的多用途或单克隆疫苗

    公开(公告)号：WO2009056965A3

    公开(公告)日：2009-07-23

    申请号：PCT/IB2008002923

    申请日：2008-10-30

    Applicant: TERRAMARK MARKENCREATION GMBH ,  DE BAEREMAECKER BARROS CARLOS

    Inventor： DE BAEREMAECKER BARROS CARLOS

    IPC: A61K39/005 ,  A61K48/00

    CPC classification number: A61K39/005 ,  A61K39/00 ,  A61K39/002 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55522 ,  A61K2039/55527

    Abstract: The main objective of the present invention is to obtain a vaccine against the Chagas disease, capable of stimulating the immune response against the trans- sialidase virulence factor of the Trypanosoma Cruzi parasite, distinguished by the fact that said vaccine comprises a multicomponent vaccine for the Chagas disease (tripanosomiasis americana) distinguished by the fact that it comprises: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions that codifying one or more immunogenic polypeptides, both portions for the Trypanosoma Cruzi derivates (i.e., T. Cruzi and or a conserved region common to many of them) where the vaccine administration is a protection against the parasite infection, eliminates it or reduces the clinical consequences of said infection. Another objective of the present invention is a monocomponent vaccine against the Chagas disease comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions that codifying one or more immunogenic polypeptides derived from Trypanosoma Cruzi (i.e. a T. Cruzi and /or a conserved region common to many of them) where the immunogenic portion or the polynucleotides group stimulates an antibody response, of CD4+ Th1 biased T cells or CD8+ T cells against the Trypanosoma Cruzi. This invention also includes: the pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.

    Abstract translation: 本发明的主要目的是获得能够刺激针对锥虫克鲁日寄生虫的唾液酸酶毒力因子的免疫应答的针对恰加斯病的疫苗，其特征在于所述疫苗包含Chagas的多组分疫苗 疾病（美国三叉虫病），其特征在于它包括：（a）由一种或多种重组或合成多肽或其部分形成的免疫原性部分和（b）一种或多种多核苷酸，其包括编码一种或多种免疫原性多肽的区域 ，其中疫苗施用是针对寄生虫感染的保护的锥虫克鲁兹衍生物（即，T. Cruzi和或其许多共有的保守区域）的两个部分消除或减少所述感染的临床后果。 本发明的另一个目的是针对恰加斯病的单组分疫苗，其包含至少一种选自由一种或多种重组或合成多肽或其部分形成的免疫原性部分的成分和一组多核苷酸，所述多核苷酸包括编码一个或多个 CD4 + Th1偏倚T细胞或CD8 + T细胞针对锥虫的免疫原性多肽衍生自锥虫克鲁兹（即克鲁尼（T. Cruzi）和/或其许多共有的保守区），其中免疫原性部分或多核苷酸组刺激抗体应答 克氏锥虫。 本发明还包括：含有所述多组分和单组分疫苗的药物组合物，获得所述疫苗的免疫原部分的程序和在该过程中使用的核酸。

    SOLID PHARMACEUTICAL FORMULATION
    8.
    发明申请
    SOLID PHARMACEUTICAL FORMULATION 审中-公开
    固体药物制剂

    公开(公告)号：WO2008148503A1

    公开(公告)日：2008-12-11

    申请号：PCT/EP2008/004306

    申请日：2008-05-30

    Applicant: THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. ,  TERRAMARK MARKENCREATION GMBH ,  BADWAN, Adnan ,  AL-REMAWI, Mayyas

    Inventor： BADWAN, Adnan ,  AL-REMAWI, Mayyas

    IPC: A61K9/28

    CPC classification number: A61K9/0056 ,  A61K9/205

    Abstract: The present invention relates to a solid pharmaceutical formulation comprising at least one hydrophilic water-soluble superdisintegrating oligo-polymer having a molecular weight in the range of 200-3000 Da and having from 3 to 20 monomeric repeating units forming the oligo-polymer as matrix and at least one active agent dispersed throughout the matrix, wherein the oligo-polymer simultaneously dissolves and disintegrates in a liquid.

    Abstract translation: 本发明涉及一种固体药物制剂，其包含至少一种分子量在200-3000Da范围内且具有3至20个单体重复单元形成低聚物作为基质的亲水性水溶性超分解性低聚合物，以及 分散在整个基质中的至少一种活性剂，其中低聚物同时在液体中溶解和分解。

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