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    SYSTEM AND METHOD FOR PROVIDING ACCESS TO FORMS AND MAINTAINING THE DATA USED TO COMPLETE THE FORMS
    3.
    发明申请
    SYSTEM AND METHOD FOR PROVIDING ACCESS TO FORMS AND MAINTAINING THE DATA USED TO COMPLETE THE FORMS 审中-公开
    提供访问表格并维护用于完成表单的数据的系统和方法

    公开(公告)号：WO0188661A3

    公开(公告)日：2002-03-14

    申请号：PCT/US0115666

    申请日：2001-05-16

    Applicant: US ARMY MED RES MAT COMMAND ,  KOELLE STEVEN K

    Inventor： KOELLE STEVEN K

    IPC: G06F17/24 ,  H04K1/00

    CPC classification number: G06F17/243 ,  G06Q20/4012

    Abstract: An apparatus and method for providing a forms system that preferably allows easy access to an an unlimited number of forms, a user to electronically sign a form, authentication of the data has not changed after the form has been electronically signed, data conversion, and external data importation into a data file. A further embodiment of the invention includes a method to incorporate signature capabilities into a form. Another aspect of the invention is consistent handling of data entered into forms by users (510).

    Abstract translation: 一种用于提供表单系统的装置和方法，其优选地允许容易地访问无限数量的形式，用户以电子方式签署表单，在表单被电子签名，数据转换和外部之后，数据的认证没有改变 数据导入数据文件。 本发明的另一实施例包括将签名能力并入到表单中的方法。 本发明的另一方面是对用户输入的数据的一致处理（510）。

    METHOD AND APPARATUS FOR EDUCATING ASTHMA SUFFERERS AND CAREGIVERS
    4.
    发明申请
    METHOD AND APPARATUS FOR EDUCATING ASTHMA SUFFERERS AND CAREGIVERS 审中-公开
    用于教育哮喘患者和患者的方法和装置

    公开(公告)号：WO0177665A3

    公开(公告)日：2002-02-21

    申请号：PCT/US0111591

    申请日：2001-04-10

    Applicant: US ARMY MED RES MAT COMMAND ,  RASCHE JEANETTE D ,  WHITLOCK WARREN L

    Inventor： RASCHE JEANETTE D ,  WHITLOCK WARREN L

    IPC: A61B5/00

    CPC classification number: A61B5/411 ,  A61B5/00

    Abstract: A method and system preferably is for use in treating asthma patients by applying a score to the severity of the asthma based on answers to a series of questions. The system further preferably includes interactive education including what is asthma, how to lessen the likelihood of asthma attacks, and how to treat an asthma attack.

    Abstract translation: 一种方法和系统优选地用于通过对一系列问题的答案对哮喘的严重程度应用评分来治疗哮喘患者。 该系统还优选包括交互式教育，包括什么是哮喘，如何减轻哮喘发作的可能性，以及如何治疗哮喘发作。

    COMPOSITIONS AND METHODS FOR DETERMINING IMMUNE STATUS
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR DETERMINING IMMUNE STATUS 审中-公开
    确定免疫状态的组合物和方法

    公开(公告)号：WO2009108170A2

    公开(公告)日：2009-09-03

    申请号：PCT/US2008012856

    申请日：2008-11-17

    Applicant: MEEGAN JAMES ,  TIKHONOV ALEX ,  SCHWEITZER BARRY ,  CHEN GENGXIN ,  ULRICH ROBERT G ,  INVITROGEN CORP ,  US ARMY MED RES MAT COMMAND

    Inventor： MEEGAN JAMES ,  TIKHONOV ALEX ,  SCHWEITZER BARRY ,  CHEN GENGXIN ,  ULRICH ROBERT G

    IPC: C12Q1/70

    CPC classification number: G01N33/6845 ,  C07K14/35

    Abstract: The present invention provides compositions and methods for identifying molecules in samples that bind to molecules associated with pathogenic agents (e.g., infectious agents). In certain aspects, the invention may be used to identify individuals that have been exposed to one or more pathogenic agent or have generated antibodies in response to one or more pathogenic agent. In other aspects, the invention is directed to the identification of molecules of one or more pathogenic agent that may be used to generate immune responses in other individuals.

    Abstract translation: 本发明提供了用于鉴定结合与致病因子相关分子（例如传染因子）的样品中的分子的组合物和方法。 在某些方面，本发明可以用于鉴定已经暴露于一种或多种病原体或已经响应于一种或多种病原体产生抗体的个体。 在其他方面，本发明涉及鉴定可用于在其他个体中产生免疫应答的一种或多种致病因子的分子。

    2-guanidinylimidazolidinedione compounds and methods of making and using thereof
    6.
    发明申请
    2-guanidinylimidazolidinedione compounds and methods of making and using thereof 审中-公开
    2-胍基咪唑烷二酮化合物及其制备和使用方法

    公开(公告)号：WO2005072082B1

    公开(公告)日：2006-05-11

    申请号：PCT/US2004038909

    申请日：2004-11-19

    Applicant: LIN AI J ,  ZHANG QUAN ,  GUAN JIAN ,  MILHOUS WILBUR K ,  US ARMY MED RES MAT COMMAND

    Inventor： LIN AI J ,  ZHANG QUAN ,  GUAN JIAN ,  MILHOUS WILBUR K

    IPC: A61K31/4168 ,  A61K31/4178 ,  C07D233/44 ,  C07D233/54 ,  C07D405/12

    CPC classification number: C07D233/96 ,  C07D233/54 ,  C07D405/12

    Abstract: Disclosed herein are 2-guanidinylimidazolidinedione compounds having the structural Formula A or B wherein R 1 and R 2 are each independently a hydrogen, halogen, alkyl, alkoxyl, amino, alkylamino or aralkyl, and wherein R 3 is an alkyl, cycloalkyl, heterocycloalkyl, acyl, aryl, heteroaryl, alkylaryl, sulfonyl, alkylsulfonyl, and pharmaceutically acceptable salts thereof, and methods of making thereof. Also disclosed are methods of treating, preventing, or inhibiting malaria with the 2-guanidinylimidazolidinedione compounds, and pharmaceutical compositions comprising the 2-guanidinylimidazolidinedione compounds, and kits.

    Abstract translation: 本文公开了具有结构式A或B的2-胍基咪唑烷二酮化合物，其中R 1和R 2各自独立地为氢，卤素，烷基，烷氧基，氨基，烷基氨基或 芳烷基，其中R 3是烷基，环烷基，杂环烷基，酰基，芳基，杂芳基，烷基芳基，磺酰基，烷基磺酰基及其药学上可接受的盐，及其制备方法。 还公开了用2-胍基咪唑烷二酮化合物治疗，预防或抑制疟疾的方法，以及包含2-胍基脒基咪唑烷二酮化合物的药物组合物和试剂盒。

    RECOMBINANT LIGHT CHAINS OF BOTULINUM NEUROTOXINS AND LIGHT CHAIN FUSION PROTEINS FOR USE IN RESEARCH AND CLINICAL THERAPY
    7.
    发明申请
    RECOMBINANT LIGHT CHAINS OF BOTULINUM NEUROTOXINS AND LIGHT CHAIN FUSION PROTEINS FOR USE IN RESEARCH AND CLINICAL THERAPY 审中-公开
    用于研究和临床治疗的嗜碱性神经毒素和光链融合蛋白的重组轻链

    公开(公告)号：WO0236758A9

    公开(公告)日：2003-04-17

    申请号：PCT/US0147230

    申请日：2001-11-06

    Applicant: US ARMY MED RES MAT COMMAND

    Inventor： SMITH LEONARD A ,  JENSEN MELODY

    IPC: C12N9/64 ,  C12N9/00

    CPC classification number: C07K14/33 ,  C12N9/6489

    Abstract: Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the synaptosomal proteins, SNAP-25, VAMP, or syntaxin at discrete sites. The present invention relates to the construction, expression, purification, and use of synthetic or recombinant botulinum neutoroxin genes. For example, a synthetic gene for the LC of the botulinum neurotoxin serotype A (BoNT/A) was constructed and overexpressed in Escherichia coli. The gene product was purified from inclusion bodies. The methods of the invention can provide 1.1 g of the LC per liter of culture. The LC product was stable in solution at 4 DEG C for at least 6 months. This rBoNT/A LC was proteolytically active, specifically cleaving the Glu-Arg bond in a 17-residue synthetic peptide of SNAP-25, the reported cleavage site of BoNT/A. Its calculated catalytic efficiency kcat/Km was higher than that reported for the native BoNT/A dichain. Treating the rBoNT/A LC with mercuric compounds completely abolished its activity, most probably by modifying the cysteine-164 residue located in the vicinity of the active site. About 70 % activity of the LC was restored by adding Zn -free, apo-LC preparation. The LC was nontoxic to mice and failed to elicit neutralizing epitope(s) when the animals were vaccinated with this protein. In addition, injecting rBoNT/A LC into sea urchin eggs inhibited exocytosis-dependent plasma membrane resealing.

    Abstract translation: 肉毒杆菌神经毒素是所有毒素中最有效的，通过抑制神经肌肉接头处的胞吐作用诱发致死性神经肌肉麻痹。 这些双链神经毒素的轻链（LC）是一类新的锌内肽酶，其在离散位点上特异性切割突触体蛋白，SNAP-25，VAMP或syntaxin。 本发明涉及合成或重组肉毒杆菌中毒素基因的构建，表达，纯化和使用。 例如，构建了肉毒杆菌神经毒素血清型A（BoNT / A）的LC的合成基因，并在大肠杆菌中过表达。 从包涵体纯化基因产物。 本发明的方法可以提供每升培养物1.1g的LC。 LC产品在4℃的溶液中稳定至少6个月。 该rBoNT / A LC具有蛋白水解活性，特异性切割了SNAP-25的17位残基合成肽中的Glu-Arg键，所述肽是BoNT / A的报道的切割位点。 其计算的催化效率kcat / Km高于天然BoNT / A二酮所报道的催化效率。 用汞化合物处理rBoNT / ALC完全消除其活性，最可能的是通过修饰位于活性位点附近的半胱氨酸164残基。 通过添加无Zn 2+的载脂蛋白制备，恢复了约70％的LC活性。 当对这些蛋白质接种动物时，LC对小鼠无毒，并且不能引发中和表位。 另外，将rBoNT / A LC注入海胆蛋抑制胞吐作用依赖性细胞膜再密封。

    SYSTEM AND METHOD FOR EVALUATING DATA SETS OVER A COMMUNICATIONS NETWORK
    8.
    发明申请
    SYSTEM AND METHOD FOR EVALUATING DATA SETS OVER A COMMUNICATIONS NETWORK 审中-公开
    用于评估通信网络中的数据集的系统和方法

    公开(公告)号：WO2006065785A3

    公开(公告)日：2007-04-05

    申请号：PCT/US2005045005

    申请日：2005-12-13

    Applicant: US ARMY MED RES MAT COMMAND ,  GUNAWARDENA JAMILA ,  REIFMAN JACQUES

    Inventor： GUNAWARDENA JAMILA ,  REIFMAN JACQUES

    IPC: G06F17/30 ,  G06F7/00 ,  G06F15/16

    CPC classification number: G06F19/3418 ,  G16H15/00

    Abstract: The present invention is directed to a system and method for providing researchers with a computer-assisted tool to evaluate, over a communications network, large electronic data sets stored on a remote server. The system allows the centralization of multiple data manipulation and analysis software modules co-located with the large data sets to reduce the amount of data from the data sets and software that has to be downloaded to a particular user's client computer. The system is designed to accommodate multiple researchers located at different geographic locations each of whom may have, with regard to the data, different scientific research objectives.

    Abstract translation: 本发明涉及一种用于向研究人员提供计算机辅助工具以用于通过通信网络评估存储在远程服务器上的大型电子数据集的系统和方法。 该系统允许将多个数据操纵和分析软件模块集中在大数据集中，以减少必须下载到特定用户的客户端计算机的数据集和软件的数据量。 该系统旨在容纳位于不同地理位置的多个研究人员，每个研究人员可能对数据有不同的科学研究目标。

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