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    IMPROVED PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS
    3.
    发明申请
    IMPROVED PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS 审中-公开
    改进的制备氧化磷脂的方法

    公开(公告)号：WO2006006161A3

    公开(公告)日：2006-10-12

    申请号：PCT/IL2005000735

    申请日：2005-07-10

    申请人： VASCULAR BIOGENICS LTD ,  HALPERIN GIDEON ,  KOVALEVSKI-ISHAI ETI

    发明人： HALPERIN GIDEON ,  KOVALEVSKI-ISHAI ETI

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07F9/10

    摘要： Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

    摘要翻译： 公开了高度适用于工业制备治疗上有益的氧化磷脂的新的合成途径。 特别地，公开了用于有效制备不含柱色谱的具有甘油主链和一个或多个与甘油主链连接的氧化部分的化合物的新方法。 还公开了将含磷部分例如磷酸酯部分引入具有甘油骨架的化合物和由此形成的中间体的新方法。

    IMPROVED PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS
    4.
    发明申请
    IMPROVED PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS 审中-公开
    用于制备氧化磷脂的改进方法

    公开(公告)号：WO2006006161A2

    公开(公告)日：2006-01-19

    申请号：PCT/IL2005/000735

    申请日：2005-07-10

    申请人： VASCULAR BIOGENICS LTD. ,  HALPERIN, Gideon ,  KOVALEVSKI-ISHAI, Eti

    发明人： HALPERIN, Gideon ,  KOVALEVSKI-ISHAI, Eti

    IPC分类号： C07F9/10

    CPC分类号： C07F9/10

    摘要： Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

    摘要翻译： 公开了高度适用于治疗有益的氧化磷脂的工业制备的新型合成路线。 特别地，公开了用于有效制备具有连接到甘油主链上的甘油主链和一个或多个氧化部分的化合物的新方法，其没有进行柱层析。 进一步公开的是将含有磷的部分例如磷酸酯部分引入具有甘油主链的化合物和由其形成的中间体的新方法。

    OXIDIZED LIPIDS AND TREATMENT OR PREVENTION OF FIBROSIS
    7.
    发明申请
    OXIDIZED LIPIDS AND TREATMENT OR PREVENTION OF FIBROSIS 审中-公开
    氧化脂肪和治疗或预防纤维化

    公开(公告)号：WO2016084023A1

    公开(公告)日：2016-06-02

    申请号：PCT/IB2015/059133

    申请日：2015-11-26

    申请人： VASCULAR BIOGENICS LTD.

    发明人： MENDEL, Itzhak ,  SALEM, Yaniv ,  YACOV, Niva ,  BREITBART, Eyal

    IPC分类号： A61K31/661

    CPC分类号： A61K31/685 ,  A61K9/0053 ,  C07F9/106

    摘要： The present invention is directed to methods of treating or preventing fibrosis comprising an oxidized lipid or pharmaceutical composition comprising the same. In some embodiments, the present invention provides methods of treating or preventing fibrosis (e.g., liver fibrosis, kidney fibrosis, focal and segmental glomerulosclerosis, or any other fibrosis described herein), comprising administering to a subject in need thereof a therapeutically effective amount of a compound having a structure according to Formula 1.

    摘要翻译： 本发明涉及治疗或预防纤维化的方法，其包含氧化脂质或包含其的药物组合物。 在一些实施方案中，本发明提供治疗或预防纤维化（例如，肝纤维化，肾纤维化，局灶性和节段性肾小球硬化或本文所述的任何其它纤维化）的方法，包括向有需要的受试者施用治疗有效量的 具有式1结构的化合物。

    TREATMENT OF INFLAMMATION
    9.
    发明申请
    TREATMENT OF INFLAMMATION 审中-公开
    治疗炎症

    公开(公告)号：WO2013088245A1

    公开(公告)日：2013-06-20

    申请号：PCT/IB2012/002930

    申请日：2012-12-11

    申请人： VASCULAR BIOGENICS LTD.

    发明人： MENDEL, Itzhak ,  FEIGE, Erez ,  YACOV, Niva ,  PROPHETE-MEIRAN, Oshrat ,  BREITBART, Eyal ,  SALEM, Yaniv

    IPC分类号： C07C53/00

    CPC分类号： A61K31/661 ,  A61K31/366 ,  A61K31/404 ,  A61K31/436 ,  A61K31/585 ,  A61K31/685 ,  A61K45/06 ,  Y02A50/414 ,  A61K2300/00

    摘要： Disclosed herein are methods of treating an inflammatory disease or disorder, as well as pharmaceutical compositions and kits useful for treating an inflammatory disease or disorder. The methods, compositions and kits utilize at least one agent, the at least one agent being capable of exhibiting at least two activities selected from the group consisting of: a) inhibiting CD 14 activity and/or a signaling pathway associated with CD 14 activity; b) inhibiting TLR2 activity and/or a signaling pathway associated with TLR2 activity; and c) inhibiting monocyte chemotaxis.

    摘要翻译： 本文公开了治疗炎性疾病或病症的方法以及可用于治疗炎性疾病或病症的药物组合物和试剂盒。 所述方法，组合物和试剂盒利用至少一种试剂，所述至少一种试剂能够显示出选自以下的至少两种活性：a）抑制CD14活性和/或与CD14活性相关的信号通路; b）抑制与TLR2活性相关的TLR2活性和/或信号通路; 和c）抑制单核细胞趋化性。