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    DRUG COATED BALLOON CATHETERS FOR NONVASCULAR STRICTURES
    1.
    发明申请
    DRUG COATED BALLOON CATHETERS FOR NONVASCULAR STRICTURES 审中-公开
    用于非血管紧张素的药物涂层气囊导管

    公开(公告)号：WO2014066085A1

    公开(公告)日：2014-05-01

    申请号：PCT/US2013/064842

    申请日：2013-10-14

    Applicant: WANG, Lixiao

    Inventor： WANG, Lixiao

    IPC: A61L31/08

    CPC classification number: A61L29/16 ,  A61L29/08 ,  A61L29/085 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/802 ,  A61L2420/06

    Abstract: Embodiments of the present invention provide a method for treatment of nonvascular body lumen strictures such as benign prostatic hyperplasia (BPH), urethral strictures, ureteral strictures, prostate cancer, esophageal strictures, sinus strictures, biliary tract strictures, asthma and chronic obstructive pulmonary disease (COPD). The method involves delivering, preferably via drug coated balloon catheters, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and one or more additives.

    Abstract translation: 本发明的实施方案提供了一种用于治疗诸如良性前列腺增生（BPH），尿道狭窄，输尿管狭窄，前列腺癌，食道狭窄，窦狭窄，胆道狭窄，哮喘和慢性阻塞性肺病的非血管性体腔狭窄的方法 COPD）。 该方法优选通过药物涂覆的气囊导管递送抗炎和抗增殖药物（雷帕霉素或紫杉醇及其类似物）和一种或多种添加剂。

    DRUG RELEASING COATINGS FOR MEDICAL DEVICES
    4.
    发明申请
    DRUG RELEASING COATINGS FOR MEDICAL DEVICES 审中-公开
    药物释放涂料用于医疗器械

    公开(公告)号：WO2008063576A3

    公开(公告)日：2009-02-05

    申请号：PCT/US2007024108

    申请日：2007-11-19

    Applicant: LUTONIX INC ,  WANG LIXIAO

    Inventor： WANG LIXIAO

    IPC: A61L29/16 ,  A61L31/16

    CPC classification number: A61L29/16 ,  A61K31/337 ,  A61K31/436 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/606 ,  A61K2300/00

    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent such as paclitaxel or rapamycine and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers. In a preferred embodiment, the additive comprises ascorbyl palmitate, polyglycerol-10 oleate, octoxynol-9, ?-isononylphenoxypolyglycidol, tyloxapol, niacinamide, thiamine hydrochloride, nicotinic acid, 2-pyrrolidone-5-carboxylic acid or albumin.

    Abstract translation: 本发明涉及一种用于将治疗剂递送至组织的医疗装置。 医疗装置具有覆盖医疗装置的外表面的层。 该层含有治疗剂如紫杉醇或雷帕霉素和添加剂。 添加剂具有亲水部分和疏水部分，并且治疗剂不包封在胶束中或包封在颗粒或控释载体中。 在一个优选的实施方案中，添加剂包括抗坏血酸棕榈酸酯，聚甘油-10油酸酯，辛辛醇-9，β-异壬基苯氧基聚缩水甘油，泰洛沙泊，烟酰胺，盐酸硫胺素，烟酸，2-吡咯烷酮-5-羧酸或白蛋白。

    LAMINATE CATHETER BALLOONS WITH ADDITIVE BURST STRENGTH AND METHODS FOR PREPARATION OF SAME
    6.
    发明申请
    LAMINATE CATHETER BALLOONS WITH ADDITIVE BURST STRENGTH AND METHODS FOR PREPARATION OF SAME 审中-公开
    具有添加剂冲击强度的层压过滤器气泡及其制备方法

    公开(公告)号：WO1997032624A1

    公开(公告)日：1997-09-12

    申请号：PCT/US1997004061

    申请日：1997-03-06

    Applicant: SCIMED LIFE SYSTEMS, INC. ,  WANG, Lixiao ,  CHEN, Jianhua ,  LEE, Nao

    Inventor： SCIMED LIFE SYSTEMS, INC.

    IPC: A61M25/00

    CPC classification number: B32B27/08 ,  A61M25/1029 ,  B29C49/24 ,  B29C2049/0089 ,  B29K2105/258 ,  B29K2995/005 ,  B29L2031/7542 ,  B32B1/08 ,  B32B7/02 ,  B32B27/281 ,  B32B27/285 ,  B32B27/34 ,  B32B27/36 ,  B32B27/40 ,  B32B2038/0028 ,  B32B2367/00 ,  B32B2371/00 ,  B32B2375/00 ,  B32B2377/00 ,  B32B2379/08 ,  B32B2535/00 ,  Y10S428/91 ,  Y10T428/1334 ,  Y10T428/1393 ,  Y10T428/24942

    Abstract: A laminated balloon comprising at least two layers of separately oriented thermoplastic polymer material, which are coextensive over the body of the balloon. The two layers may be made of different polymer materials, including an underlying layer made of a low compliant, high strength polymer, such as PET, and an overlying layer of a softer and more flexible polymer material relative to the first polymer material, such as a polyester-polyether block copolymer. The balloon structures have an additive burst pressure, meaning that they are stronger than a signal-layer reference balloon corresponding to the underlying polymer layer. The balloons are characterized by a combination of flexibility and surface softness which allows catheters to track down into lesions relatively easily, puncture resistance, abrasion resistance and refoldability, in addition to low compliance and high burst strength. The balloon may be prepared with generally linear or with stepped compliance profiles. Methods of preparation of such balloons are also disclosed.

    Abstract translation: 包括至少两层单独取向的热塑性聚合物材料的叠层气囊，其在气囊的主体上共同延伸。 两层可以由不同的聚合物材料制成，包括由低顺应性高强度聚合物（例如PET）制成的下层，以及相对于第一聚合物材料的较软和更柔性的聚合物材料的上层，例如 聚酯 - 聚醚嵌段共聚物。 气球结构具有附加爆破压力，这意味着它们比对应于下面的聚合物层的信号层参考气球更强。 气囊的特征在于灵活性和表面柔软性的组合，除了低顺应性和高爆裂强度之外，还允许导管相对容易地追踪到损伤，抗穿刺性，耐磨性和再折叠性。 球囊可以制备成大致线性或具有阶梯式顺应性曲线。 还公开了制备这种气球的方法。

    DRUG RELEASING COATINGS FOR MEDICAL DEVICES
    7.
    发明申请
    DRUG RELEASING COATINGS FOR MEDICAL DEVICES 审中-公开
    药物释放涂料用于医疗器械

    公开(公告)号：WO2011119159A1

    公开(公告)日：2011-09-29

    申请号：PCT/US2010/028599

    申请日：2010-03-25

    Applicant: WANG, Lixiao

    Inventor： WANG, Lixiao

    IPC: A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16

    CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16

    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.

    Abstract translation: 本发明涉及一种用于将治疗剂递送至组织的医疗装置。 医疗装置具有覆盖医疗装置的外表面的层。 该层含有治疗剂，抗氧化剂和添加剂。 在某些实施方案中，添加剂具有亲水部分和药物亲和部分，其中药物亲和部分是疏水部分，通过氢键与治疗剂具有亲和性的部分中的至少一个，以及具有 通过范德华相互作用对治疗剂的亲和力。 在一些实施方案中，添加剂是液体。 在其它实施方案中，添加剂是表面活性剂和化合物中的至少一种，化合物具有一个或多个羟基，氨基，羰基，羧基，酸，酰胺或酯基。

    METHODS AND APPARATUSES FOR COATING BALLOON CATHETERS
    8.
    发明申请
    METHODS AND APPARATUSES FOR COATING BALLOON CATHETERS 审中-公开
    用于涂覆气泡导管的方法和装置

    公开(公告)号：WO2010024898A2

    公开(公告)日：2010-03-04

    申请号：PCT/US2009/004868

    申请日：2009-08-27

    Applicant: LUTONIX, INC. ,  WANG, Jeffrey ,  MALINOFF, Harrison ,  WANG, Lixiao ,  BARRY, Christopher M. ,  WAHR, Dennis W. ,  NAISBITT, Scott

    Inventor： WANG, Jeffrey ,  MALINOFF, Harrison ,  WANG, Lixiao ,  BARRY, Christopher M. ,  WAHR, Dennis W. ,  NAISBITT, Scott

    IPC: B05D1/26 ,  B05D1/00

    CPC classification number: A61M25/1029 ,  A61M25/1038 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1088 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0493 ,  B05D3/107 ,  B05D5/00

    Abstract: Embodiments of the invention relate to a method and apparatus for coating a medical device. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

    Abstract translation: 本发明的实施例涉及一种用于涂覆医疗装置的方法和装置。 在一个实施方案中，制备基本上均匀的涂覆医疗装置的方法包括（1）制备包含溶剂，治疗剂和添加剂的包衣溶液; （2）用涂布液装载计量分配器; （3）围绕装置的纵向轴线旋转医疗装置和/或沿装置的纵向或横向轴线移动医疗装置; （4）将涂布溶液从计量分配器分配到医疗装置的表面上，并且在医疗装置旋转和/或线性移动时将涂布溶液流动到医疗装置的表面上; 和（5）蒸发溶剂，在医疗装置上形成基本上均匀的涂层。

    MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING A THERAPEUTIC AGENT AND A CONTRAST AGENT
    9.
    发明申请
    MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING A THERAPEUTIC AGENT AND A CONTRAST AGENT 审中-公开
    包含治疗药物和对照药物的医疗装置快速释放涂层

    公开(公告)号：WO2009051616A1

    公开(公告)日：2009-04-23

    申请号：PCT/US2008/006417

    申请日：2008-05-20

    Applicant: LUTONIX, INC. ,  WANG, Lixiao

    Inventor： WANG, Lixiao

    IPC: A61L29/16 ,  A61L31/16 ,  A61L31/18 ,  A61L29/18 ,  A61K45/06

    CPC classification number: A61L29/16 ,  A61K31/337 ,  A61K31/436 ,  A61K45/06 ,  A61L29/08 ,  A61L29/085 ,  A61L29/18 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/428 ,  A61L2300/608 ,  A61L2300/802 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  A61M2210/1025 ,  A61K2300/00

    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a. layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive. The invention also relates to a pharmaceutical composition comprising a therapeutic agent, a contrast agent, and an additive, wherein the additive comprises a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent b hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions, wherein the additive is water-soluble, wherein the additive ia at least one of a surfactant and a chemical compound.

    Abstract translation: 本发明涉及用于将治疗剂快速递送至组织的涂覆的医疗装置，其数秒至数分钟。 医疗器械有一个。 层叠在医疗装置的外表面上。 该层含有治疗剂，造影剂和添加剂。 本发明还涉及包含治疗剂，造影剂和添加剂的药物组合物，其中所述添加剂包括亲水部分和药物亲和部分，其中所述药物亲和部分是疏水部分，部分 其具有对治疗剂b氢键的亲和性，以及通过范德华相互作用对治疗剂具有亲和力的部分，其中所述添加剂是水溶性的，其中所述添加剂至少包括表面活性剂和化学品 复合。

    MEDICAL DEVICES VISIBLE BY MAGNETIC RESONANCE IMAGING
    10.
    发明申请
    MEDICAL DEVICES VISIBLE BY MAGNETIC RESONANCE IMAGING 审中-公开
    通过磁共振成像可见的医疗器械

    公开(公告)号：WO2005073745A1

    公开(公告)日：2005-08-11

    申请号：PCT/US2005/000315

    申请日：2005-01-06

    Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SMITH, Scott, R. ,  WALAK, Steven, E. ,  WANG, Lixiao ,  WEBER, Jan ,  ZHONG, Sheng-Ping

    Inventor： SMITH, Scott, R. ,  WALAK, Steven, E. ,  WANG, Lixiao ,  WEBER, Jan ,  ZHONG, Sheng-Ping

    IPC: G01R33/28

    CPC classification number: G01R33/285 ,  A61B2090/3954 ,  A61M25/0043 ,  A61M25/0127 ,  G01R33/286

    Abstract: Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft (22) and an electrically conductive path (26) extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.

    Abstract translation: 描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。 在一些实施例中，适于插入体内的医疗装置包括细长轴（22）和围绕轴的一部分螺旋地延伸的导电路径（26）。 导电路径能够连接到电流源。 医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

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