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    COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER 审中-公开

    公开(公告)号：WO2023076668A1

    公开(公告)日：2023-05-04

    申请号：PCT/US2022/048410

    申请日：2022-10-31

    申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

    发明人： PHILBROOK, Phaethon ,  OCHOA, Augusto ,  DEAN, Matthew

    IPC分类号： C07D471/04 ,  A61K31/519 ,  C07C65/24 ,  A61P5/00 ,  C07D519/00 ,  A61P37/00

    摘要： The invention provides a method of preventing or treating cancer in a subject by administering to the subject a therapeutically effective amount of a GPR84 antagonist. Also provided is a method of preventing recurrence of cancer in a subject by administering to the subject a therapeutically effective amount of a GPR84 antagonist. Further, the invention provides a method of modulating the immune system of a subject afflicted with or at risk of cancer by administering to the subject a therapeutically effective amount of a GPR84 antagonist. Still further, the invention provides a method of preventing or treating an inflammatory response in a subject by administering to the subject a therapeutically effective amount of a GPR84 agonist. Also provided is a method of preventing an immune system disease or disorder in a subject by administering to the subject a therapeutically effective amount of a GPR84 agonist. Further, the invention provides a method treating an immune system disease or disorder in a subject by administering to the subject a therapeutically effective amount of a GPR84 agonist. Also, the invention provides a method of modulating the immune system of a subject afflicted with or at risk of an immune system disease or disorder by administering to the subject a therapeutically effective amount of a GPR84 agonist.

    POLYIMIDES COMPRISING CF2O STRUCTURAL ELEMENTS
    8.
    发明申请
    POLYIMIDES COMPRISING CF2O STRUCTURAL ELEMENTS 审中-公开
    与CF2的结构元素聚酰亚胺

    公开(公告)号：WO02102756A3

    公开(公告)日：2003-04-24

    申请号：PCT/EP0206443

    申请日：2002-06-12

    申请人： MERCK PATENT GMBH ,  KIRSCH PEER ,  TAUGERBECK ANDREAS ,  LUESSEM GEORG ,  BEYER ANDREAS ,  MAIR SIEGLINDE

    发明人： KIRSCH PEER ,  TAUGERBECK ANDREAS ,  LUESSEM GEORG ,  BEYER ANDREAS ,  MAIR SIEGLINDE

    IPC分类号： C07D307/78 ,  C07C65/24 ,  C07C65/26 ,  C07D307/89 ,  C08G73/10 ,  G02F1/1337 ,  C08G73/00

    CPC分类号： C07C65/26 ,  C07C65/24 ,  C07D307/89 ,  C08G73/1039 ,  G02F1/133723

    摘要： The invention relates to chainlike polycyclic bisanhydrides, containing between 2 and 12 permanent-chain cyclenes, selected from 1,3-phenylene, 1,4-phenylene, 2,6-naphthylene, 2,7-naphthylene, 1,4-cyclohexylene, bicyclopentylene, bicyclooctylene, cubylene, which can be mono- or polysubstituted with halogen, cyano, alkyl, fluoralkyl, alkoxy and/or fluoralkoxy. Said cyclenes are linked by bridging groups, selected from a single bond, -CF2O, -OCF2-, -O-, -S-, -SO2-, -CO-, -NH-, -(CH2)1-10-, -(CF2)1-10-, -CH(CH3)-, -CH(CCI3)-, -CH(CF3)-, -C(CH3)2-, -C(CF3)2-, -CC-, -CH=CH-, -CF=CH-, -CH=CF-, -CF=CF- and the formulae in (I), with the proviso that at least one bridging group is -CF20- or -OCF2-. The polycyclenes are terminated at both ends of the chain by various groups, selected from the formulae in (II).

    摘要翻译： 本发明提供含有2至12接触网的化合物，从1,3-亚苯基，1,4-亚苯基，2,6-亚萘基，2,7-亚萘基，1,4-亚环己基，Bicyclopentylen，bicyclooctylene选择连锁的多环二酐 ，Cubylen，一种卤素，氰基，烷基，氟烷基，烷氧基和/或氟代烷氧基或可被取代超过一次，更其中通过桥连基团的周期，从一个单键，-CF 2 O - ， - OCF 2 - ， - O-， - S - ， - SO 2 - ， - CO - ， - NH - ， - （CH2）1-10-， - （CF 2）1-10-，-CH（CH3） - ， - CH（CCL3） - ， - CH （CF 3） - ， - C（CH3）2-，-C（CF3）2-， - CC-，-CH = CH-，-CF = CH - ， - CH = CF-，-CF = CF-，（ I），条件相关联的至少一个桥连基团-CF 2 O-或-OCF 2，其中，所述多环化合物是由选自以下的不同的基团在两个链端终止（II）。