公开(公告)号：WO2009070805A3

公开(公告)日：2009-09-24

申请号：PCT/US2008085178

申请日：2008-12-01

Applicant: ASURAGEN INC ,  BADER ANDREAS G ,  WIGGINS JASON F ,  PATRAWALA LUBNA ,  KELNAR KEVIN ,  BYROM MIKE ,  BROWN DAVID

Inventor： BADER ANDREAS G ,  WIGGINS JASON F ,  PATRAWALA LUBNA ,  KELNAR KEVIN ,  BYROM MIKE ,  BROWN DAVID

IPC: A61K48/00 ,  C12N15/113

CPC classification number: C12N15/1135 ,  C12N15/113 ,  C12N2310/141 ,  C12N2330/10

Abstract: The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-124, using miR-124 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.

Abstract translation: 本发明涉及使用miR-124调节基因或基因途径来鉴定由miR-124调节的基因或遗传路径的方法和组合物，所述方法和组合物用于评估患者的状况和/或用适当的 miRNA的。

公开(公告)号：WO2010039346A1

公开(公告)日：2010-04-08

申请号：PCT/US2009/054398

申请日：2009-08-20

Applicant: US SYNTHETIC CORPORATION ,  BERTAGNOLLI, Kenneth, E. ,  QIAN, Jiang ,  WIGGINS, Jason ,  VAIL, Michael, A. ,  MUKHOPADHYAY, Debkumar

Inventor： BERTAGNOLLI, Kenneth, E. ,  QIAN, Jiang ,  WIGGINS, Jason ,  VAIL, Michael, A. ,  MUKHOPADHYAY, Debkumar

IPC: C22C26/00

CPC classification number: C04B37/001 ,  B21C3/025 ,  B24D18/0009 ,  C04B2237/36 ,  C04B2237/363 ,  C22C26/00 ,  E21B10/567 ,  F16C17/02 ,  F16C17/04 ,  F16C33/043 ,  F16C33/26 ,  F16C2206/04 ,  F16C2206/82 ,  F16C2220/20 ,  F16C2240/40 ,  F16C2240/48 ,  F16C2352/00 ,  G01N27/72 ,  G01N27/80 ,  Y10T428/24058 ,  Y10T428/24997 ,  Y10T428/25 ,  Y10T428/252 ,  Y10T428/30

Abstract: Embodiments of the invention relate to polycrystalline diamond ("PCD") exhibiting enhanced diamond-to-diamond bonding. In an embodiment, PCD includes a plurality of diamond grains defining a plurality of interstitial regions. A metal-solvent catalyst occupies at least a portion of the plurality of interstitial regions. The plurality of diamond grains and the metal-solvent catalyst collectively exhibit a coercivity of about 115 Oersteds ("Oe") or more and a specific magnetic saturation of about 15 Gauss cm3/grams ("G cm 3 /g") or less. Other embodiments are directed to polycrystalline diamond compacts ("PDCs") employing such PCD, methods of forming PCD and PDCs, and various applications for such PCD and PDCs in rotary drill bits, bearing apparatuses, and wire-drawing dies.

Abstract translation: 本发明的实施方案涉及显示增强的金刚石与金刚石结合的多晶金刚石（“PCD”）。 在一个实施例中，PCD包括限定多个间隙区域的多个金刚石晶粒。 金属溶剂催化剂占据多个间隙区域的至少一部分。 多个金刚石晶粒和金属 - 溶剂催化剂共同表现出约115奥斯特（“Oe”）或更高的矫顽力和约15高斯cm 3 /克（“G cm 3 / g”）或更小的特定磁饱和度。 其他实施方案涉及采用这种PCD的多晶金刚石压块（“PDC”），形成PCD和PDC的方法，以及用于旋转钻头，轴承装置和拉丝模具中的这种PCD和PDC的各种应用。

公开(公告)号：WO2013012919A1

公开(公告)日：2013-01-24

申请号：PCT/US2012/047191

申请日：2012-07-18

Applicant: US SYNTHETIC CORPORATION ,  QIAN, Jiang ,  MCMURRAY, Eugene, C. ,  MUKHOPADHYAY, Debkumar ,  WIGGINS, Jason, K. ,  VAIL, Michael, A. ,  BERTAGNOLLI, Kenneth, E.

Inventor： QIAN, Jiang ,  MCMURRAY, Eugene, C. ,  MUKHOPADHYAY, Debkumar ,  WIGGINS, Jason, K. ,  VAIL, Michael, A. ,  BERTAGNOLLI, Kenneth, E.

IPC: B22F7/06 ,  C22C26/00 ,  E21B10/567 ,  B23B27/00

CPC classification number: B24D3/10 ,  B22F7/062 ,  B22F2005/001 ,  B24D18/0009 ,  C22C26/00 ,  E21B10/54 ,  E21B10/56 ,  E21B10/567 ,  F16C33/043 ,  F16C33/108 ,  F16C2352/00 ,  Y10T408/89

Abstract: In an embodiment, a polycrystalline diamond compact includes a substrate and a preformed polycrystalline diamond table bonded to the substrate. The table includes bonded diamond grains defining interstitial regions. The table includes an upper surface, a back surface bonded to the substrate, and at least one lateral surface extending therebetween. The table includes a first region extending inwardly from the upper surface and the lateral surface. The first region exhibits a first interstitial region concentration and includes at least one interstitial constituent disposed therein, which may be present in at least a residual amount and includes at least one metal carbonate and/or at least one metal oxide. The table includes a second bonding region adjacent to the substrate that extends inwardly from the back surface. The second bonding region exhibits a second interstitial region concentration that is greater than the first interstitial region concentration and includes a metallic infiltrant therein.

Abstract translation: 在一个实施例中，多晶金刚石致密体包括基底和结合到基底的预成型多晶金刚石台。 该表包括定义间隙区域的结合金刚石颗粒。 桌子包括上表面，与表面粘合的后表面，以及在其间延伸的至少一个侧表面。 桌子包括从上表面和侧表面向内延伸的第一区域。 第一区域表现出第一间隙区域浓度并且包括至少一个置于其中的间隙成分，其可以以至少残留量存在并且包括至少一种金属碳酸盐和/或至少一种金属氧化物。 桌子包括与衬底相邻的第二接合区域，其从后表面向内延伸。 第二结合区域表现出比第一间隙区域浓度大的第二间隙区域浓度，并且其中包括金属渗透剂。

公开(公告)号：WO2012170970A3

公开(公告)日：2012-12-13

申请号：PCT/US2012/041778

申请日：2012-06-09

Applicant: HALLIBURTON ENERGY SERVICES, INC. ,  ATKINS, Brian ,  ANDERLE, Seth G. ,  ARFELE, Robert W. ,  LADI, Ram L. ,  LINFORD, Brandon Paul ,  WIGGINS, Jason Keith ,  NGUYEN, Kevin Duy ,  QIAN, Jiang ,  BERTAGNOLLI, Kenneth Eugene ,  SCOTT, Shawn Casey ,  MUKHOPADHYAY, Debkumar ,  VAIL, Michael Alexander

Inventor： ATKINS, Brian ,  ANDERLE, Seth G. ,  ARFELE, Robert W. ,  LADI, Ram L. ,  LINFORD, Brandon Paul ,  WIGGINS, Jason Keith ,  NGUYEN, Kevin Duy ,  QIAN, Jiang ,  BERTAGNOLLI, Kenneth Eugene ,  SCOTT, Shawn Casey ,  MUKHOPADHYAY, Debkumar ,  VAIL, Michael Alexander

IPC: C22C26/00

Abstract: The disclosure provides a super abrasive element containing a substantially catalyst-free thermally stable polycrystalline diamond (TSP) body having pores and a contact surface, a base adjacent the contact surface of the TSP body; and an infiltrant material infiltrated in the base and in the pores of the TSP body at the contact surface. The disclosure additionally provides earth-boring drill bits and other devices containing such super abrasive elements. The disclosure further provides methods and mold assemblies for forming such super abrasive elements via infiltration and hot press methods

公开(公告)号：WO2011090582A1

公开(公告)日：2011-07-28

申请号：PCT/US2010/059619

申请日：2010-12-09

Applicant: US SYNTHETIC CORPORATION ,  BERTAGNOLLI, Kenneth, E. ,  MIESS, David, P. ,  QIAN, Jiang ,  WIGGINS, Jason, K. ,  VAIL, Michael, A. ,  MUKHOPADHYAY, Debkumar

Inventor： BERTAGNOLLI, Kenneth, E. ,  MIESS, David, P. ,  QIAN, Jiang ,  WIGGINS, Jason, K. ,  VAIL, Michael, A. ,  MUKHOPADHYAY, Debkumar

IPC: C22C26/00

CPC classification number: E21B10/36 ,  B22F7/08 ,  B22F2998/00 ,  B24D18/00 ,  C22C26/00 ,  E21B10/5735 ,  F16C33/043 ,  F16C2352/00 ,  Y10T428/24612 ,  Y10T428/24996 ,  Y10T428/249967 ,  C22C29/08

Abstract: Embodiments of the invention relate to polycrystalline diamond ("PCD") exhibiting enhanced diamond- to-diamond bonding. In an embodiment, polycrystalline diamond compact ("PDC") includes a PCD table having a maximum thickness. At least a portion of the PCD table includes a plurality of diamond grains defining a plurality of interstitial regions. A metal-solvent catalyst occupies at least a portion of the plurality of interstitial regions. The plurality of diamond grains and the metal-solvent catalyst collectively exhibit a coercivity of about 115 Oersteds ("Oe") or more and a specific magnetic saturation of about 15 Gauss -cm 3 /grams ("G-cm 3 /g") or less. The PDC includes a substrate having an interfacial surface that is bonded to the PCD table. The interfacial surface exhibits a substantially planar topography. Other embodiments are directed to methods of forming PCD and PDCs, and various applications for such PCD and PDCs in rotary drill bits, bearing apparatuses, and wire-drawing dies.

Abstract translation: 本发明的实施方案涉及显示增强的金刚石 - 金刚石键合的多晶金刚石（“PCD”）。 在一个实施例中，多晶金刚石复合体（“PDC”）包括具有最大厚度的PCD台。 PCD表的至少一部分包括限定多个间隙区域的多个金刚石晶粒。 金属溶剂催化剂占据多个间隙区域的至少一部分。 多个金刚石晶粒和金属 - 溶剂催化剂共同表现出约115奥斯特（“Oe”）或更高的矫顽磁力和约15高斯cm 3 /克（“G-cm 3 / g”）或更低的特定磁饱和度 。 PDC包括具有接合到PCD台的界面的基板。 界面表现出基本平坦的形貌。 其他实施例涉及形成PCD和PDC的方法，以及用于旋转钻头，轴承装置和拉丝模具中的这种PCD和PDC的各种应用。

公开(公告)号：WO2010056737A2

公开(公告)日：2010-05-20

申请号：PCT/US2009/064015

申请日：2009-11-11

Applicant: MIRNA THERAPEUTICS, INC. ,  PATRAWALA, Lubna ,  TANG, Dean, G. ,  KELNAR, Kevin ,  WIGGINS, Jason ,  VOLZ, Stephanie ,  SHELTON, Jeffrey ,  LIU, Can ,  BADER, Andreas, G. ,  BROWN, David ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： PATRAWALA, Lubna ,  TANG, Dean, G. ,  KELNAR, Kevin ,  WIGGINS, Jason ,  VOLZ, Stephanie ,  SHELTON, Jeffrey ,  LIU, Can ,  BADER, Andreas, G. ,  BROWN, David

IPC: C12N15/113 ,  A61K31/7088

CPC classification number: C12N15/113 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2310/141

Abstract: The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of developing cancer by targeting cancer stem cells.

Abstract translation: 本发明涉及用于通过靶向癌症干细胞来治疗患有，疑似患有癌症或处于发展癌症风险中的患者的方法和组合物。

公开(公告)号：WO2009131562A1

公开(公告)日：2009-10-29

申请号：PCT/US2008/008237

申请日：2008-07-03

Applicant: US SYNTHETIC CORPORATION ,  VAIL, Michael, A. ,  BERTAGNOLLI, Kenneth, E. ,  WIGGINS, Jason ,  QIAN, Jiang ,  MIESS, David, P.

Inventor： VAIL, Michael, A. ,  BERTAGNOLLI, Kenneth, E. ,  WIGGINS, Jason ,  QIAN, Jiang ,  MIESS, David, P.

IPC: B01J3/06 ,  E21B10/46

CPC classification number: E21B10/46 ,  B01J3/062 ,  B01J2203/062 ,  B01J2203/0655 ,  B01J2203/0685

Abstract: Embodiments relate to methods of fabricating PCD materials by subjecting a mixture that exhibits a broad diamond particle size distribution to a HPHT process, PCD materials so-formed, and PDCs including a polycrystalline diamond table comprising such PCD materials. In an embodiment, a method includes subjecting a mixture to heat and pressure sufficient to form a PCD material. The mixture comprises a plurality of diamond particles exhibiting a diamond particle size distribution characterized, in part, by a parameter θ that is less than about 1.0, where Φ=x/6σ, x is the average particle size of the diamond particle size distribution, and σ is the standard deviation of the diamond particle size distribution. In an embodiment, the diamond particle size distribution can be generally modeled by the following equation: CPFT/100= D n -D n s /D n l -D n s, wherein CPFT is the cumulative percent finer than, D is diamond grain size, D L is the largest- sized diamond grain, D s is the smallest-sized diamond grain, and n is a distribution modulus.

Abstract translation: 实施方案涉及通过使表现出宽金刚石粒度分布的混合物经历HPHT方法，所形成的PCD材料以及包括包含这种PCD材料的多晶金刚石台的PDC来制造PCD材料的方法。 在一个实施方案中，一种方法包括使混合物经受足以形成PCD材料的热和压力。 该混合物包括多个金刚石颗粒，其具有金刚石颗粒尺寸分布，其部分表征为参数α 小于约1.0，其中F = x / 6s，x是金刚石粒度分布的平均粒度，s是金刚石粒度分布的标准偏差。 在一个实施方案中，金刚石粒度分布通常可以通过以下等式建模：CPFT / 100 = Dn-Dn s / Dn l-Dn s，其中CPFT是比D更精细的累积百分比，D是金刚石晶粒尺寸，DL是 最大尺寸的金刚石颗粒，Ds是最小尺寸的金刚石颗粒，n是分布模量。

公开(公告)号：WO2009070805A2

公开(公告)日：2009-06-04

申请号：PCT/US2008/085178

申请日：2008-12-01

Applicant: ASURAGEN, INC. ,  BADER, Andreas, G. ,  WIGGINS, Jason, F. ,  PATRAWALA, Lubna ,  KELNAR, Kevin ,  BYROM, Mike ,  BROWN, David

Inventor： BADER, Andreas, G. ,  WIGGINS, Jason, F. ,  PATRAWALA, Lubna ,  KELNAR, Kevin ,  BYROM, Mike ,  BROWN, David

IPC: C12N15/11 ,  A61K48/00

CPC classification number: C12N15/1135 ,  C12N15/113 ,  C12N2310/141 ,  C12N2330/10

Abstract: The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-124, using miR-124 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.

Abstract translation: 本发明涉及用于鉴定miR-124调节的基因或遗传途径的方法和组合物，其使用miR-124调节基因或基因途径，使用该分布在评估患者的状况和/或以适当的方式治疗患者时 miRNA的。

公开(公告)号：WO2008079205A1

公开(公告)日：2008-07-03

申请号：PCT/US2007/025578

申请日：2007-12-14

Applicant: US SYNTHETIC CORPORATION ,  BERTAGNOLLI, Kenneth, E. ,  DEWBERRY, Jim, I. ,  QIAN, Jiang ,  VAIL, Michael, A. ,  WIGGINS, Jason ,  MIESS, David, P.

Inventor： BERTAGNOLLI, Kenneth, E. ,  DEWBERRY, Jim, I. ,  QIAN, Jiang ,  VAIL, Michael, A. ,  WIGGINS, Jason ,  MIESS, David, P.

IPC: B24D3/10 ,  B24D18/00

CPC classification number: B24D3/10 ,  B24D18/00 ,  B82Y30/00 ,  C04B35/52 ,  C04B35/6261 ,  C04B35/62802 ,  C04B35/6316 ,  C04B35/645 ,  C04B2235/3826 ,  C04B2235/383 ,  C04B2235/3834 ,  C04B2235/427 ,  C04B2235/428 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/5454 ,  C04B2235/5472 ,  C04B2235/781 ,  C04B2235/785 ,  C04B2235/786 ,  C04B2235/80 ,  C04B2235/96 ,  C04B2235/9607 ,  F16C17/02 ,  F16C17/04 ,  F16C33/043 ,  F16C33/26 ,  F16C2206/04 ,  F16C2220/20 ,  F16C2240/48 ,  F16C2352/00 ,  Y10T428/252 ,  Y10T428/30

Abstract: Embodiments of the present invention relate to diamond-silicon carbide composites, superabrasive compacts including such diamond-silicon carbide composites, and methods of fabricating such diamond-silicon carbide composites and superabrasive compacts. In one embodiment, a superabrasive compact includes a substrate and a superabrasive table bonded to the substrate. Thee superabrasive table comprises diamond-silicon carbide composite including a matrix comprising nanometer-sized silicon carbide grains and micrometer-sized diamond grains dispersed through the matrix. In another embodiment, a method of fabricating a superabrasive compact is disclosed. An assembly comprising a mixture including diamond particles and silicon is formed. The silicon comprises amorphous silicon, crystalline silicon crystallized from amorphous silicon formed by a milling process, or combinations thereof. A substrate is positioned in proximity to the mixture. The assembly is subjected to heat and pressure to form a superabrasive compact comprising a superabrasive table bonded to the substrate. The superabrasive table comprises diamond-silicon carbide composite including diamond grains dispersed through a matrix of silicon carbide grains.

Abstract translation: 本发明的实施方案涉及金刚石 - 碳化硅复合材料，包括这种金刚石 - 碳化硅复合材料的超级磨料压块，以及制造这种金刚石 - 碳化硅复合材料和超级磨料压块的方法。 在一个实施例中，超级磨料致密体包括基底和结合到基底的超研磨台。 该超级磨料台包括金刚石 - 碳化硅复合材料，其包括由纳米尺寸的碳化硅颗粒和通过基体分散的微米级金刚石颗粒的基体。 在另一个实施例中，公开了一种制造超硬磨料的方法。 形成包含金刚石颗粒和硅的混合物的组件。 硅包括非晶硅，通过研磨方法形成的非晶硅结晶的结晶硅或其组合。 衬底位于该混合物附近。 将组件经受热和压力以形成包含结合到衬底的超级磨料工作台的超硬磨料。 超级磨料台包括金刚石 - 碳化硅复合材料，其包括通过碳化硅颗粒的基体分散的金刚石颗粒。

公开(公告)号：WO2007149266A1

公开(公告)日：2007-12-27

申请号：PCT/US2007/013782

申请日：2007-06-11

Applicant: US SYNTHETIC CORPORATION ,  BERTAGNOLLI, Kenneth, E. ,  COOLEY, Craig, H. ,  WIGGINS, Jason

Inventor： BERTAGNOLLI, Kenneth, E. ,  COOLEY, Craig, H. ,  WIGGINS, Jason

IPC: B01J3/06 ,  B24D3/08 ,  E21B10/567

CPC classification number: B01J3/062 ,  B01J2203/061 ,  B01J2203/062 ,  B01J2203/0655 ,  B01J2203/0685 ,  B24D3/08 ,  E21B10/567

Abstract: Methods of manufacturing sintered superabrasive structures are disclosed. For example, a plurality of agglomerated granules comprising at least one superabrasive material may be provided and exposed to a pressure and a temperature sufficient to sinter the at least one superabrasive material. In another example, a plurality of agglomerated granules comprising diamond may be provided and exposed to a pressure and a temperature sufficient to form polycrystalline diamond. Articles of manufacture including at least one superabrasive material are disclosed. For example, a polycrystalline diamond compact may comprise a volume of polycrystalline diamond bonded to a substrate, wherein the volume of polycrystalline diamond includes a plurality of agglomerated granules which have been sintered. A drill bit comprising at least one cutting element including a volume of polycrystalline diamond bonded to a substrate wherein the volume of polycrystalline diamond includes a plurality of agglomerated granules which have been sintered is disclosed.

Abstract translation: 公开了制造烧结超级磨料结构的方法。 例如，可以提供包含至少一种超级磨料的多个附聚颗粒并暴露于足以烧结至少一种超级磨料的压力和温度。 在另一个实例中，可以提供包含金刚石的多个附聚颗粒并暴露于足以形成多晶金刚石的压力和温度。 公开了包括至少一种超级磨料的制品。 例如，多晶金刚石压块可以包括结合到衬底的多晶金刚石的体积，其中多晶金刚石的体积包括已经烧结的多个附聚颗粒。 一种钻头，其包括至少一个切割元件，该切割元件包括结合到基底的一定体积的多晶金刚石，其中多晶金刚石的体积包括已经烧结的多个附聚颗粒。