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    NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS
    1.
    发明申请
    NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS 审中-公开
    新型吡咯并[3,4-d]吡嗪化合物

    公开(公告)号：WO2011156698A3

    公开(公告)日：2012-02-09

    申请号：PCT/US2011039958

    申请日：2011-06-10

    申请人： ABBOTT LAB ,  WOLLER KEVIN R ,  CURTIN MICHAEL L ,  FRANK KRISTINE E ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  WISHART NEIL

    发明人： WOLLER KEVIN R ,  CURTIN MICHAEL L ,  FRANK KRISTINE E ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  WISHART NEIL

    IPC分类号： A01N43/38 ,  A61K31/40

    CPC分类号： C07D487/04

    摘要： The present disclosure is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

    摘要翻译： 本公开涉及新的式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。 式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如类风湿性关节炎，系统性红斑狼疮，多发性硬化症，克罗恩病 疾病，牛皮癣和哮喘。

    SULFONAMIDE COMPOUNDS HAVING 5-HT RECEPTOR ACTIVITY
    8.
    发明申请
    SULFONAMIDE COMPOUNDS HAVING 5-HT RECEPTOR ACTIVITY 审中-公开
    具有5-HT受体活性的磺酰胺化合物

    公开(公告)号：WO1998029411A1

    公开(公告)日：1998-07-09

    申请号：PCT/EP1997007034

    申请日：1997-12-15

    申请人： KNOLL AKTIENGESELLSCHAFT ,  WISHART, Neil ,  BIRCH, Alan, Martin

    发明人： KNOLL AKTIENGESELLSCHAFT

    IPC分类号： C07D405/06

    CPC分类号： C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D493/04

    摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof in which A is methylene or -O-; B is methylene or -O-; g is 0, 1, 2, 3 or 4; U is an alkylene chain optionally substituted by one or more alkyl; Q represents a divalent group containing nitrogen atoms; and T represents an aryl or heteroaryl group, have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, Parkinson's disease, obesity, hypertension, Tourette's syndrome, sexual dysfunction, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, senile dementia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders and anorexia, cardiovascular and cerebrovascular disorders, non-insulin dependent diabetes mellitus, hyperglycaemia, constipation, arrhythmia, disorders of the neuroendocrine system, stress and spasticity.

    摘要翻译： 式（I）化合物及其药学上可接受的盐，其中A是亚甲基或-O-; B是亚甲基或-O-; g为0,1,2,3或4; U是任选被一个或多个烷基取代的亚烷基链; Q表示含有氮原子的二价基团; 和T代表芳基或杂芳基，可用于治疗中枢神经系统疾病，例如抑郁症，焦虑症，精神病（例如精神分裂症），迟发性运动障碍，帕金森病，肥胖症，高血压，图雷特综合征，性功能障碍，药物 成瘾，药物滥用，认知障碍，阿尔茨海默病，老年痴呆，强迫症，恐慌发作，社交恐怖症，进食障碍和厌食症，心血管和脑血管疾病，非胰岛素依赖性糖尿病，高血糖症，便秘，心律失常， 神经内分泌系统，压力和痉挛状态。