公开(公告)号：WO2012125797A1

公开(公告)日：2012-09-20

申请号：PCT/US2012/029184

申请日：2012-03-15

Applicant: ABBOTT LABORATORIES ,  CUSACK, Kevin P. ,  GORDON, Thomas D. ,  IHLE, David C. ,  HAYES, Martin E. ,  BREINLINGER, Eric C. ,  ERICSSON, Anna M. ,  LI, Bin ,  WANG, Lei ,  MARTINEZ, Gloria Y. ,  BURCHAT, Andrew ,  HOBSON, Adrian D. ,  MULLEN, Kelly D. ,  FRIEDMAN, Michael ,  MORYTKO, Michael, J.

Inventor： CUSACK, Kevin P. ,  GORDON, Thomas D. ,  IHLE, David C. ,  HAYES, Martin E. ,  BREINLINGER, Eric C. ,  ERICSSON, Anna M. ,  LI, Bin ,  WANG, Lei ,  MARTINEZ, Gloria Y. ,  BURCHAT, Andrew ,  HOBSON, Adrian D. ,  MULLEN, Kelly D. ,  FRIEDMAN, Michael ,  MORYTKO, Michael, J.

IPC: A01N27/00 ,  A61K31/015

CPC classification number: C07D213/75 ,  C07B2200/07 ,  C07C45/62 ,  C07C45/72 ,  C07C45/74 ,  C07C49/755 ,  C07D231/54 ,  C07D235/18 ,  C07D241/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D453/04 ,  C07D487/06 ,  C07D491/20 ,  C07C49/67

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2009011850A2

公开(公告)日：2009-01-22

申请号：PCT/US2008008645

申请日：2008-07-15

Applicant: ABBOTT LAB ,  BREINLINGER ERIC C ,  CUSACK KEVIN P ,  HOBSON ADRIAN D ,  LI BIN ,  GORDON THOMAS D ,  STOFFEL ROBERT H ,  WALLACE GRIER A ,  GRONSGAARD PINTIPA ,  WANG LU

Inventor： BREINLINGER ERIC C ,  CUSACK KEVIN P ,  HOBSON ADRIAN D ,  LI BIN ,  GORDON THOMAS D ,  STOFFEL ROBERT H ,  WALLACE GRIER A ,  GRONSGAARD PINTIPA ,  WANG LU

IPC: C07D249/10 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61P35/00 ,  C07D231/14 ,  C07D261/14 ,  C07D403/12

CPC classification number: C07D249/10 ,  C07D231/14 ,  C07D249/06 ,  C07D261/14 ,  C07D261/18 ,  C07D273/02 ,  C07D333/36 ,  C07D333/38 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.

Abstract translation: 本文公开了式（I）的新化合物，其中变量如本文所定义。 式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性疾病和疾病以及增殖性疾病如癌症。

公开(公告)号：WO2007117465A3

公开(公告)日：2008-08-28

申请号：PCT/US2007008307

申请日：2007-04-02

Applicant: ABBOTT LAB ,  ERICSSON ANNA M ,  BURCHAT ANDREW ,  FRANK KRISTINE E ,  CALDERWOOD DAVID J ,  ABBOTT LILY K ,  ARGIRIADI MARIA A ,  BORHANI DAVID W ,  CUSACK KEVIN P ,  DIXON RICHARD W ,  GORDON THOMAS D ,  MULLEN KELLY D ,  TALANIAN ROBERT V ,  WU XIAOYUN ,  ZHANG XIAOLEI ,  WANG LU X ,  LI BIQIN ,  BARBERIS CLAUDE E ,  WISHART NEIL

Inventor： ERICSSON ANNA M ,  BURCHAT ANDREW ,  FRANK KRISTINE E ,  CALDERWOOD DAVID J ,  ABBOTT LILY K ,  ARGIRIADI MARIA A ,  BORHANI DAVID W ,  CUSACK KEVIN P ,  DIXON RICHARD W ,  GORDON THOMAS D ,  MULLEN KELLY D ,  TALANIAN ROBERT V ,  WU XIAOYUN ,  ZHANG XIAOLEI ,  WANG LU X ,  LI BIQIN ,  BARBERIS CLAUDE E ,  WISHART NEIL

IPC: A61K31/5377

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：WO2008079382A1

公开(公告)日：2008-07-03

申请号：PCT/US2007/026263

申请日：2007-12-21

Applicant: ABBOTT LABORATORIES ,  WALLACE, Grier A. ,  BREINLINGER, Eric C. ,  CUSACK, Kevin P. ,  FIX-STENZEL, Shannon R. ,  GORDON, Thomas D. ,  HOBSON, Adrian D. ,  HAYES, Martin E. ,  ANSELL, Graham K. ,  GRONGSAARD, Pintipa

Inventor： WALLACE, Grier A. ,  BREINLINGER, Eric C. ,  CUSACK, Kevin P. ,  FIX-STENZEL, Shannon R. ,  GORDON, Thomas D. ,  HOBSON, Adrian D. ,  HAYES, Martin E. ,  ANSELL, Graham K. ,  GRONGSAARD, Pintipa

IPC: A01N43/50 ,  A61K31/415

CPC classification number: C07D413/04 ,  C07C215/38 ,  C07C215/42 ,  C07C217/52 ,  C07C217/74 ,  C07C229/14 ,  C07C229/48 ,  C07C2601/02 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D213/30 ,  C07D263/32 ,  C07D263/52 ,  C07D271/06 ,  C07D307/22 ,  C07D307/24 ,  C07D333/16 ,  C07D491/107 ,  C07F9/091 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/3826 ,  C07F9/4006 ,  C07F9/653 ,  C07F9/65515 ,  C07F9/655345

Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.

Abstract translation: 本发明涉及作为S1P受体家族的一种或多种单独受体的激动剂或拮抗剂的新颖的，有效的和选择性的药剂。 本发明的化合物可用作治疗与S1P受体家族的各个受体的激动作用或拮抗作用相关的医学病症的治疗剂。

公开(公告)号：WO03045320A3

公开(公告)日：2003-10-16

申请号：PCT/US0237751

申请日：2002-11-21

Applicant: SOD CONSEILS RECH APPLIC ,  GORDON THOMAS D ,  MORGAN BARRY A ,  CULLER MICHAEL D

Inventor： GORDON THOMAS D ,  MORGAN BARRY A ,  CULLER MICHAEL D

IPC: A61K38/00 ,  C07K14/655

CPC classification number: C07K14/6555 ,  A61K38/00

Abstract: Claimed is a somatostatin agonist according to the formula (I): D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2, or a pharmaceutically acceptable salt thereof, and uses thereof.

Abstract translation: 要求的是根据式（I）的生长抑素激动剂：D-Phe-c（Cys-Tyr（I）-D-Trp-Lys-Val-Cys）-Thr-NH 2或其药学上可接受的盐， 它们。

公开(公告)号：WO2003045320A2

公开(公告)日：2003-06-05

申请号：PCT/US2002/037751

申请日：2002-11-21

Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. ,  GORDON, Thomas, D. ,  MORGAN, Barry, A. ,  CULLER, Michael, D.

Inventor： GORDON, Thomas, D. ,  MORGAN, Barry, A. ,  CULLER, Michael, D.

IPC: A61K

CPC classification number: C07K14/6555 ,  A61K38/00

Abstract: Claimed is a somatostatin agonist according to formula (I), D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH 2 , or a pharmaceutically acceptable salt thereof, and uses thereof.

Abstract translation: 要求的是根据式（I）的生长抑素激动剂，D-Phe-c（Cys-Tyr（I）-D-Trp和Cys）-Thr-NH 2 s 其药学上可接受的盐及其用途。

公开(公告)号：WO9965942A8

公开(公告)日：2000-02-17

申请号：PCT/US9913304

申请日：1999-06-11

Applicant: SOD CONSEILS RECH APPLIC ,  GORDON THOMAS D

Inventor： GORDON THOMAS D

IPC: C07D233/64 ,  A61K31/4164 ,  A61K38/00 ,  A61K38/22 ,  A61K38/31 ,  A61P1/00 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P13/12 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07K7/64 ,  C07K14/655 ,  A61K31/415

CPC classification number: C07K14/6555 ,  A61K38/00

Abstract: The present invention is directed to cyclic derivatives containing an imidazole cis amide bond mimetic which bind selectively to somatostatin receptor subtypes and the use thereof in treating conditions which can be treated by eliciting an agonist or antagonist effect from the somatostatin subtype receptors. This invention is also directed to methods for making the compounds of the instant invention.

Abstract translation: 本发明涉及含有与生长抑素受体亚型选择性结合的咪唑顺式酰胺键模拟物的环状衍生物及其在治疗可通过从生长抑素亚型受体引发激动剂或拮抗剂作用治疗的病症中的用途。 本发明还涉及制备本发明化合物的方法。

公开(公告)号：WO2012112841A3

公开(公告)日：2013-03-14

申请号：PCT/US2012025570

申请日：2012-02-17

Applicant: ABBOTT LAB ,  ZHANG GEOFF G ,  BRACKEMEYER PAUL J ,  CHEN SHAUNG ,  GORDON THOMAS D

Inventor： ZHANG GEOFF G ,  BRACKEMEYER PAUL J ,  CHEN SHAUNG ,  GORDON THOMAS D

IPC: A01N43/82 ,  A61K31/41

CPC classification number: C07D413/04 ,  A61K31/4245 ,  A61K31/4439 ,  C07D271/06

Abstract: The present invention relates to salts and crystalline forms of [1,2,4]oxadiazol-3-yl]-phenoxy}-cycloalkyl carboxylic acids, processes for their preparation, pharmaceutical compositions comprising such compounds, and methods of using them.

Abstract translation: 本发明涉及[1,2,4]恶二唑-3-基] - 苯氧基} - 环烷基羧酸的盐和结晶形式，其制备方法，包含这些化合物的药物组合物及其使用方法。

公开(公告)号：WO2012112841A2

公开(公告)日：2012-08-23

申请号：PCT/US2012/025570

申请日：2012-02-17

Applicant: ABBOTT LABORATORIES ,  ZHANG, Geoff G. ,  BRACKEMEYER, Paul J. ,  CHEN, Shaung ,  GORDON, Thomas D.

Inventor： ZHANG, Geoff G. ,  BRACKEMEYER, Paul J. ,  CHEN, Shaung ,  GORDON, Thomas D.

IPC: A61K31/4439 ,  C07D413/04 ,  C07D271/06 ,  A61K31/4245 ,  A61P37/06 ,  A61P35/00

CPC classification number: C07D413/04 ,  A61K31/4245 ,  A61K31/4439 ,  C07D271/06

Abstract: The present invention relates to salts and crystalline forms of [1,2,4]oxadiazol-3-yl]-phenoxy}-cycloalkyl carboxylic acids, processes for their preparation, pharmaceutical compositions comprising such compounds, and methods of using them.

Abstract translation: 本发明涉及[1,2,4]恶二唑-3-基] - 苯氧基} - 环烷基羧酸的盐和结晶形式，其制备方法，包含这些化合物的药物组合物及其使用方法。

公开(公告)号：WO2009011850A3

公开(公告)日：2009-01-22

申请号：PCT/US2008/008645

申请日：2008-07-15

Applicant: ABBOTT LABORATORIES ,  BREINLINGER, Eric, C. ,  CUSACK, Kevin, P. ,  HOBSON, Adrian, D. ,  LI, Bin ,  GORDON, Thomas, D. ,  STOFFEL, Robert, H. ,  WALLACE, Grier, A. ,  GRONSGAARD, Pintipa ,  WANG, Lu ,  WANG, Lu

Inventor： BREINLINGER, Eric, C. ,  CUSACK, Kevin, P. ,  HOBSON, Adrian, D. ,  LI, Bin ,  GORDON, Thomas, D. ,  STOFFEL, Robert, H. ,  WALLACE, Grier, A. ,  GRONSGAARD, Pintipa ,  WANG, Lu ,  WANG, Lu

IPC: A61K31/42 ,  A61K31/67 ,  A61K31/675

Abstract: Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.