公开(公告)号：WO2010093374A1

公开(公告)日：2010-08-19

申请号：PCT/US2009/040956

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC, INC. ,  WOHABREBBI, Amira

Inventor： WOHABREBBI, Amira

IPC: A61K9/22 ,  A61K31/445 ,  A61P29/00 ,  A61K47/34 ,  A61K31/485 ,  A61K31/415

CPC classification number: A61K45/06 ,  A61K9/0024 ,  A61K31/445 ,  A61K2300/00

Abstract: Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and an anti-inflammatory agent at or near a target site, one can alleviate or prevent pain while preventing undesirable levels of inflammation. This administration of bupivacaine and an anti-inflammatory agent is particularly useful following surgery.

Abstract translation: 提供了伴随手术后手术的有效治疗疼痛。 通过在目标部位或其附近施用有效量的布比卡因和抗炎剂的组合，可以减轻或预防疼痛，同时防止不良的炎症水平。 布比卡因和抗炎剂的施用在手术后特别有用。

公开(公告)号：WO2009129437A2

公开(公告)日：2009-10-22

申请号：PCT/US2009040910

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

IPC: A61K9/00 ,  A61K31/4162

CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

公开(公告)号：WO2009129210A2

公开(公告)日：2009-10-22

申请号：PCT/US2009040453

申请日：2009-04-14

Applicant: MEDTRONIC INC ,  WARSAW ORTHOPEDIC INC ,  WOHABREBBI AMIRA ,  KING VANJA MARGARETA ,  MCKAY WILLIAM F

Inventor： WOHABREBBI AMIRA ,  KING VANJA MARGARETA ,  MCKAY WILLIAM F

IPC: A61K9/16 ,  A61K9/20

CPC classification number: A61K9/0024 ,  A61K9/204 ,  A61K31/4168 ,  A61K31/445 ,  A61K45/06

Abstract: Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.

Abstract translation: 提供了伴随手术后手术的有效治疗疼痛。 通过在目标部位或其附近施用有效量的布比卡因和可乐定的组合，可以减轻或预防疼痛。 布比卡因和可乐定或其药学上可接受的盐的施用在手术后是特别有用的。

公开(公告)号：WO2010009116A3

公开(公告)日：2010-04-22

申请号：PCT/US2009050528

申请日：2009-07-14

Applicant: WARSAW ORTHOPEDIC INC ,  WOHABREBBI AMIRA

Inventor： WOHABREBBI AMIRA

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/196 ,  A61P29/00

CPC classification number: A61K31/192 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/196 ,  A61K2300/00

Abstract: Methods and compositions are provided for reducing, treating or preventing postoperative pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of diclofenac and/or ketoprofen or pharmaceutically acceptable salt thereof to a target tissue site, wherein the drug depot releases an effective amount of diclofenac and/or ketoprofen or pharmaceutically acceptable salt thereof over a period of 3 to 15 days.

Abstract translation: 提供了用于在需要这种治疗的患者中减少，治疗或预防术后疼痛和/或炎症的方法和组合物，所述方法和组合物包括施用一种或多种包含治疗有效量的双氯芬酸和/或酮洛芬的可生物降解的药物贮库或 其药学上可接受的盐存在于靶组织部位，其中药物贮库在3至15天的时间内释放有效量的双氯芬酸和/或酮洛芬或其药学上可接受的盐。

公开(公告)号：WO2009129509A3

公开(公告)日：2009-10-22

申请号：PCT/US2009/041039

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC, INC. ,  MEDTRONIC, INC. ,  KING, Vanja, Margareta ,  HOBOT, Christopher, M. ,  BIGGS, Dr. Danielle ,  SHAW, Katara ,  WOHABREBBI, Amira ,  MCKAY, William, F. ,  MCDONALD, Phillip, Edward

Inventor： KING, Vanja, Margareta ,  HOBOT, Christopher, M. ,  BIGGS, Dr. Danielle ,  SHAW, Katara ,  WOHABREBBI, Amira ,  MCKAY, William, F. ,  MCDONALD, Phillip, Edward

IPC: A61K31/4458 ,  A61P29/00 ,  A61K47/34 ,  A61K9/20

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.

公开(公告)号：WO2009129210A4

公开(公告)日：2010-11-04

申请号：PCT/US2009040453

申请日：2009-04-14

Applicant: MEDTRONIC INC ,  WARSAW ORTHOPEDIC INC ,  WOHABREBBI AMIRA ,  KING VANJA MARGARETA ,  MCKAY WILLIAM F

Inventor： WOHABREBBI AMIRA ,  KING VANJA MARGARETA ,  MCKAY WILLIAM F

IPC: A61K9/16 ,  A61K9/20

CPC classification number: A61K9/0024 ,  A61K9/204 ,  A61K31/4168 ,  A61K31/445 ,  A61K45/06

Abstract: Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.

Abstract translation: 提供了伴随手术后手术的有效治疗疼痛。 通过在目标部位或其附近施用有效量的布比卡因和可乐定的组合，可以减轻或预防疼痛。 布比卡因和可乐定或其药学上可接受的盐的施用在手术后是特别有用的。

公开(公告)号：WO2009129509A4

公开(公告)日：2010-04-08

申请号：PCT/US2009041039

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DR DANIELLE ,  SHAW KATARA ,  WOHABREBBI AMIRA ,  MCKAY WILLIAM F ,  MCDONALD PHILLIP EDWARD

Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DR DANIELLE ,  SHAW KATARA ,  WOHABREBBI AMIRA ,  MCKAY WILLIAM F ,  MCDONALD PHILLIP EDWARD

IPC: A61K31/4458 ,  A61K9/20 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K31/445 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/7007 ,  A61K31/4458

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.

Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者中的手术后疼痛的可植入药物储存库，所述可植入药物储库包含聚合物和治疗有效量的局部麻醉剂或药学上可接受的盐 其中所述药物储存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述药物储库能够释放（i）所述局部麻醉剂或药学上可接受的盐的推注剂量 （ii）在至少4天的时间内持续释放剂量的有效量的局部麻醉剂或其药学上可接受的盐。

公开(公告)号：WO2009129210A3

公开(公告)日：2009-10-22

申请号：PCT/US2009/040453

申请日：2009-04-14

Applicant: MEDTRONIC, Inc. ,  WARSAW ORTHOPEDIC, INC. ,  WOHABREBBI, Amira ,  KING, Vanja, Margareta ,  MCKAY, William, F.

Inventor： WOHABREBBI, Amira ,  KING, Vanja, Margareta ,  MCKAY, William, F.

IPC: A61K9/16 ,  A61K9/20

Abstract: Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.

公开(公告)号：WO2009129437A3

公开(公告)日：2010-02-18

申请号：PCT/US2009040910

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/4162 ,  A61K47/34

CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

公开(公告)号：WO2010009116A2

公开(公告)日：2010-01-21

申请号：PCT/US2009/050528

申请日：2009-07-14

Applicant: WARSAW ORTHOPEDIC, INC. ,  WOHABREBBI, Amira

Inventor： WOHABREBBI, Amira

IPC: A61K9/00 ,  A61P29/00 ,  A61K31/19 ,  A61K31/196 ,  A61K9/20

CPC classification number: A61K31/192 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/196 ,  A61K2300/00

Abstract: Methods and compositions are provided for reducing, treating or preventing postoperative pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of diclofenac and/or ketoprofen or pharmaceutically acceptable salt thereof to a target tissue site, wherein the drug depot releases an effective amount of diclofenac and/or ketoprofen or pharmaceutically acceptable salt thereof over a period of 3 to 15 days.

Abstract translation: 提供了用于减少，治疗或预防需要这种治疗的患者的术后疼痛和/或炎症的方法和组合物，所述方法和组合物包括施用一种或多种生物可降解药物贮库，所述生物可降解药物贮库包含治疗有效 量的双氯芬酸和/或酮洛芬或其药学上可接受的盐至靶组织部位，其中所述药物长效剂在3至15天的时间内释放有效量的双氯芬酸和/或酮洛芬或其药学上可接受的盐。