公开(公告)号：WO2019043577A1

公开(公告)日：2019-03-07

申请号：PCT/IB2018/056556

申请日：2018-08-28

Applicant: NOVARTIS AG

Inventor： HOLLAND, Troy Vernon ,  CHANG, Frank ,  DESOUSA, Ryan

IPC: B29D11/00 ,  G02B1/04

CPC classification number: B29D11/00134 ,  B29D11/00048 ,  B29K2029/04 ,  B29K2105/0002 ,  B29K2105/24 ,  C08F16/06 ,  G02B1/043 ,  C08L29/04

Abstract: Described herein is a fast curing process for producing contact lenses. This fast curing process involves adding a chain-transfer agent, such as, a thiol-containing compound, into a lens-forming composition for making contact lenses. The curing time of such a lens-forming composition can be significantly reduced, compared to a "control composition" that is free of any chain-transfer agent. Also, the elastic modulus of the contact lenses obtained from such a lens-forming composition can be reduced.

公开(公告)号：WO2017037610A1

公开(公告)日：2017-03-09

申请号：PCT/IB2016/055153

申请日：2016-08-29

Applicant: NOVARTIS AG

Inventor： QIAN, Xinming ,  CHANG, Frank ,  MATSUZAWA, Yasuo ,  SHANKAR, Venkat

IPC: B29D11/00

CPC classification number: G02B1/043 ,  B29D11/00048 ,  B29D11/00067 ,  B29D11/00125 ,  C08J7/123 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2471/00 ,  C08J2477/00

Abstract: The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.

Abstract translation: 本发明涉及一种在其上具有稳定的润滑性水凝胶涂层的硅酮水凝胶隐形眼镜的制造方法。 本发明的方法包括在硅氧烷水凝胶隐形眼镜上形成具有反应性官能团的等离子体反应性亲水聚合物混合基底涂层，并将该硅酮水凝胶隐形眼镜与混合基底涂层在水溶性和热交联性水溶液中加热 亲水性聚合物材料，以在其上形成稳定的润滑性水凝胶涂层。

公开(公告)号：WO2016173620A1

公开(公告)日：2016-11-03

申请号：PCT/EP2015/059113

申请日：2015-04-28

Applicant: OPTOTUNE AG

Inventor： ASCHWANDEN, Manuel ,  NIEDERER, David ,  SMOLKA, Stephan ,  GRÄTZEL, Chauncey ,  STADLER, David ,  PATSCHEIDER, Roman

IPC: G02C7/04 ,  G02C7/08 ,  G02B3/14 ,  B29D11/00 ,  A61F2/16

CPC classification number: G02C7/049 ,  A61F2/1635 ,  A61F2250/0001 ,  A61F2250/0002 ,  B29D11/00048 ,  B29D11/0023 ,  B29D11/00817 ,  G02B3/14 ,  G02C7/041 ,  G02C7/085

Abstract: The invention relates to a lens (1) for vision correction, wherein the lens (1) is configured to be placed directly on the surface of an eye (2) of a person or to be implanted into an eye (2) of a person, and wherein the lens (1) further comprises: a transparent base element (10) having a back side (12) and a front side (11) facing away from the back side (12), a transparent and elastically expandable membrane (20) connected to said base element (10), wherein said membrane (20) comprises a back side (22) that faces said front side (11) of the base element (10), a ring member (30) connected to said back side (22) of the membrane (20) so that the ring member (30) defines a curvature-adjustable area (23) of the membrane (20), and wherein the lens (1) comprises a lens volume (41) adjacent said curvature-adjustable area (23) of the membrane (20), which lens volume (41) is delimited by the ring member (30), and wherein the lens (1) comprises a reservoir volume (42) adjacent a boundary area (24) of said membrane (20), wherein said two volumes (41, 42) are filled with a transparent liquid (50), and wherein said volumes (41, 42) are fluidly connected or fluidly connectable to each other such that, when the reservoir volume (42) is compressed, liquid (50) residing in the reservoir volume (42) is pressed into the lens volume (41) such that the curvature of said curvature-adjustable area (23) of the membrane (22) increases and the focal length of the lens (1) decreases. Further, the invention relates to a method for manufacturing a contact lens according to the invention.

Abstract translation: 本发明涉及一种用于视力矫正的透镜（1），其中透镜（1）被配置为直接放置在人的眼睛（2）的表面上或被植入人的眼睛（2）中 ，并且其中所述透镜（1）还包括：具有背侧（12）和背侧（12）背面的前侧（11）的透明基底元件（10），透明且可弹性膨胀的膜（20） ）连接到所述基座元件（10）上，其中所述膜（20）包括面向所述基座元件（10）的所述前侧（11）的后侧（22），环形构件（30） （20）的（22），使得所述环构件（30）限定所述膜（20）的曲率可调整区域（23），并且其中所述透镜（1）包括邻近所述曲率的透镜容积（41） - 所述膜（20）的可调节区域（23），所述透镜容积（41）由所述环构件（30）限定，并且其中所述透镜（1）包括邻近边界区域 24），其中所述两个体积（41,42）填充有透明液体（50），并且其中所述体积（41,42）彼此流体连接或可流体连接，使得当 储存器容积（42）被压缩，驻留在储存器容积（42）中的液体（50）被压入透镜容积（41），使得膜（22）的所述曲率可调节区域（23）的曲率增加 并且透镜（1）的焦距减小。 此外，本发明涉及一种根据本发明的隐形眼镜的制造方法。

公开(公告)号：WO2014209472A1

公开(公告)日：2014-12-31

申请号：PCT/US2014/033998

申请日：2014-04-14

Applicant: GOOGLE INC.

Inventor： LINHART, Jeffrey, George ,  LIU, Zenghe

IPC: G02C7/04 ,  A61F2/14 ,  A61B5/00 ,  B29D11/00 ,  B29C37/00

CPC classification number: A61B3/101 ,  B29C65/522 ,  B29D11/00048 ,  B29D11/00817 ,  B32B37/185 ,  B32B2551/00 ,  G02C7/04 ,  G02C7/049 ,  G02C2202/16

Abstract: The present disclosure provides a method including forming a polymer layer defining a side of an eye-mountable device. The method may also include providing an adhesive in a ring-shaped pattern on a ring-shaped substrate or on the first polymer layer. The method may also include providing the ring-shaped substrate on the first polymer layer in a predetermined rotational orientation. The method may also include applying a force to one or more of the ring-shaped substrate and the polymer layer to adhere the first polymer layer to the ring- shaped substrate. The method may also include curing the ring-shaped substrate and the first polymer layer.

Abstract translation: 本公开提供了一种方法，包括形成限定眼睛安装装置的侧面的聚合物层。 该方法还可以包括在环形基底上或在第一聚合物层上提供呈环状图案的粘合剂。 该方法还可以包括以预定的旋转方向在第一聚合物层上提供环形基材。 该方法还可以包括向一个或多个环形基底和聚合物层施加力以将第一聚合物层粘附到环形基底上。 该方法还可以包括固化环形基底和第一聚合物层。

公开(公告)号：WO2012015639A1

公开(公告)日：2012-02-02

申请号：PCT/US2011/044618

申请日：2011-07-20

Applicant: NOVARTIS AG ,  SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  WU, Daqing ,  KUYU, Selma

Inventor： SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  WU, Daqing ,  KUYU, Selma

IPC: G02C7/04 ,  C08L83/04

CPC classification number: G02B1/043 ,  B29D11/00038 ,  B29D11/00048 ,  G02C7/04 ,  G02C7/049 ,  C08L101/14

Abstract: Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.

Abstract translation: 本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。 与使紫外线吸收性隐形眼镜相关的常规方法与包含紫外线吸收性乙烯基单体的透镜形成组合物共聚，本发明的方法涉及将具有第二反应性官能团的紫外线吸收性化合物与 其中和/或其上具有第一反应性官能团的预成型隐形眼镜。

公开(公告)号：WO2007147152A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/071410

申请日：2007-06-15

Applicant: LAI, Shui, T.

Inventor： LAI, Shui, T.

IPC: G02C7/04

CPC classification number: B29D11/00048 ,  G02C7/049 ,  G02C2202/16

Abstract: A contact lens providing high visual acuity with the comfort of a soft lens includes a thin layer of hard lens material at the front surface of the contact lens; and a second soft lens material layer at the posterior portion of the lens. The soft lens provides a contact area substantially in contact with the central region of the cornea. The first layer is bonded on top of the second layer directly or through a third elastic material layer. Manufacturing methods overcome problems of swelling of the soft lens component during hydration.

Abstract translation: 提供高视力的隐形眼镜与软透镜的舒适性在隐形眼镜的前表面包括一薄层的硬质透镜材料; 以及在透镜的后部处的第二软透镜材料层。 软透镜提供与角膜的中心区域基本上接触的接触区域。 第一层直接或通过第三弹性材料层粘合在第二层的顶部上。 制造方法克服了水合期间软透镜部件膨胀的问题。

公开(公告)号：WO2017083770A1

公开(公告)日：2017-05-18

申请号：PCT/US2016/061696

申请日：2016-11-11

Applicant: ONEFOCUS VISION, INC.

Inventor： HARANT, Adam ,  CRAMER, Neil ,  DAVENPORT, Amelia ,  WAITE, Steve ,  GUPTA, Amitava

IPC: B29D11/00 ,  G02C7/04

CPC classification number: B29D11/00 ,  B29D11/00028 ,  B29D11/00048 ,  B29D11/00067 ,  G02B1/043 ,  G02C7/04 ,  C08L33/10

Abstract: A hydrogel formulation has been developed that can be cast to form a hydrophilic cross-linked network with water content of 30-60% by weight that undergoes a volume expansion less than 5% when equilibrated in water or an aqueous solution of ionic species. This hydrogel formulation was used to cast a soft contact lens incorporating an insert that may be a sealed module filled with a fluid. Diameter of lenses cast without an insert measured within 0.5-5.0%) of the target diameter after hydration. The interface between the hydrogel and the insert in lenses cast with an insert remaining stress free after hydration, when the lens was inspected under a microscope. The formulation comprises and may consist of a mixture of hydrophilic mono-functional monomers, cross-linking agents, a photo-curing catalyst and a diluent.

Abstract translation: 已经开发了一种水凝胶制剂，其可以浇注以形成水含量为30-60重量％的亲水性交联网络，其在水中平衡时经历小于5％的体积膨胀或 离子物质的水溶液。 使用该水凝胶制剂来铸造包含插入物的软性隐形眼镜，该插入物可以是填充有流体的密封模块。 在没有插入物的情况下铸造的透镜的直径在水合后在0.5-5.0％的目标直径内测量。 当透镜在显微镜下检查时，水凝胶和插入物之间的界面与水合后保持无应力的插入物一起铸造。 该制剂包含亲水性单官能单体，交联剂，光固化催化剂和稀释剂的混合物并可由其组成。

公开(公告)号：WO2016032940A1

公开(公告)日：2016-03-03

申请号：PCT/US2015/046501

申请日：2015-08-24

Applicant: NOVARTIS AG ,  CHANG, Frank ,  HOLLAND, Troy, Vernon

Inventor： CHANG, Frank ,  HOLLAND, Troy, Vernon

IPC: C08G73/02 ,  C09D179/02 ,  G02B1/04 ,  G02B1/10 ,  A61L27/34 ,  B29D11/00

CPC classification number: G02B1/043 ,  A61L27/14 ,  A61L27/50 ,  A61L2430/16 ,  B05D5/00 ,  B29D11/00048 ,  B29D11/00125 ,  B29D11/00865 ,  C07D205/04 ,  C08G73/022 ,  C08G73/0226 ,  C08G73/0233 ,  C08G73/06 ,  C08J3/247 ,  C08J2379/02 ,  C09D5/00 ,  C09D179/02 ,  C09D179/04 ,  G02B1/10 ,  G02C7/049 ,  G02C2202/16 ,  C08L101/14 ,  C08L33/08 ,  C08L83/04

Abstract: The invention is related to poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymers and chemically-modified derivatives thereof as well as their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

Abstract translation: 本发明涉及聚（2-恶唑啉 - 共 - 乙烯亚胺） - 表氯醇共聚物及其化学修饰的衍生物，以及它们在硅氧水凝胶隐形眼镜上形成非硅氧烷水凝胶涂层的用途。

公开(公告)号：WO2016032926A1

公开(公告)日：2016-03-03

申请号：PCT/US2015/046471

申请日：2015-08-24

Applicant: NOVARTIS AG ,  ZHANG, Steve Yun

Inventor： ZHANG, Steve Yun

IPC: B29D11/00

CPC classification number: G02B1/043 ,  B05D3/0473 ,  B05D5/00 ,  B05D7/02 ,  B05D7/57 ,  B29D11/00048 ,  B29D11/00865 ,  C08J7/047 ,  C08J7/08 ,  C08J7/12 ,  C08J2333/24 ,  C08J2339/06 ,  C08J2433/02 ,  G02B1/18

Abstract: The invention is related to a method for producing silicone hydrogel contact lenses with having a stable coating thereon. A method of the invention comprises a water-based coating process (step) for forming a relatively-stable base coating of a homo- or copolymer of acrylic acid or C 1 -C 3 alkylacrylic acid onto a silicone hydrogel contact lens made from a lens formulation comprising from about 35 % to about 60 % by weight of N-vinylpyrrolidone.

Abstract translation: 本发明涉及一种在其上具有稳定涂层的硅酮水凝胶隐形眼镜的制造方法。 本发明的方法包括一种用于在由透镜制剂制成的硅氧烷水凝胶隐形眼镜上形成丙烯酸或C 1 -C 3烷基丙烯酸均聚物或共聚物的相对稳定的基底涂层的水性涂覆方法（步骤） 约35重量％至约60重量％的N-乙烯基吡咯烷酮。

公开(公告)号：WO2015031239A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/052485

申请日：2014-08-25

Applicant: JOHNSON & JOHNSON VISION CARE, INC.

Inventor： BARRE, Vincent H. ,  LUST, Victor

IPC: B29D11/00 ,  B29C65/00 ,  B29C65/18 ,  B29C65/54 ,  B29C65/78 ,  B29L11/00

CPC classification number: G02C7/085 ,  B29C65/18 ,  B29C65/542 ,  B29C65/7841 ,  B29C66/0016 ,  B29C66/118 ,  B29C66/545 ,  B29C66/71 ,  B29C66/73366 ,  B29C66/7352 ,  B29C66/81422 ,  B29C66/81423 ,  B29C66/8322 ,  B29C66/849 ,  B29D11/00048 ,  B29D11/00817 ,  B29L2011/0016 ,  B29L2011/0041 ,  G02C7/024 ,  B29K2019/00 ,  B29K2023/00 ,  B29K2025/06 ,  B29K2083/00

Abstract: The present invention provides for an optical assembly using two ultra-thin optical pieces (102, 202) defining the outer bound of the assembly with a liquid core and methods of forming said assembly. In particular, the present in invention discloses the handling and arrangements of said ultra-thin optical pieces to prevent deformation and loss of optical quality of said ultra-thin optical pieces. The ultra-thin optical pieces can be from 25-200 microns and their structural integrity can be preserved through uninterrupted support by substates (101, 201) throughout the encapsulation of one or more fluids, e.g., a saline solution (301) and an oil solution (305), which can be used to form a liquid meniscus lens. In some embodiments, interlocking features (115) included in the ultra-thin optical parts can be included in order to help create the seal and/or provide structural support to the liquid lens assembly. In another embodiment, the supporting pieces to the ultra-thin optical components have an interlocking or centering mechanism, to aid in the assembly and sealing of said optical assembly.

Abstract translation: 本发明提供了一种使用两个超薄光学片（102,202）的光学组件，其限定了具有液芯的组件的外界限和形成所述组件的方法。 特别地，本发明公开了所述超薄光学片的处理和布置，以防止所述超薄光学片的变形和光学质量的损失。 超薄光学片可以是25-200微米，并且通过在一个或多个流体例如盐水溶液（301）和油的包封过程中，子状态（101,201）的不间断支撑可以保持其结构完整性 溶液（305），其可以用于形成液体弯月透镜。 在一些实施例中，可以包括超薄光学部件中包括的互锁特征（115），以帮助产生密封和/或为液体透镜组件提供结构支撑。 在另一个实施例中，超薄光学部件的支撑件具有互锁或定心机构，以有助于所述光学组件的组装和密封。