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    CONTROLLED RELEASE MULTIPLE LAYER COATINGS
    3.
    发明申请
    CONTROLLED RELEASE MULTIPLE LAYER COATINGS 审中-公开
    控制释放多层涂料

    公开(公告)号：WO2008129507A1

    公开(公告)日：2008-10-30

    申请号：PCT/IB2008/051529

    申请日：2008-04-21

    申请人： XAVIER UNIVERSITY OF LOUISIANA ,  MANDAL, Tarun Kumar ,  CHINTA, Dakshinamurthy Devanga ,  GRAVES, Richard A.

    发明人： MANDAL, Tarun Kumar ,  CHINTA, Dakshinamurthy Devanga ,  GRAVES, Richard A.

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K31/138

    CPC分类号： A61K9/5078 ,  A61J3/005 ,  A61K9/5089 ,  A61K31/138

    摘要： A process for making controlled release pharmaceutical formulations is provided, which comprises supplying a plurality of solutions with syringe pumps for fluid bed coating, coating a substrate with a pH dependent soluble polymer solution, coating the polymer coated substrate with at least one layer of a solution of a therapeutically active substance and at least one layer of a second polymer solution, and alternating the layers so that the number, order, and volume of the layers controls the release of the therapeutically active substance. In alternate embodiments, the consecutively applied layers may contain coating materials, active ingredients or a mixture of coating materials and active ingredients; the layers can be applied in varying order. Also provided is a system for applying the coatings, wherein the syringe pumps are controlled by a computer in accordance with predetermined instructions.

    摘要翻译： 提供了一种制备控制释放药物制剂的方法，其包括向多个溶液提供用于流化床涂层的注射泵，用pH依赖性可溶性聚合物溶液涂覆底物，用至少一层溶液涂覆聚合物涂覆的基底 的治疗活性物质和至少一层第二聚合物溶液，并交替层，使得层的数量，次序和体积控制治疗活性物质的释放。 在替代实施例中，连续施加的层可以包含涂层材料，活性成分或涂层材料和活性成分的混合物; 这些层可以以不同的顺序施加。 还提供了一种用于施加涂层的系统，其中注射器泵由计算机根据预定指令控制。

    AN IMPROVED METHOD OF MICRO-ENCAPSULATION
    4.
    发明申请
    AN IMPROVED METHOD OF MICRO-ENCAPSULATION 审中-公开
    改进的微封装方法

    公开(公告)号：WO2008054659A2

    公开(公告)日：2008-05-08

    申请号：PCT/US2007/022514

    申请日：2007-10-24

    申请人： XAVIER UNIVERSITY OF LOUISIANA ,  MANDAL, Tarun, K. ,  GRAVES, Richard

    发明人： MANDAL, Tarun, K. ,  GRAVES, Richard

    IPC分类号： B01J13/04 ,  B32B9/00

    CPC分类号： B01J13/02

    摘要： A method of preparing micro-capsules. The active ingredient, preferably provided in the form of an acid salt dissolved in a basic aqueous solution, is emulsified into a polymer solution, preferably PLGA in a relatively volatile solvent such as dichloromethane, to create a water in oil emulsion. This emulsion is further emulsified into an aqueous solution having a pH of a between about 7.4 and 8.0 and most preferably between about 7.8 and 8.0 to create a water in oil in water solution. The polymer solvent is allowed to evaporate, causing the emulsified active ingredient and surrounding polymer matrix to precipitate, thereby forming the micro-capsules. The micro-capsules are separated from the suspension, washed and freeze dried. The method has a very high encapsulation efficiency, even at high loading rates. Additionally, the dissolution rate of the micro-particles produced by the method is very steady over a long period of time.

    摘要翻译： 一种制备微胶囊的方法。 优选以溶于碱性水溶液中的酸盐形式提供的活性成分在相对挥发性的溶剂如二氯甲烷中乳化成聚合物溶液，优选PLGA，以产生油包水乳液。 该乳液进一步乳化成pH为约7.4至8.0，最优选约7.8至8.0的水溶液，以在水溶液中产生水包油。 使聚合物溶剂蒸发，使乳化的活性成分和周围的聚合物基质沉淀，从而形成微胶囊。 将微胶囊与悬浮液分离，洗涤并冷冻干燥。 该方法即使在高负载率下也具有非常高的封装效率。 此外，通过该方法产生的微粒的溶解速率在长时间内非常稳定。