公开(公告)号：WO2014168912A1

公开(公告)日：2014-10-16

申请号：PCT/US2014/033268

申请日：2014-04-08

Applicant: XU, Xiaoming ,  COSTIN, Stephen A.

Inventor： XU, Xiaoming ,  COSTIN, Stephen A.

IPC: C07C229/14 ,  C07D487/08 ,  A61K6/00

CPC classification number: C07D487/08 ,  A61K6/0047 ,  C07C229/14 ,  A61K6/083 ,  C08L33/10

Abstract: Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties and are hydrolytically stable. The compounds may be utilized in dental and/or medical applications, including dental composites, dentures, bonding agents, sealants, resins and medical devices.

Abstract translation: 提供可聚合的抗微生物化合物。 这些化合物包括具有抗微生物性质的单体。 该化合物具有交联性能并且具有水解稳定性。 这些化合物可以用于牙科和/或医学应用，包括牙科复合材料，义齿，粘合剂，密封剂，树脂和医疗装置。

公开(公告)号：WO2011059763A2

公开(公告)日：2011-05-19

申请号：PCT/US2010/054546

申请日：2010-10-28

Applicant: JOYANT PHARMACEUTICALS, INC. ,  SUN, Haizhou ,  XU, Xiaoming ,  ZHOU, Ming ,  HARRAN, Susan ,  HANSON, Gunnar, James

Inventor： SUN, Haizhou ,  XU, Xiaoming ,  ZHOU, Ming ,  HARRAN, Susan ,  HANSON, Gunnar, James

CPC classification number: A61K38/08 ,  A61K38/00 ,  A61K38/06 ,  A61K38/191 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07K5/06026 ,  C07K5/0806 ,  C07K7/02 ,  C07K14/4747 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/414

Abstract: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

Abstract translation: 本发明提供Smac肽的小分子模拟物，其是具有通过连接体连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。

公开(公告)号：WO2018013213A1

公开(公告)日：2018-01-18

申请号：PCT/US2017/032739

申请日：2017-05-15

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  DENG, Changchun ,  LIPSTEIN, Mark ,  O'CONNOR, Owen ,  LANDRY, Donald W. ,  XU, Xiaoming ,  DENG, Shi-Xian ,  SERRANO, Xavier O. Jirau

Inventor： DENG, Changchun ,  LIPSTEIN, Mark ,  O'CONNOR, Owen ,  LANDRY, Donald W. ,  XU, Xiaoming ,  DENG, Shi-Xian ,  SERRANO, Xavier O. Jirau

IPC: A61K31/122 ,  A61K31/519 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04 ,  C07D473/34 ,  G01N33/57492 ,  G01N2800/52 ,  A61K2300/00

Abstract: The invention relates to new compounds that reduce c-Myc expression and useful for cancer treatment, particularly hematological cancers such as aggressive B- and T-cell lymphomas. The new compounds may be combined with adjunct c-Myc inhibor agents such as a PI3K inhibitor, CK-1 inhibitor, Akt-inhibitor, proteasome inhibitor and/or mTor inhibitor. The c-Myc reducing agent may be provided as a lead-in treatment to reduce or initiate reduction of c-Myc prior to adminstration of the adjunct cancer therapeutic agent. Treatment with a c-Myc reducing agent modulates the disease state of the c-Myc overexpressing cancer making it less malignant and more susceptible to adjunctive cancer therapies.

Abstract translation: 本发明涉及减少c-Myc表达并用于癌症治疗的新化合物，特别是血液学癌症如侵袭性B细胞和T细胞淋巴瘤。 新化合物可以与辅助c-Myc抑制剂如PI3K抑制剂，CK-1抑制剂，Akt-抑制剂，蛋白酶体抑制剂和/或mTor抑制剂组合。 c-Myc还原剂可作为引入治疗来提供，以在施用辅助癌症治疗剂之前减少或引发c-Myc的减少。 用c-Myc还原剂治疗可调节c-Myc过表达癌症的疾病状态，使其不易恶变，并更易受辅助癌症治疗的影响。

公开(公告)号：WO2012145255A3

公开(公告)日：2012-12-27

申请号：PCT/US2012033715

申请日：2012-04-15

Applicant: JOYANT PHARMACEUTICALS INC ,  WEI QI ,  ZHOU MING ,  XU XIAOMING ,  CALDWELL CHARLES ,  HARRAN SUSAN ,  WANG LAI

Inventor： WEI QI ,  ZHOU MING ,  XU XIAOMING ,  CALDWELL CHARLES ,  HARRAN SUSAN ,  WANG LAI

IPC: C07D498/22 ,  C07D413/14

CPC classification number: C07D498/06 ,  C07D491/04 ,  C07D498/08 ,  C07D498/20 ,  C07D498/22 ,  C07D519/00 ,  C07F9/6561

Abstract: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.

Abstract translation: 提供了用于治疗癌症和其他增殖性疾病的具有抗有丝分裂活性的Diazonamide类似物，以及相关的药物组合物。

公开(公告)号：WO2009089450A1

公开(公告)日：2009-07-16

申请号：PCT/US2009/030597

申请日：2009-01-09

Applicant: PURDUE RESEARCH FOUNDATION ,  GHOSH, Arun, K. ,  XU, Xiaoming

Inventor： GHOSH, Arun, K. ,  XU, Xiaoming

IPC: A61K38/00 ,  C07D321/00 ,  C07D323/00

CPC classification number: C07D493/08

Abstract: Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in need of relief from cancer or a cancer-related disease. The described processes are useful for preparing compounds containing quaternary carbons, including structural analogs and derivatives of peloruside A.

Abstract translation: 本文描述了一种用于形成用于制备大内酯的季碳的方法，（+） - 波兰半胱氨酸A的对映选择性合成以及需要缓解癌症或癌症相关疾病的患者的治疗方法。 所描述的方法可用于制备含有季碳的化合物，包括结构类似物和洋葱A的衍生物。

公开(公告)号：WO2011059763A3

公开(公告)日：2011-10-06

申请号：PCT/US2010054546

申请日：2010-10-28

Applicant: JOYANT PHARMACEUTICALS INC ,  SUN HAIZHOU ,  XU XIAOMING ,  ZHOU MING ,  HARRAN SUSAN ,  HANSON GUNNAR JAMES

Inventor： SUN HAIZHOU ,  XU XIAOMING ,  ZHOU MING ,  HARRAN SUSAN ,  HANSON GUNNAR JAMES

IPC: C07D403/12 ,  A61K31/4025 ,  A61K31/4439 ,  A61P35/00 ,  C07D207/16 ,  C07D401/12 ,  C07D403/14

CPC classification number: A61K38/08 ,  A61K38/00 ,  A61K38/06 ,  A61K38/191 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07K5/06026 ,  C07K5/0806 ,  C07K7/02 ,  C07K14/4747

Abstract: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

Abstract translation: 本发明提供了Smac肽的小分子模拟物，其是具有通过接头连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进细胞凋亡。 本发明包括包含此类化合物的药物组合物以及使用它们治疗包括癌症和自身免疫性疾病的病症的方法。

公开(公告)号：WO2008100907A3

公开(公告)日：2008-10-09

申请号：PCT/US2008053683

申请日：2008-02-12

Applicant: UNIV LOUISIANA STATE ,  XU XIAOMING ,  JAYAMACHANDRAN SHAILAJA ,  CHEN LIANG

Inventor： XU XIAOMING ,  JAYAMACHANDRAN SHAILAJA ,  CHEN LIANG

IPC: C07C69/15 ,  C07C69/155

CPC classification number: C07C69/734 ,  C07C233/49 ,  C07C237/22 ,  C07D207/46 ,  C07D213/69 ,  C07D401/12 ,  C07F7/006

Abstract: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.

Abstract translation: 公开了螯合单体和氟化物释放组合物，其可以掺入到牙科复合修复材料，牙科粘合剂或其他牙科材料中，以产生具有高氟释放速率和高氟化再灌注能力的材料。 这种牙科修复材料可以帮助减少患者的龋齿水平，特别是修复材料边缘发生的龋齿水平。

公开(公告)号：WO2008100907A2

公开(公告)日：2008-08-21

申请号：PCT/US2008/053683

申请日：2008-02-12

Applicant: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND ARGRICULTURAL AND MECHANICAL COLLEGE ,  XU, Xiaoming ,  JAYAMACHANDRAN, Shailaja ,  CHEN, Liang

Inventor： XU, Xiaoming ,  JAYAMACHANDRAN, Shailaja ,  CHEN, Liang

IPC: C07C69/15 ,  C07C69/155

CPC classification number: C07C69/734 ,  C07C233/49 ,  C07C237/22 ,  C07D207/46 ,  C07D213/69 ,  C07D401/12 ,  C07F7/006

Abstract: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.

Abstract translation: 公开了螯合单体和氟化物释放组合物，其可以并入牙齿复合材料修复材料，牙科粘合剂或其他牙科材料中，以产生具有高氟释放速率的材料和高氟化物补给能力。 这种牙齿修复材料可以帮助减少患者的龋齿水平，特别是在修复材料的边缘发生的龋齿水平。

公开(公告)号：WO2005026398A3

公开(公告)日：2005-03-24

申请号：PCT/US2004/028533

申请日：2004-09-02

Applicant: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  XU, Xiaoming

Inventor： XU, Xiaoming

IPC: D01D5/00

Abstract: Apparatus and process for making nanofibers by reactive electrospinning including an in-line mixer (6), an in-line chemical reactor (10), coil heaters (11), an electrospinning capillary (12) and a sheath gas tube (13). The reactants are separately introduced through ports (16, 17) and mixed in the mixer (6). The mixture (7) undergoes chemical reaction in the reactor (10) and commences electrospinning at an outlet (8) of the capillary (12) with the assistance of a sheath gas (19) introduced through a port (18).

公开(公告)号：WO2005026398A2

公开(公告)日：2005-03-24

申请号：PCT/US2004028533

申请日：2004-09-02

Applicant: UNIV LOUISIANA STATE ,  XU XIAOMING

Inventor： XU XIAOMING

IPC: C04B35/622 ,  C04B35/624 ,  C04B35/628 ,  C22B9/02 ,  C22B9/04 ,  C22B34/12 ,  D01D5/00 ,  D01D5/26 ,  D01F6/14 ,  D01F6/36 ,  D01F9/08

CPC classification number: C04B35/6225 ,  C04B35/62236 ,  C04B35/624 ,  C04B35/62625 ,  C04B35/6264 ,  C04B35/62844 ,  C04B2235/3225 ,  C04B2235/3244 ,  C04B2235/3418 ,  C04B2235/441 ,  C04B2235/5264 ,  C04B2235/9615 ,  D01D5/0038 ,  D01D5/38 ,  D01F6/14 ,  D01F6/36 ,  D01F9/08

Abstract: Apparatus and methods for fabricating nanofibers by reactive electrospinning are described. An electrospinning process is coupled with an in-line reactor where chemical or photochemical reactions take place. This invention expands the application of the electrospinning and allows the production of nanofibers of crosslinked polymers and other new materials, such as gel nanofibers of ceramic precursors.

Abstract translation: 描述了通过反应静电纺丝制造纳米纤维的装置和方法。 电纺丝过程与其中发生化学反应或光化学反应的直列反应器相结合。 本发明扩大了电纺丝的应用，并且允许生产交联聚合物和其它新材料的纳米纤维，例如陶瓷前体的凝胶纳米纤维。