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    STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS
    2.
    发明申请
    STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS 审中-公开
    某些三氟甲磺酸取代醇的立体选择性合成

    公开(公告)号：WO2010141331A3

    公开(公告)日：2011-01-20

    申请号：PCT/US2010036499

    申请日：2010-05-28

    Applicant: BOEHRINGER INGELHEIM INT ,  FANDRICK DANIEL ROBERT ,  REEVES JONATHAN TIMOTHY ,  SONG JINHUA J ,  TAN ZHULIN ,  QU BO ,  YEE NATHAN ,  RODRIGUEZ SONIA

    Inventor： FANDRICK DANIEL ROBERT ,  REEVES JONATHAN TIMOTHY ,  SONG JINHUA J ,  TAN ZHULIN ,  QU BO ,  YEE NATHAN ,  RODRIGUEZ SONIA

    IPC: C07D401/04

    CPC classification number: C07D401/04 ,  C07B2200/07

    Abstract: A process for stereoselective synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromelhyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; R2 and R3 are each independendy C1-C5 alkyl; R is C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C1- C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or C1-C5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone.

    Abstract translation: 一种用于立体选择性合成式（X）化合物的方法，其中：R 1是被1至3个取代基取代的芳基，其中R 1的每个取代基独立地是C 1 -C 5烷基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，卤素，羧基 ，氰基或三氟甲基，其中R 1的每个取代基任选地独立地被一至三个选自C 1 -C 3烷基，C 1 -C 3烷氧基，苯基和烷氧基苯基的取代基取代; R2和R3各自独立地为C1-C5烷基; R是C1-C5烷基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，烷基磺酰基氨基，氨基磺酰基，C1-5烷基氨基磺酰基，C1-C5二烷基氨基磺酰基，卤素，羟基，羧基，氰基，三氟甲基，三氟甲氧基，三氟甲硫基或C 1 -C 5烷硫基， 任选地被氧化成亚砜或砜。

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