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    CELL ASSAY KIT AND METHOD
    1.
    发明申请
    CELL ASSAY KIT AND METHOD 审中-公开

    公开(公告)号：WO2009076235A4

    公开(公告)日：2009-06-18

    申请号：PCT/US2008/085737

    申请日：2008-12-05

    申请人： ZYOMYX, INC. ,  ZAUGG, Frank ,  TOBIAS, Renee ,  KERNEN, Peter ,  RUIZ-TAYLOR, Laurence ,  WAGNER, Peter

    发明人： ZAUGG, Frank ,  TOBIAS, Renee ,  KERNEN, Peter ,  RUIZ-TAYLOR, Laurence ,  WAGNER, Peter

    IPC分类号： G01N33/543 ,  G01N33/49 ,  G01N33/569

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    DEVICES AND METHODS FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT
    2.
    发明申请
    DEVICES AND METHODS FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开

    公开(公告)号：WO2008156491A3

    公开(公告)日：2008-12-24

    申请号：PCT/US2007/080108

    申请日：2007-10-01

    申请人： ZYOMYX, INC. ,  WAGNER, Peter ,  ZAUGG, Frank ,  MITCHNIK, Mark

    发明人： WAGNER, Peter ,  ZAUGG, Frank ,  MITCHNIK, Mark

    IPC分类号： C12M1/34

    摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a solid substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound in a non-linear manner to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.

    METHOD AND APPARATUS FOR PROCESSING TISSUE SAMPLES
    3.
    发明申请
    METHOD AND APPARATUS FOR PROCESSING TISSUE SAMPLES 审中-公开

    公开(公告)号：WO2018102471A1

    公开(公告)日：2018-06-07

    申请号：PCT/US2017/063811

    申请日：2017-11-29

    申请人： S2 GENOMICS, INC. ,  JOVANOVICH, Stevan ,  CHEAR, Kaiwan ,  PEREIRA, Nathan ,  ZAUGG, Frank ,  MCINTOSH, Roger

    发明人： JOVANOVICH, Stevan ,  CHEAR, Kaiwan ,  PEREIRA, Nathan ,  ZAUGG, Frank ,  MCINTOSH, Roger

    IPC分类号： C12M3/00 ,  C12M3/06 ,  C12M3/08 ,  C12N1/08 ,  C12N15/09 ,  C12N15/10

    摘要： A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells or nuclei in suspension or subcellular components including nucleic acids. In some embodiments, the titer of dissociated cells is monitored at intervals and the viability determined. In some embodiments, the processing is adjusted according to the measurements of the titer and viability. In some embodiments, the single-cells or nuclei in suspension are washed and resuspended in the buffer or media of choice. In some embodiments, the conditions are chosen to produce nuclei. In other embodiments, the single-cells or nuclei are purified by affinity paramagnetic bead processing. In some embodiments, matched bulk nucleic acid to the single-cells is produced. In other embodiments, single-cell libraries, or nuclei libraries, or matched bulk libraries, or bulk libraries are produced. The single cells or nuclei can then be further processed by FACS, DNA sequencing, mass spectrometry, fluorescence, or other methods. In other embodiments, the tissue processing is integrated with an analytical system to produce a sample-to-answer system such as a tissue-to-genomics system.

    MICROSCALE PLASMA SEPARATOR
    4.
    发明申请
    MICROSCALE PLASMA SEPARATOR 审中-公开

    公开(公告)号：WO2016073415A3

    公开(公告)日：2016-05-12

    申请号：PCT/US2015/058731

    申请日：2015-11-03

    申请人： WAINAMICS, INC. ,  TAN, Ming ,  ZAUGG, Frank ,  KEMEN, Peter

    发明人： TAN, Ming ,  ZAUGG, Frank ,  KEMEN, Peter

    IPC分类号： A61M1/36 ,  B01D35/26 ,  B01D61/38 ,  B01D63/06 ,  C02F1/44

    摘要： Methods and devices for efficient separation of plasma from whole blood which are suitable for point of care use in resource poor environments. Elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port: (b) a filter chamber having an inlet and an outlet, and containing at least one filler capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in fluid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber.

    CELL ASSAY KIT AND METHOD
    5.
    发明申请
    CELL ASSAY KIT AND METHOD 审中-公开

    公开(公告)号：WO2009076235A3

    公开(公告)日：2009-10-15

    申请号：PCT/US2008085737

    申请日：2008-12-05

    申请人： ZYOMYX INC ,  ZAUGG FRANK ,  TOBIAS RENEE ,  KERNEN PETER ,  RUIZ-TAYLOR LAURENCE ,  WAGNER PETER

    发明人： ZAUGG FRANK ,  TOBIAS RENEE ,  KERNEN PETER ,  RUIZ-TAYLOR LAURENCE ,  WAGNER PETER

    IPC分类号： G01N33/49 ,  G01N33/543 ,  G01N33/569

    CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

    摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

    DEVICE AND METHOD FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT
    7.
    发明申请
    DEVICE AND METHOD FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开
    用于分析分析样品的装置和方法，分析分析内容

    公开(公告)号：WO2009123592A1

    公开(公告)日：2009-10-08

    申请号：PCT/US2008/004372

    申请日：2008-04-03

    申请人： ZYOMYX, INC. ,  WAGNER, Peter ,  ZAUGG, Frank ,  MITCHNIK, Mark

    发明人： WAGNER, Peter ,  ZAUGG, Frank ,  MITCHNIK, Mark

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/558 ,  G01N33/54366

    摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.

    摘要翻译： 一种用于确定样品中一种或多种分析物在含有流体的存在和/或浓度的系统和方法，所述系统包括含有样品入口或入口以及一个或多个分析物确定流路的基底，每个分析物确定流路 包括限定的起始点和限定的末端，并且包含至少一个含有分析物的捕获剂的捕获区，所述捕获剂或试剂沿所述流动路径或路径的一部分被固定，所述流路或路径被设计成使得 一个或多个分析物从样品中消耗并且结合到含有固定化捕获剂或试剂的流动路径或路径的部分，为分析物确定流路的开始和终点之间的每个分析物产生分析物耗尽端区。

    MICROSCALE PLASMA SEPARATOR
    8.
    发明申请
    MICROSCALE PLASMA SEPARATOR 审中-公开
    微型等离子体分离器

    公开(公告)号：WO2016073415A2

    公开(公告)日：2016-05-12

    申请号：PCT/US2015058731

    申请日：2015-11-03

    申请人： WAINAMICS INC ,  TAN MING ,  ZAUGG FRANK ,  KEMEN PETER

    发明人： TAN MING ,  ZAUGG FRANK ,  KEMEN PETER

    IPC分类号： A61M1/34

    CPC分类号： A61B5/150022 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150343 ,  A61J1/05 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3496 ,  A61M2205/3331 ,  B01L3/0217 ,  B01L3/502 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0832 ,  G01N33/491

    摘要： The invention is directed to methods and devices for efficient separation of plasma irons whole blood which are suitable for point of care use in resource poor environments, in some embodiments, elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in Quid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber for (i) drawing a predetermined volume of sample into ore SCR by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the SCR through the filter chamber and the outlet of the filter chamber by a second user action.

    摘要翻译： 本发明涉及用于有效分离血浆铁全血的方法和装置，其适用于资源不利环境中的护理点使用，在一些实施方案中，这些装置的元件包括（a）样品收集容器（SCR），其具有 至少一个端口，所述样本收集容器能够保持预定体积的通过端口抽取的未稀释全血的样本; （b）具有入口和出口的过滤室，并且当过滤室被放置在样品中时，随着样品从至少一个过滤器的入口侧流出到出口侧，并且包含至少一个能够从血细胞分离血浆的过滤器 与样品收集容器的端口进行通信; （c）与SCR和过滤室可操作地相关联的手动驱动泵，用于（i）通过第一用户动作将预定体积的样品拉入矿石SCR，以及（ii）以基本恒定的线性流在 通过过滤室和过滤室的出口通过第二用户动作从SCR通过压力不超过2psi。

    ION DETECTION USING A PILLAR CHIP
    9.
    发明申请
    ION DETECTION USING A PILLAR CHIP 审中-公开

    公开(公告)号：WO2005024378A3

    公开(公告)日：2005-03-17

    申请号：PCT/US2004/028622

    申请日：2004-09-01

    申请人： ZYOMIX, INC. ,  WAGNER, Peter ,  SCALF, Mark ,  ZAUGG, Frank

    发明人： WAGNER, Peter ,  SCALF, Mark ,  ZAUGG, Frank

    IPC分类号： G01N33/543

    摘要： The present invention provides methods and assemblies for ion detection of samples using a chip with elevated sample zones. The elevated sample zones provide a number of ion detection advantages over chips with non-elevated sample zones. Embodiments of the invention have a number of applications in drug discovery, environmental analyses for tracking and the identification of contaminants, target discovery and/or validation as well as in diagnostics in a clinical setting for staging or disease progression. In addition, the invention may also be used with research and clinical microarray systems and devices.

    ION DETECTION USING A PILLAR CHIP
    10.
    发明申请
    ION DETECTION USING A PILLAR CHIP 审中-公开
    离子检测使用支柱芯片

    公开(公告)号：WO2005024378A2

    公开(公告)日：2005-03-17

    申请号：PCT/US2004028622

    申请日：2004-09-01

    申请人： ZYOMIX INC ,  WAGNER PETER ,  SCALF MARK ,  ZAUGG FRANK

    发明人： WAGNER PETER ,  SCALF MARK ,  ZAUGG FRANK

    IPC分类号： G01N20060101 ,  G01N23/00 ,  G01N33/543 ,  G01N

    CPC分类号： H01J49/0418 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/069 ,  B01L2300/0819 ,  Y10T436/11 ,  Y10T436/114165 ,  Y10T436/143333

    摘要： The present invention provides methods and assemblies for ion detection of samples using a chip with elevated sample zones. The elevated sample zones provide a number of ion detection advantages over chips with non-elevated sample zones. Embodiments of the invention have a number of applications in drug discovery, environmental analyses for tracking and the identification of contaminants, target discovery and/or validation as well as in diagnostics in a clinical setting for staging or disease progression. In addition, the invention may also be used with research and clinical microarray systems and devices.

    摘要翻译： 本发明提供了使用具有升高的样品区的芯片离子检测样品的方法和组件。 升高的样品区与没有升高样品区的芯片相比提供了许多离子检测优势。 本发明的实施例在药物发现，用于跟踪和污染物识别的环境分析，目标发现和/或验证以及临床环境中的诊断以用于分期或疾病进展方面具有许多应用。 另外，本发明还可以与研究和临床微阵列系统和装置一起使用。