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8 条记录 (耗时 0.013 秒)

    METHODS AND SYSTEMS FOR AUTOMATED PIPETTE TRACKING
    1.
    发明申请
    METHODS AND SYSTEMS FOR AUTOMATED PIPETTE TRACKING 审中-公开

    公开(公告)号：WO2012158308A3

    公开(公告)日：2012-11-22

    申请号：PCT/US2012/034656

    申请日：2012-04-23

    申请人： ACTRACE, LLC ,  ZENG, Lei

    发明人： ZENG, Lei

    IPC分类号： B01L3/02 ,  B01L99/00

    摘要： Described are pipetting systems that automatically track the dispensing and extracting of reagents to and from arrays of well locations. The systems track the position of a pipette with respect to the well locations, and selectively illuminate those locations to indicate the progress of pipetting operations. Control logic can shepherd pipetting processes, indicating errors and guiding the user.

    METHODS OF IDENTIFYING MODULATORS OF BROMODOMAINS
    6.
    发明申请
    METHODS OF IDENTIFYING MODULATORS OF BROMODOMAINS 审中-公开
    鉴定BROMODOMAIN的调节剂的方法

    公开(公告)号：WO2006083692A2

    公开(公告)日：2006-08-10

    申请号：PCT/US2006/002840

    申请日：2006-01-27

    申请人： MOUNT SINAI SCHOOOL OF MEDICINE ,  ZHOU, Ming-ming ,  ZENG, Lei ,  WANG, Zhiyong

    发明人： ZHOU, Ming-ming ,  ZENG, Lei ,  WANG, Zhiyong

    IPC分类号： A61K31/277

    CPC分类号： C07C215/16 ,  C07C211/29 ,  C07C211/53 ,  C07C217/20 ,  C07C229/18 ,  C07C229/42 ,  C07C255/58 ,  C07D311/08 ,  C07D311/16 ,  C07D311/18

    摘要： The present invention features compounds of the following general formula (I) wherein R 1 is selected from the group consisting of hydrogen, lower alkyl, aryl, aralkyl; substituted aralkyl, heteroaryl; substituted heteroaryl, phenyl, SO 2 , NH 2 , NO 2 , SO 2 , CH 2 , CH 2 CH 3 , OCH 3 , OCOCH 3 , CH 2 COCH 3 , and OH, CN and halogen; R 2 is selected from the group consisting of hydrogen; lower alkyl, aryl, phenyl, aralkyl; substituted aralkyl, heteroaryl; substituted heteroaryl, SO 2 NH 2 NH 3 + NO 2 , SO 2 , CH 3 , CH 2 CH 3 , OCH 3 , OCOCH 3 , CH 2 COCH 3, and OH, halogen, carboxy, and alkoxy; X is selected from the group consisting of lower alkyl, SO 2 , NH, NO 2 , , CH 3 , CH 2 CH 3 , OCH 3 , OCOCH 3 , CH 2 COCH 3 , and OH, carboxy, and alkoxy; and n is an integer from O to 10 and their pharmaceutically acceptable salts of acids or bases as well as pharmaceutical compositions comprising these compounds. The invention further provides methods for preventing or inhibiting the binding of bromodomains to acetyl-lysine residues of proteins and methods for treating HIV infection and HW related disease. The present invention also features compounds of the following general formula (II) wherein: R 1 R 2 and R 3 are independently selected from the group consisting of hydrogen; lower alkyl, aryl, phenyl, aralkyl; substituted aralkyl, heteroaryl; substituted heteroaryl, SO 2 , NH 2 , NH 3 + NO 2, SO 2 , CH 3 , CH 2 CH 3 , OCH 3 , OCOCH 3 , CH 2 COCH 3 , OH, SH, halogen, carboxy; and R 4 is selected from the group consisting of lower alkyl, aryl, SO 2 , NH, NO 2 , CH 3 , CH 2 CH 3 , OCH 3 , OCOCH 3 , CH 2 COCH 3 , OH, carboxy, and alkoxy as well as pharmaceutical compositions comprising these compounds. The invention further provides methods for preventing or inhibiting the binding of bromodomains to acetyl-lysine residues of proteins and methods f treating HW infection and HIY related disease. The present invention also features compounds of formula (III) wherein R 1 , R 2 , R 3 , R 4 R 5 , and R 6 are independently selected from the group consisting of hydrogen; lower alkyl, aryl, phenyl, aralkyl; substituted aralkyl, heteroaryl, substituted heteroaryl, SO 2 NH 2 , NH 3 + , NO 2 , SO 2 , CH 3 , CH 2 CH 3 , OCH 3 , OCOCH 3 , CH 2 COCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OCH 2 COOH, OCHCH 3 COOH, OCH 2 COCH 3 , OCH 2 CONH 2 , OCOCH(CH 3 ) 2 , OCH 2 CH 2 OH, OCH 2 CH 2 CH 3 , O(CH 2 ) 3 CH 3 , OCHCH 3 COOCH 3 , OCH 2 CON(CH 3 ) 2 ,NH(CH 2 ) 3 N(CH 3 ) 2 , NH(CH 2 ) 2 N(CH 3 ) 2 , NH(CH 2 ) 2 OH, NH(CH 2 ) 3 CH 3 , NHCH 3 , SH, halogen, carboxy, and alkoxy as well as pharmaceutical compositions comprising these compounds. The invention further provides methods for preventing or inhibiting the binding of bromodomains to acetyl-lysine residues of proteins and methods for treating HIV infection and HIV related disease.

    摘要翻译： 本发明的特征在于以下通式（I）的化合物，其中R 1选自氢，低级烷基，芳基，芳烷基; 取代的芳烷基，杂芳基; 取代的杂芳基，苯基，SO 2，NH 2，NO 2，SO 2，CH 2 CH 2，CH 3，OCH 3，OCOCH 3，CH 2， CO，SO 3，OH，CN和卤素; R 2选自氢; 低级烷基，芳基，苯基，芳烷基; 取代的芳烷基，杂芳基; 取代的杂芳基，SO 2 NH 2 NH 3，

    HYBRID AIR/MAGNETIC CORE INDUCTOR
    8.
    发明申请
    HYBRID AIR/MAGNETIC CORE INDUCTOR 审中-公开
    混合空气/磁芯电感

    公开(公告)号：WO2005004178A1

    公开(公告)日：2005-01-13

    申请号：PCT/US2004/019896

    申请日：2004-06-22

    申请人： POWERWARE CORPORATION ,  OUGHTON, George, W., Jr. ,  ZENG, Lei, Winston ,  LYNAM, Larry, Van

    发明人： OUGHTON, George, W., Jr. ,  ZENG, Lei, Winston ,  LYNAM, Larry, Van

    IPC分类号： H01F27/08

    CPC分类号： H01F27/085 ,  H01F17/045 ,  H01F27/322 ,  H01F27/324 ,  H01F37/00

    摘要： An inductor includes an elongate magnetic core, a coil wrapped around the core and a spacer that separates the coil from the core to provide a coolant passage between the coil and the core. The coolant passage may include an air passage that extends substantially parallel to an axis of the core and that has first and second openings proximate respective first and second ends of the core. The coil may include a twisted bundle of individually insulated conductors. The inductor may be housed in a flux-tolerant compartment, i.e., a conductive aluminum structure that supports eddy currents with relatively acceptable resistive losses.

    摘要翻译： 电感器包括细长的磁芯，缠绕在芯上的线圈和将线圈与芯分离以在线圈和芯之间提供冷却剂通道的间隔件。 冷却剂通道可以包括空气通道，空气通道基本上平行于芯的轴线延伸，并且具有靠近芯的相应的第一和第二端的第一和第二开口。 线圈可以包括单独绝缘导体的扭绞束。 电感器可以容纳在容许容纳室中，即支持具有相对可接受的电阻损耗的涡流的导电铝结构。