Abstract:
A composition including a glucose anti-metabolite and selenium. The composition can be for a companion animal. The composition can include added selenium and endogenous selenium. The composition can be a nutritionally balanced pet food composition.
Abstract:
A system for software licence control is described that is particular useful for use in a virtualized system, such as a cloud computing system. A module can be made available for use within the virtualized network, wherein a licence fee is payable for use of the module. The module includes a licence file that can be located wherever it is required. In addition, a central licence file is provided at an administration node. The central licence file is configured such that it can only be operated from that administration node, thereby preventing the copying of that file. The licence file operating in the virtual network communicates with the central licence file. The central licence file controls the use of the licensed module.
Abstract:
A modular medical device includes a core module housing. The core module housing includes a treatment module interface configured to couple to any one of a plurality of treatment modules, and each of the plurality of treatment modules includes a treatment assembly configured to apply a medical treatment. The core housing module contains one or more processing devices coupled to the treatment module interface and configured to determine which particular treatment module, from the plurality of treatment modules, is coupled to the treatment module interface. The one or more processing devices are configured to select, based on the determination, a set of control instructions for the particular treatment module from a plurality of control instructions, and control the particular treatment module using the selected control instructions such that the treatment assembly of the particular treatment module applies the medical treatment for which the treatment assembly is configured.
Abstract:
A medical device includes a treatment module configured to apply a treatment to a patient. The medical device includes an interface configured to operatively connect to a removable storage device storing authorization data that identifies a level of treatment authorization. The medical device includes a processing device configured to perform operations in response to receiving user input indicating a treatment should be initiated. The operations include determining whether the removable storage device is valid for use with the medical device. If the removable storage device is determined to be valid, the authorization data is accessed. The processing device determines whether the treatment is authorized based on the accessed authorization data. If the treatment is determined to be authorized, the treatment module is controlled to apply the treatment. If the treatment is determined to not be authorized, the treatment module is controlled such that the treatment is not applied.
Abstract:
Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially therapeutic compounds.
Abstract:
A chimeric phosphorylation indicator (CPI) as provided herein can contain a donor molecule, a phosphorylatabe domain, a phosphoaminoacid binding domain (PAABD), and an acceptor molecule. Where the phosphorylatable domain is phosphorylatable by protein kinase C (PKC), the CPI is a c-kinase activity reporter (CKAR). Donor and acceptor molecules may be, independently, fluorescent proteins such as non-oligomerizing fluorescent proteins. A CPI can contain a phosphorylatable polypeptide and a fluorescent protein; the phosphorylatable polypeptide may be contained within the sequence of the fluorescent protein, or the fluorescent protein may be contained within the sequence of the phosphorylatable polypeptide. The spatiotemporal properties of the PKC signal pathway may be tested with CKAR, calcium-sensing fluorophores and FRET-based translocation assays. Polynucleotides encoding such CPIs, and kits containing the indicators and/or the polynucleotides, are provided. A method of using the chimeric phosphorylation indicators to detect a kinase or phosphatase in a sample is provided.
Abstract:
A method for receiving a message for which a result record is generated. One or more linked result records are generated, where a linked result record comprises a link to or from the result record of the received message. Information is updated from delivery reports relating to the delivery of linked messages generated on the basis of the received message and transmitted to one or more destination nodes to the result record of the received message and to its linked result records. The method provides a simple and conservative implementation for one-to-many and many-to-one relationship between individually addressed mobile originated and mobile terminated messages and their associated reports.
Abstract:
A method and a loan access evaluation system use a loan applicant's actual business transaction information received from an online business system on which the loan applicant conducts business. In addition to the information of the loan applicant's owner, other general background business information and historical business information of the loan applicant, the method and the system obtain detailed transaction data of the loan applicant on e-commerce systems or platforms and banks, and thus have access to dynamic business data of the applicant for a more reliable loan access appraisal.