公开(公告)号：WO2007080123A1

公开(公告)日：2007-07-19

申请号：PCT/EP2007/000272

申请日：2007-01-12

Applicant: NOVARTIS VACCINES & DIAGNOSTICS, INC. ,  KOST, Holger

Inventor： KOST, Holger

IPC: G01N33/569 ,  C12N7/02

CPC classification number: C12Q3/00 ,  C12N7/00 ,  C12N2760/16011 ,  C12N2760/16111 ,  C12N2760/16211 ,  C12Q1/04 ,  G01N33/56983 ,  G01N2333/07 ,  G01N2333/11

Abstract: The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination of the concentration of virus particles and/or virus antigens in a sample.

Abstract translation: 本发明提供了一种确定样品中病毒颗粒和/或病毒抗原浓度的方法。 特别地，本发明涉及确定样品中流感病毒颗粒/流感病毒抗原的浓度。 本发明还涉及离子交换基质用于测定样品中病毒颗粒和/或病毒抗原浓度的用途。

公开(公告)号：WO2007117607A3

公开(公告)日：2007-10-18

申请号：PCT/US2007/008592

申请日：2007-04-05

Applicant: NOVARTIS VACCINES & DIAGNOSTICS, INC. ,  RAMURTHY, Savithri ,  LIN, Xiadong ,  SUBRAMANIAN, Sharada ,  RICO, Alice, C. ,  WANG, Xiajong, M. ,  JAIN, Rama ,  MURRAY, Jeremy, M. ,  BASMAN, Steven, E. ,  WARNE, Robert, L. ,  SHU, Wei ,  ZHOU, Yasheen ,  DOVE, Jeffrey ,  AIKAWA, Mina ,  AMIRI, Payman ,  WANG, Weibo ,  JANSEN, Johanna, M. ,  WAGMAN, Allan, S. ,  PFISTER, Keith, B. ,  NG, Simon, C.

Inventor： RAMURTHY, Savithri ,  LIN, Xiadong ,  SUBRAMANIAN, Sharada ,  RICO, Alice, C. ,  WANG, Xiajong, M. ,  JAIN, Rama ,  MURRAY, Jeremy, M. ,  BASMAN, Steven, E. ,  WARNE, Robert, L. ,  SHU, Wei ,  ZHOU, Yasheen ,  DOVE, Jeffrey ,  AIKAWA, Mina ,  AMIRI, Payman ,  WANG, Weibo ,  JANSEN, Johanna, M. ,  WAGMAN, Allan, S. ,  PFISTER, Keith, B. ,  NG, Simon, C.

IPC: C07D239/94 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12

Abstract: The invention provides quinazoline compounds that are inhibitors of PDKl. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.

公开(公告)号：WO2010027872A1

公开(公告)日：2010-03-11

申请号：PCT/US2009/055086

申请日：2009-08-26

Applicant: CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND ,  GRANOFF, Dan M. ,  WELSCH, Jo Anne ,  RAM, Sanjay ,  THE UNIVERSITY OF MASSACHUSSETTS ,  NOVARTIS VACCINES & DIAGNOSTICS, INC.

Inventor： GRANOFF, Dan M. ,  WELSCH, Jo Anne ,  RAM, Sanjay

IPC: C12Q1/02 ,  A01K67/027

CPC classification number: G01N33/6857 ,  G01N2333/22 ,  G01N2333/4716 ,  G01N2469/20

Abstract: Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fhBp) are provided, as well as non-human animal models of Neisserial infection.

Abstract translation: 提供了使用具有介导结合奈赛斯因子H结合蛋白（fhBp）的人氨基酸序列的因子H多肽以及非人动物Neisserial感染模型来检测杀菌抗 - 奈司血清抗体的测定。

公开(公告)号：WO2007120787A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/009063

申请日：2007-04-12

Applicant: NOVARTIS VACCINES & DIAGNOSTICS, INC. ,  JANTAPOUR, Mary J. ,  YU, Guoying ,  TO, Robert ,  CHAN, Vivien ,  ZIMMERMAN, Deborah

Inventor： JANTAPOUR, Mary J. ,  YU, Guoying ,  TO, Robert ,  CHAN, Vivien ,  ZIMMERMAN, Deborah

IPC: A61K45/06

CPC classification number: C07K14/4748 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/34 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14

Abstract: The invention provides, inter alia, methods for treating cancer, compositions for treating cancer, and methods and compositions for diagnosing and/or detecting cancer. In particular, the present invention provides compositions and methods for treating, diagnosing and detecting cancers associated with LIV-1 overexpression.

Abstract translation: 本发明尤其提供了治疗癌症的方法，用于治疗癌症的组合物，以及用于诊断和/或检测癌症的方法和组合物。 特别地，本发明提供了用于治疗，诊断和检测与LIV-1过表达相关的癌症的组合物和方法。

公开(公告)号：WO2007056317A2

公开(公告)日：2007-05-18

申请号：PCT/US2006/043241

申请日：2006-11-06

Applicant: NOVARTIS VACCINES & DIAGNOSTICS, INC. ,  CHOU, Joyce ,  GRUENKE, Larry

Inventor： CHOU, Joyce ,  GRUENKE, Larry

IPC: G01N33/50

CPC classification number: C07D401/04

Abstract: The present invention provides methods of analyzing the identity and purity of 4-ammo-5-fluoro-3-[5-(4-methylpiperazin-1-y1)-lH-benzimidazol-2-yl]quinolin-2(lH)-one as a bulk drug substance and as the active pharmaceutical ingredient in various pharmaceutical formulations. The methods include both HPLC and thermogravimetric methods.

Abstract translation: 本发明提供了分析4-氨基-5-氟-3- [5-（4-甲基哌嗪-1-基）-1H-苯并咪唑-2-基]喹啉-2（1H） - 一种作为大量药物物质和作为各种药物制剂中的活性药物成分。 方法包括HPLC和热重分析方法。