Abstract:
An industrially advantageous process for producing an amino acid derivative. The process, which is for producing an amino acid derivative represented by the following general formula (III): (III) (wherein R
Abstract:
A process for preparing industrially and efficiently glutamic acid compounds such as monatin useful as sweeteners or intermediates for the production of drugs or the like a process for preparation of intermediates used therein novel intermediates included among them a process for preparation of optically active monatin a process for preparation of intermediates used therein and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds or salts thereof including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross-aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.
Abstract:
It is intended to newly provide crystals of non−natural stereoisomer salts of monatin which are usable as sweeteners. Because of being stable and having a high degree of sweetness, these crystals are expected as useful as sweeteners or components thereof as well as agents for imparting sweetness to foods and drinks. It is also possible to provide, for example, sweeteners and sweetened foods and drinks with the use of the above salt crystals as novel sweetening substances. These stereoisomer salts include (2S,4R), (2R,4R) and (2R,4S) isomer salts of monatin. Among all, the (2R,4R) isomer salts of monatin are particularly favorable.
Abstract translation:旨在提供丙型肝炎病毒基因,源自该基因的复制子RNA,其中转移有该复制子RNA的复制子复制细胞和使用该复制子复制细胞筛选药物的方法。 复制子复制细胞可以通过将包含以下的复制子RNA转移到细胞中构建:(A)包含SEQ ID NO:5所示的碱基序列的多核苷酸; (B)包含由SEQ ID NO:7表示的碱基序列的多核苷酸; (C)编码包含SEQ ID NO:6所示氨基酸序列的多肽的多核苷酸; (D)编码包含SEQ ID NO:8所示的氨基酸序列的多肽的多核苷酸; 或(E)包含与SEQ ID NO:5或7表示的碱基序列具有90%或更高同源性的碱基序列的多核苷酸或含有编码1804位亮氨酸的核苷酸的基因型1b的复制子RNA, 1996年位于丙型肝炎病毒多蛋白氨基酸序列的赖氨酸和编码NS4B蛋白的多核苷酸。 使用这种复制子复制细胞可以筛选药物。