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公开(公告)号：WO2015138478A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019743
申请日：2015-03-10
Applicant: 3-D MATRIX, LTD. , MEHTA, Manav , TSUKADA, Hisashi
Inventor： MEHTA, Manav , TSUKADA, Hisashi , GIL, Eun, Seok , GILBERT, Karl, Patrick , KOBAYASHI, Satoru
CPC classification number: A61K38/16 , A61B17/34 , A61K38/08 , A61K38/10 , A61M16/0463
Abstract: Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
Abstract translation: 提供了治疗肺泡的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 可以在目标部位提供水凝胶屏障以便治疗肺大疱。
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公开(公告)号：WO2015138475A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019740
申请日：2015-03-10
Applicant: 3-D MATRIX, LTD. , MEHTA, Manav , TSUKADA, Hisashi
Inventor： MEHTA, Manav , TSUKADA, Hisashi , GIL, Eun, Seok , GILBERT, Karl, Patrick , KOBAYASHI, Satoru
CPC classification number: A61L31/047 , A61B17/12104 , A61B17/12181 , A61B17/12186 , A61K38/07 , A61K49/006 , A61L31/028 , A61L31/14 , A61L31/145 , A61L31/16 , A61L2300/442 , A61L2400/06 , A61L2400/12 , A61L2430/36
Abstract: Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.
Abstract translation: 提供了形成支气管阻塞的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 可以在目标部位提供水凝胶屏障，以便提供支气管阻塞。
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Patent Agency Ranking
公开(公告)号：WO2015138473A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019738
申请日：2015-03-10
Applicant: 3-D MATRIX, LTD. , MEHTA, Manav , TSUKADA, Hisashi
Inventor： MEHTA, Manav , TSUKADA, Hisashi , GIL, Eun, Seok , GILBERT, Karl, Patrick , KOBAYASHI, Satoru
CPC classification number: A61K38/07 , A61K2121/00 , A61L26/0047 , A61L26/008 , A61L2400/06
Abstract: Materials and methods for treatment of pulmonary leakage are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary leakage.
Abstract translation: 提供了治疗肺部渗漏的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 为了治疗肺部渗漏，可以在目标部位设置水凝胶屏障。
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4.发明申请
公开(公告)号：WO2016138274A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019578
申请日：2016-02-25
Applicant: 3-D MATRIX, LTD. , GILBERT, Karl, Patrick
Inventor： GILBERT, Karl, Patrick , GIL, Eun, Seok
IPC: C12N5/00
CPC classification number: C12N5/0068 , C12N5/0062 , C12N2533/50 , C12N2539/00
Abstract: Synthetic peptide hydrogel solutions having a pH level of about 3.5 or less and a tonicity within an isotonic osmolality range for use in cell culture experimentation. Related kits and cell culture methods are also disclosed.
Abstract translation: 具有约3.5或更低的pH值的合成肽水凝胶溶液和用于细胞培养实验的等张渗透压浓度范围内的张力。 还公开了相关试剂盒和细胞培养方法。
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5.发明申请SELF-ASSEMBLING PEPTIDES COMPRISING NON-IONIC POLAR AMINO ACIDS FOR ANTI-ADHESION 审中-公开包含非离子型极性氨基酸的自组装肽用于抗粘连
公开(公告)号：WO2017106460A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066859
申请日：2016-12-15
Applicant: 3-D MATRIX, LTD. , GIL, Eun, Seok , GILBERT, Karl, Patrick
Inventor： GIL, Eun, Seok , GILBERT, Karl, Patrick , RIOULT, Marc , NAGANO, Keiji , KIYOFUJI, Toshiro , HASEGAWA, Yuya
CPC classification number: A61K38/03 , A61K38/04 , A61K38/08 , A61L27/227 , A61L27/52 , A61L2400/06 , C07K7/08
Abstract: Self-assembling peptides comprising non-ionic polar amino acids for anti-adhesion are provided herein. Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided to prevent adhesion or to provide anti-adhesion properties. Particular peptides include those consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods and kits are also provided.
Abstract translation: 本文提供了包含用于抗粘连的非离子极性氨基酸的自组装肽。 提供基本上由非离子，极性氨基酸组成的自组装肽的组合物，肽溶液和宏观支架以防止粘附或提供抗粘附性能。 具体的肽包括基本上由丝氨酸，苏氨酸，酪氨酸，半胱氨酸，谷氨酰胺，天冬酰胺，甲硫氨酸，色氨酸，羟基脯氨酸及其组合组成的那些肽。 还提供了方法和工具包。
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公开(公告)号：WO2016094829A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065302
申请日：2015-12-11
Applicant: 3-D MATRIX, LTD. , GILBERT, Karl, Patrick
Inventor： GILBERT, Karl, Patrick , GIL, Eun, Seok , RIOULT, Marc , NAGANO, Keiji , KIYOFUJI, Toshiro , HASEGAWA, Yuya
CPC classification number: A61L27/52 , A61L27/227 , A61L27/54 , A61L2300/25 , C07K7/08 , C07K14/001
Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
Abstract translation: 提供了基本上由非离子型极性氨基酸组成的自组装肽的组合物，肽溶液和宏观支架。 具体的肽包括丝氨酸，苏氨酸，酪氨酸，半胱氨酸，谷氨酰胺，天冬酰胺，甲硫氨酸，色氨酸，羟基 - 脯氨酸，或其组合的丝氨酸，苏氨酸，酪氨酸， 还提供了对自组装肽进行灭菌的方法，以及包含肽的支架。
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公开(公告)号：WO2015136370A3
公开(公告)日：2015-09-17
申请号：PCT/IB2015/000868
申请日：2015-03-10
Applicant: 3-D MATRIX, LTD.
Inventor： GIL, Eun, Seok , GILBERT, Karl, Patrick
IPC: A61L2/07
Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
Abstract translation: 用于对在高浓度下具有剪切变稀流变性质的粘性肽组合物进行灭菌的方法和设备
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