SEMI-SUBMERSIBLE MICROSCOPE OBJECTIVE WITH PROTECTIVE ELEMENT AND USE OF THE SAME IN MULTIPHOTON IMAGING METHOD
    1.
    发明申请
    SEMI-SUBMERSIBLE MICROSCOPE OBJECTIVE WITH PROTECTIVE ELEMENT AND USE OF THE SAME IN MULTIPHOTON IMAGING METHOD 审中-公开
    具有保护元件的半不可见微观显微镜及其在多光子成像方法中的应用

    公开(公告)号:WO2015084737A3

    公开(公告)日:2015-08-06

    申请号:PCT/US2014067958

    申请日:2014-12-01

    Abstract: A semi-submersible microscope objective (100) includes a microscope objective having a protective barrel (120) with an optical inlet (122) and optical outlet (124), and a protective element (130) affixed to the microscope objective, sealing the optical outlet (124) but not the optical inlet (122). A transparent portion (132) of the protective element is aligned with the optical exit (124). The protective element is separable from the microscope objective without damaging the microscope objective. Use of the semi- submersible microscope objective in a multiphoton imaging method is also disclosed.

    Abstract translation: 半潜式显微镜物镜(100)包括具有带有光学入口(122)和光学出口(124)的保护筒(120)的显微镜物镜和固定到显微物镜的保护元件(130),密封光学 出口(124)而不是光学入口(122)。 保护元件的透明部分(132)与光学出口(124)对齐。 保护元件可与显微镜物镜分离,而不会损坏显微镜物镜。 还公开了在多光子成像方法中使用半潜式显微镜物镜。

    PROCESS FOR MAKING LIGHT GUIDES WITH EXTRACTION STRUCTURES AND LIGHT GUIDES PRODUCED THEREBY
    3.
    发明申请
    PROCESS FOR MAKING LIGHT GUIDES WITH EXTRACTION STRUCTURES AND LIGHT GUIDES PRODUCED THEREBY 审中-公开
    用于制作带有提取结构的轻型指南和生产的轻型指南的过程

    公开(公告)号:WO2007137102A3

    公开(公告)日:2008-08-14

    申请号:PCT/US2007069095

    申请日:2007-05-17

    CPC classification number: G02B6/0041 B29D11/00663 G02B6/0065

    Abstract: A process comprises imagewise exposing at least a portion of a photoreactive composition to light sufficient to cause simultaneous absorption of at least two photons / thereby inducing at least one acid- or radical-initiated chemical reaction where the composition is exposed to the light, the imagewise exposing being carried out in a pattern that is effective to define at least the surface of a plurality of light extraction structures. Each one of the array of light extraction structures has at least one shape factor; the shape factor may vary across the array. At least one light extraction structure may have the geometric configuration of a truncated asphere.

    Abstract translation: 一种方法包括将至少一部分光反应性组合物成像曝光至足以引起同时吸收至少两个光子的光,从而诱导至少一种酸或自由基引发的化学反应,其中组合物暴露于光,图像 以能够至少限定多个光提取结构的表面的图案进行曝光。 光提取结构阵列中的每一个具有至少一个形状因子; 形状因子可能会在阵列上变化。 至少一个光提取结构可以具有截顶的非球面的几何构型。

    PROCESS FOR MAKING MICRONEEDLES, MICRONEEDLE ARRAYS, MASTERS, AND REPLICATION TOOLS
    4.
    发明申请
    PROCESS FOR MAKING MICRONEEDLES, MICRONEEDLE ARRAYS, MASTERS, AND REPLICATION TOOLS 审中-公开
    制作麦克风,麦克风阵列,主机和复印工具的方法

    公开(公告)号:WO2007112309A3

    公开(公告)日:2007-12-27

    申请号:PCT/US2007064789

    申请日:2007-03-23

    Abstract: A process for making a microneedle array master comprises: (a) providing a photoreactive composition, the photoreactive composition comprising: (1) at least one reactive species that is capable of undergoing an acid- or radical-initiated chemical reaction, and (2) at least one multiphoton photoinitiator system; and (b) imagewise exposing at least a portion of the composition to light sufficient to cause simultaneous absorption of at least two photons, thereby inducing at least one acid- or radical-initiated chemical reaction where the composition is exposed to the light, the imagewise exposing being carried out in a pattern that is effective to define at least the surface of a plurality of microneedles. The microneedles may be solid and the outer surface of the microneedles may be characterized by at least one concave area. The master may be used to fabricate a tool for replication.

    Abstract translation: 制备微针阵列母版的方法包括:(a)提供光反应性组合物,所述光反应性组合物包含:(1)能够经历酸或自由基引发的化学反应的至少一种反应性物质,和(2) 至少一种多光子光引发剂体系; 和(b)将组合物的至少一部分成像曝光至足以引起同时吸收至少两个光子的光,从而诱导至少一种酸或自由基引发的化学反应,其中组合物暴露于光,成像 以能有效地限定多个微针的表面的图案进行曝光。 微针可以是固体,并且微针的外表面可以由至少一个凹入区域表征。 主人可能用于制作复制工具。

    MULTIPASS MULTIPHOTON ABSORPTION METHOD AND APPARATUS
    5.
    发明申请
    MULTIPASS MULTIPHOTON ABSORPTION METHOD AND APPARATUS 审中-公开
    多通道多孔吸收方法和装置

    公开(公告)号:WO0196961A3

    公开(公告)日:2002-04-18

    申请号:PCT/US0119125

    申请日:2001-06-14

    CPC classification number: G03F7/038 B33Y30/00 G03F7/2053

    Abstract: A method of increasing the efficiency of a multiphoton absorption process and apparatus. The method includes: providing a photoreactive composition; providing a source of sufficient light for simultaneous absorption of at least two photons; exposing the photoreactive composition to at least one transit of light from the light source; and directing at least a portion of the first transit of the light back into the photoreactive composition using at least one optical element, wherein a plurality of photons not absorbed in at least one transit are used to expose the photoreactive composition in a subsequent transit.

    Abstract translation: 提高多光子吸收过程和设备效率的方法。 该方法包括:提供光反应性组合物; 提供足够的光源以同时吸收至少两个光子; 将光反应性组合物暴露于来自光源的光的至少一个转运; 以及使用至少一个光学元件将所述光的第一转运的至少一部分引导回到所述光反应性组合物中,其中使用在至少一个转运中未被吸收的多个光子在随后的转运中暴露所述光反应性组合物。

    NOZZLE AND METHOD OF MAKING SAME
    6.
    发明申请
    NOZZLE AND METHOD OF MAKING SAME 审中-公开
    喷嘴及其制作方法

    公开(公告)号:WO2012106512A3

    公开(公告)日:2012-11-08

    申请号:PCT/US2012023624

    申请日:2012-02-02

    Abstract: Nozzle and a method of making the same are disclosed. The method includes (a) providing a microstructured mold pattern defining at least a portion of a mold and comprising a plurality of replica nozzle holes and replica planar control cavities; (b) molding a first material into a nozzle forming microstructured pattern using the microstructured mold pattern, with the nozzle forming microstructured pattern comprising a plurality of nozzle hole forming features and planar control cavity forming features; (c) forming a second material into a nozzle pre-form using the nozzle forming microstructured pattern, with the nozzle pre-form comprising a plurality of nozzle pre-form holes and sacrificial planar control cavities; and (d) forming a nozzle from the nozzle pre-form, said forming the nozzle comprising removing enough of the second material to remove the sacrificial planar control cavities so as to form a top surface of the nozzle pre-form into a planar top surface of the nozzle, and to form each of the nozzle pre-form holes into a nozzle through hole.

    Abstract translation: 公开了喷嘴及其制造方法。 该方法包括(a)提供限定模具的至少一部分并且包括多个复制喷嘴孔和复制平面控制腔的微结构模具图案; (b)使用微结构化模具将第一材料模制成形成微结构图案的喷嘴,喷嘴形成微结构图案包括多个喷嘴孔形成特征和平面控制腔形成特征; (c)使用所述喷嘴形成微结构图案将喷嘴预成型形成第二材料,所述喷嘴预成型件包括多个喷嘴预成型孔和牺牲平面控制腔; 并且(d)从喷嘴预成型件形成喷嘴,所述形成喷嘴包括去除足够的第二材料以去除牺牲平面控制腔,以便将喷嘴预成型件的顶表面形成为平面顶表面 并且将每个喷嘴预成形孔形成为喷嘴通孔。

    MULTIDIRECTIONAL PHOTOREACTIVE ABSORPTION METHOD
    9.
    发明申请
    MULTIDIRECTIONAL PHOTOREACTIVE ABSORPTION METHOD 审中-公开
    多方向光电吸收法

    公开(公告)号:WO0196959A3

    公开(公告)日:2002-05-02

    申请号:PCT/US0119124

    申请日:2001-06-14

    CPC classification number: G11C7/00 B33Y30/00 G03F7/2051

    Abstract: A method for enhancing photoreactive absorption in a specified volume element of a photoreactive composition. In one embodiment, the method includes: providing a photoreactive composition; providing a source of light (preferably, a pulsed laser) sufficient for simultaneous absorption of at least two photons by the photoreactive composition, the light source having a beam capable of being divided; dividing the light beam into a plurality of equal path length exposure beams; and focusing the exposure beams in a substantially non-counter propagating manner at a single volume element of the photoreactive composition simultaneously to react at least a portion of the photoreactive composition. In another embodiment, a method includes: providing a photoreactive composition capable of photoreactive absorption; and exposing the photoreactive composition to laser light from a plurality of substantially non-counter propagating directions simultaneously, wherein the light overlaps in time and space at a predetermined focus spot.

    Abstract translation: 一种用于增强光反应性组合物的特定体积元素中的光反应性吸收的方法。 在一个实施方案中,该方法包括:提供光反应性组合物; 提供足以使光反应性组合物同时吸收至少两个光子的光源(优选地,脉冲激光器),所述光源具有能够被分割的光束; 将光束分成多个相等路径长度的曝光光束; 并且将曝光光束以基本上非反向传播的方式聚焦在光反应性组合物的单一体积元件上同时反应至少一部分光反应性组合物。 在另一个实施方案中,一种方法包括:提供能够进行光反应吸收的光反应性组合物; 并且将光反应性组合物同时从多个基本上非反向传播方向的激光曝光,其中在预定焦点处的光在时间和空间上重叠。

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