公开(公告)号：WO2022026625A1

公开(公告)日：2022-02-03

申请号：PCT/US2021/043572

申请日：2021-07-28

Applicant: 460MEDICAL, INC.

Inventor： RANSBURY, Terrance J. ,  AMIRANA, Omar

IPC: A61B18/00 ,  A61B18/02 ,  A61B18/12 ,  A61B18/18

Abstract: System and methods for optical tissue interrogation are provided. In some embodiments, a catheter for visualizing ablated tissue is provided, and can include a catheter body, and a distal tip positioned at a distal end of the catheter body. The distal tip can have one or more openings for exchange of light energy between the distal tip of the catheter and tissue.

公开(公告)号：WO2021142368A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012836

申请日：2021-01-08

Applicant: 460MEDICAL, INC.

Inventor： AMIRANA, Omar ,  RANSBURY, Terrance J. ,  JAGANATHAN, Arun

IPC: A61B18/24 ,  A61B18/18 ,  A61B18/14 ,  A61B17/320068 ,  A61B18/02 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00061 ,  A61B2017/00128 ,  A61B2017/320069 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00785 ,  A61B2018/0212 ,  A61B2018/1467 ,  A61B2018/1861 ,  A61B2018/2211 ,  A61B2218/002 ,  A61B34/20 ,  A61N1/327

Abstract: In some embodiments, a system for optical tissue interrogation comprises a catheter having a plurality of electrodes disposed in an array at a distal end of the catheter, the plurality of electrodes being configured to deliver ablation energy to tissue; and one or more optical fibers extending through the catheter to deliver light from a light source to the tissue and to deliver optical information comprising nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence from the tissue to a sensor, wherein each electrode of the plurality of electrodes is associated with at least one of the one or more optical fibers.

公开(公告)号：WO2022099013A1

公开(公告)日：2022-05-12

申请号：PCT/US2021/058262

申请日：2021-11-05

Applicant: 460MEDICAL, INC.

Inventor： RANSBURY, Terrance J. ,  AMIRANA, Omar

IPC: A61B18/14 ,  A61B1/07 ,  A61B5/00 ,  A61B18/18 ,  A61B18/24

Abstract: Systems and methods for ablation optimization are provided. In some embodiments, a catheter system is provided for determining tissue thickness and includes a catheter including a catheter body with a distal tip, source openings in the distal tip for passing light energy to tissue, and detector openings in the distal tip for passing light energy from tissue. A visualization system includes a light source, a light measuring instrument, and optical fibers extending through the catheter body. The optical fibers include source fibers to pass light energy to the tissue through the source openings and detector fibers to detect light energy from the tissue through the detector openings. The source and detector openings are aligned in a longitudinal arrangement along a length of the distal tip and are paired and spaced apart from one another by a separation distance calculated based on a thickness of the tissue to be measured.