公开(公告)号：WO2022236402A1

公开(公告)日：2022-11-17

申请号：PCT/CA2022/050695

申请日：2022-05-04

Applicant: MEDTRONIC CRYOCATH LP

Inventor： JACOB, Louis ,  EBELING, Timothy A. ,  DYALSINGH, Harold M. ,  REHBERGER, Trenton J. ,  DORMA, Craig W.

IPC: G01M3/40 ,  A61B18/02 ,  A61B2018/00351 ,  A61B2018/00666 ,  A61B2018/00708 ,  A61B2018/00732 ,  A61B2018/00779 ,  A61B2018/00898 ,  A61B2018/00922 ,  A61B2018/0212

Abstract: A system, method and leak signal discriminator for detection of a leak or mechanical breach in a catheter shaft in the presence of an electrical interferer are disclosed. According to one aspect, a leak signal discriminator having a leak detection circuit is configured to distinguish between a leak signal arising from a leak in a catheter and an interfering signal arising from an electrical interferer. The leak signal discriminator includes circuitry configured to receive from the leak detection circuit a response signal responsive to a test signal the test signal having component signals, each component signal being at a different frequency, and distinguish between a leak and an electrical interferer based at least in part on an evaluation of the response signal

公开(公告)号：WO2022239008A1

公开(公告)日：2022-11-17

申请号：PCT/IL2022/050496

申请日：2022-05-12

Applicant: VESSI MEDICAL LTD.

Inventor： KOCHAVI, Eyal ,  SIMCHON, Mordechai

IPC: A61B18/02 ,  A61B1/015 ,  A61B1/12 ,  A61B1/00091 ,  A61B1/018 ,  A61B1/05 ,  A61B1/126 ,  A61B18/0218 ,  A61B2018/0097 ,  A61B2018/0212 ,  A61B2218/002 ,  A61B2218/007

Abstract: A cryotherapy system, including, an elongated device having a body, a proximal end and a distal end, configured to be positioned inside a hollow organ, including: a cryo path fluidically connecting a cryogenic fluid source with the distal end of the device, wherein the cryo path is configured to allow cryogenic fluid flow into the hollow organ; an optics assembly inside the body configured to visualize a field of view between the device distal end and a target region inside the hollow organ; a washing path comprising at least one washing opening at the device distal end, wherein the washing path connects a washing fluid source with the at least one washing opening and configured to release washing fluid within the hollow organ; at least one flow reducer within the washing path configured to narrow an inner lumen of the washing path through which the washing fluid flows.

公开(公告)号：WO2021202052A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/021012

申请日：2021-03-05

Applicant: MEDTRONIC, INC.

Inventor： HARELAND, Scott A. ,  NAVERS, Fabrice

IPC: A61B5/11 ,  A61B5/388 ,  A61B5/395 ,  A61B5/00 ,  A61N1/00 ,  A61B18/02 ,  A61B18/1492 ,  A61B2017/00115 ,  A61B2018/0022 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B5/1106 ,  A61B5/28 ,  A61B5/296 ,  A61B5/318 ,  A61B5/389 ,  A61B5/397 ,  A61B5/4041 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/6852 ,  A61B5/7275 ,  A61B5/743 ,  A61N1/36017 ,  G16H15/00 ,  G16H20/30 ,  G16H20/40 ,  G16H50/70

Abstract: A method of monitoring a patient for phrenic nerve collateral damage during a cardiac ablation procedure. The method includes measuring at least one from the group consisting of compound motor action potential (CMAP) and accelerometer signals in response to stimulating of the phrenic nerve. Real-time data is displayed on a display, the real-time data including the at least one from the group consisting of the measured CMAP and accelerometer signals. Long-term trend data is simultaneously displayed on the display, the long-term trend data being associated with the measured at least one from the group consisting of CMAP and accelerometer signals.

公开(公告)号：WO2021142352A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012817

申请日：2021-01-08

Applicant: CHELAK MEDICAL SOLUTION INC.

Inventor： LAKKIREDDY, Dhanunjaya ,  CHENG, Jie

IPC: A61B18/02 ,  A61B18/00 ,  A61B2018/0022 ,  A61B2018/00261 ,  A61B2018/00375 ,  A61B2018/00791 ,  A61B2018/00898 ,  A61B2018/0212

Abstract: The present disclosure describes technology for preventing hypothermal injuries that are related to cryoablation. In some variations, a device may comprise a cryoballoon that is coupled to an elongate member at a proximal portion of the cryoballoon. A temperature probe may be disposed via the elongate member and may be configured to extend from a distal portion of the cryoballoon to one or more structures that are distal to the site of occlusion from the cryoballoon. Additionally or alternatively, in some variations, a device can include a cryoballoon protection device that is disposed distal to the cryoballoon. The cryoballoon protection device may be filled with an inert gas during a cryoablation procedure.

公开(公告)号：WO2021144318A1

公开(公告)日：2021-07-22

申请号：PCT/EP2021/050603

申请日：2021-01-13

Applicant: MEDLUMICS S.L.

Inventor： SANCHO DURÁ, Juan ,  MAS GÓMEZ, Sara ,  GONZALEZ, David ,  DUPERRON, Matthieu ,  SANZ MORENO, Carlos ,  JIMENEZ, Jorge ,  ROMOSCANU, Alexandre

IPC: A61B5/00 ,  A61M25/00 ,  A61B18/04 ,  A61B18/18 ,  A61B18/14 ,  A61B18/00 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/20 ,  A61B18/24 ,  A61B2017/00061 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61B2090/309 ,  A61B2090/3735 ,  A61B2090/3966 ,  A61B2218/002 ,  A61B2562/04 ,  A61B2562/06 ,  A61B5/0044 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/6869 ,  A61B5/7275

Abstract: Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.

公开(公告)号：WO2021143681A1

公开(公告)日：2021-07-22

申请号：PCT/CN2021/071300

申请日：2021-01-12

Applicant: 珠海大横琴科技发展有限公司 ,  山前（珠海）医疗科技有限公司

Inventor： 刘玥 ,  肖家华

IPC: A61B18/02 ,  A61B2018/00255 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

Abstract: 一种冷冻消融导管，包括球囊（1）和穿过球囊（1）的输送导管（2），输送导管（2）内设有：流体流入腔（21）和流体流出腔（22），流体流入腔（21）延伸至球囊（1）内，流体流入腔（21）的侧壁开设有朝向球囊（1）内注液的喷头（211），喷头（211）具有若干环设于流体流入腔（21）的外部的喷孔（2111、2112）；流体流出腔（22）的末端具有封闭流体流出腔（22）的截面（24），流体流出腔（22）在侧壁上开设有与球囊（1）连通的回流孔（221）。流体从流体流入腔（21）经过喷孔（2111、2112）流入球囊（1），喷孔（2111、2112）均匀分布于流体流入腔（21）外侧，使得球囊（1）内部均匀地充盈冷冻流体，能够保证球囊（1）轴向各部位换热的均匀性，而后流体由回流孔（221）流出。该结构设计可有效提高流体的换热效率，且生产加工工艺较为简单。

公开(公告)号：WO2021044312A1

公开(公告)日：2021-03-11

申请号：PCT/IB2020/058173

申请日：2020-09-02

Applicant: ARGA' MEDTECH SA

Inventor： WERNETH, Randell L. ,  ZARBATANY, David ,  ROMAN, Ricardo David

IPC: A61B18/14 ,  A61M25/01 ,  A61B18/18 ,  A61B18/20 ,  A61B18/00 ,  A61N7/02 ,  A61B18/02 ,  A61M25/00 ,  A61N1/362 ,  A61B5/042 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00196 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00761 ,  A61B2018/00839 ,  A61B2018/00886 ,  A61B2018/0212 ,  A61B2018/126 ,  A61B2018/1266 ,  A61B2018/1273 ,  A61B5/283 ,  A61B5/4836 ,  A61B5/6855 ,  A61B5/6856 ,  A61B5/6857 ,  A61N7/022

Abstract: The present invention relates to an ablation assembly (100) to treat target regions of a tissue (41) in organs (44) comprising : - an ablation catheter (1) comprising an elongate shaft (13) having a longitudinal main direction (X-X), said elongate shaft (13) comprising at least a shaft distal portion (17), said shaft distal portion (17) comprising a shaft distal portion distal end (19); said ablation catheter (1) comprising an inner lumen (118) arranged within the elongate shaft (13); said ablation catheter (1) comprising a shaft ablation assembly (20) fixedly disposed at said shaft distal portion (17), the shaft ablation assembly (20) being configured to deliver both thermal energy for ablating said tissue (41) and non-thermal energy for treating said tissue (41); - at least a shape setting mandrel (26) disposed within the ablation catheter (1), the shape setting mandrel (26) being insertable within the inner lumen (118) and removable from the inner lumen (118), wherein the shape setting mandrel (26) is free to move in respect of the inner lumen (118) avoiding any constraint with said shaft distal portion (17) during the shape setting mandrel insertion, wherein the shape setting mandrel (26) comprises at least a pre-shaped configuration and the shape setting mandrel (26) is reversibly deformable between at least a straight loaded configuration and said pre-shaped configuration, wherein, when the shape setting mandrel (26) is fully inserted in the shaft distal portion (17), the shape setting mandrel (26) is configured to shape set said shaft distal portion (17) with said pre-shaped configuration.

公开(公告)号：WO2021044310A1

公开(公告)日：2021-03-11

申请号：PCT/IB2020/058170

申请日：2020-09-02

Applicant: ARGA' MEDTECH SA

Inventor： WERNETH, Randell L. ,  ZARBATANY, David ,  ROMAN, Ricardo David

IPC: A61B18/12 ,  A61B18/14 ,  A61B18/00 ,  A61M25/01 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00196 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00761 ,  A61B2018/00839 ,  A61B2018/00886 ,  A61B2018/0212 ,  A61B2018/126 ,  A61B2018/1266 ,  A61B2018/1273 ,  A61B5/283 ,  A61B5/4836 ,  A61B5/6855 ,  A61B5/6856 ,  A61B5/6857 ,  A61N1/362 ,  A61N7/022

Abstract: The present invention relates to an ablation equipment (100) to treat target regions of tissue (41) in organs (44), comprising an ablation catheter (1) and a single power source (4); said ablation catheter (1) comprising : - a catheter elongated shaft (13) comprising at least an elongated shaft distal portion (17); said catheter elongated shaft (13) comprising a flexible body (207) to navigate through body vessels (208); - said ablation catheter (1) further comprising a shaft ablation assembly (20) disposed at said elongated shaft distal portion (17); - said shaft ablation assembly (2) comprising at least a plurality of electrodes (127, 113 or 114) fixedly disposed at said elongated shaft distal portion (17); all electrodes of said at least a plurality (127, 113 or 114) being electrically powered by said single power source (4) through an electric signal (S) to deliver both non-thermal energy for treating the tissue (41) and thermal energy for ablating the tissue (41); wherein said single power source (4), when requested, changes continuously said electric signal (S) in order to power the said least a plurality of electrodes (127, 113 or 114) to deliver from a non-thermal energy to a thermal energy, and vice versa, or to deliver at the same time a combination of thermal energy and non-thermal energy.

公开(公告)号：WO2023015377A8

公开(公告)日：2023-02-16

申请号：PCT/CA2022/051204

申请日：2022-08-08

Applicant: MEDTRONIC CRYOCATH LP

Inventor： COULOMBE, Nicolas ,  MAHROUCHE, Rachid ,  JACOB, Louis ,  WITTENBERGER, Dan ,  LACHARITE, Martin ,  LALONDE, Jean-Pierre

IPC: A61B18/02 ,  A61B18/00 ,  A61B18/1492 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

Abstract: A method of ablating tissue includes positioning a treatment device proximate to a target tissue area. The treatment device has an expandable treatment element. The expandable treatment element is inflated with a refrigerant during an inflation phase such that at least a portion of the expandable treatment element is in contact with the target tissue area. A first pressure measurement of the inflated expandable treatment element is recorded and compared to a predetermined pressure threshold. The refrigerant is circulated within the expandable treatment element during an ablation phase to reduce a temperature of the target tissue area to a temperature sufficient to cryoablate the target tissue area. A second pressure measurement of the expandable treatment element is recorded during the ablation phase and compared to the predetermined pressure threshold.

公开(公告)号：WO2022226626A2

公开(公告)日：2022-11-03

申请号：PCT/CA2022/050231

申请日：2022-02-17

Applicant: MEDTRONIC CRYOCATH LP

Inventor： COULOMBE, Nicolas ,  YANG, Zhongping ,  LALONDE, Jean-pierre

IPC: A61B18/00 ,  A61B18/02 ,  A61B18/12 ,  A61B18/1492 ,  A61B2018/0022 ,  A61B2018/0025 ,  A61B2018/00255 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61B2018/1467

Abstract: A method of performing bronchial denervation of a bronchus having bronchial nerves along a portion thereof is provided. The method includes providing a cryoablation device having multiple electrodes capable of delivering electrical energy and measuring impedance. At least one bronchial nerve is stimulated with electrical energy. The electrical signals from the at least one bronchial nerve are recorded to provide a first value representative of nerve function. Cryogenic treatment energy is applied to form ice in the bronchus having a thickness to encapsulate the at least one bronchial nerve to cause a reduction in nerve function. The at least one bronchial nerve is restimulated with electrical energy. The electrical signals are recorded from the restimulated at least one bronchial nerve to provide a second value that represents diminished nerve function. The first value and the second value are compared to provide an assessment of the reduction in nerve function.