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    IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USE THEREOF
    1.
    发明申请
    IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
    免疫组化及其使用方法

    公开(公告)号：WO2017033123A1

    公开(公告)日：2017-03-02

    申请号：PCT/IB2016/055016

    申请日：2016-08-22

    Applicant: AGRAWAL, Babita ,  KUMAR, Rakesh ,  GUPTA, Nancy

    Inventor： AGRAWAL, Babita ,  KUMAR, Rakesh ,  GUPTA, Nancy

    IPC: A61K39/02 ,  A61K39/00 ,  A61P29/00 ,  A61P3/00 ,  A61P31/04 ,  A61P37/02 ,  A61P37/04

    CPC classification number: A61K35/74

    Abstract: The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.

    Abstract translation: 本公开提供包含活细弧新月牙（CC）的免疫调节组合物。 本公开的免疫调节组合物可用于调节个体的免疫应答。 本公开因此提供了调节个体的免疫应答的方法，包括向个体施用包含活CC的免疫调节组合物。

    COMBINATION
    5.
    发明申请
    COMBINATION 审中-公开
    组合

    公开(公告)号：WO2012082337A2

    公开(公告)日：2012-06-21

    申请号：PCT/US2011/061985

    申请日：2011-11-23

    Applicant: GLAXO WELLCOME MANUFACTURING PTE LTD ,  KUMAR, Rakesh ,  BARUCHEL, Sylvain

    Inventor： KUMAR, Rakesh ,  BARUCHEL, Sylvain

    CPC classification number: A61K31/506 ,  A61K31/4375 ,  A61K31/4745 ,  A61K2300/00

    Abstract: The present invention relates to methods of treating neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a neuroblastoma treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino [1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

    Abstract translation: 本发明涉及治疗人类的神经母细胞瘤，骨肉瘤和横纹肌肉瘤的方法以及用于这种治疗的药物组合。 特别地，该方法涉及神经母细胞瘤治疗方法，其包括施用5 - [[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺， 或其药学上可接受的盐，和（S）-10 - [（二甲基氨基）甲基] -4-乙基-4,9-二羟基-1H-吡喃并[3'，4'：6,7]吲哚并[1,2 b]喹啉-3,14-（4H，12H） - 二酮或其药学上可接受的盐。

    METHOD AND SYSTEM FOR REVERSAL OF INTERACTIONS BETWEEN HYDROPHOBICALLY MODIFIED BIOPOLYMERS AND VESICLES OR CELL MEMBRANES
    6.
    发明申请
    METHOD AND SYSTEM FOR REVERSAL OF INTERACTIONS BETWEEN HYDROPHOBICALLY MODIFIED BIOPOLYMERS AND VESICLES OR CELL MEMBRANES 审中-公开
    用于逆转疏水改性的生物聚合物与微生物或细胞膜之间的相互作用的方法和系统

    公开(公告)号：WO2012021877A2

    公开(公告)日：2012-02-16

    申请号：PCT/US2011/047694

    申请日：2011-08-13

    Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK ,  DOWLING, Matthew ,  KUMAR, Rakesh ,  RAGHAVAN, Srinivasa, R.

    Inventor： DOWLING, Matthew ,  KUMAR, Rakesh ,  RAGHAVAN, Srinivasa, R.

    IPC: A61L15/22 ,  A61L15/28 ,  A61F13/00 ,  A61L15/42

    CPC classification number: A61K31/724 ,  A61L15/28 ,  A61L15/42 ,  A61L26/0023 ,  A61L26/0061 ,  A61L26/0076 ,  A61L2300/232 ,  A61L2400/04

    Abstract: A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.

    Abstract translation: 一种逆转附着于囊泡或细胞膜的疏水改性的生物聚合物的凝胶化的方法。 通过将超分子如环糊精应用于胶凝组合物可逆转附着于囊泡或细胞膜的疏水改性的生物聚合物的凝胶化。 超分子破坏了疏水改性的生物聚合物与囊泡或细胞膜之间的相互作用，而不影响疏水性取代基所连接的膜或疏水改性聚合物的结构。 用于治疗伤口的试剂盒，包括疏水改性的生物聚合物和超分子。 疏水改性的生物聚合物用于止血，超分子用于除去疏水改性的生物聚合物。

    SUGARCANE COATING
    7.
    发明申请
    SUGARCANE COATING 审中-公开
    SUGARCANE涂料

    公开(公告)号：WO2011159604A1

    公开(公告)日：2011-12-22

    申请号：PCT/US2011/040167

    申请日：2011-06-13

    Applicant: KUMAR, Rakesh ,  SYNGENTA PARTICIPATIONS AG

    Inventor： KUMAR, Rakesh

    IPC: C08L91/00 ,  C09D4/00

    CPC classification number: A01C1/00 ,  A01C1/06 ,  C09D191/00

    Abstract: Methods and coatings for a sugarcane stem section are shown and described. In one example, the disclosure includes a stem section that has been coated with a fatty acid component. In another example, the disclosure includes a method of growing sugarcane comprising planting a stem section that has been coated with a fatty acid component.

    Abstract translation: 显示和描述了甘蔗茎段的方法和涂层。 在一个示例中，本公开包括已经涂覆有脂肪酸组分的茎段。 在另一个实例中，本公开内容包括种植甘蔗的方法，其包括种植已经涂覆有脂肪酸组分的茎段。

    COMBINATION
    8.
    发明申请
    COMBINATION 审中-公开
    组合

    公开(公告)号：WO2011150044A1

    公开(公告)日：2011-12-01

    申请号：PCT/US2011/037881

    申请日：2011-05-25

    Applicant: GLAXOSMITHKLINE LLC ,  KUMAR, Rakesh

    Inventor： KUMAR, Rakesh

    IPC: A01N43/38 ,  A61K31/16 ,  A61K31/40

    CPC classification number: A61K31/635 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/4155 ,  A61K31/506 ,  C07D403/12 ,  C07D409/04 ,  A61K2300/00

    Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering 5-[[4-[(2,3- dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2- methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and Λ/- {(1 S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1 H- pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

    Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括施用5 - [[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺， 或其药学上可接受的盐和α/ {（1S）-2-氨基-1 - [（3-氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基-1 -1H-吡唑-5-基）-2-噻吩甲酰胺或其药学上可接受的盐。

    COMBINATION
    9.
    发明申请
    COMBINATION 审中-公开
    组合

    公开(公告)号：WO2011044414A1

    公开(公告)日：2011-04-14

    申请号：PCT/US2010/051907

    申请日：2010-10-08

    Applicant: GLAXOSMITHKLINE LLC ,  DUMBLE, Melissa ,  GILMER, Tona ,  KUMAR, Rakesh ,  LAQUERRE, Sylvie ,  LEBOWITZ, Peter, F. ,  MORRIS, Shannon, Renae

    Inventor： DUMBLE, Melissa ,  GILMER, Tona ,  KUMAR, Rakesh ,  LAQUERRE, Sylvie ,  LEBOWITZ, Peter, F. ,  MORRIS, Shannon, Renae

    IPC: A01N43/78 ,  A61K31/425

    CPC classification number: A61K31/506 ,  A61K31/4155 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N -{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and N -{(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1 H -pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

    Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基） 吡啶-2-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐和N - {（1S）-2-氨基-1 - [（3,4-二氟苯基）甲基]乙基} -4-（4-氯-1-甲基-1H-吡唑-5-基）-2-呋喃甲酰胺或其药学上可接受的盐给有需要的人。

    METHOD FOR LIFT-OFF PATTERNING FILMS ON A SUBSTRATE
    10.
    发明申请
    METHOD FOR LIFT-OFF PATTERNING FILMS ON A SUBSTRATE 审中-公开
    在基板上提升图案的方法

    公开(公告)号：WO2009088357A1

    公开(公告)日：2009-07-16

    申请号：PCT/SG2008/000003

    申请日：2008-01-07

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  RANGANATHAN, Nagarajan ,  LIAO, Ebin ,  LEE, Wen Sheng, Vincent ,  KUMAR, Rakesh

    Inventor： RANGANATHAN, Nagarajan ,  LIAO, Ebin ,  LEE, Wen Sheng, Vincent ,  KUMAR, Rakesh

    IPC: G03F7/00

    CPC classification number: G03F7/40 ,  H01L21/0272 ,  H01L21/31127

    Abstract: A method of performing lift-off patterning process is disclosed which involves dry resist film or lithography and material deposition process followed by lamination with UV sensitive or equivalent adhesive film and then delaminating the top layer of thin film due to weak adhesion of deposited material with the underlying organic layer. In an embodiment, the unwanted dry resist film is stripped or peeled-off by again laminating a fresh layer of UV sensitive film and delaminating the unwanted dry resist film mask. As the sputtered or evaporated films are usually non-conformal, the thin and weakly adhered sidewall metal films easily gets delaminated by the polymer film during the delamination process and thus resulting in smooth edges for the metal patterns.

    Abstract translation: 公开了一种执行剥离图案化工艺的方法，其中包括干燥抗蚀剂膜或光刻和材料沉积工艺，然后与UV敏感或等效的粘合剂膜层压，然后由于沉积材料与 底层有机层。 在一个实施方案中，通过再次层压新鲜的UV敏感层并剥离不需要的干燥抗蚀剂膜掩模，将不需要的干燥抗蚀剂膜剥离或剥离。 由于溅射或蒸发的膜通常是非共形的，薄的和弱粘附的侧壁金属膜在分层过程中容易被聚合物膜分层，从而导致金属图案的平滑边缘。

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