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    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    4.
    发明申请
    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
    取代的杂环化合物及其使用方法

    公开(公告)号：WO2006037117A1

    公开(公告)日：2006-04-06

    申请号：PCT/US2005/035134

    申请日：2005-09-27

    Applicant: AMGEN INC.

    Inventor： ANDERSEN, Denise, Lyn ,  CHANG, Catherine, M. ,  FALSEY, James, R. ,  FROHN, Michael, J. ,  HONG, Fang-Tsao ,  LIAO, Hongyu ,  LIU, Longbin ,  LOPEZ, Patricia ,  RETZ, Daniel, Martin ,  RISHTON, Gilbert, M. ,  RZASA, Robert, M. ,  SIEGMUND, Aaron, C. ,  TADESSE, Seifu ,  TAMAYO, Nuria ,  TEGLEY, Christopher, M.

    IPC: C07D239/48 ,  A61K31/506 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

    CPC classification number: C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

    Abstract: The present invention relates to pyridines, pyrimidines and derivatives thereof, (I) or a pharmaceutically acceptable salts thereof, wherein X 1 is N or CR 3 ; X 2 is N or CR 4 ; or -X 1 =X 2 - is -C(=O)-N(R a )- or -N(R a )-C(=O)-; X 3 is N or CR 4 ; X 4 is N or CR 4 ; X 5 is N or CR 6 ; X 6 is N or CR 6 ; wherein only 1, 2 or 3 of X 1 , X 2 , X 3 and X 4 are N; R 1 is a saturated partially saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring is substituted by 0, 1, 2 or 3 substituents. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

    Abstract translation: 本发明涉及吡啶，嘧啶及其衍生物，（I）或其药学上可接受的盐，其中X 1是N或CR 3; X 2是N或CR 4; 或-X 1 = X 2 - 是-C（= O）-N（R a） - 或-N（R 0） >一） - C（= O） - ; X 3是N或CR 4; X 4是N或CR 4; X 5是N或CR 6; X 6是N或CR 6; 其中X 1，X 2，X 3和X 4中仅有1,2或3是N; R 1是饱和的部分饱和或不饱和的含有0,1,2或3个选自N，O和S的原子的5-，6-或7-元环，其中环被 0,1,2或3个取代基。 还包括治疗炎症，类风湿性关节炎，佩吉特病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征 （ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉退化，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病 ，中风，心肌梗塞，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV-1，HIV-2，HIV-3，巨细胞病毒 ），流感病毒，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的如上所述的化合物。

    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    5.
    发明申请
    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开

    公开(公告)号：WO2005070932A3

    公开(公告)日：2005-08-04

    申请号：PCT/US2005/002013

    申请日：2005-01-21

    Applicant: AMGEN INC.

    Inventor： FROHN, Michael, J. ,  HONG, Fang-Tsao ,  LIU, Longbin ,  LOPEZ, Patricia ,  SIEGMUND, Aaron, C. ,  TADESSE, Seifu ,  TAMAYO, Nuria

    IPC: C07D487/04

    Abstract: The present invention relates to pyrimidinones and pyridones and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    8.
    发明申请
    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
    取代的杂环化合物及其使用方法

    公开(公告)号：WO2006069258A1

    公开(公告)日：2006-06-29

    申请号：PCT/US2005/046652

    申请日：2005-12-20

    Applicant: AMGEN INC

    Inventor： HONG, Fang-tsao ,  LIAO, Hongyu ,  LOPEZ, Patricia ,  TADESSE, Seifu ,  TAMAYO, Nuria A.

    IPC: C07D471/04 ,  C07D498/04 ,  A61K31/4375 ,  A61K31/5383 ,  A61P29/00

    CPC classification number: C07D471/04

    Abstract: The present invention relates to nitrogen-containing compounds according to formula (I) and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

    Abstract translation: 本发明涉及式（I）的含氮化合物及其药学上可接受的盐。 还包括治疗炎症，类风湿性关节炎，佩吉特病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征 （ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉退化，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病 ，中风，心肌梗塞，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV-1，HIV-2，HIV-3，巨细胞病毒 ），流感病毒，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的如上所述的化合物。

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