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公开(公告)号：WO2009091374A2
公开(公告)日：2009-07-23
申请号：PCT/US2008/011724
申请日：2008-10-14
申请人： AMGEN INC. , ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Erin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
发明人： ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Erin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
IPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , A61K31/4355
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：WO2009155121A3
公开(公告)日：2010-02-18
申请号：PCT/US2009045713
申请日：2009-05-29
申请人： AMGEN INC , BO YUNXIN Y , BOOKER SHON , BRYAN MARIAN , DEAK HOLLY L , LIU LONGBIN , ANDREWS KRISTIN , NISHIMURA NOBUKO , NORMAN MARK H , PANTER KATHLEEN , SCHENKEL LAURIE , SIEGMUND AARON C , TAMAYO NURIA A , YANG KEVIN
发明人： BO YUNXIN Y , BOOKER SHON , BRYAN MARIAN , DEAK HOLLY L , LIU LONGBIN , ANDREWS KRISTIN , NISHIMURA NOBUKO , NORMAN MARK H , PANTER KATHLEEN , SCHENKEL LAURIE , SIEGMUND AARON C , TAMAYO NURIA A , YANG KEVIN
IPC分类号： C07D401/04 , A61K31/4709 , A61K31/498 , A61K31/502 , A61P35/00 , C07D401/14 , C07D471/04
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物，其中Q，X 1，X 2，R 1和Z如本文所定义。
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公开(公告)号：WO2009155121A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/045713
申请日：2009-05-29
申请人： AMGEN INC. , BO, Yunxin Y. , BOOKER, Shon , BRYAN, Marian , DEAK, Holly L. , LIU, Longbin , ANDREWS, Kristin , NISHIMURA, Nobuko , NORMAN, Mark H. , PANTER, Kathleen , SCHENKEL, Laurie , SIEGMUND, Aaron C. , TAMAYO, Nuria A. , YANG, Kevin
发明人： BO, Yunxin Y. , BOOKER, Shon , BRYAN, Marian , DEAK, Holly L. , LIU, Longbin , ANDREWS, Kristin , NISHIMURA, Nobuko , NORMAN, Mark H. , PANTER, Kathleen , SCHENKEL, Laurie , SIEGMUND, Aaron C. , TAMAYO, Nuria A. , YANG, Kevin
IPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , A61K31/498 , A61K31/502 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X 1 , X 2 , R 1 and Z are as defined herein.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物，其中Q，X 1，X 2，R 1和Z如本文所定义。
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4.发明申请
公开(公告)号：WO2008086014A3
公开(公告)日：2008-12-24
申请号：PCT/US2008000329
申请日：2008-01-09
申请人： AMGEN INC , BOOKER SHON , D ANGELO NOEL , GERMAIN JULIE , HARMANGE JEAN-CHRISTOPHE , KIM TAE-SEONG , POTASHMAN MICHELE
发明人： BOOKER SHON , D ANGELO NOEL , GERMAIN JULIE , HARMANGE JEAN-CHRISTOPHE , KIM TAE-SEONG , POTASHMAN MICHELE
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4725 , A61K31/5025 , A61P35/00 , C07D401/12 , C07D403/12 , C07D471/04
CPC分类号： C07D403/12 , C07D231/22 , C07D231/56 , C07D401/12 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如c Met介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：WO2006060318A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/042935
申请日：2005-11-29
申请人： AMGEN INC. , KIM, Tae-seong , BELLON, Steven , BOOKER, Shon , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid , LEE, Matthew , LIU, Longbin , RAINBEAU, Elizabeth , SIEGMUND, Aaron, C. , TASKER, Andrew , XI, Ning , CHENG, Yuan
发明人： KIM, Tae-seong , BELLON, Steven , BOOKER, Shon , D'ANGELO, Noel , DOMINGUEZ, Celia , FELLOWS, Ingrid , LEE, Matthew , LIU, Longbin , RAINBEAU, Elizabeth , SIEGMUND, Aaron, C. , TASKER, Andrew , XI, Ning , CHENG, Yuan
IPC分类号： A61K31/4709 , C07D401/12 , C07D401/14 , A61P35/00
摘要： Selected compounds of Formula (I) are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases such as cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. R - X - W - A - Y - R Formula (I) wherein R is X is O, S, NR2 or CR3R4 W is an substituted or unsubstituted aryl or substituted or unsubstituted 5- or 6- membered heteroaryl.
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公开(公告)号：WO2009085230A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/013940
申请日：2008-12-18
申请人： AMGEN INC. , BOOKER, Shon , KIM, Tae-seong , LIAO, Hongyu , LIU, Longbin , NORMAN, Mark H. , PETERSON, Emily Anne , STEC, Markian , TAMAYO, Nuria A.
发明人： BOOKER, Shon , KIM, Tae-seong , LIAO, Hongyu , LIU, Longbin , NORMAN, Mark H. , PETERSON, Emily Anne , STEC, Markian , TAMAYO, Nuria A.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase; Formula (I) methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds.
摘要翻译： 本发明涉及抑制磷酸肌醇3-激酶的式I化合物或其药学上可接受的盐; 式（I）使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物。
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公开(公告)号：WO2009017822A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/009312
申请日：2008-08-01
申请人： AMGEN INC. , BOOKER, Shon , D'ANGELO, Noel , D'AMICO, Derin C. , KIM, Tae-seong , LIU, Longbin , MEAGHER, Kristin , NORMAN, Mark H. , PANTER, Kathleen , SCHENKEL, Laurie B. , SMITH, Adrian L. , TAMAYO, Nuria A. , WHITTINGTON, Douglas A. , XI, Ning , YANG, Kevin
发明人： BOOKER, Shon , D'ANGELO, Noel , D'AMICO, Derin C. , KIM, Tae-seong , LIU, Longbin , MEAGHER, Kristin , NORMAN, Mark H. , PANTER, Kathleen , SCHENKEL, Laurie B. , SMITH, Adrian L. , TAMAYO, Nuria A. , WHITTINGTON, Douglas A. , XI, Ning , YANG, Kevin
IPC分类号： C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04 , A61K31/423 , A61K31/424 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04
摘要： The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A 1 , A 2 , A 3 , A 4 , X, R 1 and R 2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译： 本发明包括能够调节PI3激酶活性的新一类化合物，因此可用于治疗PI3激酶介导的疾病，包括黑素瘤，癌和其它癌症相关病症。 所述化合物具有通式I，其中A1，A2，A3，A4，X，R1和R2各自在本文中定义。 本发明还包括药物组合物，治疗PI3激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号：WO2008103277A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/002007
申请日：2008-02-15
申请人： AMGEN INC. , ALBRECHT, Brian K. , BELLON, Steven , BOOKER, Shon , CHENG, Alan C. , D'AMICO, Derin , D'ANGELO, Noel , HARMANGE, Jean-christophe , KIM, Tae-seong , LIU, Longbin , NORMAN, Mark H. , SIEGMUND, Aaron C. , STEC, Markian , XI, Ning , YANG, Kevin
发明人： ALBRECHT, Brian K. , BELLON, Steven , BOOKER, Shon , CHENG, Alan C. , D'AMICO, Derin , D'ANGELO, Noel , HARMANGE, Jean-christophe , KIM, Tae-seong , LIU, Longbin , NORMAN, Mark H. , SIEGMUND, Aaron C. , STEC, Markian , XI, Ning , YANG, Kevin
IPC分类号： C07D237/16 , A61K31/4709 , A61K31/4545 , A61K31/444 , A61K31/501 , A61K31/497 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
CPC分类号： C07D237/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：WO2008086014A2
公开(公告)日：2008-07-17
申请号：PCT/US2008/000329
申请日：2008-01-09
申请人： AMGEN INC. , BOOKER, Shon , D'ANGELO, Noel , GERMAIN, Julie , HARMANGE, Jean-christophe , KIM, Tae-seong , POTASHMAN, Michele
发明人： BOOKER, Shon , D'ANGELO, Noel , GERMAIN, Julie , HARMANGE, Jean-christophe , KIM, Tae-seong , POTASHMAN, Michele
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D471/04 , A61K31/416 , A61K31/4725 , A61K31/5025 , A61P35/00
CPC分类号： C07D403/12 , C07D231/22 , C07D231/56 , C07D401/12 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如c Met介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：WO2007005668A2
公开(公告)日：2007-01-11
申请号：PCT/US2006025699
申请日：2006-06-29
申请人： AMGEN INC , KIM TAE-SEONG , HARMANGE JEAN-CHRISTOPHE , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID M , LIU LONGBIN , TASKER ANDREW , BELLON STEVEN , HARVEY TIMOTHY S , LEE MATTHEW , GERMAIN JULIE , PATEL VINOD F , KIM JOSEPH L
发明人： KIM TAE-SEONG , HARMANGE JEAN-CHRISTOPHE , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID M , LIU LONGBIN , TASKER ANDREW , BELLON STEVEN , HARVEY TIMOTHY S , LEE MATTHEW , GERMAIN JULIE , PATEL VINOD F , KIM JOSEPH L
IPC分类号： C07D409/12 , C07D333/38 , C07D401/10 , C07D401/12
CPC分类号： C07D333/38 , C07D217/02 , C07D217/24 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/10 , C07D417/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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