公开(公告)号：WO2019195777A1

公开(公告)日：2019-10-10

申请号：PCT/US2019/026138

申请日：2019-04-05

Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.

Inventor： HARWIG, Curtis ,  PETTIGREW, Jeremy, D. ,  CROSS, Jennifer ,  SEENISAMY, Jeyaprakashnarayanan ,  KEREGADDE, Mahesh, Narayan ,  IYANAR, Karthikeyan

IPC: C07D231/54 ,  C07D401/04 ,  C07D401/08 ,  C07D403/04 ,  C07D417/08 ,  C07D493/10 ,  A61K31/416 ,  A61P29/00

Abstract: Compounds of formula (I): wherein,R 1 , R 2 , R 3 , R 4a , R 4b and R 5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

公开(公告)号：WO2019195751A1

公开(公告)日：2019-10-10

申请号：PCT/US2019/026092

申请日：2019-04-05

Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.

Inventor： HARWIG, Curtis ,  PETTIGREW, Jeremy, D. ,  CROSS, Jennifer ,  SEENISAMY, Jeyaprakashnarayanan ,  KEREGADDE, Mahesh, Narayan ,  KHER, Samir, Satish

IPC: C07D263/56 ,  C07D231/54 ,  C07D239/74 ,  C07D241/42 ,  C07D261/20 ,  C07D209/08 ,  C07D277/64 ,  C07D285/14 ,  A61K31/437 ,  A61P29/00

Abstract: Compounds of formula (I) wherein, R 1 , R 2 , R 3 , R 4a , R4b and R 5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

公开(公告)号：WO2019195692A1

公开(公告)日：2019-10-10

申请号：PCT/US2019/026009

申请日：2019-04-05

Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC. ,  ROTH, Carol, Jean

Inventor： HARWIG, Curtis ,  PETTIGREW, Jeremy, D. ,  CROSS, Jennifer ,  SEENISAMY, Jeyaprakashnarayanan ,  KEREGADDE, Mahesh, Narayan ,  KHER, Samir, Satish ,  IYANAR, Karthikeyan

IPC: C07J71/00 ,  A61K31/58 ,  A61P29/00

Abstract: wherein,R 1 , R 2 , R 3 , R 4a , R 4b and R 5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

公开(公告)号：WO2017127753A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014446

申请日：2017-01-20

Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.

Inventor： HARWIG, Curtis ,  SEENISAMY, Jeyaprakashnarayanan ,  KEREGADDE, Mahesh, Narayan, ,  CHETIA, Lakshindra

IPC: C07D307/77 ,  C07C209/40 ,  C07C211/25 ,  C07C13/465

CPC classification number: C07C209/30 ,  C07B2200/07 ,  C07C213/00 ,  C07C249/12 ,  C07C2101/14 ,  C07C2102/02 ,  C07C2601/14 ,  C07C2602/02 ,  C07C2602/24 ,  C07D307/77 ,  C07D317/70 ,  C07D317/72 ,  C07J1/0011 ,  C07J1/0022 ,  C07J13/007 ,  C07J21/008 ,  C07J31/006 ,  C07J51/00 ,  C07J71/0026 ,  C07J73/003 ,  C07J73/005 ,  C07C215/42

Abstract: This invention is directed to methods of preparing AQX-1125 having the formula (I). This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.

Abstract translation: 本发明涉及制备具有式（I）的AQX-1125的方法。 本发明还涉及用于制备AQX-1125的方法中的中间体。