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    HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION
    3.
    发明申请
    HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION 审中-公开
    杂环化合物治疗肺炎衣原体感染

    公开(公告)号：WO2018013430A2

    公开(公告)日：2018-01-18

    申请号：PCT/US2017/041218

    申请日：2017-07-07

    Applicant: ARISAN THERAPEUTICS INC.

    Inventor： PLEWE, Michael ,  BROWN, Eric ,  GANTLA, Vidyasagar ,  HENKEL, Gregory ,  MCCORMACK, Kenneth ,  SOKOLOVA, Nadzeda V. ,  SHIN, Young-Jun

    IPC: A61K31/4745 ,  A61K31/4184

    Abstract: The invention relates to compounds of structural formula I, wherein A, D, and E are independently N or C-R 3 , G, H, and J are independently N or C, K is N or C-H, L is N, N-R 3 or C-R 3 , and A, D, E, G, H, J, K, and L together cannot have more than 4 N, R 1 is selected from (C 6 to C 10 ) aryl, (C 2 to C 9 ) heteroaryl, and 5-indolyl, wherein each of the said (C 6 to C 10 ) aryl and (C 2 to C 9 ) heteroaryl is substituted with at least one R 4a group, and wherein said (C 2 to C 9 ) heteroaryl is C-attached, and R 2 is selected from the group consisting of (i), (ii), (iii), and (iv).

    Abstract translation: 本发明涉及结构式I的化合物，其中A，D和E独立地为N或CR 3，G，H和J独立地为N或C ，K是N或CH，L是N，NR 3或CR 3，并且A，D，E，G，H，J，K和L一起不能 具有多于4个N，R 1选自（C 6至C 10）芳基，（C 2 其中每个所述（C 6至C 10）芳基和（C 6至C 10）芳基各自独立地选自氢， 2至C 9）杂芳基被至少一个R 4a基团取代，并且其中所述（C 2至C 4） （i），（ii），（iii）和（iv）组成的组中，R 2是C连接的，且R 2选自（i），（ii），（iii）和（iv）。

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