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    METHODS AND APPARATUS FOR INFORMATION GATHERING, ERROR DETECTION AND ANALYTE CONCENTRATION DETERMINATION DURING CONTINUOUS ANALYTE SENSING
    2.
    发明申请
    METHODS AND APPARATUS FOR INFORMATION GATHERING, ERROR DETECTION AND ANALYTE CONCENTRATION DETERMINATION DURING CONTINUOUS ANALYTE SENSING 审中-公开

    公开(公告)号：WO2021048190A2

    公开(公告)日：2021-03-18

    申请号：PCT/EP2020/075174

    申请日：2020-09-09

    Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

    Inventor： WU, Huan-Ping

    IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1495

    Abstract: A continuous glucose monitoring (CGM) device may include a wearable portion having a sensor configured to produce glucose signals from interstitial fluid, a processor, a memory and transmitter circuitry. The memory may include a pre-determined gain function based on a point-of-interest glucose signal and glucose signals measured prior to the point-of-interest glucose signal. The memory may also include computer program code stored therein that, when executed by the processor, causes the CGM device to (a) measure and store a plurality of glucose signals using the sensor and memory; (b) for a presently-measured glucose signal, employ the plurality of previously-measured glucose signals stored in the memory and the pre-determined gain function to compute a compensated glucose value; and (c) communicate the compensated glucose value to a user of the CGM device. Numerous other embodiments are provided.

    APPARATUS AND METHODS FOR PROBING SENSOR OPERATION OF CONTINUOUS ANALYTE SENSING AND AUTO-CALIBRATION
    3.
    发明申请
    APPARATUS AND METHODS FOR PROBING SENSOR OPERATION OF CONTINUOUS ANALYTE SENSING AND AUTO-CALIBRATION 审中-公开

    公开(公告)号：WO2020161099A1

    公开(公告)日：2020-08-13

    申请号：PCT/EP2020/052673

    申请日：2020-02-04

    Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

    Inventor： WU, Huan-Ping ,  CERUTTI, Mark D.

    IPC: A61B5/145 ,  A61B5/1495

    Abstract: Apparatus and methods are operative to probe the condition of a sensor either initially, at any point thereafter or continuously during a continuous sensor operation for measuring an analyte in a bodily fluid (such as performed by, e.g., a continuous glucose monitoring (CGM) sensor). Results of the probe may include calibration indices determined from electrical signals obtained during the probe. The calibration indices may indicate whether in-situ adjustment of the sensor-s calibration should be performed either initially and/or at random check points. Probing potential modulation parameters also may be used during analyte calculations to reduce the effects of lot-to-lot sensitivity variations, sensitivity drift during monitoring, temperature, interferents, and/or the like. Other aspects are disclosed.

    RISK FACTOR MONITORING
    6.
    发明申请
    RISK FACTOR MONITORING 审中-公开

    公开(公告)号：WO2018104835A1

    公开(公告)日：2018-06-14

    申请号：PCT/IB2017/057584

    申请日：2017-12-01

    Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

    Inventor： WU, Huan-Ping

    IPC: G01N27/327

    Abstract: Methods, devices, and systems are disclosed for the determination and logging of risk factor parameters associated with a sample, in association with the measurement of a concentration of an analyte in the sample. The methods, devices, and systems provide for applying an input signal to a sample via an electrode. The input signal has at least one excitation. The methods, devices, and systems further provide for measuring an output signal responsive to the input signal. The methods, devices, and systems further provide for determining a concentration of an analyte within the sample based on the output signal, and determining at least one risk factor parameter associated with at least one species in the sample other than the analyte.

    METHOD FOR ELECTROCHEMICAL ANALYSIS BY USE OF ALTERNATING OUTPUT SIGNALS FROM TWO ELECTRODES
    7.
    发明申请
    METHOD FOR ELECTROCHEMICAL ANALYSIS BY USE OF ALTERNATING OUTPUT SIGNALS FROM TWO ELECTRODES 审中-公开
    用两个电极交替输出信号进行电化学分析的方法

    公开(公告)号：WO2018011692A1

    公开(公告)日：2018-01-18

    申请号：PCT/IB2017/054133

    申请日：2017-07-07

    Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

    Inventor： WU, Huan-Ping ,  WARCHAL-WINDHAM, Mary Ellen ,  HARRISON, Bern, Everett ,  ELLIS, Nicole, D.

    IPC: G01N27/327

    Abstract: Devices and methods for determining one or more analyte concentrations in a sample, determining a sample type, and/or accounting for interference species in a sample are disclosed that include intertwining a first input signal, via a first electrode having a reagent, with a second input signal, via a second electrode lacking a reagent, by applying to the sample the first input signal having at least two excitations and a relaxation, and applying to the sample the second input signal having at least two excitations and a relaxation, such that the excitations of the first input signal are nonconcurrent with the excitations of the second input signal. The method further includes measuring a first output signal responsive to the first input signal and a second output signal responsive to the second input signal.

    Abstract translation: 公开了用于确定样本中的一个或多个分析物浓度，确定样本类型和/或考虑样本中的干扰物种的设备和方法，其包括将第一输入信号经由第一输入信号 通过向样品施加具有至少两次激发和弛豫的第一输入信号并且向样品施加具有至少两个第二输入信号的第二输入信号，所述第二输入信号具有第二输入信号，经由没有试剂的第二电极， 激励和松弛，使得第一输入信号的激励不与第二输入信号的激励同时发生。 该方法还包括响应于第一输入信号和响应于第二输入信号的第二输出信号测量第一输出信号。

    RISK FACTOR MONITORING
    9.
    发明申请
    RISK FACTOR MONITORING 审中-公开

    公开(公告)号：WO2018104835A9

    公开(公告)日：2018-06-14

    申请号：PCT/IB2017/057584

    申请日：2017-12-01

    Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

    Inventor： WU, Huan-Ping

    IPC: G01N27/327

    Abstract: Methods, devices, and systems are disclosed for the determination and logging of risk factor parameters associated with a sample, in association with the measurement of a concentration of an analyte in the sample. The methods, devices, and systems provide for applying an input signal to a sample via an electrode. The input signal has at least one excitation. The methods, devices, and systems further provide for measuring an output signal responsive to the input signal. The methods, devices, and systems further provide for determining a concentration of an analyte within the sample based on the output signal, and determining at least one risk factor parameter associated with at least one species in the sample other than the analyte.

    IMPROVED BIOSENSOR SYSTEM ANALYTE MEASUREMENT
    10.
    发明申请
    IMPROVED BIOSENSOR SYSTEM ANALYTE MEASUREMENT 审中-公开
    改进的生物传感器系统分析测量

    公开(公告)号：WO2016185352A1

    公开(公告)日：2016-11-24

    申请号：PCT/IB2016/052800

    申请日：2016-05-13

    Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

    Inventor： WU, Huan-Ping

    IPC: G01N27/327

    CPC classification number: G01N27/3274 ,  G01N27/3272 ,  G01N27/3275

    Abstract: Methods and biosensor systems for compensating an analyte measurement are provided. The methods and systems determine a secondary output signal based on the measured primary output signal in order to better approximate the effects of an extraneous stimulus on the primary output signal under actual measurement conditions. The methods and systems according to the present disclosure may provide a more accurate analyte measurement, and may be particularly useful in detecting and compensating an analyte measurement during an off-condition.

    Abstract translation: 提供了用于补偿分析物测量的方法和生物传感器系统。 方法和系统基于所测量的初级输出信号来确定次级输出信号，以便在实际测量条件下更好地近似外部刺激对初级输出信号的影响。 根据本公开的方法和系统可以提供更准确的分析物测量，并且可以特别用于在关闭状态期间检测和补偿分析物测量。

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