公开(公告)号：WO2022029161A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071740

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping ,  CERUTTI, Mark D.

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function value and the primary current signal; determining a connection function based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are provided.

公开(公告)号：WO2022029164A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071743

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping ,  CERUTTI, Mark D. ,  HARRISON, Bern

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function and a ratio of measured probing potential modulation current signals; determining a connection function value based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are disclosed.

公开(公告)号：WO2022269568A1

公开(公告)日：2022-12-29

申请号：PCT/IB2022/055901

申请日：2022-06-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： MUYRES, Dawn V. ,  KENNEDY, Stephen M. ,  DAI, Minghua

IPC: A61B5/145 ,  A61B5/00 ,  A61M5/168 ,  A61B5/053 ,  A61B5/25 ,  A61B5/1451 ,  A61B5/6833 ,  A61B5/685 ,  A61M2005/1588

Abstract: The present disclosure provides an article for detecting extravasation into a tissue. The article includes a body having a first major surface, an opposing second major surface, a first side, and an opposing second side. The article further includes a first electrode disposed on the first major surface of the body. The first electrode includes at least one skin-penetrating microfeature. The article further includes a second electrode disposed on the first major surface of the body. The second electrode includes at least one skin-penetrating microfeature. The first electrode is electrically connected to the second electrode.

公开(公告)号：WO2022207618A2

公开(公告)日：2022-10-06

申请号：PCT/EP2022/058226

申请日：2022-03-29

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： AVIROVIKJ, Dragan ,  TAYLOR, Jon

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B2560/0214 ,  A61B2560/045 ,  A61B2560/0456 ,  A61B2560/063 ,  A61B2562/164 ,  A61B2562/227 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6848 ,  A61B5/688 ,  A61B5/742

Abstract: A wearable continuous analyte monitoring (CAM) device includes a disposable sensor unit and a long-life reusable transmitter unit. The transmitter unit has no power source and has an enclosure that seals wireless transmitter circuitry within. The disposable sensor unit is configured to receive and provide power to the transmitter unit therein. Upon expiration of the disposable sensor unit, the transmitter unit can be removed from the disposable sensor unit and reused in another disposable sensor unit with a fresh power source. The CAM device has a cover constructed of a fabric material to improve aesthetics and feel of the CAM device. Methods of preparing and applying the CAM device to a user' s skin are also provided, as are other aspects.

公开(公告)号：WO2022029165A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071744

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A biosensor system is configured to establish a steady-state condition and alternate between the steady-state condition and a non-steady-state condition to determine an analyte concentration. The biosensor system includes an electrode system having at least one working electrode and one counter electrode. The working electrode is covered with an analyte catalyzing layer for converting an analyte into measurable species. A membrane system encompasses the electrode system and comprises an analyte permeable membrane. The membrane has an analyte permeability with lower analyte solubility than an analyte solubility outside the membrane. The membrane is configured to trap a measureable species within the membrane such that a steady-state of the measurable species resulting from the analyte is established near the electrode surface. A bias circuit is configured to apply a potential modulation sequence to the working electrode to cause alternating of steady-state and non-steady-state conditions within the electrode system for analyte concentration determination.

公开(公告)号：WO2021245131A1

公开(公告)日：2021-12-09

申请号：PCT/EP2021/064783

申请日：2021-06-02

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： RUSSO, Anthony P.

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/6833 ,  A61B5/6849 ,  A61B5/7225 ,  A61B5/725 ,  A61B5/7275 ,  G16H40/63

Abstract: A method of filtering a signal in a continuous analyte monitoring (CAM) system includes applying time-varying filtering to the signal using a time-varying filter to generate a filtered continuous analyte' monitoring signal during an analyte monitoring period. Other methods, apparatus, continuous analyte monitoring devices, and continuous glucose monitoring devices are also disclosed.

公开(公告)号：WO2022084539A1

公开(公告)日：2022-04-28

申请号：PCT/EP2021/079414

申请日：2021-10-22

Applicant: RSP SYSTEMS A/S [DK]/[DK]

Inventor： SCHJOLDAGER NIELSEN, Martin ,  GIBSON, Joshua, John ,  WATSON, Thomas, James

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B2562/04 ,  A61B2562/046 ,  A61B5/0075 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/7203 ,  G01J3/44 ,  G01N21/65

Abstract: The present invention relates to an apparatus and method for non-invasive in vivo measurement, by Raman spectroscopy, of glucose present in interstitial fluid in the skin of a subject. The apparatus comprises at least one detector; a plurality of vertical-cavity surface-emitting lasers spatially distributed around the at least one detector, for irradiating the skin of a subject; wherein the at least one detector is configured to receive Raman scattered radiation transmitted from the sample in response to the received radiation from the vertical-cavity surface-emitting lasers.

公开(公告)号：WO2022029162A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071741

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping ,  CERUTTI, Mark D.

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function and a measured probing potential modulation current signal; determining a connection function value based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are disclosed.

公开(公告)号：WO2021258822A1

公开(公告)日：2021-12-30

申请号：PCT/CN2021/087334

申请日：2021-04-15

Applicant: 广东职业技术学院

Inventor： 陶文娟

IPC: A61B5/145 ,  A41D13/1281 ,  A41D27/205 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/6804 ,  A61B5/746 ,  A61M5/142 ,  G16H10/60 ,  G16H40/67

Abstract: 一种基于CGM系统的血糖实时监测智能服装系统，包括：CGM检测单元（100）、开窗式暗袋结构（200）和后台终端；将CGM检测单元（100）设置在服装的开窗式暗袋结构（200）中，通过检测探头（130）通过开窗式暗袋结构（200）的开口检测皮肤间质液血糖参数信息并通过微处理器（110）进行处理将血糖参数信息发送到后台终端进行显示；实时自动化地对血糖进行测量，不需要耗费人工，节省时间和人力，方便快捷；系统实时监控检测人体血液葡萄糖浓度，避免糖尿病患者并发症的发生。

公开(公告)号：WO2021148596A1

公开(公告)日：2021-07-29

申请号：PCT/EP2021/051437

申请日：2021-01-22

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： PRAIS, Eugene ,  AVIROVIKJ, Dragan ,  MAYER, JR., Thomas A.J. ,  YOUNG, Cameron M. ,  GOFMAN, Igor Y.

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B2560/0214 ,  A61B2560/045 ,  A61B2562/164 ,  A61B2562/18 ,  A61B2562/242 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/1451 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/6802 ,  A61B5/6832 ,  A61B5/685

Abstract: In one or more embodiments, a continuous analyte monitoring wearable device includes a disposable base unit having a power source and an analyte sensor, and a reusable transmitter unit that includes electronic circuitry configured to bias the analyte sensor, measure current through the analyte sensor, and, in some embodiments, even compute analyte values based on measured current through the analyte sensor. The disposable base unit is configured to couple to the reusable transmitter unit and supply electrical power to the electronic circuitry of the reusable transmitter unit for continuous analyte monitoring. Numerous other embodiments are provided.