公开(公告)号：WO1996032025A1

公开(公告)日：1996-10-17

申请号：PCT/US1996005266

申请日：1996-04-15

Applicant: BIOELASTICS RESEARCH LTD. ,  UAB RESEARCH FOUNDATION ,  UNIVERSITY OF BRISTOL

Inventor： BIOELASTICS RESEARCH LTD. ,  UAB RESEARCH FOUNDATION ,  UNIVERSITY OF BRISTOL ,  URRY, Dan, W. ,  SHEWRY, Peter, R. ,  KARI, Umamaheswara, Prasad

IPC: A23L01/236

CPC classification number: A23G4/14 ,  A21D2/26 ,  A23G4/08 ,  A23J1/007 ,  A23J1/008 ,  A23J1/12 ,  A23L27/70 ,  A23L29/281 ,  A23L33/17

Abstract: The invention provides a method for improving the texture of a food product by incorporating in the food product or a precursor of the food product a bioelastic polypeptide in an amount sufficient to increase the elasticity of the food product, the bioelastic polypeptide having tetrapeptide or pentapeptide repeating units or mixtures thereof and the repeating units existing in a conformation having a beta -turn. The invention also provides a method for binding a food product precursor by adding a bioelastic polypeptide in an amount sufficient to bind the food product precursor, the bioelastomer having tetrapeptide or pentapeptide repeating units or mixtures thereof and the repeating units existing in a conformation having a beta -turn. The present invention further provides a food adjunct containing a bioelastic polypeptide having tetrapeptide or pentapeptide repeating units or mixtures thereof where the repeating units exist in a conformation having a beta -turn, and an edible material suitable for human or animal consumption.

Abstract translation: 本发明提供了一种通过在食物产品或食品前体中掺入足以增加食品弹性的量的生物弹性多肽来改善食品的质地的方法，所述生物弹性多肽具有四肽或五肽重复 单元或其混合物，并且存在具有β-折点的构象的重复单元。 本发明还提供了通过添加足以结合食品前体的量的生物弹性多肽来结合食品前体的方法，所述生物弹性体具有四肽或五肽重复单元或其混合物，并且存在于具有β -转。 本发明进一步提供了一种含有具有四肽或五肽重复单元或其混合物的生物弹性多肽的食品添加剂，其中重复单元以具有β转角的构象存在，以及适用于人或动物消费的可食用材料。

公开(公告)号：WO1996032406A1

公开(公告)日：1996-10-17

申请号：PCT/US1996005186

申请日：1996-04-15

Applicant: BIOELASTICS RESEARCH LTD. ,  UAB RESEARCH FOUNDATION

Inventor： BIOELASTICS RESEARCH LTD. ,  UAB RESEARCH FOUNDATION ,  URRY, Dan, W ,  McPHERSON, David, T. ,  XU, Jie

IPC: C07K01/14

CPC classification number: C07K14/78 ,  C07K14/001

Abstract: A method for purifying an artificial polymer that exhibits a reversible inverse temperature transition is provided. The method involves (a) dissolving the polymer in an aqueous medium so that the temperature of the medium is below the effective transition temperature; (b) adjusting the temperature of the aqueous medium relative to the effective transition temperature of the polymer; (c) removing any particulate material from the medium; (d) adjusting the temperature of the aqueous medium relative to the effective transition temperature of the polymer so that the temperature of the medium is above the effective transition temperature; (e) collecting the polymer from the medium as a more dense phase; and (f) optionally repeating any of steps (a)-(e) until a desired level of purity is reached; with the proviso the order of steps can be (a)-(d)-(e)-(a)-(b)-(c).

Abstract translation: 提供了一种纯化呈现出可逆逆温转变的人造聚合物的方法。 该方法包括（a）将聚合物溶解在水性介质中，使得介质的温度低于有效转变温度; （b）相对于聚合物的有效转变温度调节水性介质的温度; （c）从介质中除去任何颗粒物质; （d）相对于聚合物的有效转变温度调节水性介质的温度，使得介质的温度高于有效转变温度; （e）从介质中收集聚合物作为更致密的相; 和（f）任选地重复步骤（a） - （e）中的任何步骤，直到达到所需的纯度水平; 条件是步骤的顺序可以是（a） - （d） - （e） - （a） - （b） - （c）。

公开(公告)号：WO1995006743A2

公开(公告)日：1995-03-09

申请号：PCT/US1994009205

申请日：1994-08-16

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  DONG, Jianyun ,  FRIZZELL, Raymond, A.

IPC: C12N15/86

CPC classification number: C12N7/00 ,  C07K14/4712 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10361 ,  C12N2710/16643 ,  C12N2740/13043 ,  C12N2750/14143

Abstract: This invention provides novel methods and compositions for use in the efficient and large-scale production of recombinant adeno-associated virus (AAV). Described herein are new producer cell lines, recombinant adenovirus or herpes virus vectors and AAV constructs. Also disclosed are particularly advantageous methods of using such materials to produce recombinant AAV virions using only the efficient process of viral infection, without requiring transfection steps. The AAV produced may be used in a variety of embodiments including, for example, for transferring exogenous genes into human cell lines and for use in human gene therapy regimens.

Abstract translation: 本发明提供了用于有效和大规模生产重组腺相关病毒（AAV）的新型方法和组合物。 本文描述了新的生产细胞系，重组腺病毒或疱疹病毒载体和AAV构建体。 还公开了使用这种材料以仅使用病毒感染的有效方法产生重组AAV病毒体的特别有利的方法，而不需要转染步骤。 所生产的AAV可用于多种实施方案中，包括例如将外源基因转移到人细胞系中并用于人基因治疗方案中。

公开(公告)号：WO1993010798A1

公开(公告)日：1993-06-10

申请号：PCT/US1992010453

申请日：1992-12-04

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  GEISERT, Eldon, E., Jr.

IPC: A61K35/14

CPC classification number: C07K16/28 ,  A61K39/39533 ,  C07K14/705 ,  A61K2300/00

Abstract: A monoclonal antibody directed against a novel cell adhesion molecule of glial cells has been developed. The glial cell adhesion molecule is characterized by a molecular weight of around 106 kDa. The antibody is specific for the glial cell adhesion molecule and is marked by an ability to disrupt the formation of gliotic scars in damaged nerve tissue.

Abstract translation: 已经开发了针对胶质细胞的新型细胞粘附分子的单克隆抗体。 胶质细胞粘附分子的特征在于分子量约为106kDa。 该抗体对于神经胶质细胞粘附分子是特异性的，并且具有破坏受损神经组织中胶质性瘢痕形​​成的能力。

公开(公告)号：WO1992020698A1

公开(公告)日：1992-11-26

申请号：PCT/US1992003999

申请日：1992-05-18

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  MILLER, Donald, M.

IPC: C07H21/04

CPC classification number: C12N15/113 ,  A61K47/549 ,  C07H21/00 ,  C12N15/1132 ,  C12N15/1135 ,  C12N2310/15 ,  C12N2310/3511

Abstract: A sequence specific DNA binding molecule which comprises an oligonucleotide conjugate formed by the covalent attachment of a DNA binding drug to a triplex forming oligonucleotide and a method of modulating gene expression comprising administering to a mammal in need thereof said sequence specific binding molecule.

Abstract translation: 序列特异性DNA结合分子，其包含通过DNA结合药物共价连接到形成三链体的寡核苷酸形成的寡核苷酸缀合物和调节基因表达的方法，其包括对需要的哺乳动物施用所述序列特异性结合分子。

公开(公告)号：WO1992008466A1

公开(公告)日：1992-05-29

申请号：PCT/US1991008366

申请日：1991-11-08

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  ESKO, Jeffery, D. ,  LUGEMWA, Fulgentius, N.

IPC: A61K31/58

CPC classification number: A61K31/58 ,  A61K31/70

Abstract: Conjugates of β-D-xylose with estrogens or modified forms of estrogens are effective in stimulating the synthesis of heparan sulfate, and inhibiting the production of proteoglycan in animal subjects. Accordingly, these conjugates are useful in treating conditions where antithrombotic or antiproliferative activity is desirable.

公开(公告)号：WO1989010100A1

公开(公告)日：1989-11-02

申请号：PCT/US1989001483

申请日：1989-04-14

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  URRY, Dan, W.

IPC: A61F02/02

CPC classification number: A61L27/507 ,  A61F2/06 ,  A61F2210/0004 ,  A61L27/227 ,  A61L27/34 ,  A61L27/50 ,  C07K1/1075 ,  C07K14/46 ,  C07K14/78 ,  C08L89/00

Abstract: A vascular prosthetic material having at least one layer containing an elastomeric material capable of reversibly contracting and relaxing by an inverse temperature transition. The vascular prosthetic material matches the compliance and elasticity of vessels replaced, and is biocompatible and biodegradable. The material may also have incorporated therein chemotactic peptides and cell attachment sequences.

Abstract translation: 一种血管修复材料，其具有至少一层，其含有能够通过反向温度转变而可逆地收缩和松弛的弹性材料。 血管修复材料匹配替代血管的顺应性和弹性，并且是生物相容性和可生物降解的。 该材料还可以掺入趋化肽和细胞附着序列。

公开(公告)号：WO1998011939A1

公开(公告)日：1998-03-26

申请号：PCT/US1997016382

申请日：1997-09-16

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  KNISLEY, Stephen, B.

IPC: A61N01/00

CPC classification number: A61N1/056 ,  A61N1/0587

Abstract: An electrode terminal (12) is disclosed for delivering a stimulation pulse to the heart or other tissues containing a linear array of fibers (14). The electrode terminal (12) is elongated and adapted for orientation in a direction parallel to the tissue fibers (14). The device of the present invention further includes a power source (26) for electrically energizing the terminal such that the energizing of the terminal reduces the non-uniformity of the transmembrane voltage change in the tissue proximate the electrode which is produced during the stimulation pulse. Nonuniform transmembrane voltage changes are associated with arrhythmic conditions. The linear electrode of the present invention can be used for cardiac pacing, defibrillation, and the termination of tachycardia.

Abstract translation: 公开了用于将刺激脉冲传送到包含线性阵列纤维（14）的心脏或其他组织的电极端子（12）。 电极端子（12）是细长的并且适于在平行于组织纤维（14）的方向上取向。 本发明的装置还包括用于对端子进行电激励的电源（26），使得端子的通电减少了在刺激脉冲期间产生的靠近电极的组织中的跨膜电压变化的不均匀性。 不均匀的跨膜电压变化与心律失常状况有关。 本发明的线性电极可以用于心脏起搏，除颤和心动过速的终止。

公开(公告)号：WO1997043806A3

公开(公告)日：1997-11-20

申请号：PCT/US1997008240

申请日：1997-05-15

Applicant: UAB RESEARCH FOUNDATION ,  MIROV, Sergey, B.

Inventor： UAB RESEARCH FOUNDATION

IPC: H01S3/082

Abstract: A superbroadband or multiwavelength laser transmitter source for wavelength-division multiplexing, two-wavelength interferometry, differential lidar and optical storage applications. The superbroadband laser (100) simultaneously emits at multiple wavelengths. The system maintains simultaneous lasing operation in an optical active gain medium at different wavelengths by the use of dispersive cavity. The system creates its own microcavities each lasing at a different wavelength within the fluorescence band of the gain medium. Mode competition in the cavity is absent and spectral range of simultaneous multi-frequency generation is considerably enhanced practically to the spectral width of the active media luminescence spectrum. As a result, the radiation of each mode with its own wavelength is amplified in the active media independently from the simultaneous amplification of the rest of the wavelengths.

公开(公告)号：WO1996039113A2

公开(公告)日：1996-12-12

申请号：PCT/IB1996001051

申请日：1996-05-31

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  BRILES, David, E. ,  McDANIEL, Larry, S. ,  YAMAMOTO, Masafumi ,  KIYONO, Hiroshi

IPC: A61K00/00

CPC classification number: A61K39/092 ,  Y02A50/472

Abstract: Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, wich can lead to elimination of disease from the population as a whole.

Abstract translation: 口服或口服给药，包括胃内杀死的全肺炎球菌，肺炎球菌的裂解物和分离和纯化的PspA，以及其免疫原性片段，特别是当与佐剂如霍乱毒素一起施用时，在宿主，动物或人中提供保护， 肺炎球菌感染，包括定植和全身感染，如败血症。 在宿主中引发针对肺炎球菌定居的保护能力防止免疫个体之间的运输，这可能导致整体上消除疾病。